Expression of fibrinolytic genes in tissues from human atherosclerotic aneurysms and from obese mice.

abstract：:The oxidative modification of proteins by reactive species, especially reactive oxygen species, is implicated in the etiology or progression of a panoply of disorders and diseases. These reactive species form through a large number of physiological and non-physiological reactions. An increase in the rate of their prod...

journal_title：Annals of the New York Academy of Sciences

authors： Stadtman ER,Levine RL

更新日期：2000-01-01 00:00:00

abstract：:Resveratrol-mediated heme oxgenase-1 (HO-1) induction has been shown to occur in primary neuronal cultures and has been implicated as having potential neuroprotective action. Further, antioxidant properties of resveratrol have been reported to protect against coronary heart disease. We attempted to examine the HO-1 in...

journal_title：Annals of the New York Academy of Sciences

authors： Huang HM,Liang YC,Cheng TH,Chen CH,Juan SH

更新日期：2005-05-01 00:00:00

abstract：:Apoptosis in T and B lymphocytes is a major element controlling the immune response. Activation induced cell death (AICD) in T cells is a main mechanism for maintaining peripheral tolerance and for limiting an ongoing immune response. AICD is initiated by antigen reengagement of the T cell receptor (TCR), and mediated...

journal_title：Annals of the New York Academy of Sciences

authors： Delgado M,Ganea D

更新日期：2000-01-01 00:00:00

abstract：:Nature has been a source of medicinal agents for thousands of years, and an impressive number of modern drugs have been isolated from natural sources, many based on their use in traditional medicine. The use of herbal drugs is once more escalating in the form of complementary and alternative medicine. The past century...

journal_title：Annals of the New York Academy of Sciences

authors： Cragg GM,Newman DJ

更新日期：2001-12-01 00:00:00

abstract：:This paper describes the experimental results of a pilot-scale application of membrane technologies to textile wastewater advanced treatment, downstream of a biological activated sludge process, aimed at water reuse in textile technology processes. The chosen approach consisted of sand filtration as a pretreatment, a ...

journal_title：Annals of the New York Academy of Sciences

authors： Marcucci M,Ciabatti I,Matteucci A,Vernaglione G

更新日期：2003-03-01 00:00:00

abstract：:Anemia affects over 800 million women and children globally. Defined as a limited or insufficient functional red blood cell supply in peripheral blood, anemia causes a reduced oxygen supply to tissues and can have serious health consequences for women and children. Hemoglobin (Hb) concentration is most commonly measur...

journal_title：Annals of the New York Academy of Sciences

authors： Karakochuk CD,Hess SY,Moorthy D,Namaste S,Parker ME,Rappaport AI,Wegmüller R,Dary O,HEmoglobin MEasurement (HEME) Working Group.

更新日期：2019-08-01 00:00:00

abstract：:Dopamine-beta-hydroxylase (DbetaH) deficiency is a rare autosomal dominant disorder. Due to the absence of DbetaH, there is a blocked conversion of dopamine into norepinephrine. The biochemical hallmark of this syndrome consists of a complete absence of plasma norepinephrine and epinephrine levels in conjunction with ...

journal_title：Annals of the New York Academy of Sciences

authors： Timmers HJ,Deinum J,Wevers RA,Lenders JW

更新日期：2004-06-01 00:00:00

abstract：:We have previously identified 30 differentially expressed genes when comparing recently diagnosed type 1 diabetes mellitus (DM-1) patients and controls paired for sex, age, and ethnic background. In this article we performed the hierarchical clustering of these genes taking into account the human-leukocyte-antigen (HL...

journal_title：Annals of the New York Academy of Sciences

authors： Rassi DM,Junta CM,Fachin AL,Sandrin-Garcia P,Mello SS,Fernandes AP,Deghaide NN,Foss-Freitas MC,Foss MC,Sakamoto-Hojo ET,Passos GA,Donadi EA

更新日期：2006-10-01 00:00:00

abstract：:In this paper, I have introduced and solved a simple deterministic model of eye tracking that produces rich dynamical behavior. Some of its main features, notably the existence of a chaotic regime, are reminiscent of the anomalies reported in smooth pursuit eye tracking experiments with schizophrenia patients. By obta...

journal_title：Annals of the New York Academy of Sciences

authors： Huberman BA

更新日期：1987-01-01 00:00:00

abstract：:One of the challenges facing health and welfare policymakers as well as researchers in most developed countries is the increasing demand for aging services and aged care. Low birth rates and rapid increases in the percentages of elderly people make aging and aged care one of the top-priority issues among the national ...

