Uteroglobin binding proteins: regulation of cellular motility and invasion in normal and cancer cells.

abstract：:Interleukin (IL)-17-producing helper T (Th17) cells serve as a Th subset involved in epithelial cell- and neutrophil-mediated immune responses against extracellular microbes and in the development of various autoimmune diseases. The differentiation of Th17 cells is controlled by a number of intracellular signaling cas...

journal_title：Annals of the New York Academy of Sciences

authors： Nagai S,Kurebayashi Y,Koyasu S

更新日期：2013-03-01 00:00:00

abstract：:Dopamine-beta-hydroxylase (DbetaH) deficiency is a rare autosomal dominant disorder. Due to the absence of DbetaH, there is a blocked conversion of dopamine into norepinephrine. The biochemical hallmark of this syndrome consists of a complete absence of plasma norepinephrine and epinephrine levels in conjunction with ...

journal_title：Annals of the New York Academy of Sciences

authors： Timmers HJ,Deinum J,Wevers RA,Lenders JW

更新日期：2004-06-01 00:00:00

abstract：:Cytokine-based therapies have the potential to provide novel treatments for cancer, autoimmune diseases, and many types of infectious disease. However, to date, the full clinical potential of cytokines as drugs has been limited by a number of factors. To discuss these limitations and explore ways to overcome them, the...

journal_title：Annals of the New York Academy of Sciences

authors： Donnelly RP,Young HA,Rosenberg AS

更新日期：2009-12-01 00:00:00

abstract：:Structural analysis of secretin in solution has demonstrated extended helical domains within both amino- and carboxyl-terminal halves, with a possible turn in between. However, the conformation of this peptide as it resides in its binding site within the receptor has not been established. In the work reported here, we...

journal_title：Annals of the New York Academy of Sciences

authors： Dong M,Wang Y,Miller LJ

更新日期：2000-01-01 00:00:00

abstract：:The following on molecular mechanisms of Barrett's esophagus and adenocarcinoma contains commentaries on the mechanism of bile and gastric acid induced damage; the roles of BMP-4 and CDX-2 in the development of intestinal metaplasia; the transcription factors driving intestinalization in Barrett's esophagus; the contr...

journal_title：Annals of the New York Academy of Sciences

authors： Dvorak K,Goldman A,Kong J,Lynch JP,Hutchinson L,Houghton JM,Chen H,Chen X,Krishnadath KK,Westra WM

更新日期：2011-09-01 00:00:00

abstract：:The present experiments were conducted to determine the effects of neurotensin on secretion of a variety of anterior pituitary hormones. Conscious rats with indwelling cannulae in the third ventricle and external jugular vein were used and the effects on plasma hormone levels measured by radioimmunoassay. Neurotensin ...

journal_title：Annals of the New York Academy of Sciences

authors： McCann SM,Vijayan E,Koenig J,Krulich L

更新日期：1982-01-01 00:00:00

abstract：:In this article, we have presented an overview of fundamental issues involved in mediphotonic imaging, and reviewed some of the emerging techniques for early-light transillumination imaging of body organs. The results on human breast tissues presented here, together with the data accumulated and advances made by resea...

journal_title：Annals of the New York Academy of Sciences

authors： Alfano RR,Demos SG,Gayen SK

更新日期：1997-05-30 00:00:00

abstract：:Multiple sclerosis (MS) is an autoimmune and chronic inflammatory disease characterized by plaques, areas of destroyed myelin sheaths in the CNS, which results in multiple disabilities for patients. In addition to demyelinated plaques, pathophysiological studies have shown "shadow plaques" that represent areas of part...

journal_title：Annals of the New York Academy of Sciences

authors： Filipović R,Zecević N

更新日期：2005-06-01 00:00:00

abstract：:tRNA prepared from cells of E. coli B that had been incubated with 0.5% DL-ethionine (Ethio sRNA) was found to accept methyl groups from 14CH3-S-adenosyl-methionine in the enzymatic reaction catalyzed in vitro by tRNA methyl transferases from untreated cells of the same organism. tRNA from cells that were not exposed ...

journal_title：Annals of the New York Academy of Sciences

authors： Wainfan E,Maschio FA

更新日期：1975-08-08 00:00:00

abstract：:Results from two similar experimental systems that attempt to create laboratory geophysical analogs in spherical geometry are presented. In the first system, real time holographic interferometry and shadowgraph visualization are used to study convection in the fluid between two concentric spheres when two distinct buo...

