A role for the CISD2 gene in lifespan control and human disease.

Abstract:

:CISD2, the causative gene for Wolfram syndrome 2 (WFS2), is an evolutionarily conserved novel gene. Recently, we have demonstrated that CISD2 is involved in mammalian lifespan control; this work also establishes WFS2 as a mitochondria-mediated disorder and effectively links CISD2 gene function, mitochondrial integrity, and aging in mammals. In wild-type mice, the expression levels of CISD2 decrease in an age-dependent manner during the naturally aging process; this correlates with mitochondrial breakdown and parallels the development of an aged phenotype. Future work will examine how the CISD2 knockout mouse helps us to understand WFS2 pathogenesis, as well as exploring the potential effects of increased CISD2 expression. In addition, it will be of great interest to compare gene activity and/or protein function between normal human populations and long-lived centenarian groups. Together, human and mouse genetic studies should provide evidence as to whether CISD2 is a "master gene" for extreme old age.

journal_name

Ann N Y Acad Sci

authors

Chen YF,Wu CY,Kirby R,Kao CH,Tsai TF

doi

10.1111/j.1749-6632.2010.05619.x

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

58-64

eissn

0077-8923

issn

1749-6632

pii

NYAS5619

journal_volume

1201

pub_type

杂志文章,评审
  • From known to unknown: moving to unvisited locations in a novel sensorimotor map.

    abstract::Sensorimotor learning requires knowledge of the relationship between movements and sensory effects: a sensorimotor map. Generally, these mappings are not innate but have to be learned. During learning, the challenge is to build a continuous map from a set of discrete observations, that is, predict locations of novel t...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/nyas.13608

    authors: van Vugt FT,Ostry DJ

    更新日期:2018-03-03 00:00:00

  • Monitoring of DNA damage in individuals exposed to petroleum hydrocarbons in Ecuador.

    abstract::Currently, it is known that several chemical agents used or generated by the oil industry are classified as mutagens and/or carcinogens. Among these we have gasoline, diesel, butane gas, styrene, benzene, chloroform, and others. Studies have verified that these chemicals have effects in fertility (abortions, sterility...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1454.013

    authors: Paz-y-Miño C,López-Cortés A,Arévalo M,Sánchez ME

    更新日期:2008-10-01 00:00:00

  • Karyotype-phenotype correlation in females with X chromosome abnormalities.

    abstract::In mammals, females have a pair of X chromosomes, whereas males have one X chromosome and one Y chromosome, which is much smaller and contains fewer genes than a X chromosome. One of the pair of X chromosomes is inactivated in females. The inactivated X chromosome is late-replicating, heterochromatic, and genetically ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1997.tb52164.x

    authors: Kosmaidou-Aravidou Z

    更新日期:1997-06-17 00:00:00

  • Selected methods of investigation for blood-contact surfaces.

    abstract::It is imperative that operating personnel and regulatory agencies have secure, advance, and accurate knowledge of the true surface properties of materials to be contacted with flowing blood. The actual devices must be characterized in their sterile, immediate pre-exposure states. Although very sensitive electronic ins...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1987.tb33031.x

    authors: Baier RE

    更新日期:1987-01-01 00:00:00

  • Pathological findings of HIV-associated cardiovascular disease.

    abstract::More effective therapies have improved survival times of HIV+ patients, resulting in a higher prevalence of long-term complications of the disease. This review focuses on HIV-associated cardiovascular pathology, correlating the morphologic findings to clinical syndromes of HIV disease/AIDS. ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2001.tb03901.x

    authors: d'Amati G,di Gioia CR,Gallo P

    更新日期:2001-11-01 00:00:00

  • Dopamine, acetylcholine, and glutamate interactions in aging. Behavioral and neurochemical correlates.

    abstract::Aging, hypoxia, and thiamin deficiency diminish motor performance. Similar alterations of ACh, DA, and glutamate metabolism accompany hypoxia, thiamin deficiency, and aging. Both aging and hypoxia reduce ACh release and stimulate DA and glutamate release. Presynaptic enhancement of DA and glutamate release may be impo...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1988.tb32984.x

    authors: Freeman GB,Gibson GE

    更新日期:1988-01-01 00:00:00

  • Natural mentoring relationships among survivors of caregiver childhood abuse: findings from the Add Health Study.

