Precision medicine in diabetes: an opportunity for clinical translation.

Abstract:

:Metabolic disorders present a public health challenge of staggering proportions. In diabetes, there is an urgent need to better understand disease heterogeneity, clinical trajectories, and related comorbidities. A pressing and timely question is whether we are ready for precision medicine in diabetes. Some biological insights that have emerged during the last decade have already been used to direct clinical decision making, especially in monogenic forms of diabetes. However, much work is necessary to integrate high-dimensional explorations into complex disease architectures, less penetrant biological alterations, and broader phenotypes, such as type 2 diabetes. In addition, for precision medicine to take hold in diabetes, reproducibility, interpretability, and actionability remain key guiding objectives. In this review, we examine how mounting data sets generated during the last decade to understand biological variability are now inspiring new venues to clarify diabetes nosology and ultimately translate findings into more effective prevention and treatment strategies.

journal_name

Ann N Y Acad Sci

authors

Merino J,Florez JC

doi

10.1111/nyas.13588

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

140-152

issue

1

eissn

0077-8923

issn

1749-6632

journal_volume

1411

pub_type

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