Neurotrophins, NMDA receptors, and nitric oxide in development and protection of the auditory system.

abstract：:This has been an overview of fish health, a comparison of some aspects of fish husbandry with other animal husbandry, and comments concerning fish health research--especially where it is going. The 1972 disease survey identified current problems; it ranked the problems according to priority. More important, research e...

journal_title：Annals of the New York Academy of Sciences

authors： Wolf K

更新日期：1975-01-24 00:00:00

abstract：:Antagonists of the NMDA glutamate receptor, including phencyclidine (PCP), ketamine, and CGS-19755, produce cognitive and behavioral changes in humans. In rodents these agents produce a myriad of histopathological and neurochemical changes. Several lines of evidence suggest that a large number of these drug-induced ef...

journal_title：Annals of the New York Academy of Sciences

authors： Farber NB

更新日期：2003-11-01 00:00:00

abstract：:In his First Law (of thermodynamics), Clausius emphasized the equivalence of heat and work-conservation of energy was mentioned only indirectly. Today, the main emphasis is put on energy conservation, but the equivalence of heat and work has proven not only to be superfluous, but also highly destructive. Because of th...

journal_title：Annals of the New York Academy of Sciences

authors： Job G,Lankau T

更新日期：2003-05-01 00:00:00

abstract：:The historical reasons for the introduction of tick control during the nineteenth century are reviewed. Background and concepts for the choice between long-term tick control and tick eradication are compared. Case studies of large-scale tick control or eradication programs in Africa, Australia, the United States, and ...

journal_title：Annals of the New York Academy of Sciences

authors： Pegram RG,Wilson DD,Hansen JW

更新日期：2000-01-01 00:00:00

abstract：:Since the late sixties, several new antifungal drugs have become available. Initially, they were all intended for topical use, and, consequently, animal and human pharmacology always primarily aimed at confirming therapeutic efficacy. With the new tendency for the development of orally active antifungal drugs, human a...

journal_title：Annals of the New York Academy of Sciences

authors： Cauwenbergh G,Van Cutsem J

更新日期：1988-01-01 00:00:00

abstract：:Mitochondrial dysfunction, due to either environmental or genetic factors, can result in excessive production of reactive oxygen species, triggering the apoptotic death of dopaminergic cells in Parkinson's disease. Mitochondrial free radical production is promoted by the inhibition of electron transport at any point d...

journal_title：Annals of the New York Academy of Sciences

authors： Fiskum G,Starkov A,Polster BM,Chinopoulos C

更新日期：2003-06-01 00:00:00

abstract：:Natural systems harbor complex interactions that are fundamental parts of ecology and evolution. These interactions challenge our inclinations and training to seek the simplest explanations of patterns in nature. Not least is the likelihood that some complex processes might be missed when their patterns look similar t...

journal_title：Annals of the New York Academy of Sciences

authors： Kinnison MT,Hairston NG Jr,Hendry AP

更新日期：2015-12-01 00:00:00

abstract：:Lewisite and many other similar arsenicals are warfare vesicants developed and weaponized for use in World Wars I and II. These chemicals, when exposed to the skin and other epithelial tissues, cause rapid severe inflammation and systemic damage. Here, we show that topically applied arsenicals in a murine model produc...

journal_title：Annals of the New York Academy of Sciences

authors： Srivastava RK,Muzaffar S,Khan J,Traylor AM,Zmijewski JW,Curtis LM,George JF,Ahmad A,Antony VB,Agarwal A,Athar M

更新日期：2020-11-01 00:00:00

abstract：:Colorectal cancer is the third most frequent fatal malignant neoplasm in the United States and is expected to cause significant morbidity and mortality. The recent recall of cyclooxygenase-2 inhibitors from clinical trials highlights the need to develop other agents for cancer chemoprevention trials. Intervention stra...

journal_title：Annals of the New York Academy of Sciences

authors： Nelson MA,Goulet AC,Jacobs ET,Lance P

更新日期：2005-11-01 00:00:00

abstract：:Modern contraceptive methods represent more than a technical advance: they are the instrument of a true social revolution-the "first reproductive revolution" in the history of humanity, an achievement of the second part of the 20th century, when modern, effective methods became available. Today a great diversity of te...

journal_title：Annals of the New York Academy of Sciences

authors： Benagiano G,Bastianelli C,Farris M

更新日期：2006-12-01 00:00:00

abstract：:Choir singing is positively associated with well-being and quality of life, and requires the coordination of physiological systems within and across individuals. Informed by models of interpersonal action coordination, we delineate the network topography of choir singing by analyzing cross-frequency couplings and with...

