Abstract:
:The functions of the hypothalamic-pituitary-ovarian and -adrenal axes are intertwined, and molecular defects in either axis may cause ovarian dysfunction. Advances in molecular genetics have allowed new insights into the pathophysiology of ovarian disorders. Specific gene mutations causing delayed puberty and/or ovarian failure, and heterosexual or isosexual precocious puberty have recently been described. The molecular insights gained into ovarian dysfunction have already led to rational therapies for some of these conditions.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Kalantaridou SN,Chrousos GPdoi
10.1111/j.1749-6632.2000.tb06214.xsubject
Has Abstractpub_date
2000-01-01 00:00:00pages
40-5eissn
0077-8923issn
1749-6632journal_volume
900pub_type
杂志文章,评审abstract::Tularemia is a disease caused by several subspecies of Francisella tularensis, although the severity of the disease varies greatly from subspecies to subspecies. Currently, there are four recognized subspecies (tularensis, holarctica, mediasiatica, and novicida), in addition to a second Francisella species, F. philomi...
journal_title:Annals of the New York Academy of Sciences
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abstract::Long-term changes in catecholamine levels and expression of their biosynthetic enzymes are associated with several stress-related disorders such as elevated plasma norepinephrine in posttraumatic stress disorder and increased postmortem tyrosine hydroxylase in the locus coeruleus with major depression. Stress elevates...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
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更新日期:1998-11-20 00:00:00
abstract::Recent in vivo studies suggest a role for relaxin-3 in feeding and stress. To further elucidate the function of relaxin-3 in the central nervous system, we have employed a complementary approach, based on RNA interference, to modulate relaxin-3 expression. We have designed, constructed, and characterized three microRN...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:2009-04-01 00:00:00
abstract::In this paper a novel algorithm is proposed for space trajectory design that combines a systematic and a heuristic method for global optimization. For the systematic part of the algorithm a branching technique is used, whereas a particular implementation of evolution programming forms the core of the heuristic part. T...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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abstract::The ability to alter delayed-type hypersensitivity via hypnotic suggestion was tested in 12 highly hypnotizable, untrained subjects and 30 nonhypnotized controls. Subjects were skin-tested bilaterally with a standardized panel of delayed hypersensitivity antigens and instructed either to enhance or suppress the skin t...
journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:1989-01-01 00:00:00
abstract::Several reports indicate the presence of infection with Anaplasma phagocytophila in Europe. The first case with confirmed human granulocytic ehrlichiosis was reported from Slovenia in 1997. By 2002, 13 patients have been discovered in a prospective study on the etiology of febrile illnesses occurring within six weeks ...
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abstract::Managed care organizations and their affiliated group practices approach technology evaluation in a methodical way. This paper reviews the factors used in analysis of ultrasound for the diagnosis of fetal anomalies. It includes one group practice's strategies for ultrasound management while supporting the use of the s...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:1998-06-18 00:00:00
abstract::Acylated aldose dialkyl dithioacetals with bromine undergo replacement of one alkylthio group by bromine. These unstable bromides react, as by fusion with 2,4-bis(trimethylsilyloxy)pyrimidine, to give acylated 1-(pyrimidin-1-yl) derivatives that upon saponification afford acyclic sugar nucleoside analogues, some as se...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:1975-08-08 00:00:00
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
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更新日期:2002-05-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.2009.04920.x
更新日期:2009-09-01 00:00:00
abstract::Sphingosine 1-phosphate (S1P) is an ubiquitously present extracellular lipid mediator that is released by several cell types, particularly by activated platelets. The effects of S1P are mediated by a specific family of G protein-coupled sphingosine 1-phosphate receptors (S1P1-S1P5). We demonstrate that S1P acts on hem...
journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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更新日期:2012-08-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:2009-03-01 00:00:00
abstract::Two chemical classes of flavonoids, the flavan-3-ols (catechins and proanthocyanidins) and the anthocyanins, are the natural antioxidants present at the highest concentration in red grape and wine. In the berry, the anthocyanins are localized in the skins, similarly to other highly bioactive phenolics of grape such as...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.2002.tb02904.x
更新日期:2002-05-01 00:00:00
abstract::The recording of chemosensory event-related potentials (CSERPs) has been established as an objective method in the assessment of central odor processing in humans. In the present study CSERPs were used to investigate whether human body odor is genetically determined by the major histocompatibility complex (MHC), refer...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:1998-11-30 00:00:00
abstract::The aim of the study was to determine the IgG antibody response to spotted fever group Rickettsia (SFGR) R. conorii and R. slovaca, and its specificity and sensitivity in patients with DEBONEL/TIBOLA. A prospective study of 31 patients with DEBONEL was carried out from January 2001 to May 2004. The SFGR serology testi...
journal_title:Annals of the New York Academy of Sciences
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更新日期:2006-10-01 00:00:00
abstract::We studied the effects of change of head position in the pitch plane on the ability to hold horizontal eccentric gaze in five patients with cerebellar disorders. All patient showed a change in the time constant of horizontal centripetal drift when the head was pitched forward or back. This result suggests that otolith...
journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.2000.tb05523.x
更新日期:2000-01-01 00:00:00
abstract::Transcriptome analysis is a powerful tool to characterize changes in leukocyte gene expression patterns and reveal very early molecular abnormalities in tissue. Herein, we report on characterization of the very earliest abnormalities in the transcriptome of leukocytes from young "prepathologic" NOD and NON female mice...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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abstract::Alternative splicing of RNA transcripts is a general characteristic for NCX genes in mammals, mollusks, and arthropods. Among the family of three NCX genes in mammals, the NCX1 gene contains six exons, namely, A, B, C, D, E, and F, that make up the alternatively spliced region. Studies of the NCX1 gene transcripts sug...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
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更新日期:2002-11-01 00:00:00
abstract::The factor Xa inhibitor apixaban is one of the novel anticoagulants to emerge as alternatives to long-standing standards of care that include low-molecular-weight heparin and warfarin. The development of apixaban reflects a strategy to optimize the clinical pharmacology profile, dosing posology, trial designs, and sta...
journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
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更新日期:2005-11-01 00:00:00
abstract::Aging is the major risk factor for both the development of chronic diseases and loss of functional capacity. Geroscience provides links among the biology of aging, the biology of disease, and the physiology of frailty, three fields where enormous progress has been made in the last few decades. While, previously, the f...
journal_title:Annals of the New York Academy of Sciences
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abstract::Altered metabolism of the Alzheimer's amyloid precursor protein (APP) appears to be a key event in the pathogenesis of Alzheimer's disease (AD), and both altered phosphorylation and oxidative stress appear to affect the production of the toxic Abeta fragment. Our results show that altered processing of APP was observe...
journal_title:Annals of the New York Academy of Sciences
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更新日期:2007-01-01 00:00:00
abstract::The recent identification of lymphatic endothelial cell-specific markers and the generation of mouse models harboring mutations in many genes that encode those markers have enabled us to begin to elucidate the developmental steps that go toward establishing the lymphatic vasculature network. Understanding these basic ...
journal_title:Annals of the New York Academy of Sciences
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更新日期:2008-01-01 00:00:00
abstract::The characteristics of the sensations produced by activating one electrode at a time are summarized as follows: (a) Loudness was found to increase with current level and pitch with repetition rate. (b) Pitch and sharpness increased in the apical-to-basal direction, and vowel labels could be assigned to sensations prod...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.1983.tb31639.x
更新日期:1983-01-01 00:00:00
abstract::Ruminants are widespread in hot, arid regions. This demands adaptation to large circadian temperature fluctuations and recurrent periods of food and water shortage. Pregnancy and lactation add to the demands on the adaptive mechanisms due to the greater need for food, water, and electrolytes. The blood volume increase...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
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更新日期:2005-04-01 00:00:00