Detection of fetal NRBCs in maternal blood of pregnant carriers of beta-thalassemia using anti-gamma and anti-epsilon monoclonal antibodies.

Abstract:

:Fetal nucleated red blood cells (NRBCs) entering maternal circulation during pregnancy constitute a potential source of material for safe and reliable noninvasive prenatal diagnosis. The increased prevalence of beta-thalassemia mutations in countries like Greece may create a problem, making it difficult to distinguish between NRBCs of fetal or maternal origin. Use of Ab against embryonic hemoglobin epsilon may increase specificity for fetal NRBC detection. In the present study, Ab against embryonic hemoglobin epsilon was used in the first and second trimesters of pregnancy in order to determine if specificity for fetal NRBC detection could be increased.

journal_name

Ann N Y Acad Sci

authors

Mavrou A,Kolialexi A,Antsaklis A,Krikos X,Koratzis A,Metaxotou C

doi

10.1111/j.1749-6632.2001.tb03877.x

subject

Has Abstract

pub_date

2001-09-01 00:00:00

pages

151-2

eissn

0077-8923

issn

1749-6632

journal_volume

945

pub_type

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