Risk factors for esophageal cancer: emphasis on infectious agents.

Abstract:

:Risk factors for esophageal cancer include genetic factors (such as tylosis) and infectious agents. A variety of organisms have been implicated in esophageal carcinogenesis, either directly or indirectly. In this review, we explore the normal esophageal flora and how it may be controlled, and also the variety of organisms that may affect esophageal carcinogenesis, either directly or indirectly. The organisms with potential direct effects in squamous cell carcinoma include human papillomavirus (HPV), Epstein-Barr virus, and polyoma viruses. Interestingly, HPV is now implicated in esophageal adenocarcinoma (EAC), not in its initiation but in the development of dysplasia, in which HPV33 in particular has been associated. Indirectly, Helicobacter pylori has been associated with EAC by, initially, causing increased acid secretion that increases acid reflux, and by reducing lower esophageal sphincter pressure, which increases gastroesophageal reflux; the latter increases the risk of Barrett's esophagus, and hence EAC. Conversely, subsequent atrophic gastritis may normalize that risk.

journal_name

Ann N Y Acad Sci

authors

El-Zimaity H,Di Pilato V,Novella Ringressi M,Brcic I,Rajendra S,Langer R,Dislich B,Tripathi M,Guindi M,Riddell R

doi

10.1111/nyas.13858

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

319-332

issue

1

eissn

0077-8923

issn

1749-6632

journal_volume

1434

pub_type

杂志文章,评审
  • Ecology of avian influenza viruses in a changing world.

    abstract::Influenza A virus infections result in approximately 500,000 human deaths per year and many more sublethal infections. Wild birds are recognized as the ancestral host of influenza A viruses, and avian viruses have contributed genetic material to most human viruses, including subtypes H5N1 and H1N1. Thus, influenza vir...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2010.05451.x

    authors: Vandegrift KJ,Sokolow SH,Daszak P,Kilpatrick AM

    更新日期:2010-05-01 00:00:00

  • Androgen receptor in the ovary of postnatal bank vole females.

    abstract::In this experiment, we investigated the influence of the photoperiod upon androgen receptor (AR) distribution and steroid concentrations in ovaries of 21-day-old bank vole females. Sections (6 mum) were assayed immunohistochemically. ARs were localized in the nuclei of granulosa cells. The strongest immunoreaction was...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1327.050

    authors: Galas J,Slomczynska M,Kwasnik A

    更新日期:2005-04-01 00:00:00

  • Neurogenesis and neuroprotection in the adult brain. A putative role for 5-lipoxygenase?

    abstract::5-Lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2) are two enzymes that are critical for the synthesis of eicosanoids, the inflammatory metabolites of arachidonic acid. Both 5-LOX and COX-2 are expressed in the brain, including in CNS neurons. The physiologic role of these proteins in neuronal functioning is not clea...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2001.tb03610.x

    authors: Manev H,Uz T,Manev R,Zhang Z

    更新日期:2001-06-01 00:00:00

  • Bcl-2 and p53: role in dopamine-induced apoptosis and differentiation.

    abstract::The fate of a neuron in the developing brain to multiply, differentiate, or die in an apoptotic manner depends on the expression of genes that are involved in regulating the cell cycle. Recent studies determined the involvement of several genes, including cyclin A and B2, in dopamine-induced apoptosis in cultured chic...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1999.tb07858.x

    authors: Porat S,Simantov R

    更新日期:1999-01-01 00:00:00

  • Sphingosine-1-phosphate as an intercellular signaling molecule.

    abstract::Sphingosine-1-phosphate (Sph-1-P) has been implicated as an intracellular second messenger in many studies. Previously, we found the roles of Sph-1-P as a platelet activating lipid released from stimulated platelets and as a lipid regulator of cell motility. We first investigated the mechanism by which Sph-1-P induces...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1998.tb09659.x

    authors: Igarashi Y

    更新日期:1998-06-19 00:00:00

  • Social motor coordination during adult-child interactions.

    abstract::Social motor coordination (SMC) pertains to the timing of contingent movements during social interactions and is of high relevance for successful social and musical interactions. Semi-automated, objective methods are increasingly being used to analyze SMC, though it is unclear if these methods are feasible in naturali...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/nyas.13651

    authors: Pfeiffer R,Wallace M,Lense M

    更新日期:2018-05-04 00:00:00

  • Criteria for selecting electrodes for electrical stimulation: theoretical and practical considerations.

