Mechanism of beta-carotene-induced apoptosis of gastric cancer cells: involvement of ataxia-telangiectasia-mutated.

abstract：:Research examining brain development during adolescence is escalating rapidly along multiple dimensions, as illustrated by the remarkable diversity of trans-disciplinary work shown in this symposium. Ontogenetic transitions characteristics of adolescence are common among mammalian species. Although no other species de...

journal_title：Annals of the New York Academy of Sciences

authors： Spear LP

更新日期：2004-06-01 00:00:00

abstract：:Over the past 10 years, the continual discovery of novel forms of encephalitis associated with antibodies to cell-surface or synaptic proteins has changed the paradigms for diagnosing and treating disorders that were previously unknown or mischaracterized. We review here the process of discovery, the symptoms, and the...

journal_title：Annals of the New York Academy of Sciences

authors： Leypoldt F,Armangue T,Dalmau J

更新日期：2015-03-01 00:00:00

abstract：:Neuromodulation denotes controlled electrical stimulation of the central or peripheral nervous system. The three forms of neuromodulation described in this paper-deep brain stimulation, vagus nerve stimulation, and transcranial magnetic stimulation-were chosen primarily for their demonstrated or potential clinical use...

journal_title：Annals of the New York Academy of Sciences

authors： Andrews RJ

更新日期：2003-05-01 00:00:00

abstract：:The fracture of bone is clearly a major health concern, especially for the elderly. Medical therapies to reduce the possibility of bone fracture to date have principally centered on treating the loss in bone mass (bone mineral density) that accompanies aging (i.e., addressing the loss in bone quantity). However, it is...

journal_title：Annals of the New York Academy of Sciences

authors： Ritchie RO

更新日期：2010-03-01 00:00:00

abstract：:In this study we investigated the impact of estrogen antagonists and of 16alpha-OHE1 (an estrogen derivative that binds to and induces transactivation of estrogen receptors) on estrogen metabolism in malignant HepG2 human liver cells featured by high estrogen sulfotransferase (EST); our aim was to clarify the potentia...

journal_title：Annals of the New York Academy of Sciences

authors： Campisi I,Granata OM,Cocciadiferro L,Calabrò M,Polito LM,Carruba G

更新日期：2009-02-01 00:00:00

abstract：:Estrogen synthesized in situ plays a more important role in breast cancer cell proliferation than does circulating estrogen. Aromatase is the enzyme that converts androgen to estrogen and is expressed at a higher level in breast cancer tissue than in surrounding noncancer tissue. A promising route of chemoprevention a...

journal_title：Annals of the New York Academy of Sciences

authors： Eng ET,Williams D,Mandava U,Kirma N,Tekmal RR,Chen S

更新日期：2002-06-01 00:00:00

abstract：:Protection against stress by glucocorticoids is discussed in relation to their permissive and suppressive actions. Evidence from the last decade is summarized regarding the physiological nature of the suppressive actions, and the hypothesis that they prevent stress-activated defense mechanisms from overshooting and da...

journal_title：Annals of the New York Academy of Sciences

authors： Munck A,Náray-Fejes-Tóth A

更新日期：1994-11-30 00:00:00

abstract：:Regulation of carbohydrate and fat utilization by skeletal muscle at rest and during exercise has been the subject of investigation since the early 1960s when Randle et al. proposed the so-called glucose-fatty acid cycle to explain the reciprocal relationship between carbohydrate and fat metabolism. The suggested mech...

journal_title：Annals of the New York Academy of Sciences

authors： Jeukendrup AE

更新日期：2002-06-01 00:00:00

abstract：:Time-resolved confocal microspectrofluorometry and fluorescence microscopy imaging were applied to monitor the cellular uptake of fluorescent-labeled oligonucleotides (ONs) delivered by a porphyrin molecule. The fate of porphyrin-ON complexes inside living cells has also been monitored. Due to intrinsic fluorescence o...

journal_title：Annals of the New York Academy of Sciences

authors： Praus P,Kocisová E,Mojzes P,Stepánek J,Seksek O,Sureau F,Turpin PY

更新日期：2008-01-01 00:00:00

abstract：:Caloric restriction (CR) is well described and has received extensive attention for its multiple benefits, including longevity and stress resistance. However, some studies have shown that CR negatively influences bone, although a mechanism hasn't been provided. Adiponectin, an adipocyte-derived hormone, can affect bon...

