Continual breakdown and regeneration of myelin in progressive multiple sclerosis plaques.

abstract：:The effect of DHEA administration on the age-associated decline in immunity against influenza vaccine was studied. Increased humoral response was observed in 16- and 24-month-old mice immunized by live A/PR/8/34 (H1N1) influenza virus following DHEA treatment (a single injection adjacent to immunization). Furthermore,...

journal_title：Annals of the New York Academy of Sciences

authors： Danenberg HD,Ben-Yehuda A,Zakay-Rones Z,Friedman G

更新日期：1995-12-29 00:00:00

abstract：:Increasing evidence suggests that the tight junction is a dynamically regulated structure. Cytoskeletal reorganization, particularly myosin light chain phosphorylation--induced actomyosin contraction, has increasingly been recognized as a mediator of physiological and pathophysiological tight junction regulation. Howe...

journal_title：Annals of the New York Academy of Sciences

authors： Shen L

更新日期：2012-07-01 00:00:00

abstract：:Proopiomelanocortin (POMC) and proenkephalin (PE) are synthesized at the endoplasmic reticulum and transported to the trans-Golgi network (TGN) where they are sorted and packaged into dense-core granules of the regulated secretory pathway (RSP). The mechanism of sorting POMC and PE to the RSP in neuroendocrine cells w...

journal_title：Annals of the New York Academy of Sciences

authors： Loh YP,Maldonado A,Zhang C,Tam WH,Cawley N

更新日期：2002-10-01 00:00:00

abstract：:Multidrug-resistant tuberculosis is already a global pandemic, with focal "hot spots" of ongoing transmission. Although DOTS (directly observed treatment, short course) chemotherapy is the goal of global tuberculosis control, short-course chemotherapy will not cure multidrug-resistant tuberculosis. In settings of high...

journal_title：Annals of the New York Academy of Sciences

authors： Farmer P

更新日期：2001-12-01 00:00:00

abstract：:Over the past decade, the Firefighters' Burn Treatment Unit of the University of Alberta Hospital in Edmonton, Alberta, Canada, has treated 1399 inpatients suffering from thermal injury. Regional burn care is provided in a 10-bed intensive care unit with 18 plastic surgery reconstructive beds for a large referral regi...

journal_title：Annals of the New York Academy of Sciences

authors： Tredget EE,Shankowsky HA,Tilley WA

更新日期：1999-10-30 00:00:00

abstract：:Results of therapeutic trials of transfer factor in a number of laboratories suggest clinical benefit and enhancement of immunological reactivity in patients with primary or secondary immunodeficiency diseases. Long term follow-up of 32 patients with the Wiskott-Aldrich syndrome suggested that transfer factor caused c...

journal_title：Annals of the New York Academy of Sciences

authors： Spitler LE

更新日期：1979-01-01 00:00:00

abstract：:Bipolar disorder is a chronic, recurrent illness that ranks among the top 10 causes of disability in the developed world. As the illness progresses, major depressive episodes increasingly predominate. However, few treatment options are available that have demonstrated efficacy in the treatment of bipolar depression, e...

journal_title：Annals of the New York Academy of Sciences

authors： Loebel A,Xu J,Hsu J,Cucchiaro J,Pikalov A

更新日期：2015-11-01 00:00:00

abstract：:Altered metabolism of the Alzheimer's amyloid precursor protein (APP) appears to be a key event in the pathogenesis of Alzheimer's disease (AD), and both altered phosphorylation and oxidative stress appear to affect the production of the toxic Abeta fragment. Our results show that altered processing of APP was observe...

journal_title：Annals of the New York Academy of Sciences

authors： Domingues SC,Henriques AG,Wu W,Da Cruz e Silva EF,Da Cruz e Silva OA

更新日期：2007-01-01 00:00:00

abstract：:Aberrations in estrogen signaling increase breast cancer risk. Molecular mechanisms that impact breast cancer initiation, promotion, and progression can be investigated using genetically engineered mouse models. Increasing estrogen receptor alpha (ERα) expression levels twofold is sufficient to initiate and promote br...

journal_title：Annals of the New York Academy of Sciences

authors： Furth PA,Cabrera MC,Díaz-Cruz ES,Millman S,Nakles RE

更新日期：2011-07-01 00:00:00

abstract：:Because of the sedative/hypnotic and euphoric effects of gamma-hydroxybutyric acid (GHB), the recreational use of the drug has increased significantly. In the current study we investigated the sedative and rewarding effects of GHB in Swiss Webster mice. Although the acute administration of GHB (200 mg/kg) caused marke...

