An extended synthesis for evolutionary biology.

abstract：:Mouse Schwann cells and rat RN22 schwannoma cells cultured in the absence of neurons and fibroblasts produce typical basement membrane proteins. Heparan sulfate proteoglycan (low density form), nidogen, and protein BM-40 were identified by radioimmunoassays, immunoblotting, and by immunoprecipitation after metabolic l...

journal_title：Annals of the New York Academy of Sciences

authors： Dziadek M,Edgar D,Paulsson M,Timpl R,Fleischmajer R

更新日期：1986-01-01 00:00:00

abstract：:For more than 10 years umbilical cord blood (UCB) has been used as an alternative source of hematopoietic stem cells for allogeneic transplantation. Although the clinical results are encouraging, UCB is associated with delayed engraftment. To address these issues we have used the NOD/SCID mouse model to study the engr...

journal_title：Annals of the New York Academy of Sciences

authors： Fibbe WE,Noort WA,Schipper F,Willemze R

更新日期：2001-06-01 00:00:00

abstract：:Mast cells located in connective tissues are a potent source of vasoactive and inflammatory mediators, such as cytokines. They accumulate in tissues in a wide variety of diseases where their function in most cases in unclear. In this report we provide evidence that rat basophilic leukemia cells (RBLC) cultured with a ...

journal_title：Annals of the New York Academy of Sciences

authors： Conti P,Barbacane RC,Trakatellis M,Placido FC,Cataldo I,Reale M

更新日期：1997-12-15 00:00:00

abstract：:Visual motion is sensed by low-level (energy-based) and high-level (feature-based) mechanisms. Our interest is in the motion detectors underlying the initial ocular following responses (OFR) that are elicited at ultrashort latencies by sudden motions of large images. OFR were elicited in humans by applying horizontal ...

journal_title：Annals of the New York Academy of Sciences

authors： Chen KJ,Sheliga BM,Fitzgibbon EJ,Miles FA

更新日期：2005-04-01 00:00:00

abstract：:Oxyradicals are generally considered harmful byproducts of oxidative metabolism, causing molecular damage in living systems. They are implicated in various processes such as mutagenesis, aging, and series of pathological events. Although all this may be justified, evidence is accumulating that it is an oversimplified ...

journal_title：Annals of the New York Academy of Sciences

authors： Nagy IZ

更新日期：2001-04-01 00:00:00

abstract：:The functions of the hypothalamic-pituitary-ovarian and -adrenal axes are intertwined, and molecular defects in either axis may cause ovarian dysfunction. Advances in molecular genetics have allowed new insights into the pathophysiology of ovarian disorders. Specific gene mutations causing delayed puberty and/or ovari...

journal_title：Annals of the New York Academy of Sciences

authors： Kalantaridou SN,Chrousos GP

更新日期：2000-01-01 00:00:00

abstract：:Apolipoprotein E is a plasma cholesterol and phospholipid transporter which plays a central role in lipoprotein metabolism in the brain. Apolipoprotein E is a polymorphic protein with three common alleles in the general population, designated epsilon 2, epsilon 3 and epsilon 4 coding for proteins ApoE2, ApoE3 and ApoE...

journal_title：Annals of the New York Academy of Sciences

authors： Beffert U,Poirier J

更新日期：1996-01-17 00:00:00

abstract：:Brazilian spotted fever (BSF) is a highly lethal disease caused by Rickettsia rickettsii. In the present study, rickettsial infection was evaluated in 669 Amblyomma aureolatum adult ticks collected from naturally infested dogs in Taiaçupeba, a BSF-endemic area in the state of São Paulo. Ten (1.49%) ticks were infected...

journal_title：Annals of the New York Academy of Sciences

authors： Pinter A,Labruna MB

更新日期：2006-10-01 00:00:00

abstract：:Every year thousands of young teenagers are afflicted with different types of cancer and receive gonadotoxic chemotherapy and radiotherapy regimens, causing depletion of germ cells in the gonads and premature gonadal failure. In this review, we discuss and outline the current strategies and the future directions of fe...

journal_title：Annals of the New York Academy of Sciences

authors： Oktem O,Oktay K

更新日期：2008-01-01 00:00:00

abstract：:Thymosin β4 (Tβ4) is highly expressed in saliva of human newborns but not in adults. Here preliminary immunohistochemical analyses on different human tissues are reported. Immunoreactivity for Tβ4 in human salivary glands show high quantities of Tβ4 before birth, followed by downregulation of expression in adulthood. ...