journal_title：Annals of the New York Academy of Sciences

authors： Soar J,Seo Y

更新日期：2007-10-01 00:00:00

abstract：:Uteroglobin, a steroid-inducible, cytokine-like, secreted protein with immunomodulatory properties, has been reported to bind progesterone, polychlorinated biphenyls (PCB), and retinol. Structural studies may delineate whether binding of ligands is a likely physiological function of human uteroglobin (hUG). We report ...

journal_title：Annals of the New York Academy of Sciences

authors： Pattabiraman N,Matthews JH,Ward KB,Mantile-Selvaggi G,Miele L,Mukherjee AB

更新日期：2000-01-01 00:00:00

abstract：:Since the early 1980s biologists have recognized that skeletal muscle generates free radicals. Of particular interest are two closely related redox cascades--reactive oxygen species (ROS) and nitric oxide (NO) derivatives. The ROS cascade is initiated by superoxide anion radicals derived from the mitochondrial electro...

journal_title：Annals of the New York Academy of Sciences

authors： Reid MB,Durham WJ

更新日期：2002-04-01 00:00:00

abstract：:Venous or arterial thrombosis, abortion, and the presence of antiphospholipid antibodies (aPL) define the criteria for the antiphospholipid syndrome (APS). A heterogeneous group of antibodies against phospholipids and plasma proteins may influence several coagulation pathways and lead to thrombophilia. We investigated...

journal_title：Annals of the New York Academy of Sciences

authors： Miesbach W,Matthias T,Scharrer I

更新日期：2005-06-01 00:00:00

abstract：:Several growth factors (e.g., transforming growth factors beta and alpha, basic fibroblast growth factor), produced by hypothalamic astrocytes, participate in the control of hypothalamic gonadotrophin-releasing hormone (GnRH) neurons. On this basis, we have hypothesized that steroid hormones, like estrogens and proges...

journal_title：Annals of the New York Academy of Sciences

authors： Galbiati M,Saredi S,Melcangi RC

更新日期：2003-12-01 00:00:00

abstract：:Inflammasomes continue to generate interest in an increasing number of disciplines owing to their unique ability to integrate a myriad of signals from pathogen- and damage-associated molecular patterns into a proinflammatory response. This potent caspase-1-dependent process is capable of activating the innate immune s...

journal_title：Annals of the New York Academy of Sciences

authors： Sutterwala FS,Haasken S,Cassel SL

更新日期：2014-06-01 00:00:00

abstract：:The purpose of this study was to quantify the changes in cell membrane conductance in response to electropermeabilization, which may elucidate the mechanisms of tissue injury resulting from high-voltage electrical shock. A high-speed, space-clamp and voltage-clamp experimental configuration was used. The pulse paramet...

journal_title：Annals of the New York Academy of Sciences

authors： Gowrishankar TR,Chen W,Lee RC

更新日期：1998-09-11 00:00:00

abstract：:We cloned a kappa 3-related opioid receptor, and although it is still not clear whether this clone corresponds to the kappa 3 receptor itself or is a related gene product, the extensive antisense mapping and the antibody immunoreactivity strongly associate this clone with the kappa 3 receptor. Our approach also indica...

journal_title：Annals of the New York Academy of Sciences

authors： Pasternak GW,Pan YX,Cheng J

更新日期：1995-05-10 00:00:00

abstract：:1. One can accurately predict the contribution of each inhibitor to the total inactivation of an enzyme in plasma once its pseudo-first-order reaction rate constant and concentration are known. 2. Because the mechanism of augmentation of the inactivation rate of an enzyme by ATIII occurs via formation of an ATIII-hepa...

journal_title：Annals of the New York Academy of Sciences

authors： Colman RW,Scott CF,Pixley RA,de la Cadena RA

更新日期：1989-01-01 00:00:00

abstract：:This review focuses on the importance of bradykinin in myocardial preservation during ischemic arrest. Bradykinin is released from the heart spontaneously in response to ischemic stress, which may be viewed as a survival signal of the heart against ischemia. Bradykinin appears to function as a signaling molecule by co...

journal_title：Annals of the New York Academy of Sciences

authors： Sato M,Das DK,Engelman RM

更新日期：1999-06-30 00:00:00

abstract：:Relaxin (RLX) has antifibrotic effects in a number of tissues. Many of these effects are similar to those induced by the activators of peroxisome proliferator-activated receptor gamma (PPARgamma), raising the possibility that a mechanism for RLX's antifibrotic effects may involve activation of the PPARgamma pathway. T...

