Flow cytometric FRET analysis of erbB receptor interaction on a cell-by-cell basis.

abstract：:We and others have previously shown that heat-shock proteins (HSPs) are involved in protecting the brain from a variety of insults including stroke, epilepsy, and other related insults. While the mechanism of this protection has largely been thought to be due to their chaperone functions (i.e., preventing abnormal pro...

journal_title：Annals of the New York Academy of Sciences

authors： Yenari MA,Liu J,Zheng Z,Vexler ZS,Lee JE,Giffard RG

更新日期：2005-08-01 00:00:00

abstract：:In an effort to identify novel targets for the development of nonhormonal male contraceptives, genome-wide transcriptional profiling of the rat testis was performed. Specifically, enzymatically purified spermatogonia plus early spermatocyctes, pachytene spermatocytes, round spermatids, and Sertoli cells was analyzed a...

journal_title：Annals of the New York Academy of Sciences

authors： Johnston DS,Jelinsky SA,Zhi Y,Finger JN,Kopf GS,Wright WW

更新日期：2007-12-01 00:00:00

abstract：:The extensive literature and the work from our laboratory illustrate the large number of complex processes affected by estrogen that might contribute to the striking ability of 17-beta estradiol (E2) and its derivatives to inhibit clinical and histological signs of experimental autoimmune encephalomyelitis (EAE) in mi...

journal_title：Annals of the New York Academy of Sciences

authors： Offner H,Polanczyk M

更新日期：2006-11-01 00:00:00

abstract：:Ischemic stroke is one of the leading causes of death and morbidity worldwide, and systemic thrombolytic treatment is still the first-line therapy within 4.5 h from symptom onset. Selecting patients for treatment response is mandatory in any time window but challenging as well. The authors aim to support stroke physic...

journal_title：Annals of the New York Academy of Sciences

authors： Hametner C,Ringleb PA,Hacke W,Kellert L

更新日期：2012-09-01 00:00:00

abstract：:Methamphetamine (METH) produces nigrostriatal dopamine (DA) loss, partly resembling that which occurs in Parkinson's disease (PD). In PD there is also a marked alteration in the gut. Given the similarities between the central DA denervation produced by METH and PD, in the present study we evaluated the alterations in ...

journal_title：Annals of the New York Academy of Sciences

authors： Natale G,Kastsiuchenka O,Pasquali L,Ruggieri S,Paparelli A,Fornai F

更新日期：2008-10-01 00:00:00

abstract：:Zoonoses are animal and human diseases. Q fever is primarily a zoonosis-an animal disease that can be transmitted to humans under certain conditions. Recent epidemiological studies suggest that Q fever should be considered as a public health problem in many countries where it is present, but unrecognizable due to inad...

journal_title：Annals of the New York Academy of Sciences

authors： Beslagić E,Hamzić S,Beslagić O,Zvizdić S

更新日期：2006-10-01 00:00:00

abstract：:Hamster sperm DNA is packaged so tightly that it is the most highly condensed eukaryotic DNA known. Nevertheless, the sperm genome is also organized in a very specific fashion by two nuclear structures, the nuclear matrix and the nuclear annulus. The nuclear matrix organizes sperm DNA into loop domains approximately 4...

journal_title：Annals of the New York Academy of Sciences

authors： Farrington JE,Patel R,Ward WS

更新日期：1991-01-01 00:00:00

abstract：:The advent of highly active anti-retroviral therapy (HAART) has dramatically decreased the rate of AIDS-related mortality and significantly extended the life span of patients with AIDS. A variety of metabolic side effects are associated with these therapies, one of which is metabolic bone disease. A higher prevalence ...

journal_title：Annals of the New York Academy of Sciences

authors： Pan G,Yang Z,Ballinger SW,McDonald JM

更新日期：2006-04-01 00:00:00

abstract：:Human platelets in sufficient numbers for a therapeutic transfusion can be collected for preservation either by pooling ABO- and Rh-compatible platelets or by apheresis procedures using mechanical cell-separating machines. Human platelets have been frozen successfully with 5 or 6% dimethyl sulfoxide (DMSO) and stored ...

journal_title：Annals of the New York Academy of Sciences

authors： Valeri CR

更新日期：1985-01-01 00:00:00

abstract：:The aim of the study was to determine the IgG antibody response to spotted fever group Rickettsia (SFGR) R. conorii and R. slovaca, and its specificity and sensitivity in patients with DEBONEL/TIBOLA. A prospective study of 31 patients with DEBONEL was carried out from January 2001 to May 2004. The SFGR serology testi...

