Fate of polybrominated diphenyl ethers during wastewater treatment/polishing and sludge stabilization/disposal.

abstract：:Aging may pose a challenge to the central nervous system, increasing its susceptibility to apoptotic events. Recent findings indicate that caloric restriction (CR) may have a profound effect on brain function and vulnerability to injury and diseases, by enhancing neuroprotection, stimulating the production of new neur...

journal_title：Annals of the New York Academy of Sciences

authors： Hiona A,Leeuwenburgh C

更新日期：2004-06-01 00:00:00

abstract：:Efforts using transgenic mice are being made to understand the molecular and structural basis for dementia in Alzheimer's disease. Transgenic mice 12 to 18 months of age with amyloid plaques and impaired cognition show no neuronal or synaptic loss in the CA1 hippocampal subfield. Electrophysiological studies may yield...

journal_title：Annals of the New York Academy of Sciences

authors： Ashe KH

更新日期：2000-01-01 00:00:00

abstract：:Investigations of the I-Ek-restricted, cytochrome c-specific T-cell response in mice show that both T-cell receptor V alpha and V beta CDR3 residues and the use of particular V alpha s and V beta s are necessary for recognition. Data strongly suggest that specific CDR3 residues are important in contacting the peptide....

journal_title：Annals of the New York Academy of Sciences

authors： Davis MM,McHeyzer-Williams M,Chien YH

更新日期：1995-07-07 00:00:00

abstract：:Data show that specifically chelating lysosomal redox-active iron can prevent most H(2)O(2)-induced DNA damage. Lysosomes seem to contain the major pool of redox-active labile iron within the cell. Under oxidative stress conditions, this iron may then relocate to the nucleus and play an important role for DNA damage b...

journal_title：Annals of the New York Academy of Sciences

authors： Kurz T,Leake A,von Zglinicki T,Brunk UT

更新日期：2004-06-01 00:00:00

abstract：:We have previously demonstrated that wild-type herpes simplex virus type 1 (HSV-1), as well as nonreplicating UV-inactivated HSV-1, promptly activates the nuclear factor-kappaB (NF-kappaB) in U937 monocytoid cells and that glycoprotein D (gD) of HSV-1 is sufficient by itself to exert a similar effect. We then investig...

journal_title：Annals of the New York Academy of Sciences

authors： Teresa Sciortino M,Medici MA,Marino-Merlo F,Zaccaria D,Giuffrè M,Venuti A,Grelli S,Mastino A

更新日期：2007-01-01 00:00:00

abstract：:Copper is an essential nutrient for the physiology of live organisms, but excessive copper can be harmful. Copper radioisotopes are used for measurement of copper fluxes in live organisms using a radioactivity assay of body fluids or whole-body positron emission tomography (PET). Hybrid positron emission tomography-co...

journal_title：Annals of the New York Academy of Sciences

authors： Peng F

更新日期：2014-05-01 00:00:00

abstract：:In this short review, we have described studies that have identified Arg415 in the Ca2+ release channel as a residue that influences channel sensitivity to Ca2+ induced Ca2+ release, rate of Ca2+ release, and channel closing. We have also described studies that confirm Dr. Numa's predictions that residues 4246-4267, 4...

journal_title：Annals of the New York Academy of Sciences

authors： MacLennan DH,Chen SR

更新日期：1993-12-20 00:00:00

abstract：:Experimental and observational findings suggest that calcium intake may protect against colorectal neoplasia. To investigate this hypothesis, we conducted a randomized, double-blind trial of colorectal adenoma recurrence. Nine hundred thirty patients with a recent history of colorectal adenomas were randomly given cal...

journal_title：Annals of the New York Academy of Sciences

authors： Baron JA,Beach M,Mandel JS,van Stolk RU,Haile RW,Sandler RS,Rothstein R,Summers RW,Snover DC,Beck GJ,Frankl H,Pearson L,Bond JH,Greenberg ER

更新日期：1999-01-01 00:00:00

abstract：:Melatonin is a hormone secreted by the pineal gland, mostly in the dark period of the light/dark cycle, with corresponding fluctuations reflected in the plasma melatonin levels. This hormone plays a critical role in the regulation of various neural and endocrine processes that are synchronized with daily change in pho...

journal_title：Annals of the New York Academy of Sciences

authors： Lahiri DK,Chen D,Lahiri P,Rogers JT,Greig NH,Bondy S

更新日期：2004-12-01 00:00:00

abstract：:In this article, we have presented an overview of fundamental issues involved in mediphotonic imaging, and reviewed some of the emerging techniques for early-light transillumination imaging of body organs. The results on human breast tissues presented here, together with the data accumulated and advances made by resea...

