Antisense promoter mapping. Inhibitory methods of transcriptional analysis.

abstract：:Hybrid liver systems are being developed as temporary extracorporeal liver support therapy. The overview given here emphasizes the development of both hepatocyte culture models for bioreactors and of systems for clinical therapy. In vitro studies demonstrate long term external metabolic function in isolated primary he...

journal_title：Annals of the New York Academy of Sciences

authors： Sauer IM,Obermeyer N,Kardassis D,Theruvath T,Gerlach JC

更新日期：2001-11-01 00:00:00

abstract：UNLABELLED:Hepatocarcinogenesis is a multistep process characterized by hepatocyte inflammation, regeneration, and proliferation. These changes are believed to depend on the aberrant expression of various tumor suppressor genes, oncogenes and growth factors. Several studies have shown the involvement of cyclooxygenase-...

journal_title：Annals of the New York Academy of Sciences

authors： Giannitrapani L,Ingrao S,Soresi M,Florena AM,La Spada E,Sandonato L,D'Alessandro N,Cervello M,Montalto G

更新日期：2009-02-01 00:00:00

abstract：:Intense stress can be detrimental for tissue homeostasis and accelerates aging. On the other hand, repeated mild stresses can have beneficial and even life-prolonging effects. Hypersecretion of glucocorticoids (GCs) represents the major hormonal response to stress. However, besides its life-sustaining role, GC excess ...

journal_title：Annals of the New York Academy of Sciences

authors： Kletsas D,Pratsinis H,Gioni V,Pilichos K,Yiacoumettis AM,Tsagarakis S

更新日期：2007-04-01 00:00:00

abstract：:This study explores the mechanisms dominating the regulation of the biochemical energy consumption and the mechanical output of the actin-myosin motor units, the crossbridges (Xbs), in the cardiac sarcomere. Our analytical model, which couples Xbs cycling dynamics with the kinetics of the free Ca(2+) binding to tropon...

journal_title：Annals of the New York Academy of Sciences

authors： Landesberg A,Levy C,Yaniv Y,Sideman S

更新日期：2004-05-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) is a 28-amino acid peptide that has several functions, including the regulation of water and electrolyte secretion, hormone and cytokine release, bronchodilitation, and neurogenesis. VIP effects are mediated by specific G-protein coupled receptors. Three distinct receptor subtypes, ...

journal_title：Annals of the New York Academy of Sciences

authors： Karacay B,O'Dorisio MS,Summers M,Bruce J

更新日期：2000-01-01 00:00:00

abstract：:Delayed type hypersensitivity (DTH) reactions represent cell-mediated immune responses that exert important immunoprotective (resistance to viruses, bacteria, and fungi) or immunopathologic (allergic or autoimmune hypersensitivity) effects. We have used the skin DTH response as an in vivo model to study neuro-endocrin...

journal_title：Annals of the New York Academy of Sciences

authors： Dhabhar FS

更新日期：2003-05-01 00:00:00

abstract：:Evolutionary psychology seeks to understand the functional design underlying psychological processes and behavior. Theories of selection pressures developed within evolutionary biology are key components of this understanding. Because past selection pressures responsible for current design cannot be directly observed,...

journal_title：Annals of the New York Academy of Sciences

authors： Gangestad SW

更新日期：2000-04-01 00:00:00

abstract：:The key pathologic mechanism in rheumatoid arthritis (RA) is the destruction of cartilage by fibroblasts. In a severe combined immunodeficient (SCID) mouse model, this process can be modulated by gene transfer using invasive LS48 fibroblasts. This study aims to investigate the effect of interleukins (IL) -11 and -12 o...

journal_title：Annals of the New York Academy of Sciences

authors： Sack U,Sehm B,Kahlenberg F,Murr A,Lehmann J,Tannapfel A,Uberla K,Moessner A,Dietrich A,Emmrich F,Lange F,Jungel A,Braun JM,Anderegg U

更新日期：2005-06-01 00:00:00

abstract：:Apoptosis protease-activating factor-1 (Apaf-1), which plays a central role in the formation of the apoptosome, is absent or poorly expressed (because of a transcriptional silencing by methylation) in a substantial percentage of metastatic melanomas and melanoma cell lines, which are unable to activate caspase-9 and e...

journal_title：Annals of the New York Academy of Sciences

authors： Del Bello B,Valentini MA,Comporti M,Maellaro E

更新日期：2003-12-01 00:00:00

abstract：:This chapter considers violence prevention programs in light of aggression and violence directed toward girls and women. More specifically, current violence prevention programs, directed toward young children and/or their caregivers, are discussed with a special consideration for the Adults and Children Together (ACT)...