journal_title：Annals of the New York Academy of Sciences

authors： Santibáñez S,Ibarra V,Portillo A,Blanco JR,Martínez de Artola V,Guerrero A,Oteo JA

更新日期：2006-10-01 00:00:00

abstract：:The following, from the 12th OESO World Conference: Cancers of the Esophagus, includes commentaries on the animal reflux-inflammation models for Barrett's esophagus and esophageal adenocarcinoma; genomic/epigenomic analyses; eflornithine-based combinations; the molecular derangements that promote neoplastic transforma...

journal_title：Annals of the New York Academy of Sciences

authors： Akiyama J,Alexandre L,Baruah A,Buttar N,Chandra R,Clark AB,Hart AR,Hawk E,Kandioler D,Kappel S,Krishnadath SK,Sharma A,Singh I,Straub D,Triadafilopoulos G,Umar A,Wolf B

更新日期：2014-09-01 00:00:00

abstract：:Monoclonal antibodies reactive with desmin (D3 and D76) have been generated and their specificities validated by immunoblots, RIAs, and immunocytochemistry. No cross-reaction with other IFPs has been observed. The McAbs recognized different epitopes but both reside in the amino-terminal rod domain of desmin. Whereas M...

journal_title：Annals of the New York Academy of Sciences

authors： Fischman DA,Danto SI

更新日期：1985-01-01 00:00:00

abstract：:We reevaluated the exchange stoichiometry of the Na(+)/Ca(2+) exchange current by measuring its reversal potential. The exchange current was measured from the inside-out macropatch excised from intact sarcolemma of guinea pig ventricular myocytes. This method provides more accurate control of extracellular and cytopla...

journal_title：Annals of the New York Academy of Sciences

authors： Matsuoka S

更新日期：2002-11-01 00:00:00

abstract：:This paper presents a system dynamics policy model of nutritional food market transformation, tracing over-time interactions between the nutritional quality of supply, consumer food choice, population health, and governmental policy. Applied to the Canadian context and with body mass index as the primary outcome, we e...

journal_title：Annals of the New York Academy of Sciences

authors： Struben J,Chan D,Dubé L

更新日期：2014-12-01 00:00:00

abstract：:The statistical techniques developed herein show strong promise as a nonparametric extension of the classical Wing-Kristofferson decomposition of variance in isochronous tapping to include tempo drift. It is now important to establish the relative role of the three sources of variance in discriminating among unselecte...

journal_title：Annals of the New York Academy of Sciences

authors： Collier GL,Ogden RT

更新日期：2001-06-01 00:00:00

abstract：:The discovery of AQP4-IgG (a pathogenic antibody that targets the astrocytic water channel aquaporin-4), as the first sensitive and specific biomarker for any inflammatory central nervous system demyelinating disease (IDD), has shifted emphasis from the oligodendrocyte and myelin to the astrocyte as a central immunopa...

journal_title：Annals of the New York Academy of Sciences

authors： Pittock SJ,Lucchinetti CF

更新日期：2016-02-01 00:00:00

abstract：:In the intestine, a single layer of epithelial cells effectively separates potentially harmful luminal content from the underlying tissue. The importance of an intact mucosal layer is highlighted by pathological disorders of the gut such as inflammatory bowel disease, in which disruption of the epithelial barrier lead...

journal_title：Annals of the New York Academy of Sciences

authors： Koch S,Nusrat A

更新日期：2009-05-01 00:00:00

abstract：:Needle free jet injection guns have been used extensively in both veterinary and human health to deliver both vaccine and drugs, but in recent years, concerns have mounted for their potential to transmit blood borne disease agents among consecutive vaccinates. A Ped-O-Jet type jet injection device was used to deliver ...

journal_title：Annals of the New York Academy of Sciences

authors： Sweat JM,Abdy M,Weniger BG,Harrington R,Coyle B,Abuknesha RA,Gibbs EP

更新日期：2000-01-01 00:00:00

abstract：:To summarize (Fig. 10), the structural consequences of monocular deprivation include the following changes: the relay cells in the binocular segments of the deprived geniculate layers shrink and contain less of the possible neurotransmitter NAAG. These changes appear to be secondary to a loss of terminal synaptic arbo...

journal_title：Annals of the New York Academy of Sciences

authors： Tieman SB

更新日期：1991-01-01 00:00:00

abstract：:In this short review, we have described studies that have identified Arg415 in the Ca2+ release channel as a residue that influences channel sensitivity to Ca2+ induced Ca2+ release, rate of Ca2+ release, and channel closing. We have also described studies that confirm Dr. Numa's predictions that residues 4246-4267, 4...

