Neuroprotective effect of PACAP against kainic acid-induced neurotoxicity in rat retina.

Abstract:

:Pituitary adenylate cyclase-activating polypeptide (PACAP) is well known to protect delayed neuronal cell death in the brain of rodents. In order to investigate the neuroprotective action of PACAP in the retina, we examined the effects of PACAP on kainic acid (KA)-induced neurotoxicity in the rat retina. Many ganglion cells in the retina died after KA injection in the control group and PACAP treatment significantly promoted cell survival. These findings strongly suggest that PACAP plays very important roles in preventing cell death in the retina.

journal_name

Ann N Y Acad Sci

authors

Seki T,Nakatani M,Taki C,Shinohara Y,Ozawa M,Nishimura S,Ito H,Shioda S

doi

10.1196/annals.1317.074

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

531-4

eissn

0077-8923

issn

1749-6632

pii

1070/1/531

journal_volume

1070

pub_type

杂志文章
  • The effect of p38 mitogen-activated protein kinase on mucin gene expression and apoptosis in Helicobacter pylori-infected gastric epithelial cells.

    abstract::The loss of mucus coat continuity and apoptosis have been shown in Helicobacter pylori (H. pylori)-infected gastric tissues. Blockade of p38 mitogen-activated kinase (MAPK) produced reversal in the LPS-induced reduction in mucin synthesis and apoptosis in gastric epithelial cells. This study investigates whether H. py...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1299.014

    authors: Kim H,Seo JH,Kim KH

    更新日期:2003-12-01 00:00:00

  • ExoMars alternative escape trajectories with Soyuz/Fregat.

    abstract::The objectives of ExoMars are to inject an orbiter around Mars and to land a rover on the surface to look for possible traces of life. During the first stages of the feasibility analysis, the mass margin of the orbiter was very small for a direct transfer in the Soyuz/Fregat scenario. An analysis of the combined use o...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1370.011

    authors: Gil-Fernández J,Van Damme CC,Graziano M,Amata GB,Cogo F,Perino MA

    更新日期:2005-12-01 00:00:00

  • The effects of resveratrol and SIRT1 activation on dystrophic cardiomyopathy.

    abstract::The muscular dystrophies, which cause progressive weakening of the skeletal muscles, are frequently associated with cardiomyopathy. In fact, the leading cause of mortality in patients with Duchenne muscular dystrophy, the most common and most severe type of muscular dystrophy, is heart failure due to cardiomyopathy. T...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12812

    authors: Kuno A,Tanno M,Horio Y

    更新日期:2015-08-01 00:00:00

  • Nicotinic acetylcholine receptors on vagal afferent neurons.

    abstract::Nicotinic acetylcholine receptors (nAChRs) play an important role in various processes involved in regulating systemic blood pressure. These receptors are expressed at excitatory cholinergic synapses between sympathetic preganglionic neurons and postganglionic sympathetic neurons and link the integrative activities of...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2001.tb03670.x

    authors: Cooper E

    更新日期:2001-06-01 00:00:00

  • Redox remodeling: a candidate regulator of HMGB1 function in injured skeletal muscle.

    abstract::High-mobility group box-1 (HMGB1) is a prototypical endogenous signal that links tissue necrosis and wound healing. Extracellular HMGB1 has apparently contrasting biological actions: it sustains inflammation (with the possible establishment of autoimmunity or of self-maintaining tissue damage) while activating and rec...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2010.05748.x

    authors: Vezzoli M,Castellani P,Campana L,Corna G,Bosurgi L,Manfredi AA,Bianchi ME,Rubartelli A,Rovere-Querini P

    更新日期:2010-10-01 00:00:00

  • How harmful is the first law?

    abstract::In his First Law (of thermodynamics), Clausius emphasized the equivalence of heat and work-conservation of energy was mentioned only indirectly. Today, the main emphasis is put on energy conservation, but the equivalence of heat and work has proven not only to be superfluous, but also highly destructive. Because of th...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2003.tb06096.x

    authors: Job G,Lankau T

    更新日期:2003-05-01 00:00:00

  • Cerebellar volume and cerebellar metabolic characteristics in adults with dyslexia.

