Abstract:
:Pituitary adenylate cyclase-activating polypeptide (PACAP) is well known to protect delayed neuronal cell death in the brain of rodents. In order to investigate the neuroprotective action of PACAP in the retina, we examined the effects of PACAP on kainic acid (KA)-induced neurotoxicity in the rat retina. Many ganglion cells in the retina died after KA injection in the control group and PACAP treatment significantly promoted cell survival. These findings strongly suggest that PACAP plays very important roles in preventing cell death in the retina.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Seki T,Nakatani M,Taki C,Shinohara Y,Ozawa M,Nishimura S,Ito H,Shioda Sdoi
10.1196/annals.1317.074subject
Has Abstractpub_date
2006-07-01 00:00:00pages
531-4eissn
0077-8923issn
1749-6632pii
1070/1/531journal_volume
1070pub_type
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