CYP21A2 genetic profile in 14 Egyptian children with suspected congenital adrenal hyperplasia: a diagnostic challenge.

abstract：:Intense stress can be detrimental for tissue homeostasis and accelerates aging. On the other hand, repeated mild stresses can have beneficial and even life-prolonging effects. Hypersecretion of glucocorticoids (GCs) represents the major hormonal response to stress. However, besides its life-sustaining role, GC excess ...

journal_title：Annals of the New York Academy of Sciences

authors： Kletsas D,Pratsinis H,Gioni V,Pilichos K,Yiacoumettis AM,Tsagarakis S

更新日期：2007-04-01 00:00:00

abstract：:Brown adipose tissue (BAT) is an endocrine organ that contributes to thermogenesis and energy consumption. We investigated the effects of salt loading and surgical removal of whitened interscapular BAT (iBAT) on cardiac and adipose tissue pathology in DahlS.Z-Leprfa /Leprfa (DS/obese) rats, an animal model of metaboli...

journal_title：Annals of the New York Academy of Sciences

authors： Komatsu Y,Aoyama K,Yoneda M,Ito S,Sano Y,Kawai Y,Cui X,Yamada Y,Furukawa N,Ikeda K,Nagata K

更新日期：2020-12-19 00:00:00

abstract：:Human diploid fibroblasts (WI38) were inoculated into Rose multipurpose culture chambers, using a high population density to develop confluency. After 24 hours, cells from a 1 mm swath were scraped from the center of the chamber. This cleared path was positioned to permit an unobstructed transmission of a 0.9 X 20 mm ...

journal_title：Annals of the New York Academy of Sciences

authors： Rounds DE,Olson RS,Booher J

更新日期：1976-01-30 00:00:00

abstract：:Members of the steroid receptor superfamily, like other transcription factors, can function as transcriptional inducers as well as repressors of transcription. The mechanisms by which repression is achieved seem to be specific for the factors and [table: see text] regulatory sequences involved. Many and perhaps all of...

journal_title：Annals of the New York Academy of Sciences

authors： Renkawitz R

更新日期：1993-06-11 00:00:00

abstract：:The skin immune system includes a complex network of dendritic cells (DCs). In addition to generating cellular and humoral immunity against pathogens, skin DCs are involved in tolerogenic mechanisms that maintain immune homeostasis and in pathogenic chronic inflammation in which immune responses are unrestrained. Harn...

journal_title：Annals of the New York Academy of Sciences

authors： Klechevsky E,Banchereau J

更新日期：2013-05-01 00:00:00

abstract：:This article analyzes the serum cytokine profile of a nonrandomized group of patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA) who are destined to be treated with infliximab following failure after failure of different disease-modifiying antirheumatic drugs (DMARDs). Serial serum samples were colle...

journal_title：Annals of the New York Academy of Sciences

authors： Amital H,Barak V,Winkler RE,Rubinow A

更新日期：2007-09-01 00:00:00

abstract：:It is known that hepatocytes show the different morphology depending on the surface condition of cultural substratum. The cells form a floating cell-aggregate called spheroid on proteoglycan-coated or positively charged dishes. The liver cell functions are generally high and maintained for the long-term in the spheroi...

journal_title：Annals of the New York Academy of Sciences

authors： Kamihira M,Yamada K,Hamamoto R,Iijima S

更新日期：1997-12-31 00:00:00

abstract：:Lipogenesis occurs primarily in the liver, where dietary carbohydrates control the expression of key enzymes in glycolytic and lipogenic pathways. We have recently discovered that the transcription factor XBP1, best known as a key regulator of the unfolded protein response (UPR), is required for de novo fatty acid syn...

journal_title：Annals of the New York Academy of Sciences

authors： Glimcher LH,Lee AH

更新日期：2009-09-01 00:00:00

abstract：:Esophageal symptoms are common, and can arise from mucosal, motor, functional, and neoplastic processes, among others. Judicious use of diagnostic testing can help define the etiology of symptoms and can direct management. Endoscopy, esophageal high-resolution manometry (HRM), ambulatory pH or pH-impedance manometry, ...

journal_title：Annals of the New York Academy of Sciences

authors： Gyawali CP,de Bortoli N,Clarke J,Marinelli C,Tolone S,Roman S,Savarino E

更新日期：2018-12-01 00:00:00

abstract：:Few studies have evaluated the impact of nutritional supplementation among pregnant adolescents. We examined the effects of the Rang Din Nutrition Study (RDNS) interventions on children born to mothers <20 years of age. The RDNS was a cluster-randomized effectiveness trial with four arms: (1) women and children both r...

