Activation of the inositol phospholipid signaling system by receptors for extracellular ATP in human neutrophils, monocytes, and neutrophil/monocyte progenitor cells.

Abstract:

:We have presented evidence indicating that P2-purinergic receptors may activate the polyphosphoinositide-phospholipase C in HL60 cells via the mediation of a pertussis-toxin-sensitive GTP-binding protein, which also mediates the actions of chemotactic peptide receptors in these and other phagocytic white blood cells. However, our data also suggest that these same receptors can be coupled to the phospholipase via an additional pertussis-toxin-insensitive mechanism. This latter finding raises the possibility that undifferentiated HL60 cells express two distinct GTP-binding proteins coupled to phospholipase C; one of these is very likely to be the GHL/GC protein recently isolated from this cell line. Significantly, the data of Oinuma et al. and Falloon et al. indicate that expression of the 40-kDa alpha-subunit/toxin substrate increases upon differentiation of HL60 cells along the granulocyte pathway. It would be interesting to determine whether expression of the putative pertussis-toxin-insensitive G-protein decreases with differentiation of these and other myelomonocytic progenitor cells. Such studies, which are now in progress, should be facilitated by the fact that the P2-purinergic receptors appear to be expressed in myelopoietic cells from the promyelocytic/promonocytic stages through the terminally differentiated stages represented by circulating neutrophils and monocytes.

journal_name

Ann N Y Acad Sci

authors

Dubyak GR,Cowen DS,Lazarus HM

doi

10.1111/j.1749-6632.1988.tb22339.x

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

218-37; discussion 237-8

eissn

0077-8923

issn

1749-6632

journal_volume

551

pub_type

杂志文章
  • Psychobiology of sleep disturbances in posttraumatic stress disorder.

    abstract::Sleep disturbances are prominent complaints of PTSD patients. Some, but not all, of the polysomnographic studies support the occurrence of sleep disruption. The main dimensions of sleep disturbance in the disorder relate to arousal regulation and REM-related functions of dreaming and memory processing. Both of these i...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1997.tb48275.x

    authors: Mellman TA

    更新日期:1997-06-21 00:00:00

  • What does the head impulse test versus caloric dissociation reveal about vestibular dysfunction in Ménière's disease?

    abstract::In patients with Ménière's disease (MD), caloric testing can show, depending on the stage and activity of the disease, a variety of results. Between attacks, many, or perhaps even most, patients with unilateral early or mild MD have normal caloric tests; late MD can show abnormalities ranging from mild to severe unila...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/nyas.12687

    authors: McGarvie LA,Curthoys IS,MacDougall HG,Halmagyi GM

    更新日期:2015-04-01 00:00:00

  • Preliminary assessment of genome differences between the reference Nine Mile isolate and two human endocarditis isolates of Coxiella burnetii.

    abstract::This study investigates the complete genome sequences of the Nine Mile, K, and G isolates to improve our understanding of the unique virulence properties of C. burnetii and to provide important insight into the genome architecture and genetic diversity of this pathogen. ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1355.007

    authors: Beare PA,Porcella SF,Seshadri R,Samuel JE,Heinzen RA

    更新日期:2005-12-01 00:00:00

  • Complex interaction of alpha(2)-adrenoceptor binding sites with bovine brain and lung extracts containing clonidine-displacing substance.

    abstract::Previous studies have established that methanolic extracts of bovine brain and lung possess CDS activity with an agonist-like profile at alpha(2)-adrenoceptor binding sites (i.e., greater potency against [(3)H]-clonidine sites than against [(3)H]-RX-821001 sites). Following prolonged reflux in ethylacetate, monovalent...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1304.026

    authors: Pinthong D,Kendall DA,Wilson VG

    更新日期:2003-12-01 00:00:00

  • Cellular resistance to arbovirus infection.

    abstract::When an arbovirus enters an arthropod in an infected blood meal, several mechanisms may interact to affect its life cycle and ultimate transmissibility. Intrinsic absolute failure in the establishment of infection must be contrasted with infection that is successfully established but is variably modulated in its viral...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1975.tb35101.x

    authors: Murphy FA

    更新日期:1975-01-01 00:00:00

  • Dorsally derived spinal interneurons in locomotor circuits.

