A cooperative study of sarcoidosis in Asia and Africa: analytic epidemiology.

abstract：:The four diseases discussed in this chapter (dracunculiasis, onchocerciasis, schistosomiasis, and trachoma) are among the officially designated "Neglected Tropical Diseases," and each is also both the result of and a contributor to the poverty of many rural populations. To various degrees, they all have adverse effect...

journal_title：Annals of the New York Academy of Sciences

authors： Hopkins DR,Richards FO Jr,Ruiz-Tiben E,Emerson P,Withers PC Jr

更新日期：2008-01-01 00:00:00

abstract：:The current trend in antipoverty policy emphasizes mandated empowerment: the poor are being handed the responsibility for making things better for themselves, largely without being asked whether this is what they want. Beneficiary control is now being built into public service delivery, while microcredit and small bus...

journal_title：Annals of the New York Academy of Sciences

authors： Banerjee AV,Duflo E

更新日期：2008-01-01 00:00:00

abstract：:To live beyond the octogenarian years, population and molecular genetic studies of centenarian sibships indicate that genetic factors play an increasingly important role as the limit of life span is approached. These factors are likely to influence basic mechanisms of aging that in turn broadly influence susceptibilit...

journal_title：Annals of the New York Academy of Sciences

authors： Perls T

更新日期：2002-04-01 00:00:00

abstract：:Recent cross-cultural studies of child development reveal that child rearing, while strikingly culturally variable, is everywhere designed to make the child's experience of important lessons constant, to link those lessons to emotional arousal, and to connect them to evaluations of the child's goodness and badness. Th...

journal_title：Annals of the New York Academy of Sciences

authors： Quinn N

更新日期：2003-10-01 00:00:00

abstract：:The same retinal image motion can be produced by a variety of combinations of eye and target motion. In natural conditions, extraretinal information disambiguates retinal information for motion perception. By controlling the timing of visual motion with respect to saccades, it was possible to appraise the roles for mo...

journal_title：Annals of the New York Academy of Sciences

authors： Lee C,Lee J

更新日期：2005-04-01 00:00:00

abstract：:In this brief review, we introduce some major themes in the regulation of energy, lipid, and glucose metabolism by the central nervous system (CNS). Rather than comprehensively discussing the field, we instead will discuss some of the key findings made regarding the interaction of the hormones ghrelin and leptin with ...

journal_title：Annals of the New York Academy of Sciences

authors： Nogueiras R,Tschöp MH,Zigman JM

更新日期：2008-04-01 00:00:00

abstract：:Vitamin E has the ability to scavenge a wide spectrum of free radicals, including singlet oxygen, superoxide, and hydroxyl radicals. It has beneficial effects against several other disorders, such as atherosclerosis and ischemic heart disease, because it acts as a transcriptional regulator for gene expression via a tr...

journal_title：Annals of the New York Academy of Sciences

authors： Al-Shamsi M,Amin A,Adeghate E

更新日期：2006-11-01 00:00:00

abstract：:Aged F344 female rats (21 months) showed decreased performance, as compared to young rats (4 months), on an object recognition memory task. Golgi impregnation measured dendritic spine density of pyramidal neurons in the prefrontal cortex (layer II-III), a brain area important for recognition memory. Densities of spine...

journal_title：Annals of the New York Academy of Sciences

authors： Wallace M,Frankfurt M,Arellanos A,Inagaki T,Luine V

更新日期：2007-02-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a complex clinical entity. In contrast to previously limited diagnostic definitions, it is now apparent that COPD is a clinically and biologically heterogeneous disease process, overlapping with other airways diseases like chronic asthma. As such, symptomatic response to...

journal_title：Annals of the New York Academy of Sciences

authors： Rooney C,Sethi T

更新日期：2015-06-01 00:00:00

abstract：:Immunosuppressive therapy and clinical evolution were studied in 49 patients (29 females) with antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis. The mean age of patients at presentation was 55 years, and the mean (+/-SD) follow-up was 43 months (+/-33) (range, 3-140). Among the 49 patients, 10 ...

journal_title：Annals of the New York Academy of Sciences

authors： Kokolina E,Alexopoulos E,Dimitriadis C,Vainas A,Giamalis P,Papagianni A,Ekonomidou D,Memmos D

更新日期：2005-06-01 00:00:00

abstract：:In humans any effects of dietary saturated fats or omega-6 polyunsaturates on blood pressure appear to be mediated by changes in caloric intake and long-term weight changes. In contrast, omega-3 fatty acids have a mild antihypertensive effect which is seen most clearly in untreated subjects with higher blood pressures...

