The substance P and somatostatin interferon-gamma immunoregulatory circuit.

abstract：:Relaxin (RLX) has antifibrotic effects in a number of tissues. Many of these effects are similar to those induced by the activators of peroxisome proliferator-activated receptor gamma (PPARgamma), raising the possibility that a mechanism for RLX's antifibrotic effects may involve activation of the PPARgamma pathway. T...

journal_title：Annals of the New York Academy of Sciences

authors： Singh S,Bennett RG

更新日期：2009-04-01 00:00:00

abstract：:We have developed a rabbit model of in utero exposure to intravenous injections of cocaine given twice daily to dams from gestational days 8-29. At the doses employed (4 mg/kg, injected twice daily), no differences were found in the body weight gain of dams, time to delivery, litter size, and body weight or other phys...

journal_title：Annals of the New York Academy of Sciences

authors： Romano AG,Harvey JA

更新日期：1998-06-21 00:00:00

abstract：:Brown adipose tissue (BAT) is an endocrine organ that contributes to thermogenesis and energy consumption. We investigated the effects of salt loading and surgical removal of whitened interscapular BAT (iBAT) on cardiac and adipose tissue pathology in DahlS.Z-Leprfa /Leprfa (DS/obese) rats, an animal model of metaboli...

journal_title：Annals of the New York Academy of Sciences

authors： Komatsu Y,Aoyama K,Yoneda M,Ito S,Sano Y,Kawai Y,Cui X,Yamada Y,Furukawa N,Ikeda K,Nagata K

更新日期：2020-12-19 00:00:00

abstract：:I(2) site-selective compounds are known to interact with and inhibit monoamine oxidase (MAO), but it remains unclear as to whether this interaction occurs through an allosteric or competitive interaction. This study used the new selective, irreversible I(2) ligand BU99006, to clarify the relationship between MAO and t...

journal_title：Annals of the New York Academy of Sciences

authors： Paterson LM,Tyacke RJ,Nutt DJ,Hudson AL

更新日期：2003-12-01 00:00:00

abstract：:From the time Dan was 12 years old to the present, he always was the explorer of life. He was very fortunate in having an opportunity to see how life exists in several human societies around the world. His many professional foreign travels are presented. Dan went to a 1959 meeting in Argentina, to England in 1963, and...

journal_title：Annals of the New York Academy of Sciences

authors： Gilbert C,Gilbert RL

更新日期：2000-01-01 00:00:00

abstract：:In a placebo-controlled double-blinded study, the effect of 8 weeks of grape juice was compared to the effect of isocaloric placebo juice. Volunteers with a systolic blood pressure > 130 mmHg and diastolic blood pressure > 90 mmHg were recruited. A total of 40 healthy subjects were randomized to receive isocaloric jui...

journal_title：Annals of the New York Academy of Sciences

authors： Park YK,Lee SH,Park E,Kim JS,Kang MH

更新日期：2009-08-01 00:00:00

abstract：:Synthetic oligodeoxynucleotides (ODN) capable of "neutralizing" or "inhibiting" immune responses have been described. This review will focus on the properties of phosphorothioate ODN that mimic the immunosuppressive activity of the repetitive TTAGGG motifs present in mammalian telomeres. These TTAGGG multimers block t...

journal_title：Annals of the New York Academy of Sciences

authors： Klinman DM,Tross D,Klaschik S,Shirota H,Sato T

更新日期：2009-09-01 00:00:00

abstract：:To test the utility of the UCLA posttraumatic stress disorder (PTSD) Index for DSM-IV (U-PTSD-I)(c) for predicting PTSD diagnosis in children with and without medical illnesses. The U-PTSD-I and a standard psychiatric interview were administered to medically ill children (n = 76) and children who experienced other tra...

journal_title：Annals of the New York Academy of Sciences

authors： Shemesh E,Annunziato RA,Newcorn JH,Rockmore L,Bierer LM,Cohen JA,Schmeidler J,Yehuda R

更新日期：2006-07-01 00:00:00

abstract：:After nearly a century of inquiry, the cause of Alzheimer's disease (AD) remains to be found. In this review, basic and clinical evidence is presented that assembles and hypothetically explains most of the key pathologic events associated with the development of AD. These pathologic events are triggered in AD by impai...

journal_title：Annals of the New York Academy of Sciences

authors： de la Torre JC

更新日期：2000-01-01 00:00:00

abstract：:Sphingosine-1-phosphate (Sph-1-P) has been implicated as an intracellular second messenger in many studies. Previously, we found the roles of Sph-1-P as a platelet activating lipid released from stimulated platelets and as a lipid regulator of cell motility. We first investigated the mechanism by which Sph-1-P induces...

