T-cell receptor V-region usage and antigen specificity. The cytochrome c model system.

Abstract:

:Investigations of the I-Ek-restricted, cytochrome c-specific T-cell response in mice show that both T-cell receptor V alpha and V beta CDR3 residues and the use of particular V alpha s and V beta s are necessary for recognition. Data strongly suggest that specific CDR3 residues are important in contacting the peptide. Other experiments indicate that the requirement for V alpha:V beta conservation is not the result of strong TCR-->MHC interactions, as no correlation was found between V beta usage and changes in the alpha-helixes of the I-Ek molecule. It is also apparent that changes in V alpha or V beta usage could be elicited by changes in the side chain size of single amino acids of the antigenic peptides, suggesting that V alpha or V beta conservation is important for peptide recognition, either directly or indirectly. We also show that we can follow the cytochrome c response in vivo even in nontransgenic mice, solely by staining with anti-V region antibodies as well as mAbs directed at the activation markers CD44 and L-selectin.

journal_name

Ann N Y Acad Sci

authors

Davis MM,McHeyzer-Williams M,Chien YH

doi

10.1111/j.1749-6632.1995.tb44477.x

subject

Has Abstract

pub_date

1995-07-07 00:00:00

pages

1-11

eissn

0077-8923

issn

1749-6632

journal_volume

756

pub_type

杂志文章,评审
  • Role of exogenous and endogenous hormones in endometrial cancer: review of the evidence and research perspectives.

    abstract::Endometrial carcinoma is the most common cancer of the female reproductive organs in the United States. International comparisons reveal that the incidence of endometrial cancer vary widely between different countries with the highest rates observed in North America and Northern Europe, intermediate rates in Eastern E...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2001.tb03811.x

    authors: Akhmedkhanov A,Zeleniuch-Jacquotte A,Toniolo P

    更新日期:2001-09-01 00:00:00

  • The neurotoxicity of polybrominated biphenyls: results of a medical field survey.

    abstract::Neurologic symptoms were the earliest and most prominent symptoms recorded in Michigan farm residents exposed to PBB as compared to a non-PBB exposed control farm population in Wisconsin. In Michigan (particularly among males) those who exhibited the most marked symptoms tended to show diminished performance as assess...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1979.tb56617.x

    authors: Valciukas JA,Lilis R,Anderson HA,Wolff MS,Petrocci M

    更新日期:1979-05-31 00:00:00

  • Expression of the proneurotensin gene in the rat brain and its regulation by antipsychotic drugs.

    abstract::In this chapter, we have presented evidence for several potential levels of interaction of NT/N gene products with dopaminergic systems of the brain. We have focused on one manifestation of this interaction related to the effects of antipsychotic drugs on expression of the NT/N gene in two anatomically discrete popula...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1992.tb27339.x

    authors: Merchant KM,Dobie DJ,Dorsa DM

    更新日期:1992-01-01 00:00:00

  • Etiology of the metabolic syndrome: potential role of insulin resistance, leptin resistance, and other players.

    abstract::Obesity and Type 2 diabetes are now major public health issues in developed nations and have reached epidemic proportions in many developing nations, as well as disadvantaged groups in developed countries, e.g., Mexican-Americans, African-Americans, and Australian Aborigines. These groups all show hyperinsulinemia and...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1999.tb07783.x

    authors: Zimmet P,Boyko EJ,Collier GR,de Courten M

    更新日期:1999-11-18 00:00:00

  • The viral eukaryogenesis hypothesis: a key role for viruses in the emergence of eukaryotes from a prokaryotic world environment.

    abstract::Understanding how the gulf between prokaryotic and eukaryotic cellular design arose is a major challenge. The viral eukaryogenesis (VE) hypothesis addresses the challenge of eukaryotic origins by suggesting the first eukaryotic cell was a multimember consortium consisting of a viral ancestor of the nucleus, an archaea...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.04994.x

    authors: Bell PJ

    更新日期:2009-10-01 00:00:00

  • Public sector administration of ecological economics systems using mediated modeling.