journal_title：Annals of the New York Academy of Sciences

authors： Zhu J,Liu C,Jia J,Zhang C,Yuan W,Leng H,Xu Y,Song C

更新日期：2020-08-01 00:00:00

abstract：:The 65-kDa isoform of glutamic acid decarboxylase (GAD65) is a major autoantigen in type 1 diabetes, and most patients have serum antibodies reactive with conformational epitopes on the GAD65 molecule. The aims of this study were to prepare mutants of GAD65 to further localize the type 1 diabetes epitope in the region...

journal_title：Annals of the New York Academy of Sciences

authors： Myers MA,Fenalti G,Gray R,Scealy M,Tong JC,El-Kabbani O,Rowley MJ

更新日期：2003-11-01 00:00:00

abstract：:In thalassemia, iron overload is the joint outcome of excessive iron absorption and transfusional siderosis. While iron absorption is limited by a physiologic ceiling of about 3 mg/d, plasma iron turnover in thalassemia may be 10 to 15 times normal, caused by the wasteful, ineffective erythropoiesis of an enormously e...

journal_title：Annals of the New York Academy of Sciences

authors： Hershko C,Link G,Cabantchik I

更新日期：1998-06-30 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) is a 28-amino acid peptide that has several functions, including the regulation of water and electrolyte secretion, hormone and cytokine release, bronchodilitation, and neurogenesis. VIP effects are mediated by specific G-protein coupled receptors. Three distinct receptor subtypes, ...

journal_title：Annals of the New York Academy of Sciences

authors： Karacay B,O'Dorisio MS,Summers M,Bruce J

更新日期：2000-01-01 00:00:00

abstract：:Four weeks immobilization of the right leg of aged rats (26 months old) caused a marked 31% and 27% reduction of muscle mass of the plantaris and soleus muscles, respectively. In animals treated with 0.6 mg/kg body weight of growth hormone (GH), the reduction of weight of the above muscles was only 14.7 and 16.1%, res...

journal_title：Annals of the New York Academy of Sciences

authors： Fares FA,Gruener N,Carmeli E,Reznick AZ

更新日期：1996-06-15 00:00:00

abstract：:A cardinal feature of neurons is the morphological polarity of neurons with serious functional implications. Typically, a neuron has a single axon and several dendrites. Neuronal polarity is essential for the unidirectional signal flow from somata or dendrites to axons in neurons. The initial event in establishing a p...

journal_title：Annals of the New York Academy of Sciences

authors： Yoshimura T,Arimura N,Kaibuchi K

更新日期：2006-11-01 00:00:00

abstract：:The International Agency for Research on Cancer has initiated a program to evaluate the carcinogenic risk of chemicals to man. This program is centered on the production of monographs on individual chemicals, consisting of data on use and production, carcinogenicity in experimental animals, epidemiological studies and...

journal_title：Annals of the New York Academy of Sciences

authors： Tomatis L

更新日期：1976-01-01 00:00:00

abstract：:The molecular architecture of biological systems is heavily influenced by the highly polar interactions of water. Thus, macromolecules such as proteins that are highly water soluble must be electrically polar. Energy generation methods needed to support cell metabolic processes depend on compartmentalizing mobile ions...

journal_title：Annals of the New York Academy of Sciences

authors： Lee RC

更新日期：2005-12-01 00:00:00

abstract：:The formation of bone is a continual process in vertebrate development, initiated during fetal development and persisting in adulthood in the form of remodeling and repair. The remarkable capacity of skeletal tissues to regenerate has led to the hypothesis that the molecular signaling pathways regulating skeletogenesi...

journal_title：Annals of the New York Academy of Sciences

authors： Ferguson CM,Miclau T,Hu D,Alpern E,Helms JA

更新日期：1998-10-23 00:00:00

abstract：:Recently, cell-free fetal DNA has been found in maternal plasma and serum. This discovery opens up a new field of investigation and provides an easily accessible source of fetal genetic material for prenatal diagnosis. Prenatal diagnostic applications of fetal DNA in maternal plasma include the investigation of sex-li...

journal_title：Annals of the New York Academy of Sciences

authors： Lo YM

更新日期：2000-04-01 00:00:00

abstract：:A previous review of alternative treatments (Tx) of ADHD--those other than psychoactive medication and behavioral/psychosocial Tx--was supplemented with an additional literature search focused on adults with ADHD. Twenty-four alternative Tx were identified, ranging in scientific documentation from discrediting control...

journal_title：Annals of the New York Academy of Sciences

authors： Arnold LE

更新日期：2001-06-01 00:00:00

abstract：:Our studies to date indicate that treatment with anti-idiotype to monoclonal anti-MHC antibodies can markedly influence the repertoire of anti-MHC antibodies expressed. The antibodies discussed here appear to represent two classes, one of which is public, probably representing expression of a germ line gene, and the s...

