Abstract:
:The Dover sole was the species most often affected with eroded fins. Prevalence of the disease was highest on the Palos Verdes shelf, the site of a major municipal waste water discharge. Fin lesions in this species were characterized by a minimal inflammatory response and by the absence of associated microorganisms. The fins most frequently affected were those most often in contact with bottom sediments. Diseased specimens from the shelf had higher levels of total DDT and a tendency toward higher levels of total PCB in muscle tissue and a greater liver to body weight ratio than did unaffected specimens from the same area. Laboratory exposure of M. pacificus to contaminated sediments from the shelf resulted in the development of fin erosion. Chlorinated hydrocarbon levels and liver weight to body weight ratios in the exposed fish approached those measured in fish from the shelf. These studies suggest that fin erosion in M. pacificus is caused by exposure to contaminated sediments and that the role of chlorinated hydrocarbons should be tested directly in future experiments.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Sherwood MJ,Mearns AJdoi
10.1111/j.1749-6632.1977.tb19263.xsubject
Has Abstractpub_date
1978-09-29 00:00:00pages
177-89eissn
0077-8923issn
1749-6632journal_volume
298pub_type
杂志文章abstract::G3139 is an 18mer phosphorothioate oligonucleotide targeted to the initiation codon region of the Bcl-2 mRNA. Because of the ability of this antisense construct to downregulate the expression of Bcl-2 mRNA and protein, it has entered phase III clinical trials in a number of human cancers, including advanced melanoma. ...
journal_title:Annals of the New York Academy of Sciences
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abstract::Fetal nucleated red blood cells (NRBCs) entering maternal circulation during pregnancy constitute a potential source of material for safe and reliable noninvasive prenatal diagnosis. The increased prevalence of beta-thalassemia mutations in countries like Greece may create a problem, making it difficult to distinguish...
journal_title:Annals of the New York Academy of Sciences
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abstract::Soluble decoy receptor 3 (DcR3), a member of the tumor necrosis factor receptor superfamily, has recently been reported to increase osteoclast (OC) differentiation. Its impact on the skeleton was reinforced by a study on DcR3 transgenic mice showing a decreased bone mass through the elevation of OC number, providing s...
journal_title:Annals of the New York Academy of Sciences
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abstract::Our recently developed method, TranSIESTA, enables modelling of molecular electronic devices under operation conditions. The method is based on density functional theory, and calculates the self-consistent electronic structure of a nanostructure coupled to three-dimensional electrodes with different electrochemical po...
journal_title:Annals of the New York Academy of Sciences
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abstract::T cell protein tyrosine phosphatase (TCPTP) dephosphorylates a number of substrates, including JAK-STAT (signal transducer and activator of transcription) signaling proteins, which are activated by interferon (IFN)-γ, a major proinflammatory cytokine involved in conditions such as inflammatory bowel disease. A critica...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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abstract::The National Institutes of Health's Clinical and Translational Science Award (CTSA) program has had a profound impact on clinical research and training methods at the University of California, Davis (UC Davis). UC Davis was among the first 12 institutions to receive NIH funding for this award, and created its Clinical...
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abstract::Thymic tolerance depends on induction of apoptosis (programmed cell death) in immature thymocytes by antigen/MHC complexes on dendritic cells (and possibly other bone marrow-derived APCs). Interactions with antigen/MHC complexes on thymic epithelial cells promote maturation of double-positive thymocytes to single-posi...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
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更新日期:1992-11-21 00:00:00
abstract::We present our achievements in the synthesis and application of multifunctionalized, cross-linked, polystyrene microspheres, which remarkably and quite generally are taken up by all cell types studied to date. Importantly, the nature of these synthetic beads allows multistep solid-phase chemistry and the ability to bi...
journal_title:Annals of the New York Academy of Sciences
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abstract::A previous review of alternative treatments (Tx) of ADHD--those other than psychoactive medication and behavioral/psychosocial Tx--was supplemented with an additional literature search focused on adults with ADHD. Twenty-four alternative Tx were identified, ranging in scientific documentation from discrediting control...
journal_title:Annals of the New York Academy of Sciences
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更新日期:2001-06-01 00:00:00
abstract::Methamphetamine (METH), a highly addictive drug, can cause degeneration of monoaminergic terminals and neuronal apoptosis in the mammalian brain. In the present article, we have used serial analysis of gene expression (SAGE) to investigate patterns of gene expression in the striata of rats that were given a neurotoxic...
journal_title:Annals of the New York Academy of Sciences
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abstract::The following on proton pump inhibitors (PPIs) and chemoprevention in relation to Barrett's esophagus includes commentaries on 48-h pH monitoring, pH-impedence, bile acid testing, dyspepsia, long/short segment Barrett's esophagus, nonerosive reflux disease (NERD), functional heartburn, dual-release delivery PPIs, imme...
journal_title:Annals of the New York Academy of Sciences
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abstract::Esophageal cancer (EC) is one of the most lethal cancers and a public health concern worldwide, owing to late diagnosis and lack of efficient treatment. Esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) are main histopathological subtypes of EC that show striking differences in geographical...
journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.1990.tb17841.x
更新日期:1990-01-01 00:00:00
abstract::The damaging effects of superoxide in mitochondria leading to pathological disorders and aging are well documented and usually ascribed to superoxide's role as a precursor of reactive free radical species. However, the latest findings point out the importance of the nucleophilic properties of superoxide and its abilit...