    abstract::In today's climate of government outsourcing and multiple stakeholder involvement in public sector management and service delivery, it is more important than ever to rethink and redesign the structure of how policy decisions are made, implemented, monitored, and adapted to new realities. The traditional command-and-co...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2009.05164.x

    authors: van den Belt M,Kenyan JR,Krueger E,Maynard A,Roy MG,Raphael I

    更新日期:2010-01-01 00:00:00

  • Nutritional factors and vertical transmission of HIV-1. Epidemiology and potential mechanisms.

    abstract::Transmission of HIV from mothers to children may occur through the transplacental, intrapartum, or breastfeeding routes. Adequate nutritional status may reduce vertical transmission by affecting several maternal or fetal and child risk factors for transmission including enhancing systemic immune function in the mother...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2000.tb05478.x

    authors: Fawzi W

    更新日期:2000-11-01 00:00:00

  • Movements of vesicles on microtubules.

    abstract::Many cytoplasmic vesicles are observed to move along microtubules. Often, bidirectional movement of particles is observed on a single microtubule. We have isolated one cytoplasmic motor, kinesin, and defined another, the axoplasmic retrograde factor, which are capable of powering anionic latex beads toward the plus an...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1987.tb27227.x

    authors: Sheetz MP,Vale R,Schnapp B,Schroer T,Reese T

    更新日期:1987-01-01 00:00:00

  • Sequencing of a 15-kb Ehrlichia ruminantium clone and evaluation of the cpg1 open reading frame for protection against heartwater.

    abstract::A 1.2 kb polymorphic fragment from the Gardel isolate of Ehrlichia (formerly Cowdria) ruminantium was used to isolate a 15kb clone from the E. ruminantium Welgevonden LambdaGEM-11 library. This clone, WL2EL1, was subcloned and sequenced. Eight open reading frames (ORFs) were identified. The ORF in WL2EL1 which contain...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb04367.x

    authors: Louw E,Brayton KA,Collins NE,Pretorius A,Van Strijp F,Allsopp BA

    更新日期:2002-10-01 00:00:00

  • Behavioral effects of CB2 cannabinoid receptor activation and its influence on food and alcohol consumption.

    abstract::Consumers of marijuana typically feel a strong, compulsive desire to consume food. Although past research revealed that the CB1 cannabinoid receptor is a potent regulator of food intake, the functional presence of neuronal CB2 cannabinoid receptors in the brain has been controversial. The role of CB2 receptors in food...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1432.035

    authors: Onaivi ES,Carpio O,Ishiguro H,Schanz N,Uhl GR,Benno R

    更新日期:2008-10-01 00:00:00

  • Semantic mediation of age-related deficits in episodic recognition of common odors.

    abstract::In the present research, the relationship between various semantic memory functions and episodic odor memory across the adult life span is addressed. In contrast to earlier evidence that odors may be encoded and stored as unique, nonlinguistic whole percepts, the present work suggests that episodic odor information is...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1998.tb10644.x

    authors: Larsson M,Bäckman L

    更新日期:1998-11-30 00:00:00

  • Genetic studies on the role of proteinases and growth factors in atherosclerosis and aneurysm formation.

    abstract::Expression analysis and epidemiologic studies have provided indirect evidence that proteinases and growth factors play a role in the development of atherosclerosis and complications such as aneurysm formation and plaque rupture. Studies using genetically altered mice have proven to be an elegant tool to study the caus...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2001.tb03935.x

    authors: Luttun A,Carmeliet P

    更新日期:2001-12-01 00:00:00

  • Separation anxiety as a mediator between acute morphine administration and PTSD symptoms in injured children.

    abstract::Emerging evidence suggests that individuals who receive morphine while hospitalized demonstrate a decrease in symptoms of posttraumatic stress disorder (PTSD). However, the mechanisms of effects are not yet well understood. The goal of the current study was to examine three possible mediators for this effect. Sixty-on...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1364.004

    authors: Saxe G,Geary M,Bedard K,Bosquet M,Miller A,Koenen K,Stoddard F,Moulton S

    更新日期:2006-07-01 00:00:00

  • Current issues in the treatment of human diseases by mucosal tolerance.