journal_title：Annals of the New York Academy of Sciences

authors： Faa G,Nemolato S,Cabras T,Fanni D,Gerosa C,Fanari M,Locci A,Fanos V,Messana I,Castagnola M

更新日期：2012-10-01 00:00:00

abstract：:Genome architecture is well diversified among eukaryotes in terms of size and content, with many being radically shaped by ancient and ongoing genome conflicts with transposable elements (e.g., the large transposon-rich genomes common among plants). In ciliates, a group of microbial eukaryotes with distinct somatic an...

journal_title：Annals of the New York Academy of Sciences

authors： Maurer-Alcalá XX,Nowacki M

更新日期：2019-07-01 00:00:00

abstract：:The elderly, often defined as those 65 years or older, are the most rapidly growing segment of the population, and onset of epilepsy is higher in this age group than in any other. This paper reviews recent developments, including a new proposed definition of epilepsy, a transgenic mouse model of Alzheimer's disease th...

journal_title：Annals of the New York Academy of Sciences

authors： Leppik IE,Birnbaum AK

更新日期：2010-01-01 00:00:00

abstract：:This chapter considers violence prevention programs in light of aggression and violence directed toward girls and women. More specifically, current violence prevention programs, directed toward young children and/or their caregivers, are discussed with a special consideration for the Adults and Children Together (ACT)...

journal_title：Annals of the New York Academy of Sciences

authors： Guttman M,Mowder B,Yasik A

更新日期：2006-11-01 00:00:00

abstract：:In a prospective investigation of perioperative cardiac edema formation requiring a delayed sternal closure, we identified thrombin increase combined with a simultaneous decrease of factor XIII as a probable cause. After experimental studies additionally revealed that factor XIII could protect endothelial barrier func...

journal_title：Annals of the New York Academy of Sciences

authors： Wozniak G,Noll T,Akintürk H,Thul J,Müller M

更新日期：2001-01-01 00:00:00

abstract：:Over the past 10 years, the continual discovery of novel forms of encephalitis associated with antibodies to cell-surface or synaptic proteins has changed the paradigms for diagnosing and treating disorders that were previously unknown or mischaracterized. We review here the process of discovery, the symptoms, and the...

journal_title：Annals of the New York Academy of Sciences

authors： Leypoldt F,Armangue T,Dalmau J

更新日期：2015-03-01 00:00:00

abstract：:In type II and neonatal hair cells in the mouse utricle, the receptor potentials evoked by low-frequency sinusoidal deflections of the hair bundle are attenuated by adaptation of the mechanoelectrical transduction current and the voltage-dependent activation of a large potassium (K)-selective outwardly rectifying cond...

journal_title：Annals of the New York Academy of Sciences

authors： Holt JR,Vollrath MA,Eatock RA

更新日期：1999-05-28 00:00:00

abstract：:Taxonomic characterization of organisms in the genera Theileria and Babesia was originally based on observations of morphology and certain general phenotypic characteristics, which enabled many parasites to be unequivocally assigned to a particular genus. However, application of molecular genetic techniques, such as t...

journal_title：Annals of the New York Academy of Sciences

authors： Allsopp MT,Allsopp BA

更新日期：2006-10-01 00:00:00

abstract：:Melatonin is a hormone secreted by the pineal gland, mostly in the dark period of the light/dark cycle, with corresponding fluctuations reflected in the plasma melatonin levels. This hormone plays a critical role in the regulation of various neural and endocrine processes that are synchronized with daily change in pho...

journal_title：Annals of the New York Academy of Sciences

authors： Lahiri DK,Chen D,Lahiri P,Rogers JT,Greig NH,Bondy S

更新日期：2004-12-01 00:00:00

abstract：:Departing from the functional parallelism that undoubtedly exists between the nervous and immune system, we suggest that the latter also counts with means for information exchange that may result in a mutual influence of immune processes between nearby individuals. Our concept relies on a molecular interface that is c...

journal_title：Annals of the New York Academy of Sciences

authors： Martín PI,Sánchez PA,Rewald E

更新日期：2009-09-01 00:00:00

abstract：:Bipolar disorder is a chronic, recurrent illness that ranks among the top 10 causes of disability in the developed world. As the illness progresses, major depressive episodes increasingly predominate. However, few treatment options are available that have demonstrated efficacy in the treatment of bipolar depression, e...

