Reverse geroscience: how does exposure to early diseases accelerate the age-related decline in health?

abstract：:Efforts using transgenic mice are being made to understand the molecular and structural basis for dementia in Alzheimer's disease. Transgenic mice 12 to 18 months of age with amyloid plaques and impaired cognition show no neuronal or synaptic loss in the CA1 hippocampal subfield. Electrophysiological studies may yield...

journal_title：Annals of the New York Academy of Sciences

authors： Ashe KH

更新日期：2000-01-01 00:00:00

abstract：:The airway disease termed asthma has been recognized for centuries but is now receiving increased attention because of chronicity, high incidence in the population and rising mortality rate. Asthma is now recognized as a disease of unknown etiology characterized by a hyperactive airway which can be demonstrated by res...

journal_title：Annals of the New York Academy of Sciences

authors： Patterson R,Greenberger PA

更新日期：1991-01-01 00:00:00

abstract：:Our data show that when substance abusers are subtyped simultaneously by antisocial personality disorder and the onset of depression relative to alcohol or drug abuse, groups of people with unique personality and affective profiles are identified. The profiles are represented by measures of affect-related personality ...

journal_title：Annals of the New York Academy of Sciences

authors： Epstein EE,Ginsburg BE,Hesselbrock VM,Schwarz JC

更新日期：1994-02-28 00:00:00

abstract：:Several reports addressed the issue of how the alternative splicing of exon 7 and 8 in the APP pre-mRNA is regulated in different tissues. Of special interest here was the potential involvement of exon 7 containing APP splice isoforms, since this exon codes for a serine protease inhibitor and is therefore of putative ...

journal_title：Annals of the New York Academy of Sciences

authors： Sandbrink R,Banati R,Masters CL,Beyreuther K,König G

更新日期：1993-09-24 00:00:00

abstract：:Insulin-dependent diabetes mellitus (IDDM) is one of the most common chronic diseases. It is an autoimmune, polygenic disease, associated with several genes on different chromosomes. The most important gene is human leukocyte antigen (HLA), also known as major histocompatibility complex (MHC), which is located on chro...

journal_title：Annals of the New York Academy of Sciences

authors： Shtauvere-Brameus A,Ghaderi M,Rumba I,Sanjeevi CB

更新日期：2002-04-01 00:00:00

abstract：:1. There are several endogenous ligands that bind to I-receptors of both the I1 and I2 subclass. These include: (a) classic CDS, a partially purified entity isolated by the criteria that it displaces binding ligands to alpha 2- and I-receptors; (b) immunoreactive (ir)-CDS, a moiety that binds to antibodies raised agai...

journal_title：Annals of the New York Academy of Sciences

authors： Reis DJ,Li G,Regunathan S

更新日期：1995-07-12 00:00:00

abstract：:Replicative senescence is an in vitro biological phenomenon that results the irreversible growth arrest of mammalian cells. In contrast, cellular quiescence is reversible upon the addition of mitogens or replating. Quiescence is associated with the expression of a particular gene family--the growth arrest specific (GA...

journal_title：Annals of the New York Academy of Sciences

authors： Gonos ES

更新日期：1998-06-30 00:00:00

abstract：:Reducing emissions from deforestation and forest degradation (REDD+) provides financial compensation to land owners who avoid converting standing forests to other land uses. In this paper, we review the main opportunities and challenges for REDD+ implementation, including expectations for REDD+ to deliver on multiple ...

journal_title：Annals of the New York Academy of Sciences

authors： Venter O,Koh LP

更新日期：2012-02-01 00:00:00

abstract：:Nuclear receptors are transcription factors that are activated by ligands and subsequently bind to regulatory regions in target genes, thereby modulating their expression. Nuclear receptors thus allow the organism to integrate signals coming from the environment and to adapt by modifying the expression levels of relev...

journal_title：Annals of the New York Academy of Sciences

authors： Bocher V,Pineda-Torra I,Fruchart JC,Staels B

更新日期：2002-06-01 00:00:00

abstract：:The Na,K-ATPase is composed of two subunits, alpha and beta, and each subunit consists of multiple isoforms. In the case of alpha, four isoforms, alpha1, alpha2, alpha3, and alpha4 are present in mammalian cells. The distribution of these isoforms is tissue- and developmental-specific, suggesting that they may play sp...

journal_title：Annals of the New York Academy of Sciences

authors： Lingrel J,Moseley A,Dostanic I,Cougnon M,He S,James P,Woo A,O'Connor K,Neumann J