    abstract::Social support promotes resilience to adverse childhood events, but little is known about the role of natural mentors-caring, nonparental adults-in the lives of childhood abuse survivors. The current study draws from a large, longitudinal, nationally representative sample (Add Health) to examine the prevalence and cha...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/nyas.14313

    authors: Weber Ku EB,Hagler MA,Parnes MF,Schwartz SEO,Rhodes JE,Erickson LD

    更新日期:2021-01-01 00:00:00

  • Unfolded protein response to autophagy as a promising druggable target for anticancer therapy.

    abstract::The endoplasmic reticulum (ER) is responsible for protein processing. In rapidly proliferating tumor cells, the ER tends to be overloaded with unfolded and misfolded proteins due to high metabolic demand. With the limited protein-folding capacity of the ER, tumor cells often suffer from more ER stress than do normal c...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2012.06739.x

    authors: Suh DH,Kim MK,Kim HS,Chung HH,Song YS

    更新日期:2012-10-01 00:00:00

  • Antiproliferative effects of retinoids related to the cell cycle-specific inhibition of ornithine decarboxylase.

    abstract::The induction of ornithine decarboxylase (ODC) during G1 phase of the cell cycle appears to be universal and essential for cell cycle progression. This induction has been demonstrated in at least 23 cell types in response to various growth stimuli. Further, specific inhibitors of ODC added to several of these cell lin...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1981.tb12754.x

    authors: Russell DH,Haddox MK

    更新日期:1981-02-27 00:00:00

  • Neurogenic [corrected] and oropharyngeal dysphagia.

    abstract::Oropharyngeal dysphagia (OD) is a swallowing disorder caused by congenital abnormalities and structural damage and disease-associated damage of the oral cavity, pharynx, and upper esophageal sphincter. Patients with OD lack the protective mechanisms necessary for effective swallowing, exhibiting difficulty controlling...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12234

    authors: Rofes L,Clavé P,Ouyang A,Scharitzer M,Pokieser P,Vilardell N,Ortega O

    更新日期:2013-10-01 00:00:00

  • dOr83b--receptor or ion channel?

    abstract::Odorant signals are detected by binding of odor molecules to odorant receptors. These belong to the G protein-coupled receptor family. They in turn couple to G proteins, most of which induce cAMP production. This second messenger activates ion channels to depolarize the olfactory sensory neuron, thus providing a signa...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.04101.x

    authors: Wicher D,Schäfer R,Bauernfeind R,Stensmyr MC,Heller R,Heinemann SH,Hansson BS

    更新日期:2009-07-01 00:00:00

  • Molecular mechanisms of morning onset of myocardial infarction.

    abstract::We recently isolated a novel bHLH/PAS protein, CLIF (cycle like factor), by yeast two-hybrid screening of human umbilical endothelial cell cDNA library. CLIF is preferentially expressed in endothelial and neuronal cells. Because CLIF is expressed in vascular endothelial cells and forms a heterodimer with CLOCK, the ke...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2001.tb03972.x

    authors: Maemura K,Layne MD,Watanabe M,Perrell MA,Nagai R,Lee ME

    更新日期:2001-12-01 00:00:00

  • Discovery, characterization, and significance of the cytochrome P450 omega-hydroxylase pathway of vitamin E catabolism.

    abstract::Tocopherols are known to undergo metabolism to phytyl chain-shortened metabolites excreted in urine. We sought to characterize the pathway, including associated enzymes, involved in this biotransformation. We previously found that human hepatoblastoma (HepG2) cultures metabolized tocopherols to their corresponding sho...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1331.002

    authors: Parker RS,Sontag TJ,Swanson JE,McCormick CC

    更新日期:2004-12-01 00:00:00

  • Modeling leg sections by bioelectrical impedance analysis, dual-energy X-ray absorptiometry, and anthropometry: assessing segmental muscle volume using magnetic resonance imaging as a reference.

    abstract::This study aimed to assess the value of different DXA and BIA models for predicting muscle volume in mid-thigh segments obtained by MRI. Three DXA models were used: in model A, muscle was taken to be equivalent to fat-free soft tissue; in model B the thigh segment was divided into its constituent tissues using fixed a...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2000.tb06471.x

    authors: Elia M,Fuller NJ,Hardingham CR,Graves M,Screaton N,Dixon AK,Ward LC

    更新日期:2000-05-01 00:00:00

  • Binge-eating disorder in obese adolescent girls.

