Compensatory responses to early olfactory restriction.

abstract：:Carboxyfullerenes, including two regioisomers C3 and D3, were investigated as antioxidants against iron-induced oxidative stress in vivo and in vitro. Both C3 and D3 dose-dependently inhibited autoxidation and iron-elevated lipid peroxidation in cortical homogenates. The antioxidative property of C3 was compared to Tr...

journal_title：Annals of the New York Academy of Sciences

authors： Lin AM,Luh TY,Chou CK,Ho LT

更新日期：1999-01-01 00:00:00

abstract：:The predominance of the evidence from our studies indicates that beta 3-adrenergic-mediated thermogenesis in interscapular BAT is impaired with age. Moreover, upon exposure to cold, beta-adrenergic responsiveness in BAT is restored. However, the exact nature of the beta 3-adrenergic upregulation is unknown. When senes...

journal_title：Annals of the New York Academy of Sciences

authors： Scarpace PJ

更新日期：1997-03-15 00:00:00

abstract：:Expression of human prolactin in the mammary gland, one of the main target organs of this hormone, leads to the formation of an autocrine-paracrine proliferative loop in this tissue. Involvement of prolactin in normal and neoplastic mammary development triggered the interest in transcriptional regulation of the human ...

journal_title：Annals of the New York Academy of Sciences

authors： Baudhuin A,Manfroid I,Van De Weerdt C,Martial JA,Muller M

更新日期：2002-11-01 00:00:00

abstract：:The amyloid-beta protein (A beta), strongly implicated in the etiology of Alzheimer's disease (AD), is formed from the amyloid-beta precursor protein (APP) through sequential proteolysis by beta- and gamma-secretases. Cleavage by gamma-secretase takes place within the middle of the single transmembrane region of APP a...

journal_title：Annals of the New York Academy of Sciences

authors： Moore CL,Diehl TS,Selkoe DJ,Wolfe MS

更新日期：2000-01-01 00:00:00

abstract：:The Trk family of tyrosine-protein kinases, TrkA, TrkB, and TrkC, are the signaling receptors that mediate the biological properties of the NGF family of neurotrophins. This family of growth factors includes in addition to NGF, BDNF, NT-3, and NT-4. TrkA is the NGF receptor. TrkB serves as a receptor for both BDNF and...

journal_title：Annals of the New York Academy of Sciences

authors： Barbacid M

更新日期：1995-09-07 00:00:00

abstract：:Plasma advanced glycation end product (AGE) free adducts are increased up to 50-fold among patients on dialysis. We examined the ability of hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) to clear these compounds. The AGE free adducts Nepsilon-carboxymethyl-lysine (CML) and Nepsilon-(1-carboxyet...

journal_title：Annals of the New York Academy of Sciences

authors： Agalou S,Ahmed N,Thornalley PJ,Dawnay A

更新日期：2005-06-01 00:00:00

abstract：:Targeted depletion of immune cells expressing the interleukin-2 (IL-2) receptor can exacerbate inflammatory bowel disease (IBD) through elimination of regulatory T (Treg) cells, or ameliorate its course by depletion of cytotoxic cells. To answer this question we used a fusion protein composed of IL-2 and caspase-3 (IL...

journal_title：Annals of the New York Academy of Sciences

authors： Sagiv Y,Kaminitz A,Lorberboum-Galski H,Askenasy N,Yarkoni S

更新日期：2009-09-01 00:00:00

abstract：:We review here evidence that a large portion of the caudomedial telencephalon of songbirds, distinct from the song control circuit, is involved in the perceptual processing of birdsong. When songbirds hear song, a number of caudomedial pallial areas are activated, as revealed by expression of the activity-dependent ge...

journal_title：Annals of the New York Academy of Sciences

authors： Mello CV,Velho TA,Pinaud R

更新日期：2004-06-01 00:00:00

abstract：:The physiological status of presynaptic receptors, regulating sympathetic neurotransmitter release, remains subject to debate. Nevertheless, pharmacological techniques have shown presynaptic alpha-adrenoceptors, mediating a negative feedback inhibition of neuronal noradrenaline (NA) release, and presynaptic beta-adren...

journal_title：Annals of the New York Academy of Sciences

authors： Borkowski KR

更新日期：1990-01-01 00:00:00

abstract：:Neuroimaging research suggests that cerebral white matter (WM) integrity, as reflected in fractional anisotropy (FA) via diffusion tensor imaging (DTI), is decreased in older adults, especially in the prefrontal regions of the brain. Behavioral investigations of cognitive functioning suggest that some aspects of cogni...

