Molecular targets of vitexin and isovitexin in cancer therapy: a critical review.

Abstract:

:Cancer is a primary public health problem and the second leading cause of death worldwide. It causes life-threatening malignancies and results in high financial costs for both patients and the healthcare system. Hence, it is important to develop effective long-term strategies pertaining to prevention and control of cancers. Plant-derived secondary metabolites have been shown to have positive roles against various cancers. A number of plant extracts have been evaluated for possible use in the treatment of cancer; some have provided direction for new strategies for the research and development of antitumor agents. Here, we provide comprehensive data on various cancers, potential molecular mechanisms, and therapeutic implications of just two plant-derived compounds, vitexin and isovitexin. Information on the chemotherapeutic potential of vitexin and isovitexin was collected from a library database and through electronic searches (ScienceDirect, Pubmed, and Google Scholar). Both in vitro and in vivo studies suggest that vitexin and isovitexin are chemopreventive compounds with activity against various cancers through proapoptotic processes and/or autophagy.

journal_name

Ann N Y Acad Sci

authors

Ganesan K,Xu B

doi

10.1111/nyas.13446

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

102-113

issue

1

eissn

0077-8923

issn

1749-6632

journal_volume

1401

pub_type

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