journal_title：Annals of the New York Academy of Sciences

authors： Hegseth J,Amara K

更新日期：2002-10-01 00:00:00

abstract：:Atrial fibrillation (AF), the highest occurring cardiac arrhythmia in the Western world, is associated with substantial morbidity and increased mortality. In spite of extensive research, the cause of atrial electrical remodeling, a major factor in the self-perpetuating nature of AF, is still unknown. Downregulation of...

journal_title：Annals of the New York Academy of Sciences

authors： Beharier O,Etzion Y,Levi S,Mor M,Mor M,Dror S,Kahn J,Katz A,Moran A

更新日期：2010-02-01 00:00:00

abstract：:In contrast to that in adults, hypertension in children is frequently amenable to surgical therapy. With advancing techniques in imaging, surgery, and anesthesia, the outcomes of surgery are excellent for children with endocrine tumors causing hypertension. ...

journal_title：Annals of the New York Academy of Sciences

authors： Newman KD,Ponsky T

更新日期：2002-09-01 00:00:00

abstract：:The mesodiencephalic junction is the site of the prenuclear control of vertical eye motion. We measured vertical saccades, smooth pursuit (SP), the vertical vestibulo-ocular reflex (VOR), and its interactions with vision during active head motion in 21 patients with midbrain lesions causing palsy of vertical saccades,...

journal_title：Annals of the New York Academy of Sciences

authors： Sharpe JA,Kim JS

更新日期：2002-04-01 00:00:00

abstract：:Coccidioidomycosis is a mild to life-threatening disease in otherwise healthy humans and other mammals caused by the fungus Coccidioides spp. Understanding the development of the unique dimorphic life cycle of Coccidioides spp. and its role in pathogenesis has been an area of research focus. However, nuclear behavior ...

journal_title：Annals of the New York Academy of Sciences

authors： Li L,Schmelz M,Kellner EM,Galgiani JN,Orbach MJ

更新日期：2007-09-01 00:00:00

abstract：:Recent studies suggest that the symptoms associated with endometriosis are the result of local peritoneal inflammation. Increased concentrations of activated pelvic macrophages and lymphocytes and the elevated levels of specific cytokines and growth factors reviewed above support this hypothesis. The precise roles of ...

journal_title：Annals of the New York Academy of Sciences

authors： Taylor RN,Ryan IP,Moore ES,Hornung D,Shifren JL,Tseng JF

更新日期：1997-09-26 00:00:00

abstract：:How can people adaptively analyze and "work through" negative feelings without ruminating? This paper will briefly review findings from an integrative program of research, which suggests that a critical factor determining whether people's attempts to adaptively reason about negative experiences succeed or fail is the ...

journal_title：Annals of the New York Academy of Sciences

authors： Kross E

更新日期：2009-06-01 00:00:00

abstract：:Bacteria can exhibit high levels of resistance to one or more environmental stresses such as temperature, osmolarity, radiation, pH, starvation, as well as resistance to noxious chemicals and antibiotics. Yet evolution has not optimized stress resistance in all bacteria to all stresses. Even within a species like Esch...

journal_title：Annals of the New York Academy of Sciences

authors： Ferenci T,Spira B

更新日期：2007-10-01 00:00:00

abstract：:Clara cell protein (CC16 or CC10) is a 15.8-kDa protein secreted all along the tracheobronchial tree and especially in the terminal bronchioles where Clara cells are localized. Even though the exact in vivo function of CC16 remains to be clarified, evidence is accumulating that CC16 plays an important protective role ...

journal_title：Annals of the New York Academy of Sciences

authors： Broeckaert F,Clippe A,Knoops B,Hermans C,Bernard A

更新日期：2000-01-01 00:00:00

abstract：:This work summarizes new and emerging metrics and tools in esophageal function testing and their potential clinical impact. Because the diagnostic sensitivity and reliability of conventional impedance-pH variables are suboptimal, several novel impedance parameters, such as the postreflux swallow-induced peristaltic wa...

journal_title：Annals of the New York Academy of Sciences

authors： Akiyama J,Sumida J,Nakagawa K,Masamune A,Issariyakulkarn N,Patcharatrakul T,Shetler K,Kuribayashi S,Uraoka T,Triadafilopoulos G

更新日期：2020-12-01 00:00:00

abstract：:R-Apomorphine (APO) the catechol-derived dopamine D1-D2 receptor agonist has been shown to be highly potent iron chelator and radical scavenger and inhibitor of membrane lipid peroxidation in vitro, in vivo and in cell culture employing PC12 cells. Its potency has been compared to the prototype iron chelator desferrio...