journal_title：Annals of the New York Academy of Sciences

authors： Marks BL,Madden DJ,Bucur B,Provenzale JM,White LE,Cabeza R,Huettel SA

更新日期：2007-02-01 00:00:00

abstract：:The pronounced increases in gangliosides belonging to the gangliotetraose family during the neurite outgrowth phase of neuronal differentiation have suggested a functional requirement for these substances related to process extension, arborization, and possibly synaptogenesis. Support for this hypothesis has come from...

journal_title：Annals of the New York Academy of Sciences

authors： Ledeen RW,Wu G,Lu ZH,Kozireski-Chuback D,Fang Y

更新日期：1998-06-19 00:00:00

abstract：:Coccidioides causes coccidioidomycosis in the southwestern United States. Its clinical manifestations range from the primary asymptomatic to progressive pulmonary and extrapulmonary disease. Because of endemicity, frequent relapse, and virulent nature of Coccidioides, there is an urgent need for the development of eff...

journal_title：Annals of the New York Academy of Sciences

authors： Awasthi S

更新日期：2007-09-01 00:00:00

abstract：:We have previously shown that increased dosage of the mouse protein zero gene (Mpz) causes a dysmyelinating neuropathy in transgenic (Tg80) mice. To ask whether the dysmyelination is dose dependent, we inbred one of the Tg80 lines and compared the resulting phenotype in homozygous and heterozygous mice. Whereas hetero...

journal_title：Annals of the New York Academy of Sciences

authors： Quattrini A,Feltri ML,Previtali S,Fasolini M,Messing A,Wrabetz L

更新日期：1999-10-01 00:00:00

abstract：:During viewing of a near target, the gain of the visually modulated vestibulo-ocular reflex (vVOR) exceeds 1.0. We investigated whether retinal image slip contributes to this gain increase by measuring responses during strobe illumination. Subjects showed greater gain values during normal versus strobe illumination of...

journal_title：Annals of the New York Academy of Sciences

authors： Han YH,Kumar AN,Somers JT,Reschke MF,Leigh RJ

更新日期：2005-04-01 00:00:00

abstract：:The authors present a multifactorial model for the development of acquired immunodeficiency syndrome (AIDS) in homosexual men. It is posited that there is no specific AIDS agent; rather, AIDS is conceptualized as the result of an interaction of the known or likely effects of repeated exposures to specific environment...

journal_title：Annals of the New York Academy of Sciences

authors： Sonnabend JA,Witkin SS,Purtilo DT

更新日期：1984-01-01 00:00:00

abstract：:Regulation of pulmonary oxygen uptake (VO2p) during exercise depends on cellular energy demand, blood flow, ventilation, oxygen exchange across membranes, and oxygen utilization in the contracting skeletal muscle. In human and animal studies of metabolic processes that control cellular respiration in working skeletal ...

journal_title：Annals of the New York Academy of Sciences

authors： Zhou H,Lai N,Saidel GM,Cabrera ME

更新日期：2008-03-01 00:00:00

abstract：:Sacrocaudal afferent (SCA) stimulation is used in this work to study neural pathways involved in sensory-activation of central pattern generators (CPGs) in the isolated spinal cord of the neonatal rat. Surgical manipulations of the white matter funiculi and confocal imaging of back-labeled funicular pathways suggest t...

journal_title：Annals of the New York Academy of Sciences

authors： Lev-Tov A,Etlin A,Blivis D

更新日期：2010-06-01 00:00:00

abstract：:A beneficial effect of dimethyl sulfoxide (DMSO) in the treatment of acute focal cerebral ischemia has not been proven. In the present study, two established experimental models of acute focal cerebral ischemia were treated with DMSO. Twenty adult cats lightly anesthetized with ketamine hydrochloride underwent right m...

journal_title：Annals of the New York Academy of Sciences

authors： Little JR,Spetzler RF,Roski RA,Selman WR,Zabramski J,Lesser RP

更新日期：1983-01-01 00:00:00

abstract：:Chlorine (Cl2 ) and bromine (Br2 ) are produced in large quantities throughout the world and used in the industry and the sanitation of water. These halogens can pose a significant threat to public health when released into the atmosphere during transportation and industrial accidents, or as acts of terrorism. In this...

journal_title：Annals of the New York Academy of Sciences

authors： Lazrak A,Song W,Zhou T,Aggarwal S,Jilling T,Garantziotis S,Matalon S

更新日期：2020-11-01 00:00:00

abstract：:In this paper, I have introduced and solved a simple deterministic model of eye tracking that produces rich dynamical behavior. Some of its main features, notably the existence of a chaotic regime, are reminiscent of the anomalies reported in smooth pursuit eye tracking experiments with schizophrenia patients. By obta...