journal_title：Annals of the New York Academy of Sciences

authors： Alfano RR,Demos SG,Gayen SK

更新日期：1997-05-30 00:00:00

abstract：:The entry of resting T cells into the G1 phase of the cell cycle after stimulation by mitogens is controlled by a series of biochemical events that are independent of growth factors. These events follow the initial signals stimulated through the engagement of the T-cell receptor and include activation of the cyclin-de...

journal_title：Annals of the New York Academy of Sciences

authors： Modiano JF,Domenico J,Szepesi A,Terada N,Lucas JJ,Gelfand EW

更新日期：1995-09-07 00:00:00

abstract：:Hormones and neuropeptides may influence the activities of lymphoid organs and cells via endocrine and local autocrine/paracrine pathways. A paradigm of the interactions between the neuroendocrine and immune system is sophisticatedly represented in the thymus. Indeed, receptors for these molecules are heterogeneously ...

journal_title：Annals of the New York Academy of Sciences

authors： Ferone D,Boschetti M,Resmini E,Giusti M,Albanese V,Goglia U,Albertelli M,Vera L,Bianchi F,Minuto F

更新日期：2006-06-01 00:00:00

abstract：:Intentional exposures to toxic chemicals can stem from terrorist attacks, such as the release of sarin in the Tokyo subway system in 1995, as well as from toxic industrial accidents that are much more common. Developing effective medical interventions is a critical component of the overall strategy to overcome the cha...

journal_title：Annals of the New York Academy of Sciences

authors： Jett DA

更新日期：2016-06-01 00:00:00

abstract：:Neurotrophic factors are secreted peptides that when interacting with specific classes of membrane receptors activate intracellular signaling cascades that prevents neuronal death during embryonic development. The establishment of gene-targeted null mutant mice for the neurotrophic factors, brain-derived neurotrophic ...

journal_title：Annals of the New York Academy of Sciences

authors： Agerman K,Canlon B,Duan M,Ernfors P

更新日期：1999-11-28 00:00:00

abstract：:Previous studies in postmenopausal women have reported that estrogen treatment (ET) modulates the risk for developing Alzheimer's disease (AD). It has recently been hypothesized that there may be a "critical period" around the time of menopause during which the prescription of ET may reduce the risk of developing AD i...

journal_title：Annals of the New York Academy of Sciences

authors： Craig MC,Murphy DG

更新日期：2010-09-01 00:00:00

abstract：:Extracellular DNA in the plasma or serum of cancer patients has been recently proposed as a source of analyzable cancer-related gene sequences (qualitative approach). Furthermore, patients with different tumor types show high levels of cell-free circulating DNA both in plasma and serum (quantitative approach) at the t...

journal_title：Annals of the New York Academy of Sciences

authors： Frattini M,Gallino G,Signoroni S,Balestra D,Battaglia L,Sozzi G,Leo E,Pilotti S,Pierotti MA

更新日期：2006-09-01 00:00:00

abstract：:Despite advances in technology and medicine, death itself remains an immutable certainty. Indeed, the acceptance and understanding of our mortality are among the enduring metaphysical challenges that have confronted human beings from the beginning of time. How have we sought to cope with the inevitability of our morta...

journal_title：Annals of the New York Academy of Sciences

authors： Paulson S,Kellehear A,Kripal JJ,Leary L

更新日期：2014-11-01 00:00:00

abstract：:The musical pitch of harmonic complex sounds, such as instrumental sounds, is perceived primarily by decoding either the fundamental pitch (keynote) or spectral aspects of the stimuli, for example, single harmonics. We divided 334 professional musicians, including symphony orchestra musicians, 75 amateur musicians, an...

journal_title：Annals of the New York Academy of Sciences

authors： Schneider P,Sluming V,Roberts N,Bleeck S,Rupp A

更新日期：2005-12-01 00:00:00

abstract：:Mice deficient for complement factors C3, C4, or C5 are resistant to experimental autoimmune myasthenia gravis (EAMG). Acetylcholine receptor (AChR) immune lymph node cells (LNC) of C3 deficient mice produce less interleukin 6 (IL-6), and EAMG-resistant IL-6 deficient mice have less serum C3. Increased serum C1q-circu...

journal_title：Annals of the New York Academy of Sciences

authors： Christadoss P,Tüzün E,Li J,Saini SS,Yang H

更新日期：2008-01-01 00:00:00

abstract：:We isolated a eugenol-degrading bacterium, Pseudomonas fluorescens E118. This strain produced a novel enzyme, eugenol dehydrogenase, which catalyzes the conversion of eugenol into coniferyl alcohol. The enzyme was purified from the eugenol-induced cells of P. fluorescens E118. The purified enzyme appeared to be homoge...

