Strategy for prevention of cancers of the esophagus.

abstract：:The neuroprotective action of l-carnitine (LC) in the rat model of 3-nitropropionic acid (3-NPA)-induced mitochondrial dysfunction was examined. 3-NPA is known to produce decreases in neuronal ATP levels via inhibition of the succinate dehydrogenase (SDH) at complex II of the mitochondrial electron transport chain. SD...

journal_title：Annals of the New York Academy of Sciences

authors： Binienda ZK

更新日期：2003-05-01 00:00:00

abstract：:A hallmark of success for early career biomedical researchers is the acquisition of research funding. There are marked disparities among principal investigators who submit grants and the likelihood of receiving national funding. The National Research Mentoring Network was funded by the National Institutes of Health to...

journal_title：Annals of the New York Academy of Sciences

authors： Harwood EM,Jones AR,Erickson D,Buchwald D,Johnson-Hemming J,Jones HP,Manson S,McGee R,Smith A,Steer CJ,Vishwanatha JK,Weber-Main AM,Okuyemi KS

更新日期：2019-06-01 00:00:00

abstract：:Type 2 diabetes and obesity are major global public health problems, with migrant populations in high-income countries being particularly affected. Type 2 diabetes and obesity are also major threats in low- and middle-income countries, from which most migrant populations originate. Transitioning of societies and the r...

journal_title：Annals of the New York Academy of Sciences

authors： Agyemang C,Beune E,Meeks K,Addo J,Aikins AD,Bahendeka S,Danquah I,Mockenhaupt FP,Schulze MB,Klipstein-Grobusch K,Smeeth L,Stronks K

更新日期：2017-03-01 00:00:00

abstract：:Our recent work shows that in addition to pumping ions, Na/K-ATPase acts as a signal transducer. Binding of ouabain to Na/K-ATPase changes the interaction of the enzyme with neighboring membrane proteins and induces the formation of multiple signaling modules, resulting in activation of Src, transactivation of the EGF...

journal_title：Annals of the New York Academy of Sciences

authors： Xie Z

更新日期：2003-04-01 00:00:00

abstract：:We report here the two first cases of human ehrlichiosis described in Italy. One patient presented symptoms indicative of ehrlichiosis, such as fever, conjunctivitis, and increase of hepatic enzymes; HGE was confirmed by fourfold seroconversion for HGE antigen. The second patient, a forest worker, was affected by Lyme...

journal_title：Annals of the New York Academy of Sciences

authors： Ruscio M,Cinco M

更新日期：2003-06-01 00:00:00

abstract：:We have employed antisense methods to study the transcriptional functions of c-fos protein (Fos). Clones expressing inducible anti-fos RNA have been employed to inhibit c-fos expression, resulting in activation of c-fos transcription by inhibiting its normal repressor function. The sites of negative regulation by Fos ...

journal_title：Annals of the New York Academy of Sciences

authors： Holt JT

更新日期：1992-10-28 00:00:00

abstract：:Several reports addressed the issue of how the alternative splicing of exon 7 and 8 in the APP pre-mRNA is regulated in different tissues. Of special interest here was the potential involvement of exon 7 containing APP splice isoforms, since this exon codes for a serine protease inhibitor and is therefore of putative ...

journal_title：Annals of the New York Academy of Sciences

authors： Sandbrink R,Banati R,Masters CL,Beyreuther K,König G

更新日期：1993-09-24 00:00:00

abstract：:CDP-choline was given to patients with Alzheimer's disease (AD) at a daily dose of 1000 mg/day p.o. for one month. This compound slightly improved mental performance, tended to reduce theta activity in fronto-temporal regions, increasing alpha power in occipital areas, and enhanced cerebrovascular perfusion by increas...

journal_title：Annals of the New York Academy of Sciences

authors： Cacabelos R,Caamaño J,Gómez MJ,Fernández-Novoa L,Franco-Maside A,Alvarez XA

更新日期：1996-01-17 00:00:00

abstract：:Purified human urinary CSF-1 was used for production of polyclonal CSF antibodies in rabbits. The purified CSF was iodinated by a modified chloramine-T technique with retention of biologic activity. Dilutions of anti-CSF were reacted with 15,000 cpm of 125I-CSF in EDTA-phosphate buffer for 48 hr. Sheep antirabbit seru...

journal_title：Annals of the New York Academy of Sciences

authors： Shadduck RK,Waheed A

更新日期：1989-01-01 00:00:00

abstract：:There are multiple connections from the entorhinal cortex (EC) to the hippocampus that carry the information from the EC to the hippocampus. Layer II cells of the medial EC innervating the dentate gyrus (DG)-molecular layer possess K(+)-outward currents and inward rectifier currents that are potentially modulated by c...

