New β-lactam-β-lactamase inhibitor combinations in clinical development.

abstract：:Nanofluids consisting of nanometer-sized particles dispersed in base liquids are known to be effective in extending the saturated boiling regime and critical heat flux in pool boiling. The heat transfer characteristics of nanosilica suspensions with particle sizes of 10 and 20 nm in pool boiling with a suspended heati...

journal_title：Annals of the New York Academy of Sciences

authors： Kumar R,Milanova D

更新日期：2009-04-01 00:00:00

abstract：:Sexual dimorphism is a well-documented phenomenon that is observed at all levels of the animal kingdom. Historically, sex hormones (testosterone and estrogen) have been implicated as key players in a wide array of pathologies displaying sexual dimorphism in their etiology and progression. While these hormones clearly ...

journal_title：Annals of the New York Academy of Sciences

authors： Quinn M,Ramamoorthy S,Cidlowski JA

更新日期：2014-05-01 00:00:00

abstract：:Thymic pathology occurs in 80-90% of myasthenia gravis patients. Significant associations between different thymic alterations and clinical findings are discussed. To highlight peculiarities in thymoma-associated myasthenia gravis, we briefly review myasthenia gravis associated with thymic lymphofollicular hyperplasia...

journal_title：Annals of the New York Academy of Sciences

authors： Marx A,Müller-Hermelink HK,Ströbel P

更新日期：2003-09-01 00:00:00

abstract：:Adolescence marks the beginning of adult-level cognitive control of behavior supported by the brain maturation processes of synaptic pruning and myelination. Cognitive development studies on adolescence indicate that this period is characterized by improvements in the performance of existing abilities including speed ...

journal_title：Annals of the New York Academy of Sciences

authors： Luna B,Sweeney JA

更新日期：2004-06-01 00:00:00

abstract：:The melanocortin (MC)-4 receptor participates in regulating body weight homeostasis. We demonstrated early that acute blockage of the MC-4 receptor increases food intake and relieves anorexic conditions in rats. Our recent studies show that 4-week chronic blockage of the MC-4 receptor leads to robust increases in food...

journal_title：Annals of the New York Academy of Sciences

authors： Schiöth HB,Lagerström MC,Watanobe H,Jonsson L,Vergoni AV,Ringholm A,Skarphedinsson JO,Skuladottir GV,Klovins J,Fredriksson R

更新日期：2003-06-01 00:00:00

abstract：:Citizen soldiers (National Guard and Reserves) represent approximately 40% of the two million armed forces deployed to Afghanistan and Iraq. Twenty-five to forty percent of them develop PTSD, clinical depression, sleep disturbances, or suicidal thoughts. Upon returning home, many encounter additional stresses and hurd...

journal_title：Annals of the New York Academy of Sciences

authors： Greden JF,Valenstein M,Spinner J,Blow A,Gorman LA,Dalack GW,Marcus S,Kees M

更新日期：2010-10-01 00:00:00

abstract：:More than 10% of postmenopausal women in the United States receive thyroid hormone replacement therapy and up to 20% of these women are over-replaced inducing subclinical hyperthyroidism. Because hyperthyroidism and post menopausal osteoporosis overlap in women of advancing age, it is urgent to understand the effect o...

journal_title：Annals of the New York Academy of Sciences

authors： Abe E,Sun L,Mechanick J,Iqbal J,Yamoah K,Baliram R,Arabi A,Moonga BS,Davies TF,Zaidi M

更新日期：2007-11-01 00:00:00

abstract：:These findings support the hypothesis that a frontal-subcortical abnormality is necessary to produce symptoms of depression (e.g., mood-related signs, behavioral disturbances, neurovegetative signs) in dementia. Behavioral disturbances (e.g., disinhibition, agitation, social withdrawal) were more likely to occur in FL...

