The pituitary-skin connection in amphibians. Reciprocal regulation of melanotrope cells and dermal melanocytes.

Abstract:

:In amphibians, alpha-MSH secreted by the pars intermedia of the pituitary plays a pivotal role in the process of skin color adaptation. Reciprocally, the skin of amphibians contains a number of regulatory peptides, some of which have been found to regulate the activity of pituitary melanotrope cells. In particular, the skin of certain species of amphibians harbours considerable amounts of thyrotropin-releasing hormone, a highly potent stimulator of alpha-MSH release. Recently, we have isolated and sequenced from the skin of the frog Phyllomedusa bicolor--a novel peptide named skin peptide tyrosine tyrosine (SPYY), which exhibits 94% similarity with PYY from the frog Rana ridibunda. For concentrations ranging from 5 x 10(-10) to 10(-7) M, SPYY induces a dose-related inhibition of alpha-MSH secretion. At a dose of 10(-7) M, SPYY totally abolished alpha-MSH release. These data strongly suggest the existence of a regulatory loop between the pars intermedia of the pituitary and the skin in amphibians.

journal_name

Ann N Y Acad Sci

authors

Vaudry H,Chartrel N,Desrues L,Galas L,Kikuyama S,Mor A,Nicolas P,Tonon MC

doi

10.1111/j.1749-6632.1999.tb08664.x

subject

Has Abstract

pub_date

1999-10-20 00:00:00

pages

41-56

eissn

0077-8923

issn

1749-6632

journal_volume

885

pub_type

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