Differential responsiveness of central noradrenergic and dopaminergic neuron tyrosine hydroxylase to hypophysectomy, ACTH and glucocorticoid administration.

Abstract:

:Hypophysectomy leads to a small increase in tyrosine hydroxylase activity of all brain areas containing noradrenergic neurons or tuberoinfundibular dopamine neurons, but nigroneostriatal dopamine neurons are not so affected. ACTH or corticosterone treatment inhibited this effect of hypophysectomy in some noradrenergic neurons and in tuberoinfundibular dopamine neurons. These data showing differential responsiveness of tyrosine hydroxylase in different brain areas are compatible with differences in regulation or molecular form of tyrosine hydroxylase in central noradrenergic and dopaminergic neurons. The disparity between increased hypothalamic tyrosine hydroxylase activity and decreased norepinephrine turnover following hypophysectomy may result from a change in the rate-limiting step to the hydroxylation of dopamine.

journal_name

Ann N Y Acad Sci

authors

Van Loon GR,Sole MJ,Kamble A,Kim C,Green S

doi

10.1111/j.1749-6632.1977.tb41861.x

subject

Has Abstract

pub_date

1977-10-28 00:00:00

pages

284-94

eissn

0077-8923

issn

1749-6632

journal_volume

297

pub_type

杂志文章
  • Micronutrient status and human immunodeficiency virus (HIV) infection.

    abstract::This study surveyed serum concentrations of vitamins, electrolytes, and trace elements in subjects seropositive for HIV-1 by ELISA and confirmatory Western blot. Thirty subjects (26 males, 4 females) were recruited at a hospital clinic. Seventeen were classified as having mild or severe ARC (AIDS-related complex), 7 h...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1990.tb00146.x

    authors: Bogden JD,Baker H,Frank O,Perez G,Kemp F,Bruening K,Louria D

    更新日期:1990-01-01 00:00:00

  • The effects of dietary restriction on mitochondrial dysfunction in aging.

    abstract::Age-associated alterations in the mitochondrial electron transport system (ETS) may lead to free radical generation and contribute to aging. The complexes of the ETS were screened spectrophotometrically in gastrocnemius of young (10 month) as well as older (20 and 26 month) B6C3F1 female mice fed an ad libitum (AL) di...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1998.tb09902.x

    authors: Feuers RJ

    更新日期:1998-11-20 00:00:00

  • Is the estrogen controversy over? Deconstructing the Women's Health Initiative study: a critical evaluation of the evidence.

    abstract::The Women's Health Initiative (WHI) hormone trials have been widely interpreted as demonstrating that combined menopausal hormone therapy (HT) fails to protect against-and may increase-cardiovascular disease (CVD), stroke, and dementia in menopausal women, regardless of whether initiated early in the menopause or late...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1347.004

    authors: Harman SM,Naftolin F,Brinton EA,Judelson DR

    更新日期:2005-06-01 00:00:00

  • Using fuzzy logic to confirm the integrity of a pattern recognition algorithm for long genomic sequences: the W-curve.

    abstract::The W-curve is a numerical mapping algorithm that provides tertiary information content of long and short genomic sequences. The most popular genomic pattern recognition algorithms depend on string matching of the primary information content of short genomic sequences. Herein, we describe a way to define the fuzzy pro...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb04887.x

    authors: Cork DJ,Toguem A

    更新日期:2002-12-01 00:00:00

  • Thymic abnormalities: antigen or antibody? Response to thymectomy in myasthenia gravis.

    abstract::The therapeutic value of thymectomy for myasthenia is still questioned although it retains an important place among management modalities that strive for sustained remission. Questions derive from uncertainty as to appropriate timing, variable extent of resection and quantitation of response. Forty-seven patients, fol...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1981.tb33776.x

    authors: Penn AS,Jaretzki A 3rd,Wolff M,Chang HW,Tennyson V

    更新日期:1981-01-01 00:00:00

  • Molecular physiology of cardiac regeneration.

    abstract::Heart disease is the leading cause of death in the industrialized world. This is partially attributed to the inability of cardiomyocytes to divide in a significant manner, and therefore the heart responds to injury through scar formation. One of the challenges of modern medicine is to develop novel therapeutic strateg...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2010.05814.x

    authors: Bolli P,Chaudhry HW

    更新日期:2010-11-01 00:00:00

  • Magnetic resonance spectroscopic changes in Alzheimer's disease.