    abstract::Smaller, more charge-intensive electrodes are needed for "safe" stimulation of the nervous system. In this paper we review critical concepts and the state of the art in electrodes. Control of charge density and charge balance are essential to avoid tissue electrolysis. Chemical criteria for "safe" stimulation are revi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1983.tb31628.x

    authors: Brummer SB,Robblee LS,Hambrecht FT

    更新日期:1983-01-01 00:00:00

  • Role of nitric oxide and alcohol on gonadotropin release in vitro and in vivo.

    abstract::Alcohol suppresses reproduction in humans, monkeys, and small rodents by suppressing release of luteinizing hormone (LH). The major action is on the hypothalamus to decrease release of LH-releasing hormone (LHRH). The release of LHRH is controlled by nitric oxide (NO) as determined by in vivo and in vitro experiments....

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1998.tb09562.x

    authors: Rettori V,McCann SM

    更新日期:1998-05-01 00:00:00

  • Cerebellar volume and cerebellar metabolic characteristics in adults with dyslexia.

    abstract::Developmental dyslexia is associated with problems in a range of linguistic and non-linguistic skills. Some of those problems have been attributed to dysfunction of the cerebellum and its associated neural systems. Two studies of cerebellar structure were undertaken by our group. In Study 1, white and grey matter volu...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1416.002

    authors: Laycock SK,Wilkinson ID,Wallis LI,Darwent G,Wonders SH,Fawcett AJ,Griffiths PD,Nicolson RI

    更新日期:2008-12-01 00:00:00

  • MRI measures of Alzheimer's disease and the AddNeuroMed study.

    abstract::Here we describe the AddNeuroMed multicenter magnetic resonance imaging (MRI) study for longitudinal assessment in Alzheimer's disease (AD). The study is similar to a faux clinical trial and has been established to assess longitudinal MRI changes in AD, mild cognitive impairment (MCI), and healthy control subjects usi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1749-6632.2009.05063.x

    authors: Simmons A,Westman E,Muehlboeck S,Mecocci P,Vellas B,Tsolaki M,Kłoszewska I,Wahlund LO,Soininen H,Lovestone S,Evans A,Spenger C,AddNeuroMed Consortium.

    更新日期:2009-10-01 00:00:00

  • Fermented wheat germ extract (avemar) inhibits adjuvant arthritis.

    abstract::Anti-inflammatory efficacy of the fermented wheat germ extract (FWGE, Avemar) in the rat adjuvant arthritis (AA) model was examined. To Wistar rats with AA, different doses of FWGE and anti-inflammatory drugs (indomethacin, dexamethasone) as monotherapies were administered and FWGE and either diclofenac or dexamethaso...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1423.037

    authors: Telekes A,Resetar A,Balint G,Blazso G,Falkay G,Lapis K,Raso E,Szende B,Ehrenfeld M,Shoenfeld Y,Hidvegi M

    更新日期:2007-09-01 00:00:00

  • Global and regional trends in the nutritional status of young people: a critical and neglected age group.

    abstract::Adolescence and emerging adulthood form a critical time period for the achievement of optimal health and nutrition across all stages of the life course. We undertook a review of published literature and global data repositories for information on nutrition levels, trends, and patterns among young people aged 10-24 yea...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/nyas.13336

    authors: Akseer N,Al-Gashm S,Mehta S,Mokdad A,Bhutta ZA

    更新日期:2017-04-01 00:00:00

  • A simple theoretical model to study the voltage dependence of the electronic structure of phenyl ethylene oligomers.

    abstract::Although very few measurements have appeared in the open literature and there seems to be a controversy about the existence of the NDR phenomenon in molecules, the prospects of building such systems have attracted significant attention. In the work reported in this paper we used a model based on DFT calculations of th...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1292.004

    authors: Simón-Manso Y,Gonzalez C,Mujica V,Aray Y,Marquez M

    更新日期:2003-12-01 00:00:00

  • Effect of anionic amphophiles on erythrocyte properties.

    abstract::This preliminary study describes effects of two pharmacologic agents on erythrocyte behavior. Increased erythrocyte aggregation has been proposed as important in the pathogenesis of a number of disorders, but the exact mechanism by which it plays a role in disease production remains unclear. Several anionic amphophile...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1983.tb35216.x

    authors: McMillan DE,Utterback NG,Wujek JJ

    更新日期:1983-01-01 00:00:00

  • Association of SUMO4, as a candidate gene for IDDM5, with susceptibility to type 1 diabetes in Asian populations.