    abstract::During neuronal circuit formation, axons are guided to their targets by the help of axon guidance molecules, which are required for establishing functional circuits. A promising system to dissect the development and functionalities of neuronal circuitry is the spinal cord central pattern generator (CPG) for locomotion...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2012.06801.x

    authors: Vallstedt A,Kullander K

    更新日期:2013-03-01 00:00:00

  • The effects of resveratrol and SIRT1 activation on dystrophic cardiomyopathy.

    abstract::The muscular dystrophies, which cause progressive weakening of the skeletal muscles, are frequently associated with cardiomyopathy. In fact, the leading cause of mortality in patients with Duchenne muscular dystrophy, the most common and most severe type of muscular dystrophy, is heart failure due to cardiomyopathy. T...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12812

    authors: Kuno A,Tanno M,Horio Y

    更新日期:2015-08-01 00:00:00

  • Prior chronic in vivo glucocorticoid excess leads to an anabolic phenotype and an extension of cellular life span of skin fibroblasts in vitro.

    abstract::Intense stress can be detrimental for tissue homeostasis and accelerates aging. On the other hand, repeated mild stresses can have beneficial and even life-prolonging effects. Hypersecretion of glucocorticoids (GCs) represents the major hormonal response to stress. However, besides its life-sustaining role, GC excess ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1395.050

    authors: Kletsas D,Pratsinis H,Gioni V,Pilichos K,Yiacoumettis AM,Tsagarakis S

    更新日期:2007-04-01 00:00:00

  • Senescence marker protein-30 knockout mouse as an aging model.

    abstract::A mouse strain lacking SMP30 can be regarded as a strain showing ultimate decrease of the SMP30 molecule. After three months of age, SMP30-KO mice had an increased mortality rate, compared with the SMP30-WT mice, all of which remained alive. Electron microscopic observation of the hepatocytes from 12-month-old SMP30-K...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1297.068

    authors: Maruyama N,Ishigami A,Kuramoto M,Handa S,Kubo S,Imasawa T,Seyama K,Shimosawa T,Kasahara Y

    更新日期:2004-06-01 00:00:00

  • Indications of centromere movement during interphase and differentiation.

    abstract::Mouse and human DNA sequences from centromeric and ribosomal domains were labeled with biotinylated deoxynucleotides and hybridized in situ to paraformaldehyde-fixed tissue culture cells. Centromeres were widely dispersed in most of these interphase nuclei. At late G2 phases of the cell cycle, centromeres appeared to ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1985.tb21494.x

    authors: Manuelidis L

    更新日期:1985-01-01 00:00:00

  • Mutant DNA in plasma of lung cancer patients: potential for monitoring response to therapy.

    abstract::The hypothesis tested was that mutant tumor DNA shed into plasma would show predictive value for monitoring response to therapy in non-small cell lung carcinoma patients. Pretreatment plasma specimens from 25 patients on a phase I trial were evaluated, 12 with paired posttreatment specimens, and 138 patients on the So...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1318.010

    authors: Kimura T,Holland WS,Kawaguchi T,Williamson SK,Chansky K,Crowley JJ,Doroshow JH,Lenz HJ,Gandara DR,Gumerlock PH

    更新日期:2004-06-01 00:00:00

  • Surface morphology of the human endometrium. Basic and clinical aspects.

    abstract::The human endometrium is an extremely sensitive target for steroid hormones. During the menstrual cycle, this tissue undergoes dynamic changes that are reflected on the surface morphology of the epithelium and that can be followed by scanning electron microscopy. The morphologic changes peak at the midsecretory phase,...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2000.tb06244.x

    authors: Nikas G,Makrigiannakis A,Hovatta O,Jones HW Jr

    更新日期:2000-01-01 00:00:00

  • Oncogenes and phosphatidylinositol turnover.

    abstract::Products of phosphatidylinositol turnover have recently been implicated as regulators of cell growth and differentiation. Transformation of cells in culture by infection with certain viruses (Rous sarcoma virus, Kirsten sarcoma virus, and polyoma virus) or by transfection with the oncogenes carried by these viruses af...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1986.tb46580.x

    authors: Cantley LC,Whitman M,Chahwala S,Fleischman L,Kaplan DR,Schaffhausen BS,Roberts TM

    更新日期:1986-01-01 00:00:00

  • Audiovisual interactions in music reading. A reaction times and event-related potentials study.