journal_title：Annals of the New York Academy of Sciences

authors： Singh S,Bennett RG

更新日期：2009-04-01 00:00:00

abstract：:The gain of the angular vestibulo-ocular reflex (aVOR) was determined in monkeys by rotation about a spatial vertical axis while upright or statically tilted forward and backward. Horizontal, vertical, and roll gains were determined at each head orientation and plotted as a function of head tilt. Before canal plugging...

journal_title：Annals of the New York Academy of Sciences

authors： Yakushin SB,Dai M,Raphan T,Suzuki J,Arai Y,Cohen B

更新日期：2001-10-01 00:00:00

abstract：:Cross-species hybridizations have enabled us to isolate and clone the gene for the beta chain of human fibrinogen. Highlights of the gene for the beta chain revealed by nucleotide sequence analyses, particularly in areas that have a direct bearing on defining the overall organization of the gene, have been presented. ...

journal_title：Annals of the New York Academy of Sciences

authors： Chung DW,Rixon MW,Que BG,Davie EW

更新日期：1983-06-27 00:00:00

abstract：:The mechanism of action of tocopherol transfer protein (TTP) and its role in the intracellular processing of vitamin E were investigated using confocal fluorescence microscopy. The results from this work suggest that TTP functions by transporting vitamin E from endocytic organelles to other locations in the cell. ...

journal_title：Annals of the New York Academy of Sciences

authors： Qian J,Wilson K,Nava P,Morley S,Atkinson J,Manor D

更新日期：2004-12-01 00:00:00

abstract：:Transcriptome analysis is a powerful tool to characterize changes in leukocyte gene expression patterns and reveal very early molecular abnormalities in tissue. Herein, we report on characterization of the very earliest abnormalities in the transcriptome of leukocytes from young "prepathologic" NOD and NON female mice...

journal_title：Annals of the New York Academy of Sciences

authors： Gerling IC,Ali C,Lenchik N

更新日期：2003-11-01 00:00:00

abstract：:A variety of chemical compounds are currently being discussed as novel drug delivery strategies. One promising strategy is to selectively open the paracellular pathway of epithelia for the passage of macromolecules. A prerequisite for this effect is a rapid and reversible action of these compounds, to allow a marked t...

journal_title：Annals of the New York Academy of Sciences

authors： Rosenthal R,Heydt MS,Amasheh M,Stein C,Fromm M,Amasheh S

更新日期：2012-07-01 00:00:00

abstract：:There is now good evidence that in the AD brain, a number of neurotransmitter effector systems are defective. Such abnormalities include defective G, protein and protein kinase C function as well as a drastically reduced level of receptors for the second messenger Ins(1,4,5) P3. Such changes are probably not restricte...

journal_title：Annals of the New York Academy of Sciences

authors： Fowler CJ,Garlind A,O'Neill C,Cowburn RF

更新日期：1996-06-15 00:00:00

abstract：:Potato products contain high amounts of acrylamide, which sometimes exceeds the concentration of 1 mg/L. However, many strategies for acrylamide reduction in potato products are possible. In this work, the different approaches for reducing acrylamide formation have been reviewed, keeping in mind that in the applicatio...

journal_title：Annals of the New York Academy of Sciences

authors： Morales F,Capuano E,Fogliano V

更新日期：2008-04-01 00:00:00

abstract：:We are performing genomic searches in randomly ascertained families to identify new quantitative trait loci (QTLs) that influence atherosclerosis and its risk factors. The genetic markers used for genomic searches are random microsatellite markers distributed throughout the human chromosomes. These markers are used fo...

journal_title：Annals of the New York Academy of Sciences

authors： Hixson JE,Blangero J

更新日期：2000-05-01 00:00:00

abstract：:A method using laser-induced fluorescence (LIF) for in vivo cancer diagnosis of the esophagus is described. Autofluorescence of normal and malignant tissues was measured directly using a fiberoptic probe inserted through an endoscope. The measurements were performed in vivo during routine endoscopy. Measurement of the...

journal_title：Annals of the New York Academy of Sciences

authors： Vo-Dinh T,Panjehpour M,Overholt BF

更新日期：1998-02-09 00:00:00

abstract：:Our previous studies have demonstrated that the methanol extract of heat-processed Panax ginseng C.A. Meyer exerts antioxidative, antiinflammatory, and anti-tumor-promoting effects. In the present study, we examined the antiinflammatory effects of several ginsenosides (Rb(1), Rc, Re, Rg(1), Rg(3)) derived from P. gins...

journal_title：Annals of the New York Academy of Sciences

authors： Surh YJ,Lee JY,Choi KJ,Ko SR

更新日期：2002-11-01 00:00:00