Ascorbic acid: the concept of optimum requirements.

abstract：:Despite the aforementioned complications, noninvasive saliva collection has provided the medical and research community with an excellent medium for the monitoring of plasma steroid levels. This noninvasive method has permitted the evaluation and assessment of a multitude of endocrine studies that would have been extr...

journal_title：Annals of the New York Academy of Sciences

authors： Quissell DO

更新日期：1993-09-20 00:00:00

abstract：:Cholinesterase inhibitors used to treat Alzheimer's disease according to the principle of cholinergic replacement therapy have proved to be less beneficial than expected. The present study was designed to investigate the cerebrovascular response to physostigmine and tacrine in the experimental model of lesioning of th...

journal_title：Annals of the New York Academy of Sciences

authors： Peruzzi P,von Euw D,Lacombe P

更新日期：2000-04-01 00:00:00

abstract：:Although drugs of abuse have different chemical structures and interact with different protein targets, all appear to usurp common neuronal systems that regulate reward and motivation. Addiction is a complex disease that is thought to involve drug-induced changes in synaptic plasticity due to alterations in cell signa...

journal_title：Annals of the New York Academy of Sciences

authors： Lee AM,Messing RO

更新日期：2008-10-01 00:00:00

abstract：:Influenza remains one of the most important causes of respiratory infection despite the widespread availability of vaccines. As effective vaccines against influenza principally rely on the induction of strain-specific neutralizing antibodies for their protective efficacy, drifted escape mutants and genetically reassor...

journal_title：Annals of the New York Academy of Sciences

authors： Chiu C,Wrammert J,Li GM,McCausland M,Wilson PC,Ahmed R

更新日期：2013-04-01 00:00:00

abstract：:Hematopoietic stem cells (HSC) have been defined by their ability to establish long-term hematopoiesis in myelo-ablated hosts. Prospective isolation using combinations of cell-surface markers and/or dye exclusion can yield highly purified and nearly homogeneous phenotypically defined cells that repopulate irradiated h...

journal_title：Annals of the New York Academy of Sciences

authors： Schaniel C,Moore KA

更新日期：2009-09-01 00:00:00

abstract：:T-lymphocytes from three species of New World monkeys were susceptible to transformation in vitro with human T-cell leukemia virus. Marmoset T-lymphocytes transformed in vitro with HVS or HVA, T-lymphotropic herpesviruses of New World monkeys, were also transformed with HTLV resulting in doubly transformed T-cells. Th...

journal_title：Annals of the New York Academy of Sciences

authors： Falk LA Jr,Byington R,Silva DP

更新日期：1984-01-01 00:00:00

abstract：:Although tissue injury can evoke significant hyperalgesia in infants from the first days of life, little is known about how injury affects emergent central pain networks at the synaptic level. Recent studies have investigated whether tissue damage at different ages has distinct consequences for synaptic function in th...

journal_title：Annals of the New York Academy of Sciences

authors： Baccei ML

更新日期：2010-06-01 00:00:00

abstract：:Human immunodeficiency virus-type 1 (HIV-1) infection is characterized by increased immune cell apoptosis. Apoptosis can be triggered by signals that arise from within the cell, or by signals that are elicited by binding of extracellular "death ligands" to their "death receptors," most of which belong to the tumor nec...

journal_title：Annals of the New York Academy of Sciences

authors： Pinti M,Nasi M,Moretti L,Mussini C,Petrusca D,Esposito R,Cossarizza A

更新日期：2000-01-01 00:00:00

abstract：:The Cervico-ocular reflex (COR), which depends on proprioceptive afferents from neck muscles to the vestibular nucleus, makes little contribution to the stabilization of gaze in humans. If labyrinthine function is lost because of disease, however, the COR may increase in gain and assume greater importance in generatin...

journal_title：Annals of the New York Academy of Sciences

authors： Carmona S,Nieto D

更新日期：2005-04-01 00:00:00

abstract：:The first evidence for the role of the protein elongation factor eEF1A2 in tumorigenesis was reported by Anand and colleagues who demonstrated that eEF1A2 is overexpressed in about 30% of ovarian tumors and some established ovarian cancer cells. This abnormal expression correlates with a poor prognosis. Since this dis...

journal_title：Annals of the New York Academy of Sciences

authors： Lee MH,Surh YJ

更新日期：2009-08-01 00:00:00

abstract：:During their development, mononuclear phagocytes express a changing profile of proteinases that may participate in the degradation of elastin and other extracellular matrix components. Neutrophil elastase is produced and stored in azurophil-like granules in immature mononuclear phagocytes. Monocytes contain small amou...