    abstract::The general aim of this experiment was to investigate the processes involved in reading musical notation and to study the relationship between written music and its auditory representation. Our main interest was to determine if musicians can develop expectancies for plausible or implausible auditory events on the sole...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1284.028

    authors: Schön D,Besson M

    更新日期:2003-11-01 00:00:00

  • Surgical ablation of whitened interscapular brown fat ameliorates cardiac pathology in salt-loaded metabolic syndrome rats.

    abstract::Brown adipose tissue (BAT) is an endocrine organ that contributes to thermogenesis and energy consumption. We investigated the effects of salt loading and surgical removal of whitened interscapular BAT (iBAT) on cardiac and adipose tissue pathology in DahlS.Z-Leprfa /Leprfa (DS/obese) rats, an animal model of metaboli...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/nyas.14546

    authors: Komatsu Y,Aoyama K,Yoneda M,Ito S,Sano Y,Kawai Y,Cui X,Yamada Y,Furukawa N,Ikeda K,Nagata K

    更新日期:2020-12-19 00:00:00

  • Treatment of suicidality in schizophrenia.

    abstract::Between 4 and 13% of people with schizophrenia commit suicide and between 25 and 50% make a suicide attempt, a reflection of the devastating toll this syndrome takes on the quality of life, that is, the subjective and objective sense of well-being. Many risk factors for suicide in schizophrenia have been identified, t...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2001.tb05797.x

    authors: Meltzer HY

    更新日期:2001-04-01 00:00:00

  • The esophageal mucosa and submucosa: immunohistology in GERD and Barrett's esophagus.

    abstract::This paper presents commentaries on the microscopic morphology of esophageal squamous epithelium; the frequency of duplication of the muscularis mucosae (MM) in Barrett's esophagus (BE); the significance of multilayered epithelium; whether cells in the lamina propria reflect those in the epithelium; how stem cells are...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12241

    authors: Appelman HD,Streutker C,Vieth M,Neumann H,Neurath MF,Upton MP,Sagaert X,Wang HH,El-Zimaity H,Abraham SC,Bellizzi AM

    更新日期:2013-10-01 00:00:00

  • Comparative DNA microarray analysis of host cell transcriptional responses to infection by Coxiella burnetii or Chlamydia trachomatis.

    abstract::DNA microarray analysis was conducted to investigate the transcriptional responses of the human monocytic leukemia cell line THP-1 to infection by Chlamydia trachomatis or Coxiella burnetii. RNA was isolated from mock infected cells and cells infected for 36 hours using TRIzol reagent. Biotinylated probes synthesized ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2003.tb07447.x

    authors: Ren Q,Robertson SJ,Howe D,Barrows LF,Heinzen RA

    更新日期:2003-06-01 00:00:00

  • Congenital lymphatic malformations.

    abstract::"Vascular anomalies" represents a spectrum of vascular lesions, of unclear etiology and often with unpredictable behavior. Patients with vascular anomalies represent a unique population, in that they have focal aberrations of vascular development (in vascular malformations) or vascular proliferation (in hemangiomas). ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1413.016

    authors: Blei F

    更新日期:2008-01-01 00:00:00

  • Neurotrophic factor deprivation-induced death.

    abstract::Deprivation of sympathetic neurons of their physiological neurotrophic factor, nerve growth factor (NGF), leads to degeneration of soma and neurites, followed by loss of viability. The progression of degeneration and death are dependent upon macromolecular synthesis indicating an active participation of neuronal metab...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1993.tb18293.x

    authors: Deckwerth TL,Johnson EM Jr

    更新日期:1993-05-28 00:00:00

  • Engineering the melanocortin-4 receptor to control G(s) signaling in vivo.

    abstract::G-protein-coupled receptors (GPCRs) are the largest known family of cell surface receptors, and they control many important physiological events, including sensory perception, chemotaxis, neurotransmission, and energy homeostasis. However, GPCR signaling can be difficult to study in vivo because of the multitude of GP...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2003.tb03184.x

    authors: Srinivasan S,Vaisse C,Conklin BR

    更新日期:2003-06-01 00:00:00

  • Epigenetic regulatory mechanisms during preimplantation embryo development.