journal_title：Annals of the New York Academy of Sciences

authors： Müller V,Delius JAM,Lindenberger U

更新日期：2018-11-01 00:00:00

abstract：:Now that the human genome has been mapped, a new challenge has emerged: deciphering the various products of individual genes. Consequently, new proteomic technologies are being developed to monitor and identify protein function and interactions responsible for the total activities of the cell. The application of these...

journal_title：Annals of the New York Academy of Sciences

authors： Leak LV,Petricoin EF 3rd,Jones M,Paweletz CP,Ardekani AM,Fusaro VA,Ross S,Liotta LA

更新日期：2002-12-01 00:00:00

abstract：:Every day billions of cells die in our bodies to eliminate those that are harmful, useless, or senescent. The process can be divided into two steps: cell dying and cell clearance. In the first step, death machinery is activated in the cells and quickly kills them. During the second step, dead cells are engulfed by pha...

journal_title：Annals of the New York Academy of Sciences

authors： Nagata S

更新日期：2010-10-01 00:00:00

abstract：:The loop between transmembrane helices 6 and 7 (L6/7) of P-type ATPases has been suggested to be important for the functional linkage of ion binding and enzyme phosphorylation or to be a site of initial cation binding. To investigate the role of L6/7 in Na,K-ATPase, alanine substitutions were made for charged and cons...

journal_title：Annals of the New York Academy of Sciences

authors： Xu G,Farley RA,Kane DJ,Faller LD

更新日期：2003-04-01 00:00:00

abstract：:Cochlear implants (CIs) provide impressive speech perception for persons with severe hearing loss, but many CI recipients fail in perceiving speech prosody and music. Successful rehabilitation depends on cortical plasticity in the brain and postoperative measures. The present study evaluates the behavioral and neurolo...

journal_title：Annals of the New York Academy of Sciences

authors： Petersen B,Mortensen MV,Gjedde A,Vuust P

更新日期：2009-07-01 00:00:00

abstract：:Cancer chemoprevention entails the ingestion of dietary or pharmaceutical agents that can prevent, delay, or reverse the process of carcinogenesis. With support provided by the National Cancer Institute, we have been actively engaged in the systematic discovery and characterization of natural chemopreventive agents. T...

journal_title：Annals of the New York Academy of Sciences

authors： Pezzuto JM

更新日期：2011-01-01 00:00:00

abstract：UNLABELLED:A new Biorex molecule, BRX-220, has been shown to be effective in animal models of diabetic neuro- and retinopathy. Recent in vitro studies showed that it might also have an insulin-sensitizing action. Therefore, the effect of BRX-220 on insulin sensitivity was compared with the action of pioglitazone (PGZ) ...

journal_title：Annals of the New York Academy of Sciences

authors： Seböková E,Kürthy M,Mogyorosi T,Nagy K,Demcáková E,Ukropec J,Koranyi L,Klimes I

更新日期：2002-06-01 00:00:00

abstract：:Evidence gathered to date from topographic data, geophysical data, well logs, and drill-core samples indicates that the buried Chicxulub basin, the source crater for the approximately 65 Ma Cretaceous-Tertiary (K/T) boundary deposits, is approximately 300 km in diameter. A prominent topographic ridge and a ring of gra...

journal_title：Annals of the New York Academy of Sciences

authors： Sharpton VL,Marin LE

更新日期：1997-05-30 00:00:00

abstract：:A major challenge in systems biology is to evaluate the feasibility of a biological research project prior to its realization. Since experiments are animals-, cost- and time-consuming, approaches allowing researchers to discriminate alternative hypotheses with a minimal set of experiments are highly desirable. Given a...

journal_title：Annals of the New York Academy of Sciences

authors： Maiwald T,Kreutz C,Pfeifer AC,Bohl S,Klingmüller U,Timmer J

更新日期：2007-12-01 00:00:00

abstract：:Despite the documented association between apolipoprotein E genotype and cerebral amyloid angiopathy (CAA), a substantial proportion of CAA-related hemorrhages occur in patients without known risks for this disorder. Two other factors implicated in the pathogenesis of CAA are the amyloid-beta peptide (preferentially d...

journal_title：Annals of the New York Academy of Sciences

authors： Greenberg SM,Cho HS,O'Donnell HC,Rosand J,Segal AZ,Younkin LH,Younkin SG,Rebeck GW

更新日期：2000-04-01 00:00:00

abstract：:The development of ustekinumab as a first-in-class anti-interleukin (IL) 12/23p40 therapeutic agent for psoriasis represents an important example of modern and rational drug design and development. Psoriasis is a chronic, systemic, immune-mediated skin disorder with considerable clinical, psychosocial, and economic bu...