    abstract::Developmental dyslexia is associated with problems in a range of linguistic and non-linguistic skills. Some of those problems have been attributed to dysfunction of the cerebellum and its associated neural systems. Two studies of cerebellar structure were undertaken by our group. In Study 1, white and grey matter volu...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1416.002

    authors: Laycock SK,Wilkinson ID,Wallis LI,Darwent G,Wonders SH,Fawcett AJ,Griffiths PD,Nicolson RI

    更新日期:2008-12-01 00:00:00

  • Molecular landscape of esophageal cancer: implications for early detection and personalized therapy.

    abstract::Esophageal cancer (EC) is one of the most lethal cancers and a public health concern worldwide, owing to late diagnosis and lack of efficient treatment. Esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) are main histopathological subtypes of EC that show striking differences in geographical...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.13876

    authors: Talukdar FR,di Pietro M,Secrier M,Moehler M,Goepfert K,Lima SSC,Pinto LFR,Hendricks D,Parker MI,Herceg Z

    更新日期:2018-12-01 00:00:00

  • Hematogenous dissemination of ingested polyvinyl chloride particles.

    abstract::Persorption of large, hard, insoluble, solid particles in micrometer size range is observed with regularity. It is a normal biological effect on the food passage through the intestine. Persorbability of particles is determined by the size of the particles and by their consistency and hardness. PVC particles in microme...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1975.tb51092.x

    authors: Volkheimer G

    更新日期:1975-01-31 00:00:00

  • Structure and activity in the relaxin family of peptides.

    abstract::The availability of improved peptide synthesis procedures, convenient and sensitive assays for receptor binding and activation, together with advances in methods for structural characterization, has enabled the key structural features of the relaxin family of peptides responsible for biological activity to be defined....

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.03955.x

    authors: Tregear GW,Bathgate RA,Hossain MA,Lin F,Zhang S,Shabanpoor F,Scott DJ,Ma S,Gundlach AL,Samuel CS,Wade JD

    更新日期:2009-04-01 00:00:00

  • Searching for stem cell regulatory molecules. Some general thoughts and possible approaches.

    abstract::Hematopoietic development in the mammal can be represented as a numerically expanding hierarchy of cell populations that are progressively restricted in their self-renewal and differentiation abilities. Classical functional studies have now been extended to provide exact physical descriptions of various stages in the ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1999.tb08472.x

    authors: Lemischka I

    更新日期:1999-04-30 00:00:00

  • Neuroprotective effects of L-carnitine in induced mitochondrial dysfunction.

    abstract::The neuroprotective action of l-carnitine (LC) in the rat model of 3-nitropropionic acid (3-NPA)-induced mitochondrial dysfunction was examined. 3-NPA is known to produce decreases in neuronal ATP levels via inhibition of the succinate dehydrogenase (SDH) at complex II of the mitochondrial electron transport chain. SD...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2003.tb07536.x

    authors: Binienda ZK

    更新日期:2003-05-01 00:00:00

  • Attenuated bacteria as effectors in cancer immunotherapy.

    abstract::Despite the great strides made in understanding the basic biology of cancer and the multiple approaches to cancer therapy that have been utilized, cancer remains a major cause of death worldwide. The two properties that define the most successful tumors are low antigenicity, enabling cancer cells to escape immune syst...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1414.036

    authors: Al-Ramadi BK,Fernandez-Cabezudo MJ,El-Hasasna H,Al-Salam S,Attoub S,Xu D,Chouaib S

    更新日期:2008-09-01 00:00:00

  • Structural and functional properties of the TRK family of neurotrophin receptors.

    abstract::The Trk family of tyrosine-protein kinases, TrkA, TrkB, and TrkC, are the signaling receptors that mediate the biological properties of the NGF family of neurotrophins. This family of growth factors includes in addition to NGF, BDNF, NT-3, and NT-4. TrkA is the NGF receptor. TrkB serves as a receptor for both BDNF and...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1995.tb26693.x

    authors: Barbacid M

    更新日期:1995-09-07 00:00:00

  • Mechanisms of immediate temperature compensation: experiments with brain synaptosomes from rat and ground squirrel.