journal_title：Annals of the New York Academy of Sciences

authors： Igarashi Y

更新日期：1998-06-19 00:00:00

abstract：:Regional climate modeling bridges the gap between the coarse resolution of current global climate models and the regional-to-local scales, where the impacts of climate change are of primary interest. Here, we present a review of the added value of the regional climate modeling approach within the scope of paleoclimate...

journal_title：Annals of the New York Academy of Sciences

authors： Ludwig P,Gómez-Navarro JJ,Pinto JG,Raible CC,Wagner S,Zorita E

更新日期：2019-01-01 00:00:00

abstract：:The endocannabinoid system, through the cannabinoid receptor CB1, is involved in the modulation of adaptive responses to environmental conditions. However, little is known about the role of the cannabinergic system, particularly CB1 receptor expression, in relation to the effects induced by xenoestrogens concerning th...

journal_title：Annals of the New York Academy of Sciences

authors： Palermo FA,Angelini M,Cottone E,Virgili M,Franzoni MF,Mosconi G,Polzonetti-Magni AM

更新日期：2009-04-01 00:00:00

abstract：:The skin immune system includes a complex network of dendritic cells (DCs). In addition to generating cellular and humoral immunity against pathogens, skin DCs are involved in tolerogenic mechanisms that maintain immune homeostasis and in pathogenic chronic inflammation in which immune responses are unrestrained. Harn...

journal_title：Annals of the New York Academy of Sciences

authors： Klechevsky E,Banchereau J

更新日期：2013-05-01 00:00:00

abstract：:Since NTS neurons receive synaptic input from many sensory modalities, it is crucial to understand the neuronal mechanisms involved in synaptic processing. We have proposed that GABA-containing neurons in the NTS are the primary target for somatic afferent fibers activated by skeletal muscle contraction. In our model,...

journal_title：Annals of the New York Academy of Sciences

authors： Potts JT

更新日期：2001-06-01 00:00:00

abstract：:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare hereditary disease characterized by recurrent transient ischemic attacks, strokes, and vascular dementia. Various mutations in the Notch3 gene cause the disease, whereas the mechanism of how they cause the di...

journal_title：Annals of the New York Academy of Sciences

authors： Abe K,Murakami T,Matsubara E,Manabe Y,Nagano I,Shoji M

更新日期：2002-11-01 00:00:00

abstract：:We compared the expression of target genes of Hedgehog/Patched signaling in ovarian fibromas and ovarian dermoids. We noted that high levels of SHH appear almost regularly, especially in dermoids, usually accompanied by increased expression of SMO. GLI overexpression does not coincide with that of PTCH. Loss of hetero...

journal_title：Annals of the New York Academy of Sciences

authors： Levanat S,Musani V,Komar A,Oreskovic S

更新日期：2004-12-01 00:00:00

abstract：:Uteroglobin, a steroid-inducible, cytokine-like, secreted protein with immunomodulatory properties, has been reported to bind progesterone, polychlorinated biphenyls (PCB), and retinol. Structural studies may delineate whether binding of ligands is a likely physiological function of human uteroglobin (hUG). We report ...

journal_title：Annals of the New York Academy of Sciences

authors： Pattabiraman N,Matthews JH,Ward KB,Mantile-Selvaggi G,Miele L,Mukherjee AB

更新日期：2000-01-01 00:00:00

abstract：:Homozygous beta thalassemia affects thousands of people around the world. Current management of this condition includes regular transfusion of red cells, which leads to transfusional iron overload requiring chelation therapy: increasing hemoglobin levels while decreasing or eliminating iron overload is therefore a maj...

journal_title：Annals of the New York Academy of Sciences

authors： Dover GJ

更新日期：1998-06-30 00:00:00

abstract：:Pathogenesis of endometriosis involves growth factors, which are synthesized locally. Insulin-like growth factor-1 (IGF-1) prevents apoptosis and has mitogenic action on endometrial cells. The IGF-1 gene undergoes alternative splicing and results in three isoforms (IGF-1Ea, IGF-1Eb, and IGF-1Ec or MGF). We analyzed th...

journal_title：Annals of the New York Academy of Sciences

authors： Milingos D,Katopodis H,Milingos S,Protopapas A,Creatsas G,Michalas S,Antsaklis A,Koutsilieris M

更新日期：2006-12-01 00:00:00

abstract：:We are performing genomic searches in randomly ascertained families to identify new quantitative trait loci (QTLs) that influence atherosclerosis and its risk factors. The genetic markers used for genomic searches are random microsatellite markers distributed throughout the human chromosomes. These markers are used fo...