journal_title：Annals of the New York Academy of Sciences

authors： Guttman M,Mowder B,Yasik A

更新日期：2006-11-01 00:00:00

abstract：:Lateral interaction of c-erbB family receptors resulting in dimer formation is the key event initiating signal transduction. Consequently cross-activation and intracellular signaling is triggered with immediate impact on cell proliferation, migration, cell survival, and differentiation. In order to elucidate the conne...

journal_title：Annals of the New York Academy of Sciences

authors： Diermeier-Daucher S,Hasmann M,Brockhoff G

更新日期：2008-01-01 00:00:00

abstract：:VH replacement occurs through RAG-mediated recombination between a cryptic recombination signal sequence (cRSS) presented in a rearranged VH gene and a 23-bp RSS from an upstream VH gene. VH replacement renews the entire VH coding region and extends the immunoglobulin heavy-chain (IgH) CDR3 regions preferentially with...

journal_title：Annals of the New York Academy of Sciences

authors： Liu Y,Fan R,Zhou S,Yu Z,Zhang Z

更新日期：2005-12-01 00:00:00

abstract：:Chronic and intermittent ischemic vascular disorders represent a burgeoning clinical challenge. Previous studies have focused on the idea that therapeutic angiogenesis strategies could alleviate tissue ischemia; however, it is now appreciated that vascular disease is not simply limited to vascular wall cells but also ...

journal_title：Annals of the New York Academy of Sciences

authors： Pattillo CB,Fang K,Terracciano J,Kevil CG

更新日期：2010-10-01 00:00:00

abstract：:Despite new technological advances in the rehabilitation of audition in profoundly deaf children, auditory training remains a fundamental part of their education. Consequently, it is necessary to learn what kind of stimuli, what kind of auditory tasks, and what kind of learning procedures generate faster and more long...

journal_title：Annals of the New York Academy of Sciences

authors： Rochette F,Bigand E

更新日期：2009-07-01 00:00:00

abstract：:Ticks do not usually infest sympatric hosts species according to their availability in a given environment, and it has been suggested that habitat use by hosts is a major determinant of tick burdens. The knowledge of such infestation patterns and their relationship with host habitat use is important for the control of...

journal_title：Annals of the New York Academy of Sciences

authors： De Garine-Wichatitsky M

更新日期：2002-10-01 00:00:00

abstract：:The Guillain Barré syndromes (GBS) are the world's leading cause of acute autoimmune neuromuscular paralysis. Understanding the pathophysiological events of GBS, and improving immunotherapies are fundamental to improving the clinical outcome. Recent research into GBS and the Miller Fisher syndrome (MFS) variant has fo...

journal_title：Annals of the New York Academy of Sciences

authors： Willison HJ,Plomp JJ

更新日期：2008-01-01 00:00:00

abstract：:Over several years our group has sought to synthesize and identify selective ligands for imidazoline (I) receptors, in particular the I2 binding site. As a consequence, [3H]2-(2-benzofuranyl)-2-imidazoline (2BFI) has proved extremely useful for binding and autoradiographic studies. More recently we have synthesized a ...

journal_title：Annals of the New York Academy of Sciences

authors： Hudson AL,Gough R,Tyacke R,Lione L,Lalies M,Lewis J,Husbands S,Knight P,Murray F,Hutson P,Nutt DJ

更新日期：1999-06-21 00:00:00

abstract：:The search for molecules on the surface of mammalian sperm that are responsible for the binding of sperm to the zona pellucida has led to the identification of a number of different surface proteins. Different experimental approaches have been used to identify these proteins and the strength of the evidence for their ...

journal_title：Annals of the New York Academy of Sciences

authors： Myles DG,Primakoff P

更新日期：1991-01-01 00:00:00

abstract：:Rickettsiae primarily infect the microvascular endothelium, leading to changes in microvascular permeability that result in potentially severe pulmonary and cerebral edema. The mechanisms responsible for these changes are not well understood. One potential mechanism of increased vascular permeability is the anti-ricke...

journal_title：Annals of the New York Academy of Sciences

authors： Woods ME,Wen G,Olano JP

更新日期：2005-12-01 00:00:00

abstract：:Caloric restriction (CR) is well described and has received extensive attention for its multiple benefits, including longevity and stress resistance. However, some studies have shown that CR negatively influences bone, although a mechanism hasn't been provided. Adiponectin, an adipocyte-derived hormone, can affect bon...