    abstract::Tolerance has been defined as a lack of response to self but a more appropriate definition of tolerance is "any mechanism by which a potentially injurious immune response is prevented, suppressed, or shifted to a non-injurious class of immune response." Thus, tolerance is related to productive self-recognition, rather...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1309.053

    authors: Weiner HL

    更新日期:2004-12-01 00:00:00

  • Effect of curcumin treatment on protein phosphorylation in K562 cells.

    abstract::Deregulation of signaling pathways is a common feature observed in human cancers and other diseases. Therefore, there is a strong need for compounds that are able to modulate or inactivate upregulated signaling events. Natural compounds extracted from plants have long been used and still present a dynamic domain in th...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1397.041

    authors: Blasius R,Dicato M,Diederich M

    更新日期:2007-01-01 00:00:00

  • The Pawtucket Heart Health Program. Influencing adolescent eating patterns.

    abstract::The Pawtucket Heart Health Program, a research effort testing a process of community activation for cardiovascular risk factor behavior change, risk factor change, and coronary heart disease event rate change, utilizes risk factor behavior change programs for the entire population of a northeastern city. A diversity o...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1991.tb43741.x

    authors: Carleton RA,Sennett L,Gans KM,Levin S,Lefebvre C,Lasater TM

    更新日期:1991-01-01 00:00:00

  • Pathological findings of HIV-associated cardiovascular disease.

    abstract::More effective therapies have improved survival times of HIV+ patients, resulting in a higher prevalence of long-term complications of the disease. This review focuses on HIV-associated cardiovascular pathology, correlating the morphologic findings to clinical syndromes of HIV disease/AIDS. ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2001.tb03901.x

    authors: d'Amati G,di Gioia CR,Gallo P

    更新日期:2001-11-01 00:00:00

  • Factors regulating neurogenesis and programmed cell death in mouse olfactory epithelium.

    abstract::To identify factors regulating neurogenesis and programmed cell death in mouse olfactory epithelium (OE), and to determine the mechanisms by which these factors act, we have studied mouse OE using two major experimental paradigms: tissue culture of embryonic OE and cell types isolated from it; and ablation of the olfa...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1998.tb10571.x

    authors: Calof AL,Rim PC,Askins KJ,Mumm JS,Gordon MK,Iannuzzelli P,Shou J

    更新日期:1998-11-30 00:00:00

  • Therapeutic applications of the TAT-mediated protein transduction system for complex I deficiency and other mitochondrial diseases.

    abstract::Among the five enzyme complexes in the oxidative phosphorylation system, NADH-coenzyme Q oxidoreductase (also called complex I) is the largest, most intricate, and least understood. This enzyme complex spans the inner mitochondrial membrane and catalyzes the first step of electron transfer by the oxidation of NADH, an...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12858

    authors: Lin BY,Kao MC

    更新日期:2015-09-01 00:00:00

  • Concanavalin-A-affinity molecular heterogeneity of human hepatoma AFP and cord-serum AFP.

    abstract::Glycosylation of alpha-fetoprotein (AFP) by human primary hepatocellular carcinoma (PHC) is abnormal. Concanavalin A (Con A)-affinity molecular variant patterns of serum AFP from patients with PHC are different from those of cord-serum AFP. Different patients with PHC exhibit different Con-A-affinity AFP molecular var...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1983.tb32850.x

    authors: Smith CJ,Ajdukiewicz A,Kelleher PC

    更新日期:1983-01-01 00:00:00

  • School-based programs for health-risk reduction.

    abstract::Based on implications from the pediatric studies of cardiovascular risk, it has become imperative that practical methods be developed to begin prevention of heart disease early in life. Schools provide an excellent setting for introducing comprehensive health education and promotion as a public health approach to the ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1997.tb48208.x

    authors: Nicklas TA,Johnson CC,Webber LS,Berenson GS

    更新日期:1997-05-28 00:00:00

  • Immune responses to pollutant mixtures from indoor sources.