更新日期：2003-04-01 00:00:00

abstract：:Posttraumatic stress disorder (PTSD) is typically accompanied by both acute and chronic alterations in the stress response. These alterations have mostly been described in individuals under baseline conditions, but studies have also used a challenge model to assess the role of the hypothalamic-pituitary-adrenal (HPA) ...

journal_title：Annals of the New York Academy of Sciences

authors： Vermetten E,Vythilingam M,Schmahl C,DE Kloet C,Southwick SM,Charney DS,Bremner JD

更新日期：2006-07-01 00:00:00

abstract：:Mutualistic interactions, where two interacting species have a net beneficial effect on each other's fitness, play a crucial role in the survival and evolution of many species. Despite substantial empirical and theoretical work in past decades, the impact of these interactions on natural selection is not fully underst...

journal_title：Annals of the New York Academy of Sciences

authors： Hillesland KL

更新日期：2018-06-01 00:00:00

abstract：:In this chapter, we will review how signal transduction pathways have been assembled in the past, bringing us to our present understanding of this area of research. The methods employed have relied heavily upon the genetics of yeast, worms, flies, mice, and humans. The use of second site suppressors and epistasis has ...

journal_title：Annals of the New York Academy of Sciences

authors： Levine AJ,Hu W,Feng Z,Gil G

更新日期：2007-12-01 00:00:00

abstract：:It is thought that neuronal activity in orbitofrontal cortex (OFC) represents the value of anticipated reward; however activity in many other brain areas also seems to reflect expected reward value. For example, we have shown that in monkeys performing a memory-guided saccade task for a reward of variable size, activi...

journal_title：Annals of the New York Academy of Sciences

authors： Roesch MR,Olson CR

更新日期：2007-12-01 00:00:00

abstract：:We have examined the expression of several genes whose transcripts have increased levels in Alzheimer's disease and have found heterogeneity in these levels in different patients with this condition. The level of expression of these genes was compared to different clinical and pathological aspects of the disease. A ca...

journal_title：Annals of the New York Academy of Sciences

authors： Duguid JR,Trzepacz C,Kemper T,Tourtellote WW,Volicer L

更新日期：1993-05-28 00:00:00

abstract：:Enhanced levels of plasminogen activator inhibitor-1 (PAI-1) are considered to be a risk factor for pathological conditions associated with hypoxia or hyperinsulinemia. The expression of the PAI-1 gene is increased by insulin in different cells, although, the molecular mechanisms behind insulin-induced PAI-1 expressio...

journal_title：Annals of the New York Academy of Sciences

authors： Dimova EY,Kietzmann T

更新日期：2006-12-01 00:00:00

abstract：:We have presented evidence indicating that P2-purinergic receptors may activate the polyphosphoinositide-phospholipase C in HL60 cells via the mediation of a pertussis-toxin-sensitive GTP-binding protein, which also mediates the actions of chemotactic peptide receptors in these and other phagocytic white blood cells. ...

journal_title：Annals of the New York Academy of Sciences

authors： Dubyak GR,Cowen DS,Lazarus HM

更新日期：1988-01-01 00:00:00

abstract：:Studies in humans and in animal models have demonstrated that the receptor-dependent actions of 1,25-dihydroxyvitamin D are required for normal skeletal growth and maturation. Investigations were undertaken to address which consequences of vitamin D receptor deficiency are a direct result of impaired receptor-dependen...

journal_title：Annals of the New York Academy of Sciences

authors： Demay MB

更新日期：2006-04-01 00:00:00

abstract：:Emerging evidence suggests that individuals who receive morphine while hospitalized demonstrate a decrease in symptoms of posttraumatic stress disorder (PTSD). However, the mechanisms of effects are not yet well understood. The goal of the current study was to examine three possible mediators for this effect. Sixty-on...

journal_title：Annals of the New York Academy of Sciences

authors： Saxe G,Geary M,Bedard K,Bosquet M,Miller A,Koenen K,Stoddard F,Moulton S

更新日期：2006-07-01 00:00:00

abstract：:During food shortage, organisms activate defense mechanisms to maximize their chance of survival. At least in part, these responses are triggered by changes in hormonal status and neural status during starvation. The hypothalamus is organized as a collection of distinct autonomously active nuclei and is considered to ...

journal_title：Annals of the New York Academy of Sciences

authors： Chiba T,Fujita S,Kubota H,Inoue D,Mizuno A,Komatsu T,Yamaza H,Higami Y,Shimokawa I

更新日期：2007-11-01 00:00:00

abstract：:Although much work has been done in the field of circulating DNA, no definitive information on sequencing data of total circulating DNA is available. Characterization of total circulating DNA by sequence analysis may give valuable information about the origin and function of these nucleic acid molecules. Circulating D...