journal_title：Annals of the New York Academy of Sciences

authors： Sachs DH,Bluestone JA,Epstein SL,Rabinowitz R

更新日期：1983-01-01 00:00:00

abstract：:Propagation of a kerosene spray formed by a prefilming airblast atomizer within a pulsating flame has been investigated. The measurements were performed in a 400 kW single combustor rig at typical engine conditions of up to 0.8 MPa inlet pressure and 673 K inlet temperature. The homogeneity of the fuel spray propagati...

journal_title：Annals of the New York Academy of Sciences

authors： Schober P,Meier R,Schäfer O,Wittig S

更新日期：2002-10-01 00:00:00

abstract：:Homogenate of 30 sarcoid lymph nodes was injected into the footpads of mice and 42% of the mice showed epitheloid-cell granulomas in the sites. However, the control lymph-node homogenates obtained from nonsarcoid patients also provoked similar granulomatous changes, although the positive rate was somewhat lower. In th...

journal_title：Annals of the New York Academy of Sciences

authors： Iwai K,Takahashi S

更新日期：1976-01-01 00:00:00

abstract：:A radioimmunoassay method (RIA) with specific antisera for human and rat alpha fetoprotein (AFP) was used to study the evolution of AFP levels in humans and rats, respectively, throughout the life span. Sera of 66 rats, aged 3-70 weeks, as well as sera of 201 clinically well children, 192 healthy blood donors, and 16...

journal_title：Annals of the New York Academy of Sciences

authors： Masseyeff R,Gilli J,Krebs B,Calluaud A,Bonet C

更新日期：1975-08-22 00:00:00

abstract：:This article draws on ideas published in my "Intimations of Immortality" essay in Science (Vol. 288, No. 5463, p. 59, April 7, 2000) and my "Intimations of Immortality-The Ethics and Justice of Life Extending Therapies" in editor Michael Freeman's Current Legal Problems (Oxford University Press 2002: 65-97). This arti...

journal_title：Annals of the New York Academy of Sciences

authors： Harris J

更新日期：2004-06-01 00:00:00

abstract：:Transcription regulatory factors are rapidly induced in brain by a wide variety of stimuli and may be important in coordinating changes in gene expression under-lying neuronal plasticity. Using in situ hybridization, we found that acute cocaine administration (20 mg/kg, intraperitoneally (i.p.)) produced a robust indu...

journal_title：Annals of the New York Academy of Sciences

authors： Humblot N,Thiriet N,Gobaille S,Aunis D,Zwiller J

更新日期：1998-05-30 00:00:00

abstract：:Mutations in the INSL3 and RXFP2 genes have been associated with human cryptorchidism but with contrasting data. We analyzed the frequency of mutations in these genes in 600 newborns with cryptorchidism (396 unilateral and 204 bilateral) and 300 noncryptorchid subjects. We found five RXFP2 mutations in five bilateral ...

journal_title：Annals of the New York Academy of Sciences

authors： Ferlin A,Zuccarello D,Garolla A,Selice R,Vinanzi C,Ganz F,Zanon GF,Zuccarello B,Foresta C

更新日期：2009-04-01 00:00:00

abstract：:Nicotinamide can protect the NOD mouse from diabetes if given early enough and in sufficient dose. The effect partly wanes with time. There is reduced islet inflammation. Similar protective effects can be demonstrated in quasi-experimental interventions in humans--both diabetes related and unrelated deemed at risk of ...

journal_title：Annals of the New York Academy of Sciences

authors： Elliott RB,Pilcher CC,Stewart A,Fergusson D,McGregor MA

更新日期：1993-11-30 00:00:00

abstract：:Especially since the (re-)discovery of T cell subpopulations with specialized regulatory activities, mechanisms of anti-inflammatory T cell regulation are studied very actively and are expected to lead to the development of novel immunotherapeutic approaches, especially in chronic inflammatory diseases. Heat shock pro...

journal_title：Annals of the New York Academy of Sciences

authors： Van Eden W,Wick G,Albani S,Cohen I

更新日期：2007-10-01 00:00:00

abstract：:The nonpregnant uterus shows uterine activity throughout the menstrual cycle. This uterine activity was detected both by single strep tissue and by using intrauterine pressure recordings in vitro and in vivo. Today, ultrasound has made it possible to study this activity with a noninvasive approach and to assess uterin...

journal_title：Annals of the New York Academy of Sciences

authors： Bulletti C,DE Ziegler D,Setti PL,Cicinelli E,Polli V,Flamigni C

更新日期：2004-12-01 00:00:00