journal_title：Annals of the New York Academy of Sciences

authors： Furukawa H,Nagasawa T

更新日期：1998-12-13 00:00:00

abstract：:Amyloid precursor proteins (APP) are a member of a larger family of proteins that include the amyloid precursor-like proteins (APLP) APLPI and APLP2. We have examined the expression and metabolism of APLP2 and document that APLP2 is expressed at high levels in the nervous system and in peripheral tissues. Furthermore,...

journal_title：Annals of the New York Academy of Sciences

authors： Sisodia SS,Thinakaran G,Slunt HH,Kitt CA,Von Koch CS,Reed RR,Zheng H,Price DL

更新日期：1996-01-17 00:00:00

abstract：:Coccidioides causes coccidioidomycosis in the southwestern United States. Its clinical manifestations range from the primary asymptomatic to progressive pulmonary and extrapulmonary disease. Because of endemicity, frequent relapse, and virulent nature of Coccidioides, there is an urgent need for the development of eff...

journal_title：Annals of the New York Academy of Sciences

authors： Awasthi S

更新日期：2007-09-01 00:00:00

abstract：:The discovery of AQP4-IgG (a pathogenic antibody that targets the astrocytic water channel aquaporin-4), as the first sensitive and specific biomarker for any inflammatory central nervous system demyelinating disease (IDD), has shifted emphasis from the oligodendrocyte and myelin to the astrocyte as a central immunopa...

journal_title：Annals of the New York Academy of Sciences

authors： Pittock SJ,Lucchinetti CF

更新日期：2016-02-01 00:00:00

abstract：:The disturbances in the balance of pro- and antifibrinolytic activity, as observed in AAA and obesity, respectively, have considerable potential for influencing both intra- and extravascular fibrinolytic events and may be causally related to the development of vascular disease. For example, the wall of the aortic athe...

journal_title：Annals of the New York Academy of Sciences

authors： Samad F,Schneiderman J,Loskutoff D

更新日期：1997-04-15 00:00:00

abstract：:We have developed a rabbit model of in utero exposure to intravenous injections of cocaine given twice daily to dams from gestational days 8-29. At the doses employed (4 mg/kg, injected twice daily), no differences were found in the body weight gain of dams, time to delivery, litter size, and body weight or other phys...

journal_title：Annals of the New York Academy of Sciences

authors： Romano AG,Harvey JA

更新日期：1998-06-21 00:00:00

abstract：:A brief overview is presented of recently developed and currently emerging statistical and computational techniques that have been proved to be highly helpful in handling the avalanche of the new type of data generated by modern high-throughput technologies in experimental biology. The review, in no way comprehensive,...

journal_title：Annals of the New York Academy of Sciences

authors： Rosenfeld S

更新日期：2004-05-01 00:00:00

abstract：:Adults with better jobs enjoy better health: job title was, in fact, the social gradient metric first used to study the relationship between social class and chronic disease etiology, a core finding now replicated in most developed countries. What has been less well proved is whether this correlation is causal, and if...

journal_title：Annals of the New York Academy of Sciences

authors： Clougherty JE,Souza K,Cullen MR

更新日期：2010-02-01 00:00:00

abstract：:Evidence gathered to date from topographic data, geophysical data, well logs, and drill-core samples indicates that the buried Chicxulub basin, the source crater for the approximately 65 Ma Cretaceous-Tertiary (K/T) boundary deposits, is approximately 300 km in diameter. A prominent topographic ridge and a ring of gra...

journal_title：Annals of the New York Academy of Sciences

authors： Sharpton VL,Marin LE

更新日期：1997-05-30 00:00:00

abstract：:Risk factors for esophageal cancer include genetic factors (such as tylosis) and infectious agents. A variety of organisms have been implicated in esophageal carcinogenesis, either directly or indirectly. In this review, we explore the normal esophageal flora and how it may be controlled, and also the variety of organ...

journal_title：Annals of the New York Academy of Sciences

authors： El-Zimaity H,Di Pilato V,Novella Ringressi M,Brcic I,Rajendra S,Langer R,Dislich B,Tripathi M,Guindi M,Riddell R

更新日期：2018-12-01 00:00:00

abstract：:Hematopoietic stem cells (HSCs) have been long proposed to reside in defined anatomical locations within bone marrow (BM) tissues in direct contact or close proximity to nurturing cell types. Imaging techniques that allow the simultaneous mapping of HSCs and interacting cell types have been central to the discovery of...

journal_title：Annals of the New York Academy of Sciences

authors： Gomariz A,Isringhausen S,Helbling PM,Nombela-Arrieta C

更新日期：2020-04-01 00:00:00