Inhibition of methylated nucleoside synthesis in vivo: accumulation of incompletely methylated transfer RNA in ethionine-treated cells of Escherichia coli B.

abstract：:Both hereditary and environmental factors influence the risk of cancer. Four risk categories, or oncodemes, can exist for a particular kind of cancer, depending upon the presence of neither, one, or both factors: (1) spontaneous, or background; (2) hereditary; (3) environmental; (4) interactive. In the second, mutatio...

journal_title：Annals of the New York Academy of Sciences

authors： Knudson AG

更新日期：1997-12-29 00:00:00

abstract：:Clumps of corona cells were separated from oocytes at the moment of fertilization control and were subsequently processed and cut into 1-mu sections to study their general morphologic patterns. This study revealed an extensive phagocytosis of spermatozoa by corona cells. Clumps of mural granulosa cells of comparable s...

journal_title：Annals of the New York Academy of Sciences

authors： Pijnenborg R,Gordts S,Ongkowidjojo R,Brosens I

更新日期：1985-01-01 00:00:00

abstract：:In electrical impedance cardiography, Kubicek's formula is often used to measure stroke volume from thoracic impedance variations synchronously to heart activity. To calculate stroke volume from impedance variations, the so-called outflow problem should be adequately solved. This outflow problem refers to the joint ca...

journal_title：Annals of the New York Academy of Sciences

authors： Faes TJ,Raaijmakers E,Meijer JH,Goovaerts HG,Heethaar RM

更新日期：1999-04-20 00:00:00

abstract：:Ruminants are widespread in hot, arid regions. This demands adaptation to large circadian temperature fluctuations and recurrent periods of food and water shortage. Pregnancy and lactation add to the demands on the adaptive mechanisms due to the greater need for food, water, and electrolytes. The blood volume increase...

journal_title：Annals of the New York Academy of Sciences

authors： Olsson K

更新日期：2005-04-01 00:00:00

abstract：:Anticardiolipin antibodies (aCLAs) and antibodies to oxidized-low density lipoproteins (oxLDL) are associated with two distinct diseases: the antiphospholipid syndrome and atherosclerosis. Because both diseases may be apparent in patients with systemic lupus erythematosus (SLE), it is important to establish the relati...

journal_title：Annals of the New York Academy of Sciences

authors： Damoiseaux J,Jeyasekharan AD,Theunissen R,Tervaert JW

更新日期：2005-06-01 00:00:00

abstract：:Plasma advanced glycation end product (AGE) free adducts are increased up to 50-fold among patients on dialysis. We examined the ability of hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) to clear these compounds. The AGE free adducts Nepsilon-carboxymethyl-lysine (CML) and Nepsilon-(1-carboxyet...

journal_title：Annals of the New York Academy of Sciences

authors： Agalou S,Ahmed N,Thornalley PJ,Dawnay A

更新日期：2005-06-01 00:00:00

abstract：:CDP-choline was given to patients with Alzheimer's disease (AD) at a daily dose of 1000 mg/day p.o. for one month. This compound slightly improved mental performance, tended to reduce theta activity in fronto-temporal regions, increasing alpha power in occipital areas, and enhanced cerebrovascular perfusion by increas...

journal_title：Annals of the New York Academy of Sciences

authors： Cacabelos R,Caamaño J,Gómez MJ,Fernández-Novoa L,Franco-Maside A,Alvarez XA

更新日期：1996-01-17 00:00:00

abstract：:This paper explores aspects of the role that laboratory instruments have played in establishing psychology as a science. Comparisons of earlier instruments with their more modern counterparts indicate that many problems and methods still of interest today were explored in the laboratories of psychology's pioneers. Suc...

journal_title：Annals of the New York Academy of Sciences

authors： Caudle FM

更新日期：1983-01-01 00:00:00

abstract：:An 8-year follow-up of Ceravital middle ear prostheses showed there was extremely good tolerance in the middle ear space. Incompatibility phenomena were not observed, and inflammatory reactions were neither caused nor supported by the implants. The tympanoplasties were always performed without interposition of cartila...

journal_title：Annals of the New York Academy of Sciences

authors： Reck R,Störkel S,Meyer A

更新日期：1988-01-01 00:00:00

abstract：:We studied the GABAergic control of the spinal locomotor network using an isolated brain stem/spinal cord from newborn rats, in which locomotor-like activity was recorded. We demonstrate that endogenously released GABA controls the locomotor network, by decreasing or completely abolishing all locomotor-like activity. ...