    abstract::Within the past few years, developmental scientists have switched their attention from the study of DNA sequencing to the epigenetic state of the genome. Studying epigenetics could present the key to understanding gene expression changes without altering the basic structure of DNA. For example, the blastocyst, trophec...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2010.05937.x

    authors: Palini S,De Stefani S,Scala V,Dusi L,Bulletti C

    更新日期:2011-03-01 00:00:00

  • The course of myasthenia gravis and therapies affecting outcome.

    abstract::The course of 1,487 patients with myasthenia gravis followed between 1940 and 1985 for a mean of 18 years provides further evidence that the distribution, severity, and outcome of the disease are determined during the first 1 to 3 (occasionally 5) years after onset, suggesting that injury to acetylcholine receptors oc...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 历史文章,杂志文章,评审

    doi:10.1111/j.1749-6632.1987.tb51317.x

    authors: Grob D,Arsura EL,Brunner NG,Namba T

    更新日期:1987-01-01 00:00:00

  • High performance perfluoropolymer films and membranes.

    abstract::Membrane processes are receiving increasing attention in the scientific community and in industry because in many cases they offer a favorable alternative to processes that are not easy to achieve by conventional routes. In this context, membranes made with perfluorinated polymers are of particular interest because of...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2003.tb06002.x

    authors: Arcella V,Ghielmi A,Tommasi G

    更新日期:2003-03-01 00:00:00

  • Quinolinic acid accumulation during neuroinflammation. Does it imply excitotoxicity?

    abstract::It is often proposed that quinolinic acid (QUIN) contributes to the pathophysiology of neuroinflammation because this kynurenine pathway metabolite is a selective agonist of N-methyl-D-aspartate (NMDA) receptors, and both its brain tissue and cerebrospinal fluid concentrations increase markedly with inflammation. Howe...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2001.tb03605.x

    authors: Obrenovitch TP

    更新日期:2001-06-01 00:00:00

  • A Swedish/European view of bioterrorism.

    abstract::Bioterrorism includes possible use of Weapons of Mass Destruction (WMD), preferably biological agents, by non-state terrorist groups as well as criminal clusters. The threat from terrorists to utilize biological agents to achieve goals is not new, but the threshold to realize the threats seems to be lower than previou...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:

    authors: Sandström G

    更新日期:2000-01-01 00:00:00

  • How youth mentoring relationships end and why it matters: a mixed-methods, multi-informant study.

    abstract::Scant empirical attention has been devoted to understanding endings in youth mentoring relationships, despite the frequency with which they occur. This study examined data from a mixed-methods study of mentoring relationship endings in which youth mentees, the youth's parents or guardians, mentors, and program staff w...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/nyas.14290

    authors: Spencer R,Keller TE,Perry M,Drew AL,Clark-Shim H,Horn JP,Miranda-Díaz M,McCormack MJ

    更新日期:2021-01-01 00:00:00

  • Functional neuroimaging of semantic and episodic musical memory.

    abstract::The distinction between episodic and semantic memory has become very popular since it was first proposed by Tulving in 1972. So far, very few neuropsychological, psychophysical, and imaging studies have related to the mnemonic aspects of music, notably on the long-term memory features, and practically nothing is known...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1360.010

    authors: Platel H

    更新日期:2005-12-01 00:00:00

  • Characterization of a leukocyte-derived endogenous mediator responsible for increased plasma fibrinogen.

    abstract::Fibrinogen has been the plasma protein most frequently studied after tissue injury. This report presents evidence that leukocytic endogenous mediator (LEM) from macrophages promotes fibrinogen synthesis. LEM has a molecular weight of 13,000-16,000, an isoelectric point (pI) at pH 7.3, is heat labile, and is inactivate...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1982.tb22148.x

    authors: Kampschmidt RF,Upchurch HF,Pulliam LA

    更新日期:1982-01-01 00:00:00

  • Ambulatory blood pressure monitoring. Application to clinical medicine and antihypertension medication trials.

    abstract::The wide use of ABPM has resulted in greater appreciation of the circadian time structure of BP variability and its clinical relevance. It is now recognized that the day-night change in BP results from an interplay of circadian rhythms in neurohumoral mechanisms coupled with temporal patterns in physical activity and ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1996.tb26724.x

    authors: Smolensky MH,Portaluppi F

    更新日期:1996-08-15 00:00:00