journal_title：Annals of the New York Academy of Sciences

authors： Huberman BA

更新日期：1987-01-01 00:00:00

abstract：:We have created genetically altered mice to investigate how expression of the Na(+)-Ca(2+) exchange protein alters excitation-contraction (E-C) coupling. Whereas low levels of exchanger overexpression have minimal effects on E-C coupling properties, high levels of overexpression in homozygous animals results in suscep...

journal_title：Annals of the New York Academy of Sciences

authors： Goldhaber JI,Henderson SA,Reuter H,Pott C,Philipson KD

更新日期：2005-06-01 00:00:00

abstract：:The following paper on the molecular biology of Barrett's esophagus (BE) includes commentaries on signaling pathways central to the development of BE including Hh, NF-κB, and IL-6/STAT3; surgical approaches for esophagectomy and classification of lesions by appropriate therapy; the debate over the merits of minimally ...

journal_title：Annals of the New York Academy of Sciences

authors： Gibson MK,Dhaliwal AS,Clemons NJ,Phillips WA,Dvorak K,Tong D,Law S,Pirchi ED,Räsänen J,Krasna MJ,Parikh K,Krishnadath KK,Chen Y,Griffiths L,Colleypriest BJ,Farrant JM,Tosh D,Das KM,Bajpai M

更新日期：2013-10-01 00:00:00

abstract：:Coccidioidomycosis is a potentially serious fungal infection contracted in endemic areas of the desert southwestern United States. Limited information exists about its incidence and clinical course in patients with rheumatic diseases, who may be at higher risk of symptomatic or disseminated coccidioidomycosis because ...

journal_title：Annals of the New York Academy of Sciences

authors： Mertz LE,Blair JE

更新日期：2007-09-01 00:00:00

abstract：:The overall goal of this study is to unravel the role(s) played by glial cell line-derived neurotrophic factor (GDNF) in the fate of spermatogonial stem cells. There is great interest in the biology of spermatogonial stem cells, or A(single) spermatogonia, because of their importance in the treatment of infertility, t...

journal_title：Annals of the New York Academy of Sciences

authors： Braydich-Stolle L,Nolan C,Dym M,Hofmann MC

更新日期：2005-12-01 00:00:00

abstract：:Insulin-dependent diabetes mellitus (IDDM) is a multifactorial disease. Besides a genetic predisposition environmental factors have been implicated in the pathogenesis of beta cell destruction. Among these environmental factors viruses have been the focus of many studies. Some viruses are diabetogenic in animals, and ...

journal_title：Annals of the New York Academy of Sciences

authors： Jaeckel E,Manns M,Von Herrath M

更新日期：2002-04-01 00:00:00

abstract：:We have developed an assay to detect mucosally delivered antibody to Cryptosporidium parvum sporozoite antigens. We absorbed a recombinant 23-kD sporozoite protein to polystyrene microspheres, and used flow cytometry to detect, titer, and determine the isotype of antibody to p23 that was shed in the feces of experimen...

journal_title：Annals of the New York Academy of Sciences

authors： Wyatt CR,Perryman LE

更新日期：2000-01-01 00:00:00

abstract：:The discrepancy between dynamical mass measures of objects such as galaxies and the observed distribution of luminous matter in the universe is typically explained by invoking an unseen "dark matter" component. Dark matter must necessarily be nonbaryonic. We introduce a simple hypothesis to do away with the necessity ...

journal_title：Annals of the New York Academy of Sciences

authors： Kinney WH,Brisudova M

更新日期：2001-06-01 00:00:00

abstract：:For various esophageal diseases, the search for alternative techniques for tissue repair has led to significant developments in basic and translational research in the field of tissue engineering. Applied to the esophagus, this concept is based on the in vitro combination of elements judged necessary for in vivo impla...

journal_title：Annals of the New York Academy of Sciences

authors： Arakelian L,Kanai N,Dua K,Durand M,Cattan P,Ohki T

更新日期：2018-12-01 00:00:00

abstract：:The dentate gyrus of the rat forms in three developmental phases, each of which is characterized by neuronal birth, migration and death. Recent evidence indicates that adrenal steroids regulate neuronal birth, death, and possibly migration throughout the life of the animal. However, the observation that very few neuro...

journal_title：Annals of the New York Academy of Sciences

authors： Gould E

更新日期：1994-11-14 00:00:00

abstract：:Several orphan G-protein-coupled receptors (GPCRs), LGR7 and LGR8, GPCR135 and GPCR142, were recently identified as putative, native receptors for different relaxin-family peptides, and their cell signaling mechanisms were elucidated in stably transfected cell lines. Anatomic studies have demonstrated that discrete po...

journal_title：Annals of the New York Academy of Sciences

authors： Ortinau S,Lin F,Wade JD,Tregear GW,Bathgate RA,Gundlach AL

更新日期：2005-05-01 00:00:00