    abstract::Thirty percent of 51 obese adolescent girls seeking treatment for their obesity engaged in binge eating. Two psychometric measures, "disinhibition" and "happiness and satisfaction" predicted 63% of the variance in severity of binge eating. There was no difference in the history of dieting between obese subjects who bi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1993.tb18850.x

    authors: Berkowitz R,Stunkard AJ,Stallings VA

    更新日期:1993-10-29 00:00:00

  • Assembly of PRR-containing receptors on scaffolds: a model for imidazoline I(1)-receptor action.

    abstract::IRAS, a putative clone of the I(1)-imidazoline receptor, possesses a proline-rich region (PRR) motif, which might interact with SH3 regions on tyrosine kinases, and an integrin-binding motif. Receptors with a PRR motif can generally assemble onto multi-element signaling complexes (eg., the beta(3)-receptor on the EGF ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1304.055

    authors: Musgrave IF,Dehle FC,Piletz J

    更新日期:2003-12-01 00:00:00

  • Calmodulin-an often-ignored signal in osteoclasts.

    abstract::Calcium signaling plays a key role in bone turnover, regulating both osteoblasts and osteoclasts. Despite this the role of calmodulin, the primary intracellular calcium receptor regulatory protein, has received little attention. In this brief review, the function of Ca(2+)/calmodulin signaling in osteoclast developmen...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2009.05242.x

    authors: Williams JP,Micoli K,McDonald JM

    更新日期:2010-03-01 00:00:00

  • Natural and synthetic Huperzine A: effect on cholinergic function in vitro and in vivo.

    abstract::Huperzine A has been shown to be useful in the treatment of symptoms of dementia of the Alzheimer type. Our initial attempts to synthesize (-)Huperzine A resulted in the racemic mixture of (+/-)Huperzine A. We have therefore compared the in vitro and in vivo effects of (+/-)Huperzine A with those of (-)Huperzine A in ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1993.tb23071.x

    authors: Hanin I,Tang XC,Kindel GL,Kozikowski AP

    更新日期:1993-09-24 00:00:00

  • Genes, cognition, and communication: insights from neurodevelopmental disorders.

    abstract::Twin and family studies have demonstrated that most cognitive traits are moderately to highly heritable. Neurodevelopmental disorders such as dyslexia, autism, and specific language impairment (SLI) also show strong genetic influence. Nevertheless, it has proved difficult for researchers to identify genes that would e...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2009.04419.x

    authors: Bishop DV

    更新日期:2009-03-01 00:00:00

  • Gross elevation of TT virus genome load in the peripheral blood mononuclear cells of cancer patients.

    abstract::TT virus (TTV) is a recently described circular DNA virus of about 3.8 kb, which is related to the circoviridae viruses. It is commonly detected in healthy subjects and no association with any specific disease has been established. TTV was initially thought to be hepatotropic, but subsequent reports have shown that it...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2001.tb03868.x

    authors: Zhong S,Yeo W,Tang MW,Lin XR,Mo F,Ho WM,Hui P,Johnson PJ

    更新日期:2001-09-01 00:00:00

  • Molecular mechanisms of Na/K-ATPase-mediated signal transduction.

    abstract::Our recent work shows that in addition to pumping ions, Na/K-ATPase acts as a signal transducer. Binding of ouabain to Na/K-ATPase changes the interaction of the enzyme with neighboring membrane proteins and induces the formation of multiple signaling modules, resulting in activation of Src, transactivation of the EGF...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2003.tb07234.x

    authors: Xie Z

    更新日期:2003-04-01 00:00:00

  • Nephroblastoma overexpressed (Nov) is a novel bone morphogenetic protein antagonist.

    abstract::Nephroblastoma overexpressed (Nov), a member of the CCN family of proteins, is expressed by osteoblasts and its transcription is regulated by transforming growth factor (TGF)-beta and bone morphogenetic proteins (BMP). CCN proteins can interact with TGF-beta, BMPs, and Wnt. We explored the function of Nov in skeletal ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1402.055

    authors: Canalis E

    更新日期:2007-11-01 00:00:00

  • Application of genomic technologies to measure and monitor antibiotic resistance in animals.

    abstract::One of the richest reservoirs of antibiotic-resistant bacteria and genes, animal intestinal microbiota contributes to the spread of antibiotic resistance in the environment and, potentially, to human pathogens. Both culture-based genomic technology and culture-independent metagenomics have been developed to investigat...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.13296

    authors: Su JQ,Cui L,Chen QL,An XL,Zhu YG

    更新日期:2017-01-01 00:00:00

  • The NIH Countermeasures Against Chemical Threats Program: overview and special challenges.

