Mechanism of beta-carotene-induced apoptosis of gastric cancer cells: involvement of ataxia-telangiectasia-mutated.

abstract：:Although pancreatic adenocarcinoma has become one of the best characterized malignant diseases, severe diagnostic and therapeutic problems are still associated with this disease. The establishment of a molecular model of pancreatic carcinogenesis may provide tools that could result in earlier diagnosis of this disease...

journal_title：Annals of the New York Academy of Sciences

authors： Jesnowski R,Müller P,Schareck W,Liebe S,Löhr M

更新日期：1999-06-30 00:00:00

abstract：:Contemporary management of atrial fibrillation imposes many challenges, particularly in the setting of our aging population. In addition to well-recognized consequences, such as stroke and mortality, emerging evidence relates atrial fibrillation to elevated risk of dementia, posing further therapeutic challenges. As t...

journal_title：Annals of the New York Academy of Sciences

authors： Chinitz JS,Castellano JM,Kovacic JC,Fuster V

更新日期：2012-04-01 00:00:00

abstract：:Factors that regulate various pathways of Maillard reaction leading to aroma, color, or carcinogen generation have not been identified, due to the difficulties associated with analyzing complex reaction mixtures. In particular, the role played by oxidation in directing aromagenic, chromogenic, or carcinogenic pathways...

journal_title：Annals of the New York Academy of Sciences

authors： Yaylayan VA,Haffenden L,Chu FL,Wnorowski A

更新日期：2005-06-01 00:00:00

abstract：:Cancer remains one of the leading causes of death worldwide. Thus, to identify any useful biomarkers is still a need. We performed "cancer immunomics" to identify autoantibody signatures produced in response to the presence of either breast or colorectal cancer. SERological proteome analysis (SERPA) was performed by t...

journal_title：Annals of the New York Academy of Sciences

authors： Hardouin J,Lasserre JP,Sylvius L,Joubert-Caron R,Caron M

更新日期：2007-06-01 00:00:00

abstract：:Previous research on development of the Xenopus olfactory bulb from our laboratory has shown that mitral cells begin to differentiate after olfactory axons make contact with the olfactory bulb, and the number of olfactory axons is correlated with the number of mitral cells throughout development. In embryos, removal o...

journal_title：Annals of the New York Academy of Sciences

authors： Burd GD,Sein V

更新日期：1998-11-30 00:00:00

abstract：:1 alpha,25-Dihydroxyvitamin D3, the active form of vitamin D3, induced maturation of circulating monocytes to form macrophage-epithelioid cells and multinucleated giant cells in vitro. Calcitriol not only promoted the differentiation of monocytes, as shown by the marked morphological changes and enhanced secretion of ...

journal_title：Annals of the New York Academy of Sciences

authors： Ohta M,Okabe T,Ozawa K,Urabe A,Takaku F

更新日期：1986-01-01 00:00:00

abstract：:This study describes the features of the marginal zone (MZ) B cells of human tonsils and spleens and compares them with those of the follicular mantle (FM) B cells from the same tissues. The two B cell subpopulations displayed marked differences in phenotype, in response capacity to T cell-independent antigens and pol...

journal_title：Annals of the New York Academy of Sciences

authors： Dono M,Zupo S,Colombo M,Massara R,Gaidano G,Taborelli G,Ceppa P,Burgio VL,Chiorazzi N,Ferrarini M

更新日期：2003-04-01 00:00:00

abstract：:Peripheral administration of lipopolysaccharide (LPS) in an amount that produces acute stress has been found to affect the catecholamine systems in the brain. Acute peripheral LPS administration activated norepinephrine (NE) metabolism in the locus ceruleus (LC). Approximately 40% of murine LC neurons project to the o...

journal_title：Annals of the New York Academy of Sciences

authors： Ota A,Mori K,Kaneko YS,Nakashima A,Nagatsu I,Nagatsu T

更新日期：2008-12-01 00:00:00

abstract：:Ibogaine, an alkaloid extracted from Tabemanthe iboga, is being studied as a potential long-acting treatment for oploid and stimulant abuse as well as for alcoholism and smoking. Studies in this laboratory have used animal models to characterize ibogaine's interactions with drugs of abuse, and to investigate the mecha...

journal_title：Annals of the New York Academy of Sciences

authors： Glick SD,Maisonneuve IS

更新日期：1998-05-30 00:00:00

abstract：:The essential trace element selenium is of fundamental importance to human biology. Information on the membrane-bound selenoproteins was obtained by labeling of rats in vivo with (75)Se-selenite, subcellular fractionation of the tissue homogenates, separation of the proteins by SDS-PAGE, two-dimensional electrophoresi...