journal_title：Annals of the New York Academy of Sciences

authors： Shapiro SD,Campbell EJ,Welgus HG,Senior RM

更新日期：1991-01-01 00:00:00

abstract：:Plaques with lipid macrophages and macrophages containing undigested myelin fragments from five multiple sclerosis patients were studied by light microscopy of epoxy-embedded tissue (five cases) and electron microscopy (one case). Cell counts determined electron microscopically revealed that oligodendrocytes were redu...

journal_title：Annals of the New York Academy of Sciences

authors： Prineas JW,Kwon EE,Cho ES,Sharer LR

更新日期：1984-01-01 00:00:00

abstract：:Risk factors for esophageal cancer include genetic factors (such as tylosis) and infectious agents. A variety of organisms have been implicated in esophageal carcinogenesis, either directly or indirectly. In this review, we explore the normal esophageal flora and how it may be controlled, and also the variety of organ...

journal_title：Annals of the New York Academy of Sciences

authors： El-Zimaity H,Di Pilato V,Novella Ringressi M,Brcic I,Rajendra S,Langer R,Dislich B,Tripathi M,Guindi M,Riddell R

更新日期：2018-12-01 00:00:00

abstract：:Murine schistosomiasis mansoni is a parasitic disease in which flukes living in the portal vein of the host produce ova that deposit in the liver and intestines. In these organs, ova release antigens that induce chronic, focal granulomatous inflammation. IFN-gamma is an inflammatory cytokine important in macrophage ac...

journal_title：Annals of the New York Academy of Sciences

authors： Weinstock JV,Elliott D

更新日期：1998-05-01 00:00:00

abstract：:Zoonoses are animal and human diseases. Q fever is primarily a zoonosis-an animal disease that can be transmitted to humans under certain conditions. Recent epidemiological studies suggest that Q fever should be considered as a public health problem in many countries where it is present, but unrecognizable due to inad...

journal_title：Annals of the New York Academy of Sciences

authors： Beslagić E,Hamzić S,Beslagić O,Zvizdić S

更新日期：2006-10-01 00:00:00

abstract：:Results of therapeutic trials of transfer factor in a number of laboratories suggest clinical benefit and enhancement of immunological reactivity in patients with primary or secondary immunodeficiency diseases. Long term follow-up of 32 patients with the Wiskott-Aldrich syndrome suggested that transfer factor caused c...

journal_title：Annals of the New York Academy of Sciences

authors： Spitler LE

更新日期：1979-01-01 00:00:00

abstract：:Unfortunately, all of the problems of the hemophiliac have not been solved by the availability of concentrated factor VIII products. Patients still are faced with the crippling effects of arthritis, problems with employment, problems with ignorance (both medical and lay), and an increased risk of premature death even ...

journal_title：Annals of the New York Academy of Sciences

authors： Breckenridge RT

更新日期：1975-01-20 00:00:00

abstract：:Controls and calibrators in autoimmune assays are typically developed from patient sera. However, the use of sera is accompanied by a number of disadvantages, such as lack of monospecificity, lack of assay comparability, and supply limitations. Ideally, the control reagent would be an antigen-specific human monoclonal...

journal_title：Annals of the New York Academy of Sciences

authors： Knappik A,Capuano F,Frisch C,Ylera F,Bonelli F

更新日期：2009-09-01 00:00:00

abstract：:The definition of polycystic ovary syndrome in very young girls is complicated by the fact that many features typical of the syndrome can also be seen as physiological stages in the maturation of the hypothalamus-pituitary-ovarian axis. The role of reduced insulin sensitivity in the pathogenesis and evolution of the d...

journal_title：Annals of the New York Academy of Sciences

authors： Bruni V,Dei M,Nannini S,Balzi D,Nuvolone D

更新日期：2010-09-01 00:00:00

abstract：:In a placebo-controlled double-blinded study, the effect of 8 weeks of grape juice was compared to the effect of isocaloric placebo juice. Volunteers with a systolic blood pressure > 130 mmHg and diastolic blood pressure > 90 mmHg were recruited. A total of 40 healthy subjects were randomized to receive isocaloric jui...

journal_title：Annals of the New York Academy of Sciences

authors： Park YK,Lee SH,Park E,Kim JS,Kang MH

更新日期：2009-08-01 00:00:00

abstract：:Rapamycin (RAPA), an inhibitor of mTORC signaling, has been shown to extend life span in mice and other organisms. Recently, animal and human studies have suggested that inhibition of mTORC signaling can alleviate or prevent the development of cardiomyopathy. In view of this, we used a murine model of type 2 diabetes ...

