Hormonal regulation of tumor necrosis factor-alpha, interleukin-12 and interleukin-10 production by activated macrophages. A disease-modifying mechanism in rheumatoid arthritis and systemic lupus erythematosus?

abstract：:The measurement of autoantibodies specific for double-stranded DNA (anti-dsDNA) is a useful tool for the diagnosis and the prognosis of systemic lupus erythematosus (SLE). A new quantitative enzyme-linked immunosorbent assay (ELISA), ORG anti-dsDNA, is recently available for the determination of anti-dsDNA antibodies....

journal_title：Annals of the New York Academy of Sciences

authors： Bardin N,Ragot C,Sanmarco M

更新日期：2007-08-01 00:00:00

abstract：:The loss of mucus coat continuity and apoptosis have been shown in Helicobacter pylori (H. pylori)-infected gastric tissues. Blockade of p38 mitogen-activated kinase (MAPK) produced reversal in the LPS-induced reduction in mucin synthesis and apoptosis in gastric epithelial cells. This study investigates whether H. py...

journal_title：Annals of the New York Academy of Sciences

authors： Kim H,Seo JH,Kim KH

更新日期：2003-12-01 00:00:00

abstract：:Cotyledons of dark-grown watermelon seedlings contain during the first period of germination, 4 and later 5 MDH isoenzymes. Whereas isoenzymes I, II, and IV belong to the cytosol, isoenzyme III is confined to the mitochondria (mMDH) and isoenzyme V to the glyoxysomes (gMDH). The organelle-bound MDHs were purified to h...

journal_title：Annals of the New York Academy of Sciences

authors： Hock B,Gietl C

更新日期：1982-01-01 00:00:00

abstract：:Familial British dementia (FBD) is a disorder characterized by the presence of amyloid deposits in cerebral blood vessels and brain parenchyma coexisting with neurofibrillary tangles in limbic areas. The amyloid subunit (ABri) is a 4 kDa fragment of a 266 amino acid type II single-spanning transmembrane precursor prot...

journal_title：Annals of the New York Academy of Sciences

authors： Ghiso J,Vidal R,Rostagno A,Miravalle L,Holton JL,Mead S,Révész T,Plant G,Frangione B

更新日期：2000-01-01 00:00:00

abstract：:The following on molecular aspects of esophageal development contains commentaries on esophageal striated myogenesis and transdifferentiation; conversion from columnar into stratified squamous epithelium in the mouse esophagus; the roles for BMP signaling in the developing esophagus and forestomach; and evidence of a ...

journal_title：Annals of the New York Academy of Sciences

authors： Rishniw M,Rodriguez P,Que J,Burke ZD,Tosh D,Chen H,Chen X

更新日期：2011-09-01 00:00:00

abstract：:The past three decades of clinical disappointments in treating stroke must compel us to rethink our strategy. Given the enormous complexity of the clinical disease, the "one size fits all" approach to stroke treatment is unlikely to succeed. The effective treatment of stroke aimed at reversing ischemic injury will req...

journal_title：Annals of the New York Academy of Sciences

authors： Joshi S,Agarwal S

更新日期：2010-06-01 00:00:00

abstract：:Regardless of how creative, innovative, and elegant our computational methods, the ultimate proof of an algorithm's worth is the experimentally validated quality of its predictions. Unfortunately, this truism is hard to reduce to practice. Usually, modelers produce hundreds to hundreds of thousands of predictions, mos...

journal_title：Annals of the New York Academy of Sciences

authors： Stolovitzky G,Prill RJ,Califano A

更新日期：2009-03-01 00:00:00

abstract：:The harmful effects of oxidative processes in living organisms, in addition to chemical and biochemical media, can be reduced by antioxidants. The efficacy of an antioxidant depends on its reduction potential and kinetics of elimination of diverse free radicals. Redox potentials and reaction rate constants of selected...

journal_title：Annals of the New York Academy of Sciences

authors： Jovanovic SV,Simic MG

更新日期：2000-01-01 00:00:00

abstract：:The alteration of oligosaccharide structures through genetic manipulation of glycosyltransferase activities is now a reality. It is apparent that this technique has greater consequences on oligosaccharide structure when an exogenous enzyme is introduced into cells, and in particular when this enzyme is responsible for...

journal_title：Annals of the New York Academy of Sciences

authors： Youakim A,Shur BD

更新日期：1994-11-30 00:00:00

abstract：:Adults with better jobs enjoy better health: job title was, in fact, the social gradient metric first used to study the relationship between social class and chronic disease etiology, a core finding now replicated in most developed countries. What has been less well proved is whether this correlation is causal, and if...

