Abstract:
:Methamphetamine (METH) produces nigrostriatal dopamine (DA) loss, partly resembling that which occurs in Parkinson's disease (PD). In PD there is also a marked alteration in the gut. Given the similarities between the central DA denervation produced by METH and PD, in the present study we evaluated the alterations in the gut following upon METH administration. To compare these effects with those occurring in PD, we also administered the parkinsonism-inducing neurotoxin MPTP. METH and MPTP were administered to mice, and after 7 days we investigated the immunostaining for tyrosine hydroxylase in nervous plexuses. These data indicate that METH did not alter the catecholamine-containing axons and autonomic neurons, while MPTP markedly reduced these components.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Natale G,Kastsiuchenka O,Pasquali L,Ruggieri S,Paparelli A,Fornai Fdoi
10.1196/annals.1432.015subject
Has Abstractpub_date
2008-10-01 00:00:00pages
345-9eissn
0077-8923issn
1749-6632pii
NYAS1139015journal_volume
1139pub_type
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