Abstract:
:Rapid advances in the biomedical sciences are producing new means of intervention against many of the major tropical diseases. The discovery of new drugs, vaccines and diagnostic tests, however, is only the first, though important, step down an often long and difficult road to their effective deployment in disease control programs. The blossoming of interest in tropical diseases among those in the laboratory sciences has not been paralleled by the required expansion in the number of scientists undertaking field research in the areas where such diseases are endemic. In consequence, it may be difficult to ensure the proper evaluation of new interventions in realistic disease control situations. There is also a danger that some tools developed for research purposes may be uncritically introduced into control programs without adequate consideration of their true utility. Developing field research capacity in the tropical disease endemic areas is an urgent priority if the new tools and interventions are to be employed optimally. Some methods for achieving this are discussed and possible epidemiologic approaches to the evaluation of interventions against tropical diseases are outlined.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Smith PGdoi
10.1111/j.1749-6632.1989.tb27372.xsubject
Has Abstractpub_date
1989-01-01 00:00:00pages
219-30eissn
0077-8923issn
1749-6632journal_volume
569pub_type
杂志文章,评审abstract::Data on 3080 mother-infant pairs from Cebu in the Philippines were used to conduct a logistics hazards analysis to determine the effect of supplemental calories and the types of supplements that the infant ingests on return to menses. Breast feeding had a significant reduced odds of the mother returning to menses (od...
journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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更新日期:1976-01-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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journal_title:Annals of the New York Academy of Sciences
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更新日期:2007-03-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:2009-02-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:2013-04-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
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更新日期:2007-04-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.1979.tb56574.x
更新日期:1979-01-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:2006-11-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:1991-01-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
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更新日期:2011-01-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
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journal_title:Annals of the New York Academy of Sciences
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更新日期:1986-01-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:1975-06-30 00:00:00
abstract::Adult animals that had been subjected to a single prolonged episode of maternal deprivation (MD) [24 h, postnatal day (PND) 9-10] show long-term behavioral alterations that resemble specific symptoms of schizophrenia. Moreover, at adolescence MD rats showed depressive-like behavior and altered motor responses. Accordi...
journal_title:Annals of the New York Academy of Sciences
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更新日期:2009-02-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
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更新日期:2008-01-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
abstract::The psychostimulant 3,4-,ethylenedioxymethamphetamine (MDMA, "ecstasy") is known to induce hyperthermia and alterations in neurochemical metabolism in the CNS. However, the detailed cellular or molecular mechanisms behind MDMA-induced neurotoxicity are still not well known. Since MDMA induces profound hyperthermia tha...
journal_title:Annals of the New York Academy of Sciences
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更新日期:2008-10-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
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更新日期:1991-01-01 00:00:00
abstract::The behavior of neurons in the basal ganglia is severely disrupted in Parkinson's disease (PD). In nonhuman parkinsonian primate models, the disturbance in neurons in basal ganglia output structures include increased firing, bursting, an augmented synchrony, correlated activity, and a tendency towards loss of specific...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:2003-06-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
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更新日期:2012-08-01 00:00:00