journal_title：Annals of the New York Academy of Sciences

authors： Clougherty JE,Souza K,Cullen MR

更新日期：2010-02-01 00:00:00

abstract：:We studied 13 patients with unilateral peripheral vestibular lesions following removal of acoustic neurinomas. The time constant of the VOR after surgery was 6.4 +/- 2.6 seconds (normal is 18.5 +/- 7.7 seconds). The time constant of OKAN after surgery was 7.2 +/- 1.8 seconds (normal is 11.3 +/- 3.2 seconds). The mean ...

journal_title：Annals of the New York Academy of Sciences

authors： Hain TC,Zee DS

更新日期：1992-05-22 00:00:00

abstract：:Adhesive interactions are recognized requirements for cellular proliferation, migration and differentiation during normal morphogenesis as well as disease. By differential cloning, osteopontin was identified as an adhesive protein upregulated during vascular remodeling and neointima formation in both rat models and hu...

journal_title：Annals of the New York Academy of Sciences

authors： Giachelli CM,Liaw L,Murry CE,Schwartz SM,Almeida M

更新日期：1995-04-21 00:00:00

abstract：:Alternative splicing of RNA transcripts is a general characteristic for NCX genes in mammals, mollusks, and arthropods. Among the family of three NCX genes in mammals, the NCX1 gene contains six exons, namely, A, B, C, D, E, and F, that make up the alternatively spliced region. Studies of the NCX1 gene transcripts sug...

journal_title：Annals of the New York Academy of Sciences

authors： Schulze DH,Polumuri SK,Gille T,Ruknudin A

更新日期：2002-11-01 00:00:00

abstract：:Twenty-month-old Swiss mice were allocated into three groups: (A) control; (B) infected group; and (C) infected but treated with 5 mg of the phytocompound MMT. Mice were infected intranasally with 30 microL of 75 HA viral units. MMT markedly blunted the nasal signs of virus infection and the febrile response. Formazan...

journal_title：Annals of the New York Academy of Sciences

authors： Cervi J,Marotta F,Bater C,Masulair K,Minelli E,Harada M,Marandola P

更新日期：2006-05-01 00:00:00

abstract：:We studied hearing impairment and cochlear ultrastructure in C57BL/6J mice containing the cpk mutant gene. Heterozygous cpk/+ mutant mice, 6-8 months old, showed a marked hearing loss as demonstrated by auditory evoked potentials with some showing hearing loss at 90 db sound pressure. Ultrastructural studies of first ...

journal_title：Annals of the New York Academy of Sciences

authors： Cho H,Buchanan J,Strong D,Yamada Y,Yoo TJ

更新日期：1991-01-01 00:00:00

abstract：:Since the publication of Heinz Kohut's last book in 1984, "self psychology" has become much more diverse in its perspectives and even fragmented in its applications. Perhaps due in large part to Kohut's own inconsistencies and lack of clarity on certain major points of theory and technique, self psychology currently l...

journal_title：Annals of the New York Academy of Sciences

authors： Gehrie MJ

更新日期：2009-04-01 00:00:00

abstract：:The plasma levels and the glycosylation of acute-phase proteins (APP) are subject to marked changes during acute and chronic inflammation. The pathophysiological variations in different glycoforms of APP in serum most likely result from changes in the glycosylation process during their biosynthesis in the parenchymal ...

journal_title：Annals of the New York Academy of Sciences

authors： Van Dijk W,Mackiewicz A

更新日期：1995-07-21 00:00:00

abstract：:A recent study showed a significant association between schizophrenia in European samples and the glutamate cysteine ligase modifier (GCLM) subunit gene, which is the key glutathione (GSH)-synthesizing enzyme. Since the symptoms of methamphetamine (METH)-induced psychosis are similar to those of schizophrenia, the GCL...

journal_title：Annals of the New York Academy of Sciences

authors： Kishi T,Ikeda M,Kitajima T,Yamanouchi Y,Kinoshita Y,Kawashima K,Inada T,Harano M,Komiyama T,Hori T,Yamada M,Iyo M,Sora I,Sekine Y,Ozaki N,Ujike H,Iwata N

更新日期：2008-10-01 00:00:00

abstract：:The envelope glycoprotein complex (Env), encoded by the human immunodeficiency virus (HIV-1), kills uninfected cells expressing CD4 and/or the chemokine receptor CXCR4 or CCR5, via at least three independent mechanisms. First, the soluble Env product gp120 can induce the apoptotic cell death of lymphocytes, neurons, a...