    abstract::Recent study demonstrated that M55V variant in SUMO4 at IDDM5 was associated with susceptibility to type 1 diabetes. Subsequent studies, however, showed inconsistency in the association. To clarify the population-wide effect on the association of SUMO4 with type 1 diabetes, we have performed meta-analysis including ou...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,meta分析,评审

    doi:10.1196/annals.1375.006

    authors: Noso S,Ikegami H,Fujisawa T,Kawabata Y,Asano K,Hiromine Y,Sugihara S,Lee I,Kawasaki E,Awata T,Ogihara T

    更新日期:2006-10-01 00:00:00

  • History of the spruce-fir forest in the Catskill Mountains of New York.

    abstract::Red spruce (Picea rubens Sarg.) and balsam fir (Abies balsamea (L.) Mill.) were present by 13,700 years B.C.E. in the Catskills Mountains of southeastern New York State. These conifers were, and still are, largely confined to the eastern and far western portions of the region. A gap in the distribution exists between ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/nyas.12274

    authors: Kudish M

    更新日期:2013-09-01 00:00:00

  • Propofol specifically inhibits mitochondrial membrane potential but not complex I NADH dehydrogenase activity, thus reducing cellular ATP biosynthesis and migration of macrophages.

    abstract::Propofol is a widely used intravenous anesthetic agent. Our previous study showed that a therapeutic concentration of propofol can modulate macrophage functions. Mitochondria play critical roles in the maintenance of macrophage activities. This study attempted to evaluate further the effects of mitochondria on the pro...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1338.019

    authors: Wu GJ,Tai YT,Chen TL,Lin LL,Ueng YF,Chen RM

    更新日期:2005-05-01 00:00:00

  • Arousal regulation, emotional flexibility, medial amygdala function, and the impact of early experience: comments on the paper of Lewis et al.

    abstract::The balance between optimal levels of emotional arousal and cognitive performance reflects the integration of several dopaminergically and adrenergically regulated neural systems. The amygdalar system is a key region for gating stimulation to cortical regions and the medial amygdala appears to play an especially key r...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 评论,杂志文章,评审

    doi:10.1196/annals.1376.018

    authors: Mayes LC

    更新日期:2006-12-01 00:00:00

  • Identification of chronic cocaine-induced gene expression through dopamine d1 receptors by using cDNA microarrays.

    abstract::A major goal of drug abuse research is to understand the molecular mechanisms underlying the behavioral changes caused by repeated exposure to cocaine. Enduring behavioral changes, such as behavioral sensitization, can be induced in rodents by repeated cocaine administration. The neurobiological mechanisms underlying ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb04146.x

    authors: Zhang J,Zhang D,Xu M

    更新日期:2002-06-01 00:00:00

  • Detection of Astrakhan fever rickettsia from ticks in Kosovo.

    abstract::Astrakhan fever is a summer spotted fever resembling Mediterranean spotted fever, endemic in Astrakhan, a region of Russia located by the Caspian sea. Its agent is a spotted fever group rickettsia, member of the Rickettsia conorii complex, transmitted to humans by Rhipicephalus sanguineus and Rhipicephalus pumilio tic...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2003.tb07357.x

    authors: Fournier PE,Durand JP,Rolain JM,Camicas JL,Tolou H,Raoult D

    更新日期:2003-06-01 00:00:00

  • Fate of alpha-hemoglobin chains and erythrocyte defects in beta-thalassemia.

    abstract::The fate of alpha-hemoglobin chains and the cause of membrane protein defects in thalassemic erythrocytes have been studied in: (1) human beta-thalassemia syndromes, (2) mouse beta-thalassemia, and (3) normal human erythrocytes loaded with purified alpha-hemoglobin chains. The similarity and differences observed in th...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1990.tb24296.x

    authors: Rouyer-Fessard P,Scott MD,Leroy-Viard K,Garel MC,Bachir D,Galacteros F,Beuzard Y

    更新日期:1990-01-01 00:00:00

  • Origins of pathogenic anti-DNA idiotypes in the NZB X SWR model of lupus nephritis.