    abstract::Glucose conversion by brain synaptosomes can be regarded as a special case of intrinsic kinetic properties of the enzyme substrate system. Temperature modulation of apparent K(m) for this process can be described with our kinetic model. Using experimental data and the kinetic model, the minimal K(m) value for glucose ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1342.005

    authors: Marjanović M,Zivadinović D,Dzakula Z,Andjus RK

    更新日期:2005-06-01 00:00:00

  • Characterization of peripheral blood lymphocytes in sarcoidosis.

    abstract::In the basal state, patients with sarcoidosis have reduced numbers of circulating T lymphocytes and a normal number of circulating B lymphocytes. The lymphocytes show impaired DNA synthesis in response to several mitogens and antigens and impaired K-cell cytotoxicity. Circulating atypical cells of lymphocytic origin a...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1976.tb47020.x

    authors: Hedfors E

    更新日期:1976-01-01 00:00:00

  • Perceiving prosody in speech. Effects of music lessons.

    abstract::In two experiments, musically trained and untrained adults were tested on their ability to match spoken utterances with their tonal analogues (tone sequences that retained the pitch and temporal patterns of the utterances). In both cases, musical training was associated with superior performance, indicating an enhance...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1284.067

    authors: Thompson WF,Schellenberg EG,Husain G

    更新日期:2003-11-01 00:00:00

  • Calcium-activated neutral proteinases as regulators of cellular function. Implications for Alzheimer's disease pathogenesis.

    abstract::Evidence is emerging that calcium-activated neutral proteinases (CANPs) not only participate in intracellular protein turnover but help to regulate the functional reorganization of cytoskeletal proteins in response to calcium and second-messenger stimulation. The high concentration of CANPs in certain neurons has sugg...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1989.tb12509.x

    authors: Nixon RA

    更新日期:1989-01-01 00:00:00

  • Effects of chemically modified tetracycline, CMT-8, on bone loss and osteoclast structure and function in osteoporotic states.

    abstract::We examined the effects of a nonantimicrobial tetracycline analogue, CMT-8, on bone loss and osteoclasts in ovariectomized (OVX) rats. Three-month-old female rats were OVX, and, one week later, distributed into three groups: sham-operated non-OVX controls, untreated OVX controls, and CMT-8-treated OVX rats. After 145 ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1999.tb07694.x

    authors: Sasaki T,Ohyori N,Debari K,Ramamurthy NS,Golub LM

    更新日期:1999-06-30 00:00:00

  • Genetic control of macrophage responses.

    abstract::A short review of current concepts concerning the origin and kinetics of monocytes and macrophages is given, and the humoral regulation of monocyte production by FIM, a factor synthesized and secreted by macrophages, is discussed. Genetic control of the responsiveness of monocyte precursors to FIM and that of the phag...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1986.tb18476.x

    authors: van Furth R,Sluiter W,van Dissel JT

    更新日期:1986-01-01 00:00:00

  • Modulation of developing dorsal horn synapses by tissue injury.

    abstract::Although tissue injury can evoke significant hyperalgesia in infants from the first days of life, little is known about how injury affects emergent central pain networks at the synaptic level. Recent studies have investigated whether tissue damage at different ages has distinct consequences for synaptic function in th...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.05425.x

    authors: Baccei ML

    更新日期:2010-06-01 00:00:00

  • Clinical and experimental studies on adenine, various nucleosides and their analogs in hematology.

    abstract::In red blood cells as well as in platelets there appears to be a decrease in adenine nucleotides during storage under blood bank conditions. This can be decreased by use of anticoagulant preservatives with higher phosphate content than the standard ACD solution, through the addition of adenine and inosine. Maintenance...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1975.tb29250.x

    authors: Ambrus JL,Ambrus CM,Odake K,Mink IB,Shields R,Warner W,Bishop C,Tritsch GL,Golden G,Mittelman A

    更新日期:1975-08-08 00:00:00

  • Cellular and molecular neuropathology of the parahippocampal region in schizophrenia.