journal_title：Annals of the New York Academy of Sciences

authors： Cazalets JR,Bertrand S,Sqalli-Houssaini Y,Clarac F

更新日期：1998-11-16 00:00:00

abstract：:The homeostasis of skeletal tissues requires tight regulation of a variety of signaling pathways, and the onset and progression of skeletal diseases are often caused by signaling abnormalities. MicroRNAs (miRNAs) are short noncoding RNA molecules that have emerged as a new dimension of gene regulation. MiRNAs have bee...

journal_title：Annals of the New York Academy of Sciences

authors： Zhao W,Zhang S,Wang B,Huang J,Lu WW,Chen D

更新日期：2016-11-01 00:00:00

abstract：:Dysregulation of apoptosis is associated with the pathogenesis of organ-specific autoimmune diseases, through altered target organ susceptibility. Apoptosis signaling pathways can be initiated through activation of death receptors such as Fas. A comparative analysis of the expression of Fas and FasL, the antiapoptotic...

journal_title：Annals of the New York Academy of Sciences

authors： Salmaso C,Bagnasco M,Pesce G,Montagna P,Brizzolara R,Altrinetti V,Richiusa P,Galluzzo A,Giordano C

更新日期：2002-06-01 00:00:00

abstract：:During the annual Ramazzini Days, the Mayor of Carpi confers the Ramazzini Award on scientists deemed by the Collegium Ramazzini to have made outstanding contributions to furthering the aims of Bernardino Ramazzini in safeguarding public health. Dr. Lorenzo Tomatis was the Ramazzini Award recipient in 2005, and the pr...

journal_title：Annals of the New York Academy of Sciences

authors： Tomatis L

更新日期：2006-09-01 00:00:00

abstract：:The adrenal glands are a major source of steroid hormone biosynthesis. In normal physiology, the pituitary hormone corticotropin (ACTH) regulates the secretion of glucocorticoids via its G protein-coupled receptor (ACTHR), the product of the MC2R gene. Aldosterone is another major product of the adrenal gland; its reg...

journal_title：Annals of the New York Academy of Sciences

authors： Bourdeau I,Stratakis CA

更新日期：2002-06-01 00:00:00

abstract：:We have established several tumor T cell lines, both from the skin and from the blood of a patient with an MHC class II-/class I+, CD4+ cutaneous T cell lymphoma (CTCL). These cell lines, like the initial tumor cells, had a CD3+CD4+CD8- phenotype. We also isolated two cytotoxic T lymphocyte clones from the tumor site ...

journal_title：Annals of the New York Academy of Sciences

authors： Bagot M,Nikolova M,Schirm-Chabanette F,Wechsler J,Boumsell L,Bensussan A

更新日期：2001-09-01 00:00:00

abstract：:Various hypotheses on the origin of cerebellar downbeat nystagmus (DBN) have been presented; the exact pathomechanism, however, is still not known. Based on previous anatomical and electrophysiological studies, we propose that an asymmetry in the distribution of on-directions of vertical gaze-velocity Purkinje cells l...

journal_title：Annals of the New York Academy of Sciences

authors： Marti S,Straumann D,Glasauer S

更新日期：2005-04-01 00:00:00

abstract：:While dopamine (DA) receptors mediate acute effects of amphetamine and cocaine, chronic drug administration produces many glutamate-dependent adaptations, including LTP in reward-related neuronal circuits. An important question presents itself: How do DA receptors influence glutamate-dependent synaptic plasticity? Alt...

journal_title：Annals of the New York Academy of Sciences

authors： Wolf ME,Mangiavacchi S,Sun X

更新日期：2003-11-01 00:00:00

abstract：:A beneficial effect of dimethyl sulfoxide (DMSO) in the treatment of acute focal cerebral ischemia has not been proven. In the present study, two established experimental models of acute focal cerebral ischemia were treated with DMSO. Twenty adult cats lightly anesthetized with ketamine hydrochloride underwent right m...

journal_title：Annals of the New York Academy of Sciences

authors： Little JR,Spetzler RF,Roski RA,Selman WR,Zabramski J,Lesser RP

更新日期：1983-01-01 00:00:00

abstract：:Experiments with enzymes in situ that are dependent on ascorbic acid for maximum activity will provide critical information about ascorbic acid requirements. Our work with chromaffin tissue as a model system eventually will result in the determination of two dose-response curves for norepinephrine biosynthesis, repres...

journal_title：Annals of the New York Academy of Sciences

authors： Levine M,Hartzell W

更新日期：1987-01-01 00:00:00

abstract：:Copper is an important cofactor in numerous biological processes in all living organisms. However, excessive copper can be extremely toxic, so it is vital that the copper level within a cell is tightly regulated. The damaging effect of copper is seen in several hereditary forms of copper toxicity in humans and animals...