journal_title：Annals of the New York Academy of Sciences

authors： Yeilding N,Szapary P,Brodmerkel C,Benson J,Plotnick M,Zhou H,Goyal K,Schenkel B,Giles-Komar J,Mascelli MA,Guzzo C

更新日期：2011-03-01 00:00:00

abstract：:Thymosin proteins, originally isolated from fractionation of thymus tissue, represent a class of compounds that we now know are present in numerous other tissues, are unrelated to each other in a genetic sense, and appear to have different functions within the cell. Thymosin α1 (generic drug name thymalfasin; trade na...

journal_title：Annals of the New York Academy of Sciences

authors： Volk DE,Tuthill CW,Elizondo-Riojas MA,Gorenstein DG

更新日期：2012-10-01 00:00:00

abstract：:A brief overview of the different techniques used to estimate the probable maximum precipitation (PMP) is presented. As a particular case, the 1-day PMP over Catalonia has been calculated and mapped with a high spatial resolution. For this purpose, the annual maximum daily rainfall series from 145 pluviometric station...

journal_title：Annals of the New York Academy of Sciences

authors： Casas MC,Rodríguez R,Nieto R,Redaño A

更新日期：2008-12-01 00:00:00

abstract：:A rabbit antimouse brain theta reagent was made specific for cells of the T lineage by absorption in vivo in nude mice. When used in double fluorescence together with an antimouse immunoglobulin reagent, four types of cells were found in spleen and lymph nodes of both normal and nude mice: Ig+thetaBr-, Ig-thetaBr+, Ig...

journal_title：Annals of the New York Academy of Sciences

authors： Loor F,Roelants GE

更新日期：1975-06-30 00:00:00

abstract：:Myasthenia gravis (MG) is usually caused by autoantibodies against muscle nicotinic acetylcholine receptor (AChR), which is composed of five subunits (alpha(2)betagammadelta or alpha(2)betaepsilondelta). Current treatments, including plasmapheresis, are nonspecific, causing several side effects. We aim to develop an a...

journal_title：Annals of the New York Academy of Sciences

authors： Tzartos SJ,Bitzopoulou K,Gavra I,Kordas G,Jacobson L,Kostelidou K,Lagoumintzis G,Lazos O,Poulas K,Sideris S,Sotiriadis A,Trakas N,Zisimopoulou P

更新日期：2008-01-01 00:00:00

abstract：:(a) The PR elicited by excitotoxic destruction of intrinsic neurons in the CN has a rapid onset, peaks within 2 weeks, and persists indefinitely; (b) the majority of the proliferating cells are not intrinsic to the CNS but are of hematic origin; (c) a small mirror-image response is seen in the contralateral CN; (d) th...

journal_title：Annals of the New York Academy of Sciences

authors： Katz IR,Iacovitti L,Reis DJ

更新日期：1988-01-01 00:00:00

abstract：:High-mobility group box-1 (HMGB1) is a prototypical endogenous signal that links tissue necrosis and wound healing. Extracellular HMGB1 has apparently contrasting biological actions: it sustains inflammation (with the possible establishment of autoimmunity or of self-maintaining tissue damage) while activating and rec...

journal_title：Annals of the New York Academy of Sciences

authors： Vezzoli M,Castellani P,Campana L,Corna G,Bosurgi L,Manfredi AA,Bianchi ME,Rubartelli A,Rovere-Querini P

更新日期：2010-10-01 00:00:00

abstract：:Studies of musical abilities in dementia have for the most part been rather general assessments of abilities, for instance, assessing retention of music learned premorbidly. Here, we studied patients with dementias with contrasting cognitive profiles to explore specific aspects of music cognition under challenge. Pati...

journal_title：Annals of the New York Academy of Sciences

authors： Halpern AR,Golden HL,Magdalinou N,Witoonpanich P,Warren JD

更新日期：2015-03-01 00:00:00

abstract：:Rat striatal synaptosomes showed a reduced capacity to generate a membrane potential after being exposed to methamphetamine (METH) for 1 h. As a consequence, the dopamine (DA) synaptosomes were impeded in their electrogenic-dependent reuptake of dopamine. The capacity for METH-exposed nerve terminals to generate a mem...

journal_title：Annals of the New York Academy of Sciences

authors： Westphalen RI,Stadlin A

更新日期：2000-09-01 00:00:00

abstract：:IRAS, a putative clone of the I(1)-imidazoline receptor, possesses a proline-rich region (PRR) motif, which might interact with SH3 regions on tyrosine kinases, and an integrin-binding motif. Receptors with a PRR motif can generally assemble onto multi-element signaling complexes (eg., the beta(3)-receptor on the EGF ...

journal_title：Annals of the New York Academy of Sciences

authors： Musgrave IF,Dehle FC,Piletz J

更新日期：2003-12-01 00:00:00