journal_title：Annals of the New York Academy of Sciences

authors： Loebel A,Xu J,Hsu J,Cucchiaro J,Pikalov A

更新日期：2015-11-01 00:00:00

abstract：:As the second synapse in the central gustatory pathway of the rodent, the parabrachial nucleus of the pons (PbN) receives information about taste stimuli directly from the nucleus of the solitary tract (NTS). Data show that NTS cells amplify taste responses before transmitting taste-related signals to the PbN. NTS cel...

journal_title：Annals of the New York Academy of Sciences

authors： Di Lorenzo PM,Platt D,Victor JD

更新日期：2009-07-01 00:00:00

abstract：:A radioimmunoassay method (RIA) with specific antisera for human and rat alpha fetoprotein (AFP) was used to study the evolution of AFP levels in humans and rats, respectively, throughout the life span. Sera of 66 rats, aged 3-70 weeks, as well as sera of 201 clinically well children, 192 healthy blood donors, and 16...

journal_title：Annals of the New York Academy of Sciences

authors： Masseyeff R,Gilli J,Krebs B,Calluaud A,Bonet C

更新日期：1975-08-22 00:00:00

abstract：:Astronomers and physicists of diverse interest are teaming up to study enigmatic cosmic phenomena, such as the life cycle of black holes. A "disruptive innovation" is about to emerge during the next decade: Advanced gravitational-wave observatories. The emergence of gravitational-wave physics as a viable observational...

journal_title：Annals of the New York Academy of Sciences

authors： Márka S

更新日期：2012-07-01 00:00:00

abstract：:Glucose conversion by brain synaptosomes can be regarded as a special case of intrinsic kinetic properties of the enzyme substrate system. Temperature modulation of apparent K(m) for this process can be described with our kinetic model. Using experimental data and the kinetic model, the minimal K(m) value for glucose ...

journal_title：Annals of the New York Academy of Sciences

authors： Marjanović M,Zivadinović D,Dzakula Z,Andjus RK

更新日期：2005-06-01 00:00:00

abstract：:Contemporary management of atrial fibrillation imposes many challenges, particularly in the setting of our aging population. In addition to well-recognized consequences, such as stroke and mortality, emerging evidence relates atrial fibrillation to elevated risk of dementia, posing further therapeutic challenges. As t...

journal_title：Annals of the New York Academy of Sciences

authors： Chinitz JS,Castellano JM,Kovacic JC,Fuster V

更新日期：2012-04-01 00:00:00

abstract：:Apoptosis plays a critical role in acetaminophen (AAP)-induced hepatic injury, since inhibiting apoptosis also prevents the development of acute liver failure. In this study, the mechanism of apoptosis induction by AAP was investigated in the human hepatoblastoma cell line HuH7. AAP caused marked cytotoxicity in HuH7 ...

journal_title：Annals of the New York Academy of Sciences

authors： Kass GE,Macanas-Pirard P,Lee PC,Hinton RH

更新日期：2003-12-01 00:00:00

abstract：:In summary, the exon/intron structure of the chicken type II collagen gene is identical with that of the chicken alpha 2(I) collagen gene and differs at only one known position from the human and mouse alpha 1(I) genes. However, the chicken type II gene is different from the chicken alpha 2(I) gene in that it is consi...

journal_title：Annals of the New York Academy of Sciences

authors： Upholt WB,Strom CM,Sandell LJ

更新日期：1985-01-01 00:00:00

abstract：:Experiments with enzymes in situ that are dependent on ascorbic acid for maximum activity will provide critical information about ascorbic acid requirements. Our work with chromaffin tissue as a model system eventually will result in the determination of two dose-response curves for norepinephrine biosynthesis, repres...

journal_title：Annals of the New York Academy of Sciences

authors： Levine M,Hartzell W

更新日期：1987-01-01 00:00:00

abstract：:The arterial baroreflex has two important functions. First, the arterial baroreflex is a negative feedback reflex that regulates arterial pressure around a preset value called a set or operating point. Second, the arterial baroreflex also establishes the prevailing systemic arterial pressure when the operating point i...

journal_title：Annals of the New York Academy of Sciences

authors： DiCarlo SE,Bishop VS

更新日期：2001-06-01 00:00:00

abstract：:Constitutively active GPCR have revealed novel properties of drugs that exhibit classical competitive antagonism at the native forms of GPCR. These drugs reverse basal levels of constitutive activity, indicating that they have inverse agonist activity. We were interested in determining if competitive antagonists of th...

journal_title：Annals of the New York Academy of Sciences

authors： Egan C,Herrick-Davis K,Teitler M

更新日期：1998-12-15 00:00:00