journal_title：Annals of the New York Academy of Sciences

authors： Youdim MB,Grünblatt E,Mandel S

更新日期：1999-01-01 00:00:00

abstract：:The potential of a transdisciplinary research method--Quali-Quantitative Analysis (QQA)--for delivering better evidence for healthy aging is explored. Illustrative reviews from the literature on healthy aging are summarized, as are papers on methodology by Charles Ragin and colleagues. The evidence needs for healthy a...

journal_title：Annals of the New York Academy of Sciences

authors： Bell E

更新日期：2007-10-01 00:00:00

abstract：:Fibrinogen, a clottable plasma glycoprotein, participates in cell adhesion phenomena involving prokaryotic cells, e.g. staphylococci, and eukaryotic cell fragments, e.g. platelets. Among the three chains (alpha, beta, gamma) of human fibrinogen, the gamma chain bears the main site recognizing the staphylococcal clumpi...

journal_title：Annals of the New York Academy of Sciences

authors： Hawiger J,Kloczewiak M,Timmons S,Strong D,Doolittle RF

更新日期：1983-06-27 00:00:00

abstract：:Frontal lobe functions include a range of cognitive, emotional, and social abilities that enable goal-directed behavior. Although a number of studies have plotted the development of frontal lobe functions in childhood, few have extended into the adolescent years. There is also little information on which cognitive and...

journal_title：Annals of the New York Academy of Sciences

authors： Rosso IM,Young AD,Femia LA,Yurgelun-Todd DA

更新日期：2004-06-01 00:00:00

abstract：:Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) frequently develop and progress in settings in which sympathoadrenomedullary and gonadal hormone levels are changing, e.g., during pregnancy, postpartum period, menopause, estrogen administration. This paper addresses the view that adrenal and gonadal ho...

journal_title：Annals of the New York Academy of Sciences

authors： Wilder RL,Elenkov IJ

更新日期：1999-06-22 00:00:00

abstract：:The pronounced increases in gangliosides belonging to the gangliotetraose family during the neurite outgrowth phase of neuronal differentiation have suggested a functional requirement for these substances related to process extension, arborization, and possibly synaptogenesis. Support for this hypothesis has come from...

journal_title：Annals of the New York Academy of Sciences

authors： Ledeen RW,Wu G,Lu ZH,Kozireski-Chuback D,Fang Y

更新日期：1998-06-19 00:00:00

abstract：:Mounting evidence indicates increased susceptibility to cell death and increased oxidative damage as common features in neurons from sporadic Alzheimer's disease (AD) patients but also from familial AD (FAD) cases. Autosomal dominant forms of FAD are caused by mutations of the amyloid precursor protein (APP) gene and ...

journal_title：Annals of the New York Academy of Sciences

authors： Eckert A,Marques CA,Keil U,Schüssel K,Müller WE

更新日期：2003-12-01 00:00:00

abstract：:Recent controversies in the existence of saturable binding of general anesthetics in brain tissues prompted a careful examination of specific binding of anesthetics to neural receptors. We examined the binding of both local and general anesthetics using electron spin resonance and radioligand criteria. Our results sug...

journal_title：Annals of the New York Academy of Sciences

authors： Lin L,Koblin DD,Wang HH

更新日期：1991-01-01 00:00:00

abstract：:The dentate gyrus of the rat forms in three developmental phases, each of which is characterized by neuronal birth, migration and death. Recent evidence indicates that adrenal steroids regulate neuronal birth, death, and possibly migration throughout the life of the animal. However, the observation that very few neuro...

journal_title：Annals of the New York Academy of Sciences

authors： Gould E

更新日期：1994-11-14 00:00:00

abstract：:Deposition of amyloid beta protein in the brain is the major pathological feature of Alzheimer's disease. Amyloid beta protein is generated from beta-amyloid precursor protein by beta-secretase and gamma-secretase. Proteolytic processing of amyloid precursor protein at the beta site by BACE1 is essential to generate a...

journal_title：Annals of the New York Academy of Sciences

authors： Zhou W,Qing H,Tong Y,Song W

更新日期：2004-12-01 00:00:00

abstract：:The aim of this study was to reevaluate the role of infection in inflammatory bowel disease (IBD). Sera from 119 patients with IBD [80 with Crohn's disease (CD); 39 with ulcerative colitis] and 98 healthy controls were assessed using the Bio-Rad BioPlex 2200 for the presence of Toxoplasma gondii, cytomegalovirus, Epst...

journal_title：Annals of the New York Academy of Sciences

authors： Lidar M,Langevitz P,Barzilai O,Ram M,Porat-Katz BS,Bizzaro N,Tonutti E,Maieron R,Chowers Y,Bar-Meir S,Shoenfeld Y

更新日期：2009-09-01 00:00:00