Biochemical pharmacology of acyclic nucleotide analogues.

abstract：:The fate of a neuron in the developing brain to multiply, differentiate, or die in an apoptotic manner depends on the expression of genes that are involved in regulating the cell cycle. Recent studies determined the involvement of several genes, including cyclin A and B2, in dopamine-induced apoptosis in cultured chic...

journal_title：Annals of the New York Academy of Sciences

authors： Porat S,Simantov R

更新日期：1999-01-01 00:00:00

abstract：:In all patients and volunteers, the levels of immunoreactive SP measured in saliva were about 100 times higher than the levels measured in plasma. SP per mg protein was consistently lower in both plasma and saliva of chronic pain patients than in healthy volunteers. These findings suggest that a simple noninvasive obj...

journal_title：Annals of the New York Academy of Sciences

authors： Parris WC,Sastry BV,Kambam JR,Naukam RJ,Johnson BW

更新日期：1993-09-20 00:00:00

abstract：:Metacommunity ecology combines local (e.g., environmental filtering and biotic interactions) and regional (e.g., dispersal and heterogeneity) processes to understand patterns of species abundance, occurrence, composition, and diversity across scales of space and time. As such, it has a great potential to generalize an...

journal_title：Annals of the New York Academy of Sciences

authors： Chase JM,Jeliazkov A,Ladouceur E,Viana DS

更新日期：2020-06-01 00:00:00

abstract：:The orbital evolution of about 26,000 Jupiter-crossing objects and 1,500 resonant asteroids under the gravitational influence of planets was investigated. The rate of their collisions with terrestrial planets was estimated by computing the probabilities of collisions based on random-phase approximations and the orbita...

journal_title：Annals of the New York Academy of Sciences

authors： Ipatov SI,Mather JC

更新日期：2004-05-01 00:00:00

abstract：:Within the past few years, developmental scientists have switched their attention from the study of DNA sequencing to the epigenetic state of the genome. Studying epigenetics could present the key to understanding gene expression changes without altering the basic structure of DNA. For example, the blastocyst, trophec...

journal_title：Annals of the New York Academy of Sciences

authors： Palini S,De Stefani S,Scala V,Dusi L,Bulletti C

更新日期：2011-03-01 00:00:00

abstract：:Although the hippocampus expresses nicotinic acetylcholine receptors (nAChRs) and receives cholinergic innervation, the functional roles of these receptors are not completely understood. Our results indicated that presynaptic nAChRs mediated a calcium influx that enhanced the release of both glutamate and GABA. Fura-2...

journal_title：Annals of the New York Academy of Sciences

authors： Radcliffe KA,Fisher JL,Gray R,Dani JA

更新日期：1999-04-30 00:00:00

abstract：:In this paper we first present methods and preliminary results of pilot surveys of "serious" mental retardation (IQ less than or equal to 55); the surveys included screening and diagnostic components and were carried out in the less-developed world. Next we discuss two problems raised by these surveys: one is the diag...

journal_title：Annals of the New York Academy of Sciences

authors： Stein Z,Durkin M,Belmont L

更新日期：1986-01-01 00:00:00

abstract：:Clinically potent skeletal muscle relaxants are used primarily for their effects on the central nervous system. But they also have direct effects on muscle contraction that possibly involve Ca2+ channels. We compared the effects of dantrolene, an agent known to have a direct action on vertebrate skeletal muscle, with ...

journal_title：Annals of the New York Academy of Sciences

authors： Helland LA,Lopez JR,Taylor SR,Trube G,Wanek LA

更新日期：1988-01-01 00:00:00

abstract：:Many therapeutic options exist for the management of patients with Ménière's disease. In the last few years, the use of intratympanic gentamicin has been investigated as an alternative treatment to vestibular nerve section or labyrinthectomy. In humans, the concentration of gentamicin used for intratympanic treatment ...

journal_title：Annals of the New York Academy of Sciences

authors： Quaranta A,Aloisi A,De Benedittis G,Scaringi A

更新日期：1999-11-28 00:00:00

abstract：:The effect of DHEA administration on the age-associated decline in immunity against influenza vaccine was studied. Increased humoral response was observed in 16- and 24-month-old mice immunized by live A/PR/8/34 (H1N1) influenza virus following DHEA treatment (a single injection adjacent to immunization). Furthermore,...

journal_title：Annals of the New York Academy of Sciences

authors： Danenberg HD,Ben-Yehuda A,Zakay-Rones Z,Friedman G

更新日期：1995-12-29 00:00:00

abstract：:Amperometry is a powerful tool for studying the exocytotic process. Catecholamines released from a single secretory vesicle are oxidized by a carbon fiber microelectrode placed on a chromaffin cell membrane. This phenomenon can be recorded online as an amperometric signal. Each event of exocytosis is called a secretor...