    abstract::Indoor air pollution occurs as an undesirable consequence of urbanization, energy conservation, indoor bioaerosol contamination, and use of synthetic materials and new technologies, and has become a worldwide concern. It is important to comprehend not only the diversity of pollutant hazards but also to develop novel m...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1992.tb16544.x

    authors: Brooks BO,Aldrich FD,Utter GM,DeBroy JA,Schimke RD

    更新日期:1992-04-30 00:00:00

  • Human T-cell leukemia virus: transformation in vitro of nonhuman primate T-lymphocytes and experimental inoculation of nonhuman primates.

    abstract::T-lymphocytes from three species of New World monkeys were susceptible to transformation in vitro with human T-cell leukemia virus. Marmoset T-lymphocytes transformed in vitro with HVS or HVA, T-lymphotropic herpesviruses of New World monkeys, were also transformed with HTLV resulting in doubly transformed T-cells. Th...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1984.tb37186.x

    authors: Falk LA Jr,Byington R,Silva DP

    更新日期:1984-01-01 00:00:00

  • Tissue protein biomarker candidates to predict progression of esophageal squamous cell carcinoma and precancerous lesions.

    abstract::Esophageal squamous cell carcinoma (ESCC) is one of the most predominant malignancies worldwide. The 5-year survival rate is still relatively low due to few symptoms presenting with the early disease, diagnosis at middle to late stage, and high risk of recurrence after therapy. Novel protein biomarkers for early detec...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.13863

    authors: Wang M,Smith JS,Wei WQ

    更新日期:2018-12-01 00:00:00

  • What is new for resveratrol? Is a new set of recommendations necessary?

    abstract::Numerous scientific papers have suggested health-promoting effects of resveratrol, including claims in the prevention of diseases such as coronary heart disease, diabetes, and cancer. Therefore, it was proposed that the scientific community needed to express recommendations on the human use of resveratrol. Such recomm...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12173

    authors: Vang O

    更新日期:2013-07-01 00:00:00

  • Early upregulation of T cell IL-10 production plays an important role in oral tolerance induction.

    abstract::Early in oral tolerance induction, IL-10-producing CD4(+) T cells were increased, and adoptive transfer of IL-10-deficient CD4(+) T cells failed induction of oral tolerance, suggesting a key role of IL-10 production in such a process. ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1309.037

    authors: Cong Y,Liu C,Weaver CT,Elson CO

    更新日期:2004-12-01 00:00:00

  • Emerging roles of lymphatics in inflammatory bowel disease.

    abstract::The mobilization and recruitment of blood and lymphatic vasculatures are widely described in inflammatory bowel diseases (IBDs). Although angiogenesis contributes to intense gut inflammation, it remains unclear whether and when lymphangiogenesis amplifies or protects in IBD. The prolonged maintenance of lymphatic (ove...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2010.05757.x

    authors: Alexander JS,Chaitanya GV,Grisham MB,Boktor M

    更新日期:2010-10-01 00:00:00

  • Adolescent and adult rats' aversion to flavors previously paired with nicotine.

    abstract::Despite the high prevalence of adolescent smoking, few studies have examined nicotine sensitivity during this developmental period. In the present study we examined adolescent and adult rats' preference/aversion for a flavor previously paired with nicotine. Paired (nicotine + Kool-Aid) and unpaired (Kool-Aid) solution...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1308.065

    authors: Wilmouth CE,Spear LP

    更新日期:2004-06-01 00:00:00

  • Effector memory CD8+ T cells are resistant to apoptosis.

    abstract::Based upon their migrating properties and effector functions, CD8(+) T cells have been further classified into central memory (T(CM)) and two types of effector memory (T(EM) and T(EMRA)) cells. These memory cells display distinct replicative characteristics. Because apoptosis plays an important role in cellular homeos...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1398.017

    authors: Gupta S,Gollapudi S

    更新日期:2007-08-01 00:00:00

  • Criteria for selecting electrodes for electrical stimulation: theoretical and practical considerations.

    abstract::Smaller, more charge-intensive electrodes are needed for "safe" stimulation of the nervous system. In this paper we review critical concepts and the state of the art in electrodes. Control of charge density and charge balance are essential to avoid tissue electrolysis. Chemical criteria for "safe" stimulation are revi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1983.tb31628.x

    authors: Brummer SB,Robblee LS,Hambrecht FT

    更新日期:1983-01-01 00:00:00