journal_title：Annals of the New York Academy of Sciences

authors： MacLennan DH,Chen SR

更新日期：1993-12-20 00:00:00

abstract：:Obesity is a phenotype resulting from a series of causative factors with a variable risk of complications. Etiologic diversity requires personalized prevention and treatment. Imaging procedures offer the potential to investigate the interplay between organs and pathways underlying energy intake and consumption in an i...

journal_title：Annals of the New York Academy of Sciences

authors： Iozzo P

更新日期：2015-09-01 00:00:00

abstract：:Intracerebral administration of the excitotoxin ibotenate to new-born mice induced white-matter lesions mimicking the periventricular leukomalacia occurring in human premature babies. In this model, co-injection of vasoactive intestinal peptide (VIP) prevented white-matter lesions. VIP did not prevent the initial appe...

journal_title：Annals of the New York Academy of Sciences

authors： Gressens P

更新日期：1999-01-01 00:00:00

abstract：:The secretory granules function as the major IP(3)-sensitive intracellular Ca(2+) store of secretory cells. Recently it was found that the secretory granules contain three isoforms of inositol 1,4,5-trisphosphate receptor (IP(3)R)/Ca(2+) channels and high-capacity, low-affinity Ca(2+) storage proteins chromogranins A ...

journal_title：Annals of the New York Academy of Sciences

authors： Yoo SH,So SH,Huh YH,Park HY

更新日期：2002-10-01 00:00:00

abstract：:Previous studies reported that constitutive androstane receptor (CAR) does not transactivate phenobarbital responsive unit (PBRU)2C1luciferase reporter gene in COS cells in which endogenous CYP2B1 gene is not induced with PB. In order to understand molecular mechanism(s) whereby PBRU is transactivated, this article de...

journal_title：Annals of the New York Academy of Sciences

authors： Min G

更新日期：2006-12-01 00:00:00

abstract：:Noninvasive and/or nondestructive techniques can provide structural information about bone, beyond simple bone densitometry. While the latter provides important information about osteoporotic fracture risk, many studies indicate that bone mineral density (BMD) only partly explains bone strength. Quantitative assessmen...

journal_title：Annals of the New York Academy of Sciences

authors： Genant HK,Jiang Y

更新日期：2006-04-01 00:00:00

abstract：:We have studied the conductance of molecular films as a function of orientation of the molecules in the film with respect to electrodes. Depending on the angle between the axis of the molecules and the normal to the electrode, the conductance may change by more than an order of magnitude. This is a consequence of the ...

journal_title：Annals of the New York Academy of Sciences

authors： Kornilovitch PE,Bratkovsky AM

更新日期：2002-04-01 00:00:00

abstract：:Recent studies have shown that cirazoline, an alpha 1-adrenoceptor agonist, has greater affinity than do other imidazoline or guanidinium compounds at imidazoline recognition sites. In this report we used [3H]cirazoline as a probe to characterize imidazoline recognition sites present in membrane homogenates of rat bra...

journal_title：Annals of the New York Academy of Sciences

authors： Angel I,Le Rouzic M,Pimoule C,Graham D,Arbilla S

更新日期：1995-07-12 00:00:00

abstract：:The Na,K-ATPase is composed of two subunits, alpha and beta, and each subunit consists of multiple isoforms. In the case of alpha, four isoforms, alpha1, alpha2, alpha3, and alpha4 are present in mammalian cells. The distribution of these isoforms is tissue- and developmental-specific, suggesting that they may play sp...

journal_title：Annals of the New York Academy of Sciences

authors： Lingrel J,Moseley A,Dostanic I,Cougnon M,He S,James P,Woo A,O'Connor K,Neumann J

更新日期：2003-04-01 00:00:00

abstract：:The aim of the present article was to investigate the occurrence and temporary changes of pituitary adenylate cyclase-activating polypeptide (PACAP)-38 and vasoactive intestinal peptide (VIP) in various brain areas of chicken embryos by means of radioimmunoassay. The highest concentrations of PACAP-38 were measured in...

journal_title：Annals of the New York Academy of Sciences

authors： Jozsa R,Hollosy T,Nemeth J,Tamás A,Lubics A,Jakab B,Olah A,Arimura A,Reglödi D

更新日期：2006-07-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) is well known to protect delayed neuronal cell death in the brain of rodents. In order to investigate the neuroprotective action of PACAP in the retina, we examined the effects of PACAP on kainic acid (KA)-induced neurotoxicity in the rat retina. Many ganglion...

journal_title：Annals of the New York Academy of Sciences

authors： Seki T,Nakatani M,Taki C,Shinohara Y,Ozawa M,Nishimura S,Ito H,Shioda S

更新日期：2006-07-01 00:00:00