journal_title：Annals of the New York Academy of Sciences

authors： Fedoseienko A,Bartuzi P,van de Sluis B

更新日期：2014-05-01 00:00:00

abstract：:The adaptation of the vestibulo-ocular reflex (VOR) was studied in 26 normal subjects and 26 patients with cerebellar lesions, using horizontal vision-reversal prisms. In normal subjects, the adaptation of gain after wearing prisms for one hour was approximately 50% of the VOR value in the dark. In contrast to this, p...

journal_title：Annals of the New York Academy of Sciences

authors： Yagi T,Shimizu M,Sekine S,Kamio T,Suzuki JI

更新日期：1981-01-01 00:00:00

abstract：:Indirect evidence suggests that dopamine within the brain may participate in the regulation of immune responses in both man and rodents. The aim of the present study was to investigate the possible role played by the specific dopamine D1 receptor subtype within the central amygdala in the modulation of immunity. Mitog...

journal_title：Annals of the New York Academy of Sciences

authors： Nistico G,Caroleo MC,Arbitrio M,Pulvirenti L

更新日期：1994-11-25 00:00:00

abstract：:This study describes the features of the marginal zone (MZ) B cells of human tonsils and spleens and compares them with those of the follicular mantle (FM) B cells from the same tissues. The two B cell subpopulations displayed marked differences in phenotype, in response capacity to T cell-independent antigens and pol...

journal_title：Annals of the New York Academy of Sciences

authors： Dono M,Zupo S,Colombo M,Massara R,Gaidano G,Taborelli G,Ceppa P,Burgio VL,Chiorazzi N,Ferrarini M

更新日期：2003-04-01 00:00:00

abstract：:In two series of antiarrhythmic drugs tested, as the octanol/water partition coefficient increases so do the following: elimination from the body by biotransformation, first-pass biotransformation in the liver and gastrointestinal tract after oral administration, protein binding to some extent, and penetration into br...

journal_title：Annals of the New York Academy of Sciences

authors： Drayer DE

更新日期：1984-01-01 00:00:00

abstract：:This paper reports preliminary results for pool film boiling on a wire immersed in almost saturated FC72 recently obtained during an experimental campaign performed in low gravity on the European Space Agency Zero-G airplane, (reduced gravity level 10(-2)). This is part of a long-term research program on the effect of...

journal_title：Annals of the New York Academy of Sciences

authors： Di Marco P,Grassi W,Trentavizi F

更新日期：2002-10-01 00:00:00

abstract：:Over the past 10 years, the continual discovery of novel forms of encephalitis associated with antibodies to cell-surface or synaptic proteins has changed the paradigms for diagnosing and treating disorders that were previously unknown or mischaracterized. We review here the process of discovery, the symptoms, and the...

journal_title：Annals of the New York Academy of Sciences

authors： Leypoldt F,Armangue T,Dalmau J

更新日期：2015-03-01 00:00:00

abstract：:Conventional and thiophosphonate-derivatized oligonucleotides were employed to specifically regulate functional gene expression in murine T-cell hybridomas. For example, induction of apoptotic cell death following activation of T-cell hybridomas was examined using antisense oligonucleotides corresponding to several pr...

journal_title：Annals of the New York Academy of Sciences

authors： Green DR,Zheng H,Shi Y

更新日期：1992-10-28 00:00:00

abstract：:The role of gamma-glutamyl-carboxylated growth arrest-specific 6 (cGas6) in mediating the beneficial effect of vitamin K (VK) on regulating glucose metabolism remains elusive. We took a three-pronged approach-evaluating human type 2 diabetes (T2D), high-fat diet (HFD)-fed mice, and in vitro cultured myotubes-to addres...

journal_title：Annals of the New York Academy of Sciences

authors： Dihingia A,Ozah D,Borah T,Kalita J,Manna P

更新日期：2020-02-01 00:00:00

abstract：:Osmotic opening of the blood-brain barrier (BBB) most likely is mediated by modification of interendothelial tight junctions, subsequent to shrinkage of cerebrovascular endothelial cells, and not by stimulation of transendothelial vesicular transport or by channel formation. This paper summarizes evidence for this con...

journal_title：Annals of the New York Academy of Sciences

authors： Rapoport SI,Robinson PJ

更新日期：1986-01-01 00:00:00

abstract：:Atrial fibrillation (AF), the highest occurring cardiac arrhythmia in the Western world, is associated with substantial morbidity and increased mortality. In spite of extensive research, the cause of atrial electrical remodeling, a major factor in the self-perpetuating nature of AF, is still unknown. Downregulation of...

journal_title：Annals of the New York Academy of Sciences

authors： Beharier O,Etzion Y,Levi S,Mor M,Mor M,Dror S,Kahn J,Katz A,Moran A

更新日期：2010-02-01 00:00:00