journal_title：Annals of the New York Academy of Sciences

authors： Kyriakopoulos A,Bertelsmann H,Graebert A,Hoppe B,Kuhbacher M,Behne D

更新日期：2002-11-01 00:00:00

abstract：:Despite the global transition to overnutrition, stunting affected approximately 159 million children worldwide in 2014, while an estimated 50 million children were wasted. India is an important front in the fight against malnutrition and is grappling with the coexistence of undernutrition, overnutrition, and micronutr...

journal_title：Annals of the New York Academy of Sciences

authors： Shankar B,Agrawal S,Beaudreault AR,Avula L,Martorell R,Osendarp S,Prabhakaran D,Mclean MS

更新日期：2017-05-01 00:00:00

abstract：:Mitochondrial dysfunction is a common characteristic of all neurodegenerative diseases. However, the cause of this dysfunction remains a mystery. Here, we discuss the potential role of mitochondrial fission and fusion in the onset and progression of neurodegenerative diseases. Specifically, we propose that an imbalanc...

journal_title：Annals of the New York Academy of Sciences

authors： Knott AB,Bossy-Wetzel E

更新日期：2008-12-01 00:00:00

abstract：:Imatinib is a selective tyrosine kinase inhibitor used for the treatment of Philadelphia chromosome-positive leukemias and other malignancies. An important clinical observation is that imatinib can affect the function of normal nonmalignant cells resulting in myelosuppression in treated patients. This observation is s...

journal_title：Annals of the New York Academy of Sciences

authors： Balabanov S,Appel S,Kanz L,Brossart P,Brümmendorf TH

更新日期：2005-06-01 00:00:00

abstract：:Different estrogen-3-sulfates (estrone-3-sulfate, estradiol-3-sulfate, and estriol-3-sulfate) can provoke important biologic responses in different mammary cancer cell lines; there is a significant increase in progesterone receptor. However, no significant effect was observed with estrogen-17-sulfates. The reason for ...

journal_title：Annals of the New York Academy of Sciences

authors： Pasqualini JR,Gelly C,Nguyen BL

更新日期：1990-01-01 00:00:00

abstract：:A broad biological approach makes it possible to understand why aging exists and also why different mammalian species have very different maximum longevities. The adult organism is maintained in a functional state by at least ten major mechanisms, which together constitute a substantial proportion of all biological pr...

journal_title：Annals of the New York Academy of Sciences

authors： Holliday R

更新日期：1998-11-20 00:00:00

abstract：:Tazobactam was the most recent β-lactamase inhibitor to be approved in 1993. Since the approval of piperacillin-tazobactam, the complexity of β-lactamase-mediated resistance among Gram-negative bacilli has increased enormously. After more than 20 years since the first such combination, amoxicillin-clavulanic acid, was...

journal_title：Annals of the New York Academy of Sciences

authors： Shlaes DM

更新日期：2013-01-01 00:00:00

abstract：:It is often proposed that quinolinic acid (QUIN) contributes to the pathophysiology of neuroinflammation because this kynurenine pathway metabolite is a selective agonist of N-methyl-D-aspartate (NMDA) receptors, and both its brain tissue and cerebrospinal fluid concentrations increase markedly with inflammation. Howe...

journal_title：Annals of the New York Academy of Sciences

authors： Obrenovitch TP

更新日期：2001-06-01 00:00:00

abstract：:To identify a selective inhibitor of mammalian agmatinase, screening was performed on four analogues of agmatine with modifications directly to the guanidine group, six analogues with modifications to the carbon-amine chain, and one analogue with modifications at both ends of the molecule. Control compounds were amino...

journal_title：Annals of the New York Academy of Sciences

authors： Huang MJ,Regunathan S,Botta M,Lee K,McClendon E,Yi GB,Pedersen ML,Berkowitz DB,Wang G,Travagli M,Piletz JE

更新日期：2003-12-01 00:00:00

abstract：:Obesity is a multifactorial heterogenous condition. The location of excess fat on the body determines the risk of morbidity and mortality for significant disease. Visceral, or intraabdominal, fat is the fat depot most highly associated with illness and death from cardiocerebrovascular disease and diabetes. Visceral fa...

journal_title：Annals of the New York Academy of Sciences

authors： Peeke PM,Chrousos GP

更新日期：1995-12-29 00:00:00

abstract：:Many autoimmune diseases are chronic conditions that progress over the course of years, and are characterized by the presence of autoantibodies that precede the overt disease by months or years. As examples, the presence of two islet cell antibodies (ICA) are associated with a 50% risk of developing diabetes mellitus ...