journal_title：Annals of the New York Academy of Sciences

authors： Gomez JF,Brioso MA,Machado JD,Sanchez JL,Borges R

更新日期：2002-10-01 00:00:00

abstract：:Homogenate of 30 sarcoid lymph nodes was injected into the footpads of mice and 42% of the mice showed epitheloid-cell granulomas in the sites. However, the control lymph-node homogenates obtained from nonsarcoid patients also provoked similar granulomatous changes, although the positive rate was somewhat lower. In th...

journal_title：Annals of the New York Academy of Sciences

authors： Iwai K,Takahashi S

更新日期：1976-01-01 00:00:00

abstract：:We have established several tumor T cell lines, both from the skin and from the blood of a patient with an MHC class II-/class I+, CD4+ cutaneous T cell lymphoma (CTCL). These cell lines, like the initial tumor cells, had a CD3+CD4+CD8- phenotype. We also isolated two cytotoxic T lymphocyte clones from the tumor site ...

journal_title：Annals of the New York Academy of Sciences

authors： Bagot M,Nikolova M,Schirm-Chabanette F,Wechsler J,Boumsell L,Bensussan A

更新日期：2001-09-01 00:00:00

abstract：:Motivation can be defined as a class of central nervous processes determining the likelihood of display of a behavior and the intensity of the behavior if displayed. All behavior is, according to this definition, caused and controlled by motivation. Although the concept of motivation eventually could be replaced by an...

journal_title：Annals of the New York Academy of Sciences

authors： Hernández-González M,Guevara MA,Agmo A

更新日期：2008-01-01 00:00:00

abstract：:The counterregulatory response to hypoglycemia is a complex and well-coordinated process. As blood glucose concentration declines, peripheral and central glucose sensors relay this information to central integrative centers to coordinate neuroendocrine, autonomic, and behavioral responses and avert the progression of ...

journal_title：Annals of the New York Academy of Sciences

authors： Tesfaye N,Seaquist ER

更新日期：2010-11-01 00:00:00

abstract：:Continuous dopamine (DA) stimulation is a therapeutic approach that applies to the treatment of motor fluctuations due to pulsatile DA stimulation in Parkinson's disease (PD), to cure the abuse of drugs, such as cocaine or amphetamine (which produce short-lasting peaks of extracellular DA), and as a safe therapeutic a...

journal_title：Annals of the New York Academy of Sciences

authors： Biagioni F,Busceti CL,Molinaro G,Battaglia G,Giorgi FS,Ruggieri S,Fornai F

更新日期：2006-08-01 00:00:00

abstract：:Babesia felis, originally identified in wild cats in the Sudan, was subsequently found to cause clinical disease in domestic cats. Although babesiosis in domestic cats has been reported sporadically from various countries, as a significant disease it appears to be a distinctly South African phenomenon. Apart from an i...

journal_title：Annals of the New York Academy of Sciences

authors： Penzhorn BL,Schoeman T,Jacobson LS

更新日期：2004-10-01 00:00:00

abstract：:Gastrointestinal peptides play important roles regulating feeding and energy homeostasis. Most gastrointestinal peptides including glucagon like peptide-1, peptide YY, amylin, and oxytomodulin are anorectic, and only ghrelin is an orexigenic peptide. Ghrelin increases appetite, modulates energy balance, suppresses inf...

journal_title：Annals of the New York Academy of Sciences

authors： Ueno H,Shiiya T,Nakazato M

更新日期：2010-07-01 00:00:00

abstract：:Experiments with enzymes in situ that are dependent on ascorbic acid for maximum activity will provide critical information about ascorbic acid requirements. Our work with chromaffin tissue as a model system eventually will result in the determination of two dose-response curves for norepinephrine biosynthesis, repres...

journal_title：Annals of the New York Academy of Sciences

authors： Levine M,Hartzell W

更新日期：1987-01-01 00:00:00

abstract：:A recombinant major histocompatibility complex (MHC) with the same class III region as the NOD mouse, but different class II region from the NOD mouse was identified in the NON mouse, and NOD mice congenic for this recombinant MHC, NOD.NON-H2, was established. None of the congenic mice homozygous for the NON MHC devel...

journal_title：Annals of the New York Academy of Sciences

authors： Yamaji K,Ikegami H,Fujisawa T,Noso S,Nojima K,Babaya N,Itoi-Babaya M,Kobayashi M,Hiromine Y,Makino S,Ogihara T

更新日期：2006-10-01 00:00:00

abstract：:The surprising discovery in 1990 that estrogen modulates hippocampal structural plasticity launched a whole new field of scientific inquiry. Over the past two decades, estrogen-induced spinogenesis has been described in several brain areas involved in cognition in a number of species, in both sexes and on multiple tim...