    abstract::The entorhinal cortex, subiculum, and hippocampus have been regions of great interest in both clinical and neuropathological investigations of schizophrenia. Postmortem studies have identified numerous abnormalities, although many remain controversial or unconfirmed. Among the cellular and molecular neuropathological ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2000.tb06732.x

    authors: Arnold SE

    更新日期:2000-06-01 00:00:00

  • Précis of implicit nationalism.

    abstract::While the study of nationalism has received much attention throughout the social sciences and humanities, the experimental investigation of it lags behind. In this paper we review recent advances in the examination of implicit nationalism. In the first set of experiments we survey, the Palestinian, Israeli, Italian, a...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.04734.x

    authors: Hassin RR,Ferguson MJ,Kardosh R,Porter SC,Carter TJ,Dudareva V

    更新日期:2009-06-01 00:00:00

  • Molecular evidence of Coxiella-like microorganism harbored by Haemaphysalis concinnae ticks in the Russian Far East.

    abstract::Twenty female imago of Haemaphysalis concinnae ticks collected from wild vegetation in May of 2001 in the Obor region near Khabarovsk in the Russian Far East were studied. DNA was extracted with commercially available kits following manufacturer's instructions. We used broad range primers SFG3 and SFG6 proposed for am...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2003.tb07367.x

    authors: Mediannikov O,Ivanov L,Nishikawa M,Saito R,Sidelnikov YN,Zdanovskaya NI,Tarasevich IV,Suzuki H

    更新日期:2003-06-01 00:00:00

  • The specificity and sensitivity of uninhibited COR in labyrinthine-defective patients.

    abstract::The Cervico-ocular reflex (COR), which depends on proprioceptive afferents from neck muscles to the vestibular nucleus, makes little contribution to the stabilization of gaze in humans. If labyrinthine function is lost because of disease, however, the COR may increase in gain and assume greater importance in generatin...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1325.055

    authors: Carmona S,Nieto D

    更新日期:2005-04-01 00:00:00

  • Glutamate cysteine ligase modifier (GCLM) subunit gene is not associated with methamphetamine-use disorder or schizophrenia in the Japanese population.

    abstract::A recent study showed a significant association between schizophrenia in European samples and the glutamate cysteine ligase modifier (GCLM) subunit gene, which is the key glutathione (GSH)-synthesizing enzyme. Since the symptoms of methamphetamine (METH)-induced psychosis are similar to those of schizophrenia, the GCL...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1432.022

    authors: Kishi T,Ikeda M,Kitajima T,Yamanouchi Y,Kinoshita Y,Kawashima K,Inada T,Harano M,Komiyama T,Hori T,Yamada M,Iyo M,Sora I,Sekine Y,Ozaki N,Ujike H,Iwata N

    更新日期:2008-10-01 00:00:00

  • Evolutionary genetics of host shifts in herbivorous insects: insights from the age of genomics.

    abstract::Adaptation to different host taxa is a key driver of insect diversification. Herbivorous insects are classic models for ecological and evolutionary research, but it is recent advances in sequencing, statistics, and molecular technologies that have cleared the way for investigations into the proximate genetic mechanism...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.13311

    authors: Vertacnik KL,Linnen CR

    更新日期:2017-02-01 00:00:00

  • Transcription of the human prolactin gene in mammary cells.

    abstract::Expression of human prolactin in the mammary gland, one of the main target organs of this hormone, leads to the formation of an autocrine-paracrine proliferative loop in this tissue. Involvement of prolactin in normal and neoplastic mammary development triggered the interest in transcriptional regulation of the human ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb04682.x

    authors: Baudhuin A,Manfroid I,Van De Weerdt C,Martial JA,Muller M

    更新日期:2002-11-01 00:00:00

  • Deciphering the role of microRNAs in mustard gas-induced toxicity.

    abstract::Mustard gas (sulfur mustard, SM), a highly vesicating chemical warfare agent, was first deployed in warfare in 1917 and recently during the Iraq-Iran war (1980s) and Syrian conflicts (2000s); however, the threat of exposure from stockpiles and old artillery shells still looms large. Whereas research has been long ongo...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.14539

    authors: Mishra N,Raina K,Agarwal R

    更新日期:2020-12-10 00:00:00