    abstract::In vitro and in vivo 31P magnetic resonance (MR) spectroscopy studies of Alzheimer's disease (AD) brain have revealed alterations in membrane phospholipid metabolism and high-energy phosphate metabolism. Mildly demented AD patients compared with control subjects have increased levels of phosphomonoesters, decreased le...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1997.tb48480.x

    authors: Pettegrew JW,Klunk WE,Panchalingam K,McClure RJ,Stanley JA

    更新日期:1997-09-26 00:00:00

  • ER stress induces the expression of Jpk, which inhibits cell cycle progression in F9 teratocarcinoma cell.

    abstract::Jopock (Jpk), a transacting factor associated with the position-specific regulatory element of murine Hoxa-7, has shown to induce cell death in both prokaryotic and eukaryotic cells when introduced and overexpressed. Since Jpk protein harbors a transmembrane domain (TM) and a putative endoplasmic reticulum (ER) -reten...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1397.011

    authors: Kim HS,Kong KA,Chung H,Park S,Kim MH

    更新日期:2007-01-01 00:00:00

  • Adaptation to environmental stress at different timescales.

    abstract::Environments are changing rapidly, and to cope with these changes, organisms have to adapt. Adaptation can take many shapes and occur at different speeds, depending on the type of response, the trait, the population, and the environmental conditions. The biodiversity crisis that we are currently facing illustrates tha...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.13974

    authors: Kristensen TN,Ketola T,Kronholm I

    更新日期:2020-09-01 00:00:00

  • Sphingosine-1-phosphate inhibits haptotactic motility by overproduction of focal adhesion sites in B16 melanoma cells through EDG-induced activation of Rho.

    abstract::We investigated the molecular mechanism by which Sph-1-P affects the FN-dependent haptotactic motility of serum-starved mouse melanoma B16/F10 cells. We found that EDG-5-induced Rho activation followed by enhanced tyrosine phosphorylation of FAK and paxillin, and beta 1-integrin activation leading to overexpression of...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2000.tb06566.x

    authors: Yamamura S,Hakomori S,Wada A,Igarashi Y

    更新日期:2000-04-01 00:00:00

  • Lysosomal acid hydrolases of the cathepsin family are novel targets of INSL3 in human thyroid carcinoma cells.

    abstract::Insulin-like peptide 3 (INSL3) is present in hyperactive and neoplastic thyrocytes, but the functional role of this relaxin-like peptide hormone during carcinogenesis in the thyroid gland is currently unknown. We generated new cell models of stable transfectants of the human follicular thyroid carcinoma cell line FTC-...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.03832.x

    authors: Bialek J,Hombach-Klonisch S,Fiebig B,Weber E,Hoang-Vu C,Klonisch T

    更新日期:2009-04-01 00:00:00

  • Synthesis of alpha-fetoprotein by rat ascites hepatoma cells.

    abstract::AH-66 rat ascites hepatoma cells incorporated [14C]leucine into the AFP fraction. In a cell-free system, hepatoma ribosomes were found to be active in AFP synthesis whereas the supernatant fraction from hepatoma had no specific effect on AFP production. The amount of [14C]leucine incorporated in AFP by membrane-bound ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1975.tb25399.x

    authors: Kanai K,Endo Y,Oda T,Kaneko Y

    更新日期:1975-08-22 00:00:00

  • Interleukin-6-type cytokine-induced changes in acute phase protein glycosylation.

    abstract::The plasma levels and the glycosylation of acute-phase proteins (APP) are subject to marked changes during acute and chronic inflammation. The pathophysiological variations in different glycoforms of APP in serum most likely result from changes in the glycosylation process during their biosynthesis in the parenchymal ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1995.tb32336.x

    authors: Van Dijk W,Mackiewicz A

    更新日期:1995-07-21 00:00:00

  • The UNESCO biosphere reserve concept as a tool for urban sustainability: the CUBES Cape Town case study.