journal_title：Annals of the New York Academy of Sciences

authors： Beilin LJ

更新日期：1993-06-14 00:00:00

abstract：:It has previously been shown that stimulation of muscarinic m1 or m3 receptors can, by generating diacylglycerol (DAG) and activating protein kinase C (PKC), accelerate the breakdown of the amyloid precursor protein (APP) to form soluble, non-amyloidogenic peptides (APPs). This relationship has been demonstrated in hu...

journal_title：Annals of the New York Academy of Sciences

authors： Lee RK,Jimenez J,Cox AJ,Wurtman RJ

更新日期：1996-01-17 00:00:00

abstract：:Hyperactivity of the hypothalamo-pituitary-adrenal (HPA) axis is often observed in association with and even prior to the onset of major depression. It is presently unclear (1) which molecular and cellular processes contribute to hyperactivity of parvocellular hypothalamic neurons (key regulators of the HPA system) an...

journal_title：Annals of the New York Academy of Sciences

authors： Joëls M,Verkuyl JM,Van Riel E

更新日期：2003-12-01 00:00:00

abstract：:Because of the sedative/hypnotic and euphoric effects of gamma-hydroxybutyric acid (GHB), the recreational use of the drug has increased significantly. In the current study we investigated the sedative and rewarding effects of GHB in Swiss Webster mice. Although the acute administration of GHB (200 mg/kg) caused marke...

journal_title：Annals of the New York Academy of Sciences

authors： Itzhak Y,Ali SF

更新日期：2002-06-01 00:00:00

abstract：:The aim of this study was to examine the role of activating pathways of plasminogen in the natural history of abdominal aortic aneurysms (AAA). To fulfill this objective 70 male patients with small AAA (> 3 cm) were interviewed and examined. Their blood samples were taken at diagnosis. The patients were scanned annual...

journal_title：Annals of the New York Academy of Sciences

authors： Lindholt JS

更新日期：2006-11-01 00:00:00

abstract：:Soluble decoy receptor 3 (DcR3), a member of the tumor necrosis factor receptor superfamily, has recently been reported to increase osteoclast (OC) differentiation. Its impact on the skeleton was reinforced by a study on DcR3 transgenic mice showing a decreased bone mass through the elevation of OC number, providing s...

journal_title：Annals of the New York Academy of Sciences

authors： Brunetti G,Oranger A,Mori G,Centonze M,Colaianni G,Rizzi R,Liso V,Zallone A,Grano M,Colucci S

更新日期：2010-03-01 00:00:00

abstract：:Reprogramming of energy metabolism is one of the hallmarks of cancer. In normal conditions, cells rely on mitochondrial oxidative phosphorylation to provide energy for cellular activities. Cancer cells are characterized by increased glycolysis and reduced mitochondrial respiratory function. In the past decade, somatic...

journal_title：Annals of the New York Academy of Sciences

authors： Kaipparettu BA,Ma Y,Wong LJ

更新日期：2010-07-01 00:00:00

abstract：:A short review of current concepts concerning the origin and kinetics of monocytes and macrophages is given, and the humoral regulation of monocyte production by FIM, a factor synthesized and secreted by macrophages, is discussed. Genetic control of the responsiveness of monocyte precursors to FIM and that of the phag...

journal_title：Annals of the New York Academy of Sciences

authors： van Furth R,Sluiter W,van Dissel JT

更新日期：1986-01-01 00:00:00

abstract：:Thymic pathology occurs in 80-90% of myasthenia gravis patients. Significant associations between different thymic alterations and clinical findings are discussed. To highlight peculiarities in thymoma-associated myasthenia gravis, we briefly review myasthenia gravis associated with thymic lymphofollicular hyperplasia...

journal_title：Annals of the New York Academy of Sciences

authors： Marx A,Müller-Hermelink HK,Ströbel P

更新日期：2003-09-01 00:00:00

abstract：:Oxyradicals are generally considered harmful byproducts of oxidative metabolism, causing molecular damage in living systems. They are implicated in various processes such as mutagenesis, aging, and series of pathological events. Although all this may be justified, evidence is accumulating that it is an oversimplified ...

journal_title：Annals of the New York Academy of Sciences

authors： Nagy IZ

更新日期：2001-04-01 00:00:00

abstract：:Aging is amenable to intervention and prevention by mild stress-induced hormesis. Previously, we have reported that repeated mild heat stress has antiaging and other beneficial effects on growth and a range of cellular and biochemical characteristics of normal human skin fibroblasts and keratinocytes undergoing aging ...

