Aortic aneurysms as a source of circulating interleukin-6.

Abstract:

:In keeping with the inflammatory paradigm of abdominal aortic aneurysm (AAA) pathophysiology, in vitro studies suggest that aneurysms secrete the proinflammatory cytokine interleukin-6 (IL-6). Circulating IL-6 levels are higher in patients with AAA with elevated circulating IL-6 an independent risk factor for cardiovascular mortality. To investigate whether aneurysms secrete IL-6 into the circulation, arterial IL-6 was measured from within the aorta in three groups of patients undergoing endovascular procedures; 27 AAA, 10 thoracic aneurysms (TA), and 15 controls. Overall, IL-6 was higher in the aneurysm groups (P < 0.0008) with significant rises corresponding to positions downstream to the aneurysm in both AAA and TA. There were no significant differences in IL-6 with aortic position in the control group. These data support the hypothesis that aneurysms secrete IL-6 into the circulation and may account for the high cardiovascular mortality observed in patients with aneurysms.

journal_name

Ann N Y Acad Sci

authors

Dawson J,Cockerill G,Choke E,Loftus I,Thompson MM

doi

10.1196/annals.1383.009

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

320-3

eissn

0077-8923

issn

1749-6632

pii

1085/1/320

journal_volume

1085

pub_type

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