journal_title：Annals of the New York Academy of Sciences

authors： Heinemann U,Schmitz D,Eder C,Gloveli T

更新日期：2000-06-01 00:00:00

abstract：:Our previous results demonstrate the gastroprotective but not ulcerogenic action of glucocorticoids released in response to ulcerogenic stress factors. The present study was undertaken to investigate the possible mechanisms underlying the gastroprotective action of glucocorticoids in rat stomachs. The effects of defic...

journal_title：Annals of the New York Academy of Sciences

authors： Filaretova LP,Podvigina TT,Bagaeva TR,Tanaka A,Takeuchi K

更新日期：2004-06-01 00:00:00

abstract：:Taking into account that methamphetamine (MA) is a popular recreational drug among young adult women, i.e., in gestational age, the present model aims to assess the effects of its exposure during development. In this experimental model, MA effects are assessed in the rat during the first month of life, regarding both ...

journal_title：Annals of the New York Academy of Sciences

authors： Gomes-DA-Silva J,Silva MC,Tavares MA

更新日期：1998-05-01 00:00:00

abstract：:SOX8 is a transcription factor that belongs to the SoxE group of high mobility group (HMG) superfamily of genes. As Sox8 is widely expressed during development, and has male-specific expression at the critical period for sex determination, it was initially hypothesized that its inactivation would result in abnormal se...

journal_title：Annals of the New York Academy of Sciences

authors： Kennedy CL,Koopman P,Mishina Y,O'Bryan MK

更新日期：2007-12-01 00:00:00

abstract：:The overarching role of coenzyme Q(10) in gene regulation, bioenergy formation, cellular redox poise regulation, and hydrogen peroxide formation is presented. Coenzyme Q(10) has a central role acting as a prooxidant in the generation of H(2)O(2). Contrary to the dogma that superoxide and H(2)O(2) formation are highly ...

journal_title：Annals of the New York Academy of Sciences

authors： Linnane AW,Eastwood H

更新日期：2006-05-01 00:00:00

abstract：:This paper is dedicated to the transient liquid crystal technique measurements for multiple view access by using a novel digital recording and image processing system. The transient liquid crystal technique is widely used for heat transfer investigations in turbomachinery. It has been applied in our laboratory in seve...

journal_title：Annals of the New York Academy of Sciences

authors： Vogel G,Boelcs A

更新日期：2001-05-01 00:00:00

abstract：:Human female reproductive aging consists of multiple processes and interacts with other physiological systems in unique ways. Here we discuss eight recent longitudinal, epidemiologic studies of female reproductive aging that include endocrine data to highlight their contributions to our understanding of these various ...

journal_title：Annals of the New York Academy of Sciences

authors： Ferrell RJ,Sowers M

更新日期：2010-08-01 00:00:00

abstract：:The preventive effects of the phytoalexin trans-resveratrol toward cancer have been largely described at the cellular and molecular levels in both in vivo and in vitro models; however, its primary targets are still poorly identified. In this review, we show the crucial role of cell membrane microdomains, that is, lipi...

journal_title：Annals of the New York Academy of Sciences

authors： Delmas D,Aires V,Colin DJ,Limagne E,Scagliarini A,Cotte AK,Ghiringhelli F

更新日期：2013-07-01 00:00:00

abstract：:Hypophysectomy leads to a small increase in tyrosine hydroxylase activity of all brain areas containing noradrenergic neurons or tuberoinfundibular dopamine neurons, but nigroneostriatal dopamine neurons are not so affected. ACTH or corticosterone treatment inhibited this effect of hypophysectomy in some noradrenergic...

journal_title：Annals of the New York Academy of Sciences

authors： Van Loon GR,Sole MJ,Kamble A,Kim C,Green S

更新日期：1977-10-28 00:00:00

abstract：:The implications of recent precision Z-pole, W mass, and weak neutral current data for testing the standard electroweak model, constraining that t quark and Higgs masses, αs (MZ), and grand unification are discussed. A fit to all data yields sin(2)θw(MZ)= 0.2325 ± 0.0024 (on-shell), where the uncertainties are mainly ...

journal_title：Annals of the New York Academy of Sciences

authors： Langacker P

更新日期：1993-06-01 00:00:00

abstract：:Rheumatoid arthritis is the most common of a number of diseases in which inflammation and tissue destruction is driven by an autoimmune process. Current therapy is inadequate, and this has prompted major research efforts, both in academia and industry, to understand more about the pathogenesis, and hence provide the r...