journal_title：Annals of the New York Academy of Sciences

authors： van der Vaart M,Pretorius PJ

更新日期：2008-08-01 00:00:00

abstract：:Cyclosporin A (CsA) is an immunosuppressive drug commonly given to transplant patients. Its application is accompanied by severe side effects related to calcium, among them hypertension and nephrotoxicity. The Na+/Ca2+ exchanger (NCX) is a major calcium regulator expressed in the surface membrane of all excitable and ...

journal_title：Annals of the New York Academy of Sciences

authors： Rahamimoff H,Elbaz B,Alperovich A,Kimchi-Sarfaty C,Gottesman MM,Lichtenstein Y,Eskin-Shwartz M,Kasir J

更新日期：2007-03-01 00:00:00

abstract：:T cell protein tyrosine phosphatase (TCPTP) dephosphorylates a number of substrates, including JAK-STAT (signal transducer and activator of transcription) signaling proteins, which are activated by interferon (IFN)-γ, a major proinflammatory cytokine involved in conditions such as inflammatory bowel disease. A critica...

journal_title：Annals of the New York Academy of Sciences

authors： Krishnan M,McCole DF

更新日期：2017-10-01 00:00:00

abstract：:Nocturnal cortisol release in humans is synergistically regulated by circadian rhythm and sleep. Cortisol concentrations typically reach a nadir during the slow wave sleep-rich periods of early nocturnal sleep, whereas during the late night, when rapid eye movement (REM) sleep predominates, cortisol levels are enhance...

journal_title：Annals of the New York Academy of Sciences

authors： Born J,Wagner U

更新日期：2004-12-01 00:00:00

abstract：:Autoimmune disease affects a significant proportion of the population. The etiology of most autoimmune diseases is largely unknown, but it is thought to be multifactorial with both environmental and genetic influences. Rare monogenic autoimmune diseases, however, offer an invaluable window into potential disease mecha...

journal_title：Annals of the New York Academy of Sciences

authors： Waterfield M,Anderson MS

更新日期：2010-12-01 00:00:00

abstract：:High-mobility group box-1 (HMGB1) is a prototypical endogenous signal that links tissue necrosis and wound healing. Extracellular HMGB1 has apparently contrasting biological actions: it sustains inflammation (with the possible establishment of autoimmunity or of self-maintaining tissue damage) while activating and rec...

journal_title：Annals of the New York Academy of Sciences

authors： Vezzoli M,Castellani P,Campana L,Corna G,Bosurgi L,Manfredi AA,Bianchi ME,Rubartelli A,Rovere-Querini P

更新日期：2010-10-01 00:00:00

abstract：:Alzheimer's disease (AD) impairs olfaction, but it is uncertain how early this occurs in the disease process and whether the effect can be accounted for by other behavioral or genetic markers of the disease. We administered the Brief Smell Identification Test (BSIT) to 471 older people without dementia or cognitive im...

journal_title：Annals of the New York Academy of Sciences

authors： Wilson RS,Arnold SE,Schneider JA,Boyle PA,Buchman AS,Bennett DA

更新日期：2009-07-01 00:00:00

abstract：:Nicergoline (NE)--a cerebral vasodilator with nicotinic acid esterified in its molecule--and Antagonic-Stress (AS) composition--a neurometabolic nootropic, also containing nicotinic acid but with fast and prolonged release--were evaluated in senile dementia of Alzheimer's type (SDAT), mild to moderate intensity (DSM-I...

journal_title：Annals of the New York Academy of Sciences

authors： Schneider F,Popa R,Mihalas G,Stefanigă P,Mihalas IG,Măties R,Mateescu R

更新日期：1994-06-30 00:00:00

abstract：:Beta-carotene acts as an antioxidant or a pro-oxidant depending on the concentrations that cells are treated with. Oxidative DNA damage is related to apoptosis of various cells. Ataxia-telangiectasia-mutated (ATM), a sensor for DNA-damaging agents, activates a variety of effectors in multiple signaling pathways, such ...

journal_title：Annals of the New York Academy of Sciences

authors： Jang SH,Lim JW,Kim H

更新日期：2009-08-01 00:00:00

abstract：:The investigation of immune senescence has uncovered many changes in B cell development, maintenance, and function with increasing age. However, most of these studies have focused on conventional B cell subsets in the spleen. The B-1 cell subset is an essential arm of the innate immune system, which in general has bee...

journal_title：Annals of the New York Academy of Sciences

authors： Holodick NE,Rothstein TL

更新日期：2015-12-01 00:00:00