journal_title：Annals of the New York Academy of Sciences

authors： Zhu J,Liu C,Jia J,Zhang C,Yuan W,Leng H,Xu Y,Song C

更新日期：2020-08-01 00:00:00

abstract：:In this paper we have sought to identify differences in alcohol consumption patterns and problems among young adult males from white, black, and Hispanic ethnic groups entering drug treatment programs. In overall consumption patterns we found results similar to those obtained in general population studies. However, ab...

journal_title：Annals of the New York Academy of Sciences

authors： Hubbard RL,Schlenger WE,Rachal JV,Bray RM,Craddock SG,Cavanaugh ER,Ginzburg HM

更新日期：1986-01-01 00:00:00

abstract：:In two series of antiarrhythmic drugs tested, as the octanol/water partition coefficient increases so do the following: elimination from the body by biotransformation, first-pass biotransformation in the liver and gastrointestinal tract after oral administration, protein binding to some extent, and penetration into br...

journal_title：Annals of the New York Academy of Sciences

authors： Drayer DE

更新日期：1984-01-01 00:00:00

abstract：:Mass changes of skeletal muscles occur in a variety of species during the migratory period. Phenotypic flexibility of flight muscle mass is considered to represent adaptations of the flight muscle to changing power requirements associated with changes in body mass. We analyzed the relationship between muscle masses an...

journal_title：Annals of the New York Academy of Sciences

authors： Bauchinger U,Biebach H

更新日期：2005-06-01 00:00:00

abstract：:As recently as ten years ago, the nature of the T-cell receptor for antigen was a mystery, as was the precise role of histocompatibility molecules in antigen-presentation to T cells. Although T-cell receptors have now been cloned and crystal structures of MHC/peptide molecules exist, our understanding of the parameter...

journal_title：Annals of the New York Academy of Sciences

authors： Boniface JJ,Davis MM

更新日期：1995-09-07 00:00:00

abstract：:Uteroglobin, a steroid-inducible, cytokine-like, secreted protein with immunomodulatory properties, has been reported to bind progesterone, polychlorinated biphenyls (PCB), and retinol. Structural studies may delineate whether binding of ligands is a likely physiological function of human uteroglobin (hUG). We report ...

journal_title：Annals of the New York Academy of Sciences

authors： Pattabiraman N,Matthews JH,Ward KB,Mantile-Selvaggi G,Miele L,Mukherjee AB

更新日期：2000-01-01 00:00:00

abstract：:The underlying etiology and pathogenesis of Gulf War veterans' illnesses continue to be under intense investigation. Reports have suggested the basis for these illnesses may be an altered immune system, but compelling evidence is lacking. We sought to determine whether in vitro immune responses were abnormal in sympto...

journal_title：Annals of the New York Academy of Sciences

authors： Everson MP,Shi K,Aldridge P,Bartolucci AA,Blackburn WD

更新日期：2002-06-01 00:00:00

abstract：:Propagation of a kerosene spray formed by a prefilming airblast atomizer within a pulsating flame has been investigated. The measurements were performed in a 400 kW single combustor rig at typical engine conditions of up to 0.8 MPa inlet pressure and 673 K inlet temperature. The homogeneity of the fuel spray propagati...

journal_title：Annals of the New York Academy of Sciences

authors： Schober P,Meier R,Schäfer O,Wittig S

更新日期：2002-10-01 00:00:00

abstract：:The neurotransmitter serotonin (5-HT) has been implicated in the modulation of aggression in animals and humans. A longstanding dogma that aggression and serotonergic activity are inversely related has to be abandoned in light of many new findings. Trait and state aggression are differentially regulated by the 5-HT sy...

journal_title：Annals of the New York Academy of Sciences

authors： Olivier B

更新日期：2004-12-01 00:00:00

abstract：:The mechanisms controlling ATP generation in the transition from normal resting conditions to either high work states or ischemia are poorly understood. ATP generation depends upon compartmentation between the mitochondria and cytosol of metabolic pathways and key energy transfer species that cannot be easily assessed...

journal_title：Annals of the New York Academy of Sciences

authors： Zhou L,Yu X,Cabrera ME,Stanley WC

更新日期：2006-10-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) causes neuronal degeneration and, at a late stage, creates HIV-associated dementia (HAD) and other neurological abnormalities. Therefore, the need for neuroprotective agents is great. However, therapeutic agents that reduce HIV neurotoxicity are difficult to characterize and...

journal_title：Annals of the New York Academy of Sciences

authors： Mocchetti I,Nosheny RL,Tanda G,Ren K,Meyer EM

更新日期：2007-12-01 00:00:00