Sensory-induced activation of pattern generators in the absence of supraspinal control.

Abstract:

:Sacrocaudal afferent (SCA) stimulation is used in this work to study neural pathways involved in sensory-activation of central pattern generators (CPGs) in the isolated spinal cord of the neonatal rat. Surgical manipulations of the white matter funiculi and confocal imaging of back-labeled funicular pathways suggest that the CPGs are activated during SCA stimulation by crossed and uncrossed multifunicular projections of sacral neurons and that activation of short projecting proprioneurons is sufficient for the generation of the rhythm by SCA stimulation. The versatile organization of the pathways involved in the SCA-induced rhythm makes it a potent and durable activator of the CPGs in the absence of descending control from the brain. The significance of our findings and their potential clinical use are discussed.

journal_name

Ann N Y Acad Sci

authors

Lev-Tov A,Etlin A,Blivis D

doi

10.1111/j.1749-6632.2009.05424.x

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

54-62

eissn

0077-8923

issn

1749-6632

pii

NYAS5424

journal_volume

1198

pub_type

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