    abstract::Intentional exposures to toxic chemicals can stem from terrorist attacks, such as the release of sarin in the Tokyo subway system in 1995, as well as from toxic industrial accidents that are much more common. Developing effective medical interventions is a critical component of the overall strategy to overcome the cha...

    journal_title:Annals of the New York Academy of Sciences

    pub_type:

    doi:10.1111/nyas.13179

    authors: Jett DA

    更新日期:2016-06-01 00:00:00

  • Myasthenia gravis in individuals over 40.

    abstract::Myasthenia gravis (MG) in individuals over 40 years of age comprises three groups: early-onset MG with prolonged disease duration, late-onset MG with thymoma, and late-onset of nonthymomatous MG. The clinical features do not differ between the three groups, except that early-onset patients with prolonged disease durat...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1254.055

    authors: Aarli JA,Romi F,Skeie GO,Gilhus NE

    更新日期:2003-09-01 00:00:00

  • Angiotensin II AT1 receptor blockade prevents gastric ulcers during cold-restraint stress.

    abstract::Cold-restraint stress reduces gastric blood flow and produces acute gastric ulcers. We studied the role of Angiotensin II (Ang II) on gastric blood flow and gastric ulceration during stress. Spontaneously hypertensive rats, a stress-sensitive strain, were pretreated for 14 days with the AT(1) receptor antagonist cande...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1296.044

    authors: Bregonzio C,Armando I,Ando H,Jezova M,Baiardi G,Saavedra JM

    更新日期:2004-06-01 00:00:00

  • Glutamate cysteine ligase modifier (GCLM) subunit gene is not associated with methamphetamine-use disorder or schizophrenia in the Japanese population.

    abstract::A recent study showed a significant association between schizophrenia in European samples and the glutamate cysteine ligase modifier (GCLM) subunit gene, which is the key glutathione (GSH)-synthesizing enzyme. Since the symptoms of methamphetamine (METH)-induced psychosis are similar to those of schizophrenia, the GCL...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1432.022

    authors: Kishi T,Ikeda M,Kitajima T,Yamanouchi Y,Kinoshita Y,Kawashima K,Inada T,Harano M,Komiyama T,Hori T,Yamada M,Iyo M,Sora I,Sekine Y,Ozaki N,Ujike H,Iwata N

    更新日期:2008-10-01 00:00:00

  • Lack of definitive severe mitochondrial signs and symptoms among deceased HIV-uninfected and HIV-indeterminate children < or = 5 years of age, Pediatric Spectrum of HIV Disease project (PSD), USA.

    abstract:BACKGROUND:In response to recent reports of mitochondrial dysfunction in HIV-uninfected infants exposed to antiretroviral (ARV) prophylaxis, the Perinatal Safety Review Working Group reviewed deaths in five large HIV-exposed perinatal cohorts in the United States to determine if similar cases of severe mitochondrial to...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1749-6632.2000.tb05493.x

    authors: Dominguez K,Bertolli J,Fowler M,Peters V,Ortiz I,Melville S,Rakusan T,Frederick T,Hsu H,D'Almada P,Maldonado Y,Wilfert C,PSD Consortium. Perinatal Safety Review Working Group.

    更新日期:2000-11-01 00:00:00

  • Biodiversity conservation through the lens of metacommunity ecology.

    abstract::Metacommunity ecology combines local (e.g., environmental filtering and biotic interactions) and regional (e.g., dispersal and heterogeneity) processes to understand patterns of species abundance, occurrence, composition, and diversity across scales of space and time. As such, it has a great potential to generalize an...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.14378

    authors: Chase JM,Jeliazkov A,Ladouceur E,Viana DS

    更新日期:2020-06-01 00:00:00

  • Mechanisms of immediate temperature compensation: experiments with brain synaptosomes from rat and ground squirrel.

    abstract::Glucose conversion by brain synaptosomes can be regarded as a special case of intrinsic kinetic properties of the enzyme substrate system. Temperature modulation of apparent K(m) for this process can be described with our kinetic model. Using experimental data and the kinetic model, the minimal K(m) value for glucose ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1342.005

    authors: Marjanović M,Zivadinović D,Dzakula Z,Andjus RK

    更新日期:2005-06-01 00:00:00