journal_title：Annals of the New York Academy of Sciences

authors： Dewey KG,Matias SL,Mridha MK,Arnold CD

更新日期：2020-05-01 00:00:00

abstract：:Since NTS neurons receive synaptic input from many sensory modalities, it is crucial to understand the neuronal mechanisms involved in synaptic processing. We have proposed that GABA-containing neurons in the NTS are the primary target for somatic afferent fibers activated by skeletal muscle contraction. In our model,...

journal_title：Annals of the New York Academy of Sciences

authors： Potts JT

更新日期：2001-06-01 00:00:00

abstract：:Dr. Josep Font (Barcelona, 1953-2006) devoted his professional career to the care of patients with systemic autoimmune diseases (SAD). In 1995, he created the Department of Autoimmune Diseases at the Hospital Clinic in Barcelona, a pioneering unit in Europe specifically dedicated to the clinical management of these pa...

journal_title：Annals of the New York Academy of Sciences

authors： Ramos-Casals M,Khamashta MA

更新日期：2007-06-01 00:00:00

abstract：:Weight reduction through caloric restriction (CR) or exercise can have opposite effects on bone. This study investigated the effects of comparable weight reduction through CR and/or exercise on body composition and bone structure in an obese rat model. Male 6-week-old rats were fed either a normal-fat diet for 6 month...

journal_title：Annals of the New York Academy of Sciences

authors： Cao JJ

更新日期：2018-12-01 00:00:00

abstract：:Manifest pre-eclampsia is associated with activation of peripheral neutrophils as well as elevations in maternal cell-free DNA. For this reason, we were very intrigued by recent reports indicating that activated circulatory neutrophils secrete nuclear DNA to generate extracellular DNA lattices, termed NETs (neutrophil...

journal_title：Annals of the New York Academy of Sciences

authors： Gupta A,Hasler P,Gebhardt S,Holzgreve W,Hahn S

更新日期：2006-09-01 00:00:00

abstract：:The aim of the study was to determine the frequency of patients with gestational diabetes mellitus (GDM) who have serological markers typical of autoimmune type 1 DM. The specific pancreatic markers, ICAs, glutamic decarboxylase (GADAbs), and second islet antigen (IA2Abs), were measured in 70 women with GDM during the...

journal_title：Annals of the New York Academy of Sciences

authors： Lapolla A,Fedele D,Pedini B,Dal Fra MG,Sanzari M,Masin M,Zanchetta R,Betterle C

更新日期：2002-04-01 00:00:00

abstract：:The constitution of platelet-fibrin(ogen) contacts, the separation of the platelets initially aggregated, and the rearrangement of the platelet cytoskeleton during clot formation (0.5 to 60 minutes after thrombin stimulation) were investigated using ultrastructural and immunocytochemical techniques. After aggregation,...

journal_title：Annals of the New York Academy of Sciences

authors： Morgenstern E,Daub M,Dierichs R

更新日期：2001-01-01 00:00:00

abstract：:Delayed type hypersensitivity (DTH) reactions represent cell-mediated immune responses that exert important immunoprotective (resistance to viruses, bacteria, and fungi) or immunopathologic (allergic or autoimmune hypersensitivity) effects. We have used the skin DTH response as an in vivo model to study neuro-endocrin...

journal_title：Annals of the New York Academy of Sciences

authors： Dhabhar FS

更新日期：2003-05-01 00:00:00

abstract：:Human mesenchymal stem cells (hMSCs) from bone marrow are a source of osteoblast progenitors in vivo, and under appropriate conditions they differentiate into osteoblasts ex vivo. The cells provide a convenient cell culture model for the study of osteogenic tissue repair in an experimentally accessible system. Recent ...

journal_title：Annals of the New York Academy of Sciences

authors： Gregory CA,Gunn WG,Reyes E,Smolarz AJ,Munoz J,Spees JL,Prockop DJ

更新日期：2005-05-01 00:00:00

abstract：:Seleno-glutathione peroxidase (GSHPx) is considered to be the major enzymatic activity in charge of removing excess cytosolic and mitochondrial H2O2 in most tissues including brain. Intracellular GSHPx activity is therefore hypothesized to be one important factor that contributes to minimize hydroxyl radical formation...

journal_title：Annals of the New York Academy of Sciences

authors： Mirault ME,Tremblay A,Furling D,Trepanier G,Dugre F,Puymirat J,Pothier F

更新日期：1994-11-17 00:00:00

abstract：:These data suggest that shock stress during adolescence increases ETOH consumption and may contribute to an increase in aggression in early adulthood. Interestingly, shock stress without ETOH results in timid behavior in early adulthood. One might speculate that adolescent hamsters "self-medicate" to deal with continu...

journal_title：Annals of the New York Academy of Sciences

authors： Ferris CF,Brewer J

更新日期：1996-09-20 00:00:00

abstract：:Pregnant female Sprague-Dawley rats were injected with either 40 mg/kg (-)cocaine hydrochloride or an equivalent volume of 0.9% saline, subcutaneously (s.c.), once daily from gestational day 12 (GD 12) to GD 21. Gestational cocaine exposure had no effect on maternal weight gain, length of gestation, birthweight, fetal...