journal_title：Annals of the New York Academy of Sciences

authors： Reifsnyder PC,Ryzhov S,Flurkey K,Anunciado-Koza RP,Mills I,Harrison DE,Koza RA

更新日期：2018-04-01 00:00:00

abstract：:Currently, several rickettsioses are officially being reported in the Russian Federation. These are epidemic typhus and Brill-Zinsser disease, both caused by Rickettsia prowazekii which has a historic prevalence in Russia. Nowadays only single sporadic cases of R. prowazekii infection are reported. The last significan...

journal_title：Annals of the New York Academy of Sciences

authors： Tarasevich IV,Mediannikov OY

更新日期：2006-10-01 00:00:00

abstract：:The relationship between chaos and quantum mechanics has been somewhat uneasy--even stormy, in the minds of some people. However, much of the confusion may stem from inappropriate comparisons using formal analyses. In contrast, our starting point here is that a complete dynamical description requires a full understand...

journal_title：Annals of the New York Academy of Sciences

authors： Habib S,Bhattacharya T,Greenbaum B,Jacobs K,Shizume K,Sundaram B

更新日期：2005-06-01 00:00:00

abstract：:GABAA receptor heterogeneity is based on the combinatorial assembly of a large family of subunits into distinct receptor subtypes. A neuron-specific expression pattern of receptor subtypes has been demonstrated in adult rat brain, which can be reproduced in vitro in primary neuron cultures. This suggests that genetic ...

journal_title：Annals of the New York Academy of Sciences

authors： Penschuck S,Paysan J,Giorgetta O,Fritschy JM

更新日期：1999-04-30 00:00:00

abstract：:A host of missense mutations in muscle nicotinic receptor subunits have been identified as the cause of congenital myasthenic syndromes (CMS). Two classes of CMS phenotypes have been identified: slow channel myasthenic syndromes (SCCMSs) and fast channel myasthenic syndromes (FCCMSs). Although both have similar phenot...

journal_title：Annals of the New York Academy of Sciences

authors： Sine SM,Wang HL,Ohno K,Shen XM,Lee WY,Engel AG

更新日期：2003-09-01 00:00:00

abstract：:Despite the great strides made in understanding the basic biology of cancer and the multiple approaches to cancer therapy that have been utilized, cancer remains a major cause of death worldwide. The two properties that define the most successful tumors are low antigenicity, enabling cancer cells to escape immune syst...

journal_title：Annals of the New York Academy of Sciences

authors： Al-Ramadi BK,Fernandez-Cabezudo MJ,El-Hasasna H,Al-Salam S,Attoub S,Xu D,Chouaib S

更新日期：2008-09-01 00:00:00

abstract：:To study the role of the LDL receptor pathway for the maintenance of alpha-tocopherol concentrations in tissues of intact animals, we have compared vitamin E levels in plasma and tissues of normal rabbits and WHHL rabbits. WHHL rabbits are deficient in LDL receptor activity. For WHHL rabbits, alpha-tocopherol plasma c...

journal_title：Annals of the New York Academy of Sciences

authors： Cohn W,Kuhn H

更新日期：1989-01-01 00:00:00

abstract：:The purpose of this article is to review recent findings regarding the mechanisms by which GM1 may mimic or potentiate certain actions of neurotrophic factors, including promotion of neuronal survival. It is proposed that the neuroprotective activity of GM1 is due, at least in part, to its ability to favor the dimeriz...

journal_title：Annals of the New York Academy of Sciences

authors： Ferrari G,Greene LA

更新日期：1998-06-19 00:00:00

abstract：:Healthy CD45 KO mice show a Th2-type cytokine secretion profile in their small intestines. Dietary supplementation with human infant formula induced colitis and a shift toward a Th1-type profile, suggesting that diet can alter cytokine secretion. ...

journal_title：Annals of the New York Academy of Sciences

authors： Lópeza MC,Holmes N

更新日期：2004-12-01 00:00:00

abstract：:Classical swine fever (CSF) is a viral transboundary animal disease that is highly contagious among domestic and wild pigs, such as boars and peccaries. Today, far from being what was classically described historically, the disease is characterized as having a varied clinical picture, and its diagnosis depends on reso...

journal_title：Annals of the New York Academy of Sciences

authors： Vargas Terán M,Calcagno Ferrat N,Lubroth J

更新日期：2004-10-01 00:00:00