journal_title：Annals of the New York Academy of Sciences

authors： Feldmann M,Brennan FM,Elliott MJ,Williams RO,Maini RN

更新日期：1995-09-07 00:00:00

abstract：:Vitamin E is essential for normal neurological function. It is the major lipid-soluble, chain-breaking antioxidant in the body, protecting the integrity of membranes by inhibiting lipid peroxidation. Mostly on the basis of symptoms of primary vitamin E deficiency, it has been demonstrated that vitamin E has a central ...

journal_title：Annals of the New York Academy of Sciences

authors： Sen CK,Khanna S,Roy S

更新日期：2004-12-01 00:00:00

abstract：:Nicotine has been found to improve memory performance in a variety of tests in rats, monkeys, and humans. Interactions of nicotinic systems with dopamine (DA) systems may be important for this effect. We conducted a series of studies of nicotinic agonist and antagonist interactions with DA systems using rats in a win-...

journal_title：Annals of the New York Academy of Sciences

authors： Levin ED,Rose JE

更新日期：1995-05-10 00:00:00

abstract：:Modern contraceptive methods represent more than a technical advance: they are the instrument of a true social revolution-the "first reproductive revolution" in the history of humanity, an achievement of the second part of the 20th century, when modern, effective methods became available. Today a great diversity of te...

journal_title：Annals of the New York Academy of Sciences

authors： Benagiano G,Bastianelli C,Farris M

更新日期：2006-12-01 00:00:00

abstract：:This paper discusses the repatriation of human remains to indigenous peoples in Australia and the United States and the role anthropologists play in the construction of past, present, and future identities for contemporary indigenous peoples. Using examples from both countries, I suggest that many of the participants ...

journal_title：Annals of the New York Academy of Sciences

authors： Cantwell AM

更新日期：2000-01-01 00:00:00

abstract：:Multiple subsets of nociceptive, parasympathetic, and sympathetic nerves innervate human nasal mucosa. These play carefully coordinated roles in regulating glandular, vascular, and other processes. These functions are vital for cleaning and humidifying ambient air before it is inhaled into the lungs. The recent identi...

journal_title：Annals of the New York Academy of Sciences

authors： Baraniuk JN,Merck SJ

更新日期：2009-07-01 00:00:00

abstract：:We have studied the developmental patterns of vasoactive intestinal polypeptide (VIP) binding sites in the human hypothalamus. VIP recognition sites were widely distributed throughout the rostrocaudal extent of the hypothalamus. VIP binding was generally low in the fetal and neonatal periods and a tendency in increasi...

journal_title：Annals of the New York Academy of Sciences

authors： Najimi M,Rachidi F,Afif A,Chigr F

更新日期：2006-07-01 00:00:00

abstract：:We review here evidence that a large portion of the caudomedial telencephalon of songbirds, distinct from the song control circuit, is involved in the perceptual processing of birdsong. When songbirds hear song, a number of caudomedial pallial areas are activated, as revealed by expression of the activity-dependent ge...

journal_title：Annals of the New York Academy of Sciences

authors： Mello CV,Velho TA,Pinaud R

更新日期：2004-06-01 00:00:00

abstract：:The objectives of ExoMars are to inject an orbiter around Mars and to land a rover on the surface to look for possible traces of life. During the first stages of the feasibility analysis, the mass margin of the orbiter was very small for a direct transfer in the Soyuz/Fregat scenario. An analysis of the combined use o...

journal_title：Annals of the New York Academy of Sciences

authors： Gil-Fernández J,Van Damme CC,Graziano M,Amata GB,Cogo F,Perino MA

更新日期：2005-12-01 00:00:00

abstract：:Monoclonal antibodies reactive with desmin (D3 and D76) have been generated and their specificities validated by immunoblots, RIAs, and immunocytochemistry. No cross-reaction with other IFPs has been observed. The McAbs recognized different epitopes but both reside in the amino-terminal rod domain of desmin. Whereas M...

journal_title：Annals of the New York Academy of Sciences

authors： Fischman DA,Danto SI

更新日期：1985-01-01 00:00:00

abstract：:Reports on patients with hemiparalysis indicate the importance of the nervous system for the pathophysiology of rheumatoid arthritis (RA) or osteoarthritis (OA). Norepinephrine (NE) and opioids seem to be more antiinflammatory neurotransmitters whereas substance P is proinflammatory. The study aimed to investigate the...

journal_title：Annals of the New York Academy of Sciences

authors： Miller LE,Wessinghage D,Müller-Ladner U,Schölmerich J,Falk W,Kerner T,Straub RH

更新日期：1999-06-22 00:00:00