journal_title：Annals of the New York Academy of Sciences

authors： Harel M,Shoenfeld Y

更新日期：2006-06-01 00:00:00

abstract：:This paper discusses the repatriation of human remains to indigenous peoples in Australia and the United States and the role anthropologists play in the construction of past, present, and future identities for contemporary indigenous peoples. Using examples from both countries, I suggest that many of the participants ...

journal_title：Annals of the New York Academy of Sciences

authors： Cantwell AM

更新日期：2000-01-01 00:00:00

abstract：:The large-scale differential gene expression in lymphomononuclear cells of six patients with recently diagnosed type), and six normal individuals matched to patients for sex and age were studied. Glass slides containing 4608 cDNAs from the IMAGE library were spotted using robotic technology. Statistical analysis was c...

journal_title：Annals of the New York Academy of Sciences

authors： Rassi DM,Junta CM,Fachin AL,Sandrin-Garcia P,Mello S,Marques MM,Fernandes AP,Foss-Freitas MC,Foss MC,Sakamoto-Hojo ET,Passos GA,Donadi EA

更新日期：2006-10-01 00:00:00

abstract：:Increasing evidence suggests that the tight junction is a dynamically regulated structure. Cytoskeletal reorganization, particularly myosin light chain phosphorylation--induced actomyosin contraction, has increasingly been recognized as a mediator of physiological and pathophysiological tight junction regulation. Howe...

journal_title：Annals of the New York Academy of Sciences

authors： Shen L

更新日期：2012-07-01 00:00:00

abstract：:According to a current paradigm cardiovascular diseases can be initiated by exposure of vascular cells to qualitatively modified low-density lipoproteins (LDL). Capillary leakage, an early feature of diabetic retinopathy, results in the exposure of retinal pericytes to modified LDL, including glycated (G-LDL) and heav...

journal_title：Annals of the New York Academy of Sciences

authors： Song W,Barth JL,Lu K,Yu Y,Huang Y,Gittinger CK,Argraves WS,Lyons TJ

更新日期：2005-06-01 00:00:00

abstract：:Successful introduction of nucleic acids into mammalian neurons has revolutionized the analyses of gene regulation and cellular function. Various methods, including viral infection, have been developed to introduce plasmid DNA into primary neuronal cultures. However, transfection of primary cultures of neurons using t...

journal_title：Annals of the New York Academy of Sciences

authors： Anji A,Shaik KA,Kumari M

更新日期：2003-05-01 00:00:00

abstract：:By a combination of trace techniques and various biochemical methods, information about the characteristics of a 15-kDa selenoprotein was obtained. After labeling of rats in vivo with [(75)Se]selenite, subcellular fractionation of the homogenates of the prostate, lung, brain, thyroid gland, and large intestine, and ge...

journal_title：Annals of the New York Academy of Sciences

authors： Kyriakopoulos A,Bukalis K,Roethlein D,Hoppe B,Graebert A,Behne D

更新日期：2004-12-01 00:00:00

abstract：:In this note epistemological problems in general theories about living systems are considered; in particular, the question of hidden connections between different areas of experience, such as folk biology and scientific biology, and hidden connections between central concepts of theoretical biology, such as function, ...

journal_title：Annals of the New York Academy of Sciences

authors： Emmeche C

更新日期：2000-01-01 00:00:00

abstract：:Decreased postural stability is observed in most astronauts immediately following spaceflight. Because ataxia may present postflight operational hazards, it is important to determine the incidence of postural instability immediately following landing and the dynamics of recovery of normal postural equilibrium control....

journal_title：Annals of the New York Academy of Sciences

authors： Paloski WH,Reschke MF,Black FO,Doxey DD,Harm DL

更新日期：1992-05-22 00:00:00

abstract：:The role of dopaminergic activity in susceptibility of methamphetamine (MAP) psychosis (flashbacks) to subsequent spontaneous recurrences was studied. Plasma monoamine metabolite levels were assayed in 23 flashbackers, of whom 10 experienced a single flashback, 8 exhibited subsequent flashbacks and 5 with the last epi...

journal_title：Annals of the New York Academy of Sciences

authors： Yui K,Goto K,Ikemoto S

更新日期：2004-10-01 00:00:00

abstract：:Signal hyperintensities on magnetic resonance imaging (MRI) are increased in the white matter (WMH) and deep gray matter in dementia and depression and may have similar pathologies. However, no previous study has examined WMH in subjects with major depression. We carried out in vitro MRI on brain tissue from elderly s...

journal_title：Annals of the New York Academy of Sciences

authors： Thomas AJ,Perry R,Barber R,Kalaria RN,O'Brien JT

更新日期：2002-11-01 00:00:00