Abstract:
:Molecular redundancy refers to the ability of genes to back up damaged genes or gene loss. Although this term is widely discussed in many scientific circles, the process is still ill-defined, as shown by reviewing examples from the literature. Exploring the collagen-induced arthritis model in the context of CD44 knockout mice, we suggest a mechanistic explanation for molecular redundancy that depends neither on upregulation of the compensating molecule nor on structural similarity between the original molecule and the replacement molecule. The backup process is dependent, however, on two key properties shared by the two molecules: ligand binding and support of cell trafficking.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Naor D,Nedvetzki S,Assayag N,Thurmond RL,Huang JF,Turley EAdoi
10.1196/annals.1313.007subject
Has Abstractpub_date
2005-06-01 00:00:00pages
52-63eissn
0077-8923issn
1749-6632pii
1050/1/52journal_volume
1050pub_type
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