    abstract::The investigations with the NZB X SWR model show that the development of systemic autoimmune disease is a multistep, multigene process. Severe lupus nephritis in the NZB X SWR hybrids results from the interaction of genes inherited from both the autoimmune NZB and the normal SWR parents. A similar genetic interaction ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1986.tb20855.x

    authors: Datta SK,Gavalchin J

    更新日期:1986-01-01 00:00:00

  • Uncertainty in biomonitoring and kinetic modeling.

    abstract::Uncertainty in exposure assessment and uncertainty in kinetic models of early effects after exposure to a toxin are addressed in this paper. Sources of uncertainty in the determination of exposure of workers in chemical industry exposed to dioxins are exhibited and a simple kinetic model for biomonitor measurements of...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1999.tb08078.x

    authors: Edler L

    更新日期:1999-01-01 00:00:00

  • Fast action of neuroactive steroids on plasma membrane calcium pump in PC12 cells.

    abstract::Calcium ions are essential to proper neurotransmission. Impairment in cytosolic Ca(2+) concentration and Ca(2+) signaling disturbs neuronal activity, leading to pathological consequences. In cells, a high-affinity plasma membrane calcium pump (PMCA) keeps free Ca(2+) in the nanomolar range. Among four genes encoding t...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1410.077

    authors: Zylinska L,Kowalska I,Kozaczuk A

    更新日期:2008-12-01 00:00:00

  • Effects of calcium "antagonists" on vertebrate skeletal muscle cells.

    abstract::Clinically potent skeletal muscle relaxants are used primarily for their effects on the central nervous system. But they also have direct effects on muscle contraction that possibly involve Ca2+ channels. We compared the effects of dantrolene, an agent known to have a direct action on vertebrate skeletal muscle, with ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1988.tb33363.x

    authors: Helland LA,Lopez JR,Taylor SR,Trube G,Wanek LA

    更新日期:1988-01-01 00:00:00

  • Alterations in stress reactivity after long-term treatment with paroxetine in women with posttraumatic stress disorder.

    abstract::Posttraumatic stress disorder (PTSD) is typically accompanied by both acute and chronic alterations in the stress response. These alterations have mostly been described in individuals under baseline conditions, but studies have also used a challenge model to assess the role of the hypothalamic-pituitary-adrenal (HPA) ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,随机对照试验

    doi:10.1196/annals.1364.014

    authors: Vermetten E,Vythilingam M,Schmahl C,DE Kloet C,Southwick SM,Charney DS,Bremner JD

    更新日期:2006-07-01 00:00:00

  • Influence of cytokines and growth factors on distinct steroidogenic enzymes in vitro: a short tabular data collection.

    abstract::Cytokines (IL-1, IL-6, IL-8, IL-11, TNF, IFN-gamma, and TGF-beta) and growth factors (EGF, bFGF, aFGF, and KGF) play an important role in modulation of hormone secretion by directly influencing specific enzyme steps of steroidogenesis in various endocrine cell types. For this tabular data collection, the following enz...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2002.tb04213.x

    authors: Herrmann M,Scholmerich J,Straub RH

    更新日期:2002-06-01 00:00:00

  • Effect of paclitaxel on intracellular localization of c-Myc and P-c-Myc in prostate carcinoma cell lines.

    abstract::The proto-oncogene c-myc is involved in multiple cell pathways with opposite effects on cell outcome of death or proliferation. It has been proposed that these different roles depend on the sequestration of c-Myc protein in cellular compartments and/or its phosphorylation. We speculated that subcellular localization o...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1397.021

    authors: Supino R,Favini E,Cuccuru G,Zunino F,Scovassi AI

    更新日期:2007-01-01 00:00:00

  • Screwworm eradication in the Americas.

    abstract::The screwworm fly, Cochliomyia hominivorax (Coquerel), is a parasite that attacks all warm-blooded animals including humans. This parasite has caused significant losses to the livestock industries of the Americas. Since the screwworm eradication program was initiated in the Southeastern United States in 1957, the erad...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2000.tb05289.x

    authors: Wyss JH

    更新日期:2000-01-01 00:00:00

  • Exosomes: biology, therapeutic potential, and emerging role in musculoskeletal repair and regeneration.

    abstract::Exosomes are nanovesicles secreted from cells that play key roles in intercellular communication. They carry unique content derived from parental cells and are capable of transferring this cargo between cells. The role and function of exosomes largely depends on the origin and functional status of the parental cells. ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.13469

    authors: Cobelli NJ,Leong DJ,Sun HB

    更新日期:2017-12-01 00:00:00