journal_title：Annals of the New York Academy of Sciences

authors： Rattan SI,Sejersen H,Fernandes RA,Luo W

更新日期：2007-11-01 00:00:00

abstract：:The balance between optimal levels of emotional arousal and cognitive performance reflects the integration of several dopaminergically and adrenergically regulated neural systems. The amygdalar system is a key region for gating stimulation to cortical regions and the medial amygdala appears to play an especially key r...

journal_title：Annals of the New York Academy of Sciences

authors： Mayes LC

更新日期：2006-12-01 00:00:00

abstract：:Aging is the major risk factor for both the development of chronic diseases and loss of functional capacity. Geroscience provides links among the biology of aging, the biology of disease, and the physiology of frailty, three fields where enormous progress has been made in the last few decades. While, previously, the f...

journal_title：Annals of the New York Academy of Sciences

authors： Kohanski RA,Deeks SG,Gravekamp C,Halter JB,High K,Hurria A,Fuldner R,Green P,Huebner R,Macchiarini F,Sierra F

更新日期：2016-12-01 00:00:00

abstract：:Nitric oxide (NO) is an important signaling molecule that is generated through the catalytic activity of nitric oxide synthase (NOS). In the brain, NO mediates neuronal survival, synaptic plasticity, vascular smooth muscle relaxation, and endothelial cell permeability. Previous studies demonstrated aberrant expression...

journal_title：Annals of the New York Academy of Sciences

authors： de la Monte SM,Sohn YK,Etienne D,Kraft J,Wands JR

更新日期：2000-04-01 00:00:00

abstract：:Atherosclerotic coronary heart disease and other forms of cardiovascular disease (CVD) are the major cause of mortality in type II diabetes (T2DM) as well as a major contributor to morbidity and lifetime costs. The purpose of this article is the identification of the biochemical parameters in plasma, which may serve a...

journal_title：Annals of the New York Academy of Sciences

authors： Kalofoutis C,Piperi C,Zisaki A,Singh J,Harris F,Phoenix D,Alaveras A,Kalofoutis A

更新日期：2006-11-01 00:00:00

abstract：:One of the challenges facing health and welfare policymakers as well as researchers in most developed countries is the increasing demand for aging services and aged care. Low birth rates and rapid increases in the percentages of elderly people make aging and aged care one of the top-priority issues among the national ...

journal_title：Annals of the New York Academy of Sciences

authors： Soar J,Seo Y

更新日期：2007-10-01 00:00:00

abstract：:The HLA DQB1*0302 allele on DR4 haplotypes is a well-known marker for T1D susceptibility. The contribution of this DQ molecule to overall disease susceptibility may be genotype dependent. On Asian DR4 haplotypes, not only DQB1*0302, but also DQB1*0401 confer susceptibility to T1D, which is mediated by DRB1*0405 on the...

journal_title：Annals of the New York Academy of Sciences

authors： Park Y,Tait BD,Kawasaki E,Rowley M,Mackay IR

更新日期：2004-12-01 00:00:00

abstract：:The discrepancy between dynamical mass measures of objects such as galaxies and the observed distribution of luminous matter in the universe is typically explained by invoking an unseen "dark matter" component. Dark matter must necessarily be nonbaryonic. We introduce a simple hypothesis to do away with the necessity ...

journal_title：Annals of the New York Academy of Sciences

authors： Kinney WH,Brisudova M

更新日期：2001-06-01 00:00:00

abstract：:Melatonin is a hormone secreted by the pineal gland, mostly in the dark period of the light/dark cycle, with corresponding fluctuations reflected in the plasma melatonin levels. This hormone plays a critical role in the regulation of various neural and endocrine processes that are synchronized with daily change in pho...

journal_title：Annals of the New York Academy of Sciences

authors： Lahiri DK,Chen D,Lahiri P,Rogers JT,Greig NH,Bondy S

更新日期：2004-12-01 00:00:00

abstract：:The discovery of RNA interference (RNAi) in C. elegans and in plants has revolutionized current approaches to biology and medicine. RNAi silences genes in a sequence-specific manner through the actions of small pieces of double-stranded RNAs (siRNAs and miRNAs). RNAi has been found as a widespread natural phenomenon i...

journal_title：Annals of the New York Academy of Sciences

authors： Zheng ZM,Tang S,Tao M

更新日期：2005-11-01 00:00:00