journal_title：Annals of the New York Academy of Sciences

authors： Hixson JE,Blangero J

更新日期：2000-05-01 00:00:00

abstract：:Fibrinogen has been the plasma protein most frequently studied after tissue injury. This report presents evidence that leukocytic endogenous mediator (LEM) from macrophages promotes fibrinogen synthesis. LEM has a molecular weight of 13,000-16,000, an isoelectric point (pI) at pH 7.3, is heat labile, and is inactivate...

journal_title：Annals of the New York Academy of Sciences

authors： Kampschmidt RF,Upchurch HF,Pulliam LA

更新日期：1982-01-01 00:00:00

abstract：:Nicotinamide can protect the NOD mouse from diabetes if given early enough and in sufficient dose. The effect partly wanes with time. There is reduced islet inflammation. Similar protective effects can be demonstrated in quasi-experimental interventions in humans--both diabetes related and unrelated deemed at risk of ...

journal_title：Annals of the New York Academy of Sciences

authors： Elliott RB,Pilcher CC,Stewart A,Fergusson D,McGregor MA

更新日期：1993-11-30 00:00:00

abstract：:The balance between optimal levels of emotional arousal and cognitive performance reflects the integration of several dopaminergically and adrenergically regulated neural systems. The amygdalar system is a key region for gating stimulation to cortical regions and the medial amygdala appears to play an especially key r...

journal_title：Annals of the New York Academy of Sciences

authors： Mayes LC

更新日期：2006-12-01 00:00:00

abstract：:Human diploid fibroblasts (WI38) were inoculated into Rose multipurpose culture chambers, using a high population density to develop confluency. After 24 hours, cells from a 1 mm swath were scraped from the center of the chamber. This cleared path was positioned to permit an unobstructed transmission of a 0.9 X 20 mm ...

journal_title：Annals of the New York Academy of Sciences

authors： Rounds DE,Olson RS,Booher J

更新日期：1976-01-30 00:00:00

abstract：:The quest for new control strategies for ticks can profit from high throughput genomics. In order to identify genes that are involved in oogenesis and development, in defense, and in hematophagy, the transcriptomes of ovaries, hemocytes, and salivary glands from rapidly ingurgitating females, and of salivary glands fr...

journal_title：Annals of the New York Academy of Sciences

authors： Santos IK,Valenzuela JG,Ribeiro JM,de Castro M,Costa JN,Costa AM,da Silva ER,Neto OB,Rocha C,Daffre S,Ferreira BR,da Silva JS,Szabó MP,Bechara GH

更新日期：2004-10-01 00:00:00

abstract：:We discuss the relevance of studying ecology within the framework of Complexity Science from a statistical mechanics approach. Ecology is concerned with understanding how systems level properties emerge out of the multitude of interactions among large numbers of components, leading to ecosystems that possess the proto...

journal_title：Annals of the New York Academy of Sciences

authors： Jensen HJ,Arcaute E

更新日期：2010-05-01 00:00:00

abstract：:Cardiac development is characterized by a complex interplay of chemical, mechanical, and electrical forces, which together contribute to the proper formation of the heart muscle. In adult myocardium, cardiomyocytes are elongated, well-coupled by gap junctions, and organized in spatially well-defined muscle fibers. Thi...

journal_title：Annals of the New York Academy of Sciences

authors： Pijnappels DA,Gregoire S,Wu SM

更新日期：2010-02-01 00:00:00

abstract：:In many scientific and technical applications, a three-dimensional (3D) object must be reconstructed, either to assist in understanding the object's structure or to ease its automatic handling and analysis. Volume reconstruction has been used in health care to diagnose, simulate, facilitate surgical planning, develop ...

journal_title：Annals of the New York Academy of Sciences

authors： Masero V,León-Rojas JM,Moreno J

更新日期：2002-12-01 00:00:00

abstract：:Wisdom is a special kind of virtue. It is not to be identified with any outstanding cognitive ability-like having a prodigious memory or knowing a lot. Rather it consists in seeing what is most important and most valuable, either within a particular domain or in life as a whole. In the life of a wise person, that insi...

journal_title：Annals of the New York Academy of Sciences

authors： Kitcher P

更新日期：2016-11-01 00:00:00

abstract：:The presented paper describes a multi-disciplinary cooling selection approach applied to major gas turbine engine hot section components, including turbine nozzles, blades, discs, combustors and support structures, which maintain blade tip clearances. The paper demonstrates benefits of close interaction between partic...

journal_title：Annals of the New York Academy of Sciences

authors： Glezer B

更新日期：2001-05-01 00:00:00