    abstract::The Cape Town Case Study (CTCS) was a multi-institutional collaborative project initiated by CUBES, a knowledge networking initiative of UNESCO's Ecological Sciences Division and the Earth Institute at Columbia University. Cape Town was selected as a CUBES site on the basis of its high biological and cultural signific...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1319.003

    authors: Stanvliet R,Jackson J,Davis G,De Swardt C,Mokhoele J,Thom Q,Lane BD

    更新日期:2004-06-01 00:00:00

  • Hematopoietic stem cell-independent B-1a lineage.

    abstract::The accepted dogma has been that a single long-term hematopoietic stem cell (LT-HSC) can reconstitute all components of the immune system. However, our single-cell transfer studies have shown that highly purified LT-HSCs selectively fail to reconstitute B-1a cells in otherwise fully reconstituted hosts (i.e., LT-HSCs ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12881

    authors: Ghosn EE,Yang Y

    更新日期:2015-12-01 00:00:00

  • Cardiovascular risk factors predicting the development of distal symmetrical polyneuropathy in people with type 1 diabetes: A 9-year follow-up study.

    abstract::The aim of the article was to use prospectively collected data on people with type 1 diabetes to examine which routinely collected clinical measures predict the development of peripheral neuropathy in people with type 1 diabetes. Within the Newcastle Diabetes Services, structured data collection at an annual review ha...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1372.036

    authors: Sibal L,Law HN,Gebbie J,Home P

    更新日期:2006-11-01 00:00:00

  • A cooperative study of sarcoidosis in Asia and Africa: analytic epidemiology.

    abstract::The characteristics of about 2,000 Japanese sarcoidosis cases collected by the Japan Sarcoidosis Committee during the 10-yr period, 1963-1972, were chronological increase with decreasing infectious diseases (represented by tuberculosis), north-to-south decline in sarcoidosis incidence in accordance with the Oxford Atl...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1976.tb47046.x

    authors: Hosoda Y,Hiraga Y,Odaka M,Yangawa H,Ito Y,Shiegematsu I,Chiba Y

    更新日期:1976-01-01 00:00:00

  • Cloning of fibrinogen genes and their cDNA.

    abstract::Cross-species hybridizations have enabled us to isolate and clone the gene for the beta chain of human fibrinogen. Highlights of the gene for the beta chain revealed by nucleotide sequence analyses, particularly in areas that have a direct bearing on defining the overall organization of the gene, have been presented. ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1983.tb23265.x

    authors: Chung DW,Rixon MW,Que BG,Davie EW

    更新日期:1983-06-27 00:00:00

  • RAGE: a new pleiotropic antagonistic gene?

    abstract::Advanced glycation end products (AGEs) are the result of a nonenzymatic reaction of reducing sugars with primary amino groups of proteins (Maillard reaction). They accumulate in various tissues in the course of aging. Because AGEs induce protein cross-links and oxidative stress (radicals) within cells and tissues, the...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1297.038

    authors: Simm A,Bartling B,Silber RE

    更新日期:2004-06-01 00:00:00

  • Functional neuroimaging of semantic and episodic musical memory.

    abstract::The distinction between episodic and semantic memory has become very popular since it was first proposed by Tulving in 1972. So far, very few neuropsychological, psychophysical, and imaging studies have related to the mnemonic aspects of music, notably on the long-term memory features, and practically nothing is known...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1360.010

    authors: Platel H

    更新日期:2005-12-01 00:00:00

  • ExoMars alternative escape trajectories with Soyuz/Fregat.

    abstract::The objectives of ExoMars are to inject an orbiter around Mars and to land a rover on the surface to look for possible traces of life. During the first stages of the feasibility analysis, the mass margin of the orbiter was very small for a direct transfer in the Soyuz/Fregat scenario. An analysis of the combined use o...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1370.011

    authors: Gil-Fernández J,Van Damme CC,Graziano M,Amata GB,Cogo F,Perino MA

    更新日期:2005-12-01 00:00:00

  • Visual skills and cross-modal plasticity in deaf readers: possible implications for acquiring meaning from print.