journal_title：Annals of the New York Academy of Sciences

authors： Itzhak Y,Ali SF

更新日期：2002-06-01 00:00:00

abstract：:The possible role of the cerebellum for the control of saccades and gaze holding is reconsidered using a computational modeling approach. As suggested by previous research, control of gaze holding is assumed to be enhanced by the floccular lobe, whereas control of the saccadic pulse is governed by the oculomotor vermi...

journal_title：Annals of the New York Academy of Sciences

authors： Glasauer S

更新日期：2003-10-01 00:00:00

abstract：:The adult respiratory distress syndrome (ARDS) is not confined only to late shock states but is a typical finding in intoxications with such oxidizing agents as O3, NO2, chlorate, or paraquat. Under experimental conditions, alpha-tocopherol in a high enteric dosage (2 x 50 mg/kg) was able to prevent alterations of pul...

journal_title：Annals of the New York Academy of Sciences

authors： Wolf HR,Seeger HW

更新日期：1982-01-01 00:00:00

abstract：:Expression of human prolactin in the mammary gland, one of the main target organs of this hormone, leads to the formation of an autocrine-paracrine proliferative loop in this tissue. Involvement of prolactin in normal and neoplastic mammary development triggered the interest in transcriptional regulation of the human ...

journal_title：Annals of the New York Academy of Sciences

authors： Baudhuin A,Manfroid I,Van De Weerdt C,Martial JA,Muller M

更新日期：2002-11-01 00:00:00

abstract：:Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disorder caused by antibodies directed against the voltage-gated calcium channels that provide the calcium ion flux that triggers acetylcholine release at the neuromuscular junction. To study the pathophysiology of LEMS and test candidate therapeutic strategies...

journal_title：Annals of the New York Academy of Sciences

authors： Meriney SD,Tarr TB,Ojala KS,Wu M,Li Y,Lacomis D,Garcia-Ocaña A,Liang M,Valdomir G,Wipf P

更新日期：2018-01-01 00:00:00

abstract：:Hyperprolactinemia is often observed in lymphocytic hypophysitis (LYH). To clarify the possible autoimmune pituitary involvement in patients with apparently idiopathic hyperprolactinemia we investigated the presence of antipituitary antibodies (APA) in hyperprolactinemic patients with idiopathic hyperprolactinemia and...

journal_title：Annals of the New York Academy of Sciences

authors： De Bellis A,Colao A,Pivonello R,Savoia A,Battaglia M,Ruocco G,Tirelli G,Lombardi G,Bellastella A,Bizzarro A

更新日期：2007-06-01 00:00:00

abstract：:Two types of mixed matrix membranes were developed by UOP in the late 1980s. The first type includes adsorbent polymers, such as silicalite-cellulose acetate (CA), NaX-CA, and AgX-CA mixed matrix membranes. The silicalite-CA has a CO(2)/H(2) selectivity of 5.15 +/- 2.2. In contrast, the CA membrane has a CO(2)/H(2) se...

journal_title：Annals of the New York Academy of Sciences

authors： Kulprathipanja S

更新日期：2003-03-01 00:00:00

abstract：:Long-term exposure to estrogens influences the development of breast cancer in women, but the precise mechanisms involved are not clearly defined. Our working hypothesis is that estrogen modulates this process by two separate processes. One involves the binding of estradiol to estrogen receptor (ER) alpha with stimula...

journal_title：Annals of the New York Academy of Sciences

authors： Santen R,Cavalieri E,Rogan E,Russo J,Guttenplan J,Ingle J,Yue W

更新日期：2009-02-01 00:00:00

abstract：:In this paper we consider the evolution of Alzheimer's-like neuropathology in the aging primate brain. In particular, we examine the evolutionary pressures that have likely selected for the neuroprotective effects of estrogen and of the apolipoprotein E2 and E3 isoforms. We analyze this in the context of the altricial...

journal_title：Annals of the New York Academy of Sciences

authors： Sapolsky RM,Finch CE

更新日期：2000-01-01 00:00:00

abstract：:Aging, hypoxia, and thiamin deficiency diminish motor performance. Similar alterations of ACh, DA, and glutamate metabolism accompany hypoxia, thiamin deficiency, and aging. Both aging and hypoxia reduce ACh release and stimulate DA and glutamate release. Presynaptic enhancement of DA and glutamate release may be impo...

journal_title：Annals of the New York Academy of Sciences

authors： Freeman GB,Gibson GE

更新日期：1988-01-01 00:00:00

abstract：:Paget's disease is a common skeletal disorder with a strong genetic component, which is characterized by focal increases in disorganized bone remodeling, predominantly affecting the axial skeleton. Current evidence suggests that classical Paget's disease of bone (PDB) is caused by a combination of rare alleles of larg...