journal_title：Annals of the New York Academy of Sciences

authors： Dumitriu D,Rapp PR,McEwen BS,Morrison JH

更新日期：2010-08-01 00:00:00

abstract：:We studied ligand-receptor interactions between relaxin (RLN), insulin-like 3 peptide (INSL3), and LGR7 and LGR8 receptors. The phenotypic effects of deficiency for Lgr7 and Lgr8 receptors, transgenic overexpression of Rln1 and Insl3, and different combinations of these mutations in mice were analyzed. It was reported...

journal_title：Annals of the New York Academy of Sciences

authors： Feng S,Bogatcheva NV,Kamat AA,Agoulnik AI

更新日期：2005-05-01 00:00:00

abstract：:Cowdria ruminantium is an obligate intracellular rickettsial pathogen which is responsible for a tick-borne disease of domestic and wild ruminants called heartwater or cowdriosis. Although several genes have been cloned and partially sequenced, the genome size, gross structure, and organization of the C. ruminantium g...

journal_title：Annals of the New York Academy of Sciences

authors： de Villiers EP,Brayton KA,Zweygarth E,Allsopp BA

更新日期：1998-06-29 00:00:00

abstract：:The Women's Health Initiative (WHI) hormone trials have been widely interpreted as demonstrating that combined menopausal hormone therapy (HT) fails to protect against-and may increase-cardiovascular disease (CVD), stroke, and dementia in menopausal women, regardless of whether initiated early in the menopause or late...

journal_title：Annals of the New York Academy of Sciences

authors： Harman SM,Naftolin F,Brinton EA,Judelson DR

更新日期：2005-06-01 00:00:00

abstract：:The effect of 310 courses of corticotropin, methylprednisolone, prednisone, and dexamethasone were studied in 62 patients with generalized myasthenia gravis who were poorly responsive to anticholinesterase medication and most of whom required assisted respiration. Improvement in strength and response to anticholinest...

journal_title：Annals of the New York Academy of Sciences

authors： Brunner NG,Berger CL,Namba T,Grob D

更新日期：1976-01-01 00:00:00

abstract：:Azole resistance in Aspergillus species may be on the rise, with significant potential implications for the management of invasive aspergillosis. The main mechanism of azole resistance in Aspergillus fumigatus is via alterations of the target enzyme CYP51A. Such azole resistance is either primary or secondary (in the ...

journal_title：Annals of the New York Academy of Sciences

authors： Georgiadou SP,Kontoyiannis DP

更新日期：2012-12-01 00:00:00

abstract：:Hormones and neuropeptides may influence the activities of lymphoid organs and cells via endocrine and local autocrine/paracrine pathways. A paradigm of the interactions between the neuroendocrine and immune system is sophisticatedly represented in the thymus. Indeed, receptors for these molecules are heterogeneously ...

journal_title：Annals of the New York Academy of Sciences

authors： Ferone D,Boschetti M,Resmini E,Giusti M,Albanese V,Goglia U,Albertelli M,Vera L,Bianchi F,Minuto F

更新日期：2006-06-01 00:00:00

abstract：:Our previous studies have demonstrated that the methanol extract of heat-processed Panax ginseng C.A. Meyer exerts antioxidative, antiinflammatory, and anti-tumor-promoting effects. In the present study, we examined the antiinflammatory effects of several ginsenosides (Rb(1), Rc, Re, Rg(1), Rg(3)) derived from P. gins...

journal_title：Annals of the New York Academy of Sciences

authors： Surh YJ,Lee JY,Choi KJ,Ko SR

更新日期：2002-11-01 00:00:00

abstract：:At a given cytosolic domain of a chromaffin cell, the rate and amplitude of the Ca(2+) concentration, [Ca(2+)](c), depend on at least three efficient regulatory mechanisms: (1) the plasmalemmal Ca(2+) channels; (2) the endoplasmic reticulum (ER); and (3) the mitochondria. High-voltage activated Ca(2+) channels of the ...

journal_title：Annals of the New York Academy of Sciences

authors： Cuchillo-Ibanez I,Albillos A,Aldea M,Arroyo G,Fuentealba J,Garcia AG

更新日期：2002-10-01 00:00:00

abstract：:While the ovaries are the principal source of systemic estrogen in the premenopausal nonpregnant woman, other sites of estrogen biosynthesis are present throughout the body and these become the major sources of estrogen beyond menopause. These extragonadal sources of estrogen are small, but may play an important, thou...

journal_title：Annals of the New York Academy of Sciences

authors： Simpson ER,Clyne C,Speed C,Rubin G,Bulun S

更新日期：2001-12-01 00:00:00