    abstract::Most research on reading skill acquisition in deaf individuals has been conducted from the perspective of a hearing child learning to read. This approach may limit our understanding of how a deaf child approaches the task of learning to read and successfully acquires reading skills. An alternative approach is to consi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1416.013

    authors: Dye MW,Hauser PC,Bavelier D

    更新日期:2008-12-01 00:00:00

  • Influence of cytokines and growth factors on distinct steroidogenic enzymes in vitro: a short tabular data collection.

    abstract::Cytokines (IL-1, IL-6, IL-8, IL-11, TNF, IFN-gamma, and TGF-beta) and growth factors (EGF, bFGF, aFGF, and KGF) play an important role in modulation of hormone secretion by directly influencing specific enzyme steps of steroidogenesis in various endocrine cell types. For this tabular data collection, the following enz...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2002.tb04213.x

    authors: Herrmann M,Scholmerich J,Straub RH

    更新日期:2002-06-01 00:00:00

  • Hormone replacement therapy in breast cancer survivors.

    abstract::It is well known that women with breast cancer who undergo therapies beyond the surgical intervention (adjuvant chemotherapy, hormone therapy, or both) often suffer from the lack of estrogen, manifesting as climacteric symptoms in either treated premenopausal or postmenopausal women. Although HRT (hormone replacement ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1365.032

    authors: Xydakis AM,Sakkas EG,Mastorakos G

    更新日期:2006-12-01 00:00:00

  • The skeletal dysplasias: clinical-molecular correlations.

    abstract::The skeletal dysplasias or osteochondrodysplasias are a clinically and genetically heterogeneous group of disorders of bone and/or cartilage. They are characterized by abnormalities in pattering, linear growth, differentiation, and maintenance of the human skeleton. While they have been considered to be generalized di...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1402.072

    authors: Rimoin DL,Cohn D,Krakow D,Wilcox W,Lachman RS,Alanay Y

    更新日期:2007-11-01 00:00:00

  • Cognitive and emotional components of frontal lobe functioning in childhood and adolescence.

    abstract::Frontal lobe functions include a range of cognitive, emotional, and social abilities that enable goal-directed behavior. Although a number of studies have plotted the development of frontal lobe functions in childhood, few have extended into the adolescent years. There is also little information on which cognitive and...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1308.045

    authors: Rosso IM,Young AD,Femia LA,Yurgelun-Todd DA

    更新日期:2004-06-01 00:00:00

  • Role of animal and human pharmacology in antifungal drug design.

    abstract::Since the late sixties, several new antifungal drugs have become available. Initially, they were all intended for topical use, and, consequently, animal and human pharmacology always primarily aimed at confirming therapeutic efficacy. With the new tendency for the development of orally active antifungal drugs, human a...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1988.tb40412.x

    authors: Cauwenbergh G,Van Cutsem J

    更新日期:1988-01-01 00:00:00

  • Involvement of DPPIV/CD26 in epithelial morphology and suppressed invasive ability in ovarian carcinoma cells.

    abstract::Dipeptidyl peptidase IV (DPPIV) is a multifunctional cell surface aminopeptidase with ubiquitous expression and it has a variety of functional properties in the development of human malignancies. In the present study, we showed the possible correlation between DPPIV/CD26 expression and less migratory potential with de...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1377.007

    authors: Kajiyama H,Shibata K,Terauchi M,Ino K,Nawa A,Kikkawa F

    更新日期:2006-11-01 00:00:00

  • Functional validation of genes implicated in lymphomagenesis: an in vivo selection assay using a Myc-induced B-cell tumor.

    abstract::The involvement of the c-Myc transcription factor in neoplastic transformation is well documented. However, which of its numerous target genes are crucial for tumorigenesis remains a frequently contested issue. We have recently established a non-transgenic murine model for B-cell lymphoma based on neoplastic conversio...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1339.047

    authors: Yu D,Cozma D,Park A,Thomas-Tikhonenko A

    更新日期:2005-11-01 00:00:00

  • Status of the Standard Model.

    abstract::The implications of recent precision Z-pole, W mass, and weak neutral current data for testing the standard electroweak model, constraining that t quark and Higgs masses, αs (MZ), and grand unification are discussed. A fit to all data yields sin(2)θw(MZ)= 0.2325 ± 0.0024 (on-shell), where the uncertainties are mainly ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1993.tb43885.x

    authors: Langacker P

    更新日期:1993-06-01 00:00:00