journal_title：Annals of the New York Academy of Sciences

authors： Ralston SH,Albagha OM

更新日期：2011-12-01 00:00:00

abstract：:Liquid diffusion experiments conducted on the MIR space station using the Canadian Space Agency QUELD II processing facility and the microgravity isolation mount (MIM) showed that g-jitter significantly increased the measured solute diffusion coefficients. In some experiments, milli-g forced vibration was superimposed...

journal_title：Annals of the New York Academy of Sciences

authors： Smith RW,Yang BJ,Huang WD

更新日期：2004-11-01 00:00:00

abstract：:Proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha) might be, at least partially, responsible for the development of osteopenia or osteoporosis in Crohn's disease. We investigated whether anti-TNF therapy for Crohn's disease could have any skeletal impact. Therefore, we studied the effects of ...

journal_title：Annals of the New York Academy of Sciences

authors： Pazianas M,Rhim AD,Weinberg AM,Su C,Lichtenstein GR

更新日期：2006-04-01 00:00:00

abstract：:In the present study we analyzed the morphology of testes and efferent ducts as well as the localization of androgen receptors (AR) in the tissues of XY, YY, and XX male rainbow trout Oncorhynchus mykiss Walbaum. Testes of the XX trout differed distinctly from those of XY and YY males; the interstitial space was very ...

journal_title：Annals of the New York Academy of Sciences

authors： Galas JF,Hejmej A,Glogowski J,Bilińska B

更新日期：2009-04-01 00:00:00

abstract：:Substitution of T4 with T3 for T4 replacement in patients with hypothyroidism was undertaken using a randomized placebo controlled study design. Forty individuals were included who had depressive symptoms on stable doses of levothyroxine. Combined T4 plus T3 did not have a significantly different effect on mood and we...

journal_title：Annals of the New York Academy of Sciences

authors： Joffe RT,Sawka AM,Marriott MJ,MacQueen GM,Gernstein HC

更新日期：2004-12-01 00:00:00

abstract：:During neuronal circuit formation, axons are guided to their targets by the help of axon guidance molecules, which are required for establishing functional circuits. A promising system to dissect the development and functionalities of neuronal circuitry is the spinal cord central pattern generator (CPG) for locomotion...

journal_title：Annals of the New York Academy of Sciences

authors： Vallstedt A,Kullander K

更新日期：2013-03-01 00:00:00

abstract：:The purpose of this study was to determine the seroprevalence against Bartonella henselae and Bartonella quintana among a risk group, patients with HIV infection, and to identify the epidemiological factors involved. Our data indicate that the prevalence of Bartonella infection among HIV-infected patients is much grea...

journal_title：Annals of the New York Academy of Sciences

authors： Pape M,Kollaras P,Mandraveli K,Tsona A,Metallidis S,Nikolaidis P,Alexiou-Daniel S

更新日期：2005-12-01 00:00:00

abstract：:Uteroglobin (UG) is a multifunctional, secreted protein with anti-inflammatory and antichemotactic properties. While its anti-inflammatory effects, in part, stem from the inhibition of soluble phospholipase A2 (sPLA2) activity, the mechanism(s) of its antichemotactic effects is not clearly understood. Although specifi...

journal_title：Annals of the New York Academy of Sciences

authors： Kundu GC,Zhang Z,Mantile-Selvaggi G,Mandal A,Yuan CJ,Mukherjee AB

更新日期：2000-01-01 00:00:00

abstract：:The life expectancy of patients with thalassemia major has significantly increased in recent years, as reported by several groups in different countries. However, complications are still frequent and affect the patients' quality of life. In a recent study from the United Kingdom, it was found that 50% of the patients ...

journal_title：Annals of the New York Academy of Sciences

authors： Borgna-Pignatti C,Cappellini MD,De Stefano P,Del Vecchio GC,Forni GL,Gamberini MR,Ghilardi R,Origa R,Piga A,Romeo MA,Zhao H,Cnaan A

更新日期：2005-01-01 00:00:00

abstract：:We present our achievements in the synthesis and application of multifunctionalized, cross-linked, polystyrene microspheres, which remarkably and quite generally are taken up by all cell types studied to date. Importantly, the nature of these synthetic beads allows multistep solid-phase chemistry and the ability to bi...

journal_title：Annals of the New York Academy of Sciences

authors： Sánchez-Martín RM,Alexander L,Bradley M

更新日期：2008-01-01 00:00:00

abstract：:We discuss the relevance of studying ecology within the framework of Complexity Science from a statistical mechanics approach. Ecology is concerned with understanding how systems level properties emerge out of the multitude of interactions among large numbers of components, leading to ecosystems that possess the proto...

journal_title：Annals of the New York Academy of Sciences

authors： Jensen HJ,Arcaute E

更新日期：2010-05-01 00:00:00