journal_title：Annals of the New York Academy of Sciences

authors： Choi SJ,Mazzio E,Soliman KF

更新日期：1998-05-30 00:00:00

abstract：:Acute phase proteins (APPs) are a group of serum proteins that undergo dramatic changes in concentration during times of inflammation. Many APPs are heavily glycosylated, and their sugar content and complexity change in the presence of cancer-induced chronic inflammation. These changes in glycosylation are currently b...

journal_title：Annals of the New York Academy of Sciences

authors： Dempsey E,Rudd PM

更新日期：2012-04-01 00:00:00

abstract：:The quasibiennial oscillation (QBO) dominates the variability of the equatorial stratosphere and also affects the circulation and temperature of the extratropical region. In this paper we review previous work showing that the mid- to high-latitude circulation is weaker (stronger) when QBO easterlies (westerlies) domin...

journal_title：Annals of the New York Academy of Sciences

authors： Peña-Ortiz C,García-Herrera R,Ribera P,Calvo N

更新日期：2008-12-01 00:00:00

abstract：:DNA microarray analysis was conducted to investigate the transcriptional responses of the human monocytic leukemia cell line THP-1 to infection by Chlamydia trachomatis or Coxiella burnetii. RNA was isolated from mock infected cells and cells infected for 36 hours using TRIzol reagent. Biotinylated probes synthesized ...

journal_title：Annals of the New York Academy of Sciences

authors： Ren Q,Robertson SJ,Howe D,Barrows LF,Heinzen RA

更新日期：2003-06-01 00:00:00

abstract：:Force and shortening in striated muscle are driven by a structural working stroke in the globular portion of the myosin molecules-the myosin head-that cross-links the myosin-containing filaments and the actin-containing filaments. We use time-resolved X-ray diffraction in single fibers from frog skeletal muscle to lin...

journal_title：Annals of the New York Academy of Sciences

authors： Reconditi M,Linari M,Lucii L,Stewart A,Sun YB,Narayanan T,Irving T,Piazzesi G,Irving M,Lombardi V

更新日期：2005-06-01 00:00:00

abstract：:We review the effects of two transcription factor decoy oligonucleotides on apoptosis of human osteoclasts (OCs). The first decoy molecule was designed to inhibit nuclear factor kappa-B (NF-kappaB) binding to target sequence, the second to increase estrogen receptor (ER) alpha expression. We found that both decoy mole...

journal_title：Annals of the New York Academy of Sciences

authors： Piva R,Penolazzi L,Zennaro M,Bianchini E,Magri E,Borgatti M,Lampronti I,Lambertini E,Tavanti E,Gambari R

更新日期：2006-12-01 00:00:00

abstract：:Rituximab (RTX) is currently used in many diseases, but its efficacy and safety in juvenile systemic lupus erythematosus (SLEj) is still unknown. In this chapter we present four case reports of children treated with RTX: three SLE and one immune thrombocytopenic purpura (ITP). Two of the three SLEj patients had class ...

journal_title：Annals of the New York Academy of Sciences

authors： Polido-Pereira J,Ferreira D,Rodrigues AM,Nascimento C,Costa P,Almeida M,da Silva JE,Simão C,Stone R,Ramos F,Neto A,da Costa JC,Melo-Gomes J,Gomes-Pedro J,Viana-Queiroz M,Canhão H,Fonseca JE

更新日期：2009-09-01 00:00:00

abstract：:Neocortex is an important part of the mammalian brain that is quite different from its homologue of the dorsal cortex in the reptilian brain. Whereas dorsal cortex is small, thin, and composed of a single layer of neurons, neocortex is thick and has six layers, while being variable across species in size, number of fu...

journal_title：Annals of the New York Academy of Sciences

authors： Kaas JH

更新日期：2011-04-01 00:00:00

abstract：:Acanthamoeba castellanii (A. castellanii) is a common soil- or water-borne protozoon that feeds on bacteria by phagocytosis. A. castellanii can grow between 4 and 32 degrees C and has to adapt quickly to chilling in order to survive. We have identified a Delta12-fatty acid desaturase as key to low temperature adaptati...

journal_title：Annals of the New York Academy of Sciences

authors： Harwood JL

更新日期：2007-10-01 00:00:00

abstract：:Blood-borne beta-amyloids (A beta s) could affect brain function by (1) crossing the BBB to directly interact with brain tissues or (2) altering BBB function by interacting with the brain capillaries that make up the BBB. Several radioactively labeled A beta s have been examined for such interactions. Blood-borne A be...

journal_title：Annals of the New York Academy of Sciences

authors： Banks WA,Kastin AJ,Maness LM,Banks MF,Shayo M,McLay RN

更新日期：1997-09-26 00:00:00