journal_title:Annals of the New York Academy of Sciences
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abstract::tRNA prepared from cells of E. coli B that had been incubated with 0.5% DL-ethionine (Ethio sRNA) was found to accept methyl groups from 14CH3-S-adenosyl-methionine in the enzymatic reaction catalyzed in vitro by tRNA methyl transferases from untreated cells of the same organism. tRNA from cells that were not exposed ...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.1975.tb29261.x
更新日期:1975-08-08 00:00:00
abstract::Recent findings indicate that complement activation--involving specifically C3 and C5--contributes to antiphospholipid (aPL)-mediated thrombosis. Two complement effector pathways are initiated by the cleavage of C5, C5a and C5b, which leads to the formation of the C5b-9 membrane attack complex. To delineate and distin...
journal_title:Annals of the New York Academy of Sciences
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更新日期:2007-06-01 00:00:00
abstract::Preventable chronic diseases are the leading cause of death in the majority of countries throughout the world, and this trend will continue for the foreseeable future. The potential to offset the social, economic, and personal burdens associated with such conditions depends on our ability to influence people's thought...
journal_title:Annals of the New York Academy of Sciences
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abstract::The survival of M. leprae and M. tuberculosis in the human host is dependent upon their ability to produce gene products that counteract the bactericidal activities of macrophages. To identify such mycobacterial genes and gene products, recombinant DNA libraries of mycobacterial DNA in E. coli were passed through macr...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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abstract::McCune-Albright syndrome (MAS) is caused by postzygotic somatic activating mutations of GNAS and is classically characterized by the clinical triad of peripheral precocious puberty, café-au-lait pigmentation, and polyostotic fibrous dysplasia. It can also present with other hyperfunctioning endocrinopathies, including...
journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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abstract::Early dissemination, blood circulation, or homing of single tumor cells in bone marrow and other organs is usually undetectable at primary diagnosis, even by high resolution imaging technologies. However, ultrasensitive approaches now enable the detection of "occult" tumor cells. Many researchers are currently focusin...
journal_title:Annals of the New York Academy of Sciences
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更新日期:2010-10-01 00:00:00
abstract::Friendship pervades the human social landscape. These bonds are so important that disrupting them leads to health problems, and difficulties forming or maintaining friendships attend neuropsychiatric disorders like autism and depression. Other animals also have friends, suggesting that friendship is not solely a human...
journal_title:Annals of the New York Academy of Sciences
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更新日期:2014-05-01 00:00:00
abstract::Extracellular DNA in the plasma or serum of cancer patients has been recently proposed as a source of analyzable cancer-related gene sequences (qualitative approach). Furthermore, patients with different tumor types show high levels of cell-free circulating DNA both in plasma and serum (quantitative approach) at the t...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:2006-09-01 00:00:00
abstract::The aim of our work was to detect minor loci acting as Alzheimer's disease (AD) genetic markers. We divided 206 AD patients and 186 individuals as controls into six age at onset/age-dependent groups. We studied polymorphisms of the genes of apolipoprotein E (APOE) and its promoter, cathepsin D, butyrylcholinesterase, ...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:2005-12-01 00:00:00
abstract::While the study of nationalism has received much attention throughout the social sciences and humanities, the experimental investigation of it lags behind. In this paper we review recent advances in the examination of implicit nationalism. In the first set of experiments we survey, the Palestinian, Israeli, Italian, a...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.2009.04734.x
更新日期:2009-06-01 00:00:00
abstract::The aim of the study was to determine the frequency of patients with gestational diabetes mellitus (GDM) who have serological markers typical of autoimmune type 1 DM. The specific pancreatic markers, ICAs, glutamic decarboxylase (GADAbs), and second islet antigen (IA2Abs), were measured in 70 women with GDM during the...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:2002-04-01 00:00:00
abstract::Ibogaine, an alkaloid extracted from Tabemanthe iboga, is being studied as a potential long-acting treatment for oploid and stimulant abuse as well as for alcoholism and smoking. Studies in this laboratory have used animal models to characterize ibogaine's interactions with drugs of abuse, and to investigate the mecha...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:
更新日期:1998-05-30 00:00:00
abstract::Pulmonary sarcoidosis is a disease characterized by increased numbers of T lymphocytes within the alveolar structures and the consequent spontaneous release of a variety of mediators relevant to the pathogenesis of this disorder. This phenomenon is associated with a different expansion of the T cell subpopulations pre...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.1986.tb18488.x
更新日期:1986-01-01 00:00:00
abstract::Shigella, a Gram-negative bacterial species of the family Enterobacteriaceae, causes bacillary dysentery in humans, an acute rectocolitis that reflects the capacity of the microorganism to disrupt, invade, and cause the inflammatory destruction of the intestinal epithelium. Here, the pathogenesis of Shigella infection...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
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更新日期:2006-08-01 00:00:00
abstract::Understanding the predictive relationships between climate variability and coccidioidomycosis is of great importance for the development of an effective public health decision-support system. Preliminary regression-based climate modeling studies have shown that about 80% of the variance in seasonal coccidioidomycosis ...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1196/annals.1406.024
更新日期:2007-09-01 00:00:00