journal_title：Annals of the New York Academy of Sciences

authors： Castedo M,Perfettini JL,Andreau K,Roumier T,Piacentini M,Kroemer G

更新日期：2003-12-01 00:00:00

abstract：:Nanofluids consisting of nanometer-sized particles dispersed in base liquids are known to be effective in extending the saturated boiling regime and critical heat flux in pool boiling. The heat transfer characteristics of nanosilica suspensions with particle sizes of 10 and 20 nm in pool boiling with a suspended heati...

journal_title：Annals of the New York Academy of Sciences

authors： Kumar R,Milanova D

更新日期：2009-04-01 00:00:00

abstract：:The song system of oscine birds has become a versatile model system that is used to study diverse problems in neurobiology. Because the song system is often studied with the intention of applying the results to mammalian systems, it is important to place song system brain nuclei in a broader context and to understand ...

journal_title：Annals of the New York Academy of Sciences

authors： Farries MA

更新日期：2004-06-01 00:00:00

abstract：:In mammals, females have a pair of X chromosomes, whereas males have one X chromosome and one Y chromosome, which is much smaller and contains fewer genes than a X chromosome. One of the pair of X chromosomes is inactivated in females. The inactivated X chromosome is late-replicating, heterochromatic, and genetically ...

journal_title：Annals of the New York Academy of Sciences

authors： Kosmaidou-Aravidou Z

更新日期：1997-06-17 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I) and IGF-I receptor (IGF-IR), despite their well-known roles in cell survival and proliferation, can also weakly enhance apoptosis. To study the relationships between the IGF-IR and Bax as well as Bak, 144 cases of colorectal cancer were examined by immunohistochemistry, using the a...

journal_title：Annals of the New York Academy of Sciences

authors： Koda M,Reszec J,Sulkowska M,Kanczuga-Koda L,Sulkowski S

更新日期：2004-12-01 00:00:00

abstract：UNLABELLED:After long periods of status epilepticus, selective neuronal necrosis is incurred in the neocortex (layer III-IV), in the hippocampus (CA1 and CA4), and in the thalamus (VPL-VPM). In these areas the cerebral metabolic rate for glucose is increased to between 200-300% of control, indicating a correlation betw...

journal_title：Annals of the New York Academy of Sciences

authors： Ingvar M

更新日期：1986-01-01 00:00:00

abstract：:The pronounced increases in gangliosides belonging to the gangliotetraose family during the neurite outgrowth phase of neuronal differentiation have suggested a functional requirement for these substances related to process extension, arborization, and possibly synaptogenesis. Support for this hypothesis has come from...

journal_title：Annals of the New York Academy of Sciences

authors： Ledeen RW,Wu G,Lu ZH,Kozireski-Chuback D,Fang Y

更新日期：1998-06-19 00:00:00

abstract：:Positron emission tomography (PET) is currently the only technology affording three-dimensional measurement of the brain's energy metabolism which is closely coupled to brain function. Studies of glucose metabolism by PET of (18F)-2-fluoro-2-deoxy-D-glucose are therefore widely applied to show the contribution of vari...

journal_title：Annals of the New York Academy of Sciences

authors： Heiss WD,Szelies B,Kessler J,Herholz K

更新日期：1991-01-01 00:00:00

abstract：:A cross-sectional study of raw meat samples from the local meat market of Kathmandu Metropolitan City was carried out during September 2002 to May 2003 with special emphasis on isolation and identification of Salmonella bacteria. A total of 123 raw meat samples (55 chicken, 37 buffalo, and 31 goat) were collected and ...

journal_title：Annals of the New York Academy of Sciences

authors： Maharjan M,Joshi V,Joshi DD,Manandhar P

更新日期：2006-10-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) play a central role in successful control of HIV. Induction of effective CTL responses may therefore be an essential requirement of HIV vaccines. Knowledge of CTL epitopes targeted either in natural infection or following vaccination will be critical to understanding the anti-HIV immune r...

journal_title：Annals of the New York Academy of Sciences

authors： Goulder PJ

更新日期：2000-11-01 00:00:00

abstract：:This paper considers issues arising from presentations by Barry Everitt and Gorica Petrovich concerning amygdalar involvement in appetitive conditioning. Studies reported by these researchers are beginning to unravel the distribution of associative functions among amygdalar nuclei and their efferent targets. The main ...

journal_title：Annals of the New York Academy of Sciences

authors： Gabriel M,Burhans L,Kashef A

更新日期：2003-04-01 00:00:00

abstract：:This review discusses the available clinical trials in which steroids have been used in the (adjuvant) treatment of rheumatoid arthritis. Glucocorticosteroids have a positive effect on symptoms and signs of inflammation, but probably not on structural damage. Therefore glucocorticosteroids should be used as part of a ...

journal_title：Annals of the New York Academy of Sciences

authors： Bijlsma JW

更新日期：1999-06-22 00:00:00