journal_title：Annals of the New York Academy of Sciences

authors： Lopez OL,Gonzalez MP,Becker JT,Reynolds CF 3rd,Sudilovsky A,DeKosky ST

更新日期：1995-12-15 00:00:00

abstract：:Undernutrition and inadequate stimulation both negatively influence child health and development and have a long-term impact on school attainment and income. This paper reports data from India and Pakistan looking at how families interact, play with, and feed children; their expectations of growth and development; and...

journal_title：Annals of the New York Academy of Sciences

authors： Lingam R,Gupta P,Zafar S,Hill Z,Yousafzai A,Iyengar S,Sikander S,Haq Zu,Mehta S,Skordis-Worrel J,Rahman A,Kirkwood B

更新日期：2014-01-01 00:00:00

abstract：:The coordinated regulation between cellular glucose uptake and endogenous glucose production is indispensable for the maintenance of constant blood glucose concentrations. The liver contributes significantly to this process by altering the levels of hepatic glucose release, through controlling the processes of de novo...

journal_title：Annals of the New York Academy of Sciences

authors： Hatting M,Tavares CDJ,Sharabi K,Rines AK,Puigserver P

更新日期：2018-01-01 00:00:00

abstract：:One of the most studied effects of verbal working memory (WM) is the influence of the length of the words that compose the list to be remembered. This work aims to investigate the nature of musical WM by replicating the word length effect in the musical domain. Length and rate of presentation were manipulated in a rec...

journal_title：Annals of the New York Academy of Sciences

authors： Akiva-Kabiri L,Vecchi T,Granot R,Basso D,Schön D

更新日期：2009-07-01 00:00:00

abstract：:Uteroglobin, a steroid-inducible, cytokine-like, secreted protein with immunomodulatory properties, has been reported to bind progesterone, polychlorinated biphenyls (PCB), and retinol. Structural studies may delineate whether binding of ligands is a likely physiological function of human uteroglobin (hUG). We report ...

journal_title：Annals of the New York Academy of Sciences

authors： Pattabiraman N,Matthews JH,Ward KB,Mantile-Selvaggi G,Miele L,Mukherjee AB

更新日期：2000-01-01 00:00:00

abstract：:The possible role of the cerebellum for the control of saccades and gaze holding is reconsidered using a computational modeling approach. As suggested by previous research, control of gaze holding is assumed to be enhanced by the floccular lobe, whereas control of the saccadic pulse is governed by the oculomotor vermi...

journal_title：Annals of the New York Academy of Sciences

authors： Glasauer S

更新日期：2003-10-01 00:00:00

abstract：UNLABELLED:After long periods of status epilepticus, selective neuronal necrosis is incurred in the neocortex (layer III-IV), in the hippocampus (CA1 and CA4), and in the thalamus (VPL-VPM). In these areas the cerebral metabolic rate for glucose is increased to between 200-300% of control, indicating a correlation betw...

journal_title：Annals of the New York Academy of Sciences

authors： Ingvar M

更新日期：1986-01-01 00:00:00

abstract：:Obstructive sleep apnea is often regarded as a structural disorder causing narrowing of the airway. This article reviews the neurological aspects of obstructive sleep apnea, including the upper airway reflex, cortical arousal thresholds, and motor function as they pertain to the pathophysiology of disease. We also dis...

journal_title：Annals of the New York Academy of Sciences

authors： Broderick M,Guilleminault C

更新日期：2008-10-01 00:00:00

abstract：:Learning to play a musical instrument requires complex multimodal skills involving simultaneous perception of several sensory modalities: auditory, visual, and somatosensory as well as the motor system. Musical training thus provides an adequate neuroscientific model to study multimodal integration and plasticity in m...

journal_title：Annals of the New York Academy of Sciences

authors： Pantev C,Lappe C,Herholz SC,Trainor L

更新日期：2009-07-01 00:00:00

abstract：:Recent observations indicate that autoimmune disorders and allergies are more closely connected to each other than traditionally considered. Both diseases are characterized by a break of immunological tolerance and in both Th1- and Th2-driven mechanisms may be involved. Moreover, patients suffering from severe chronic...

journal_title：Annals of the New York Academy of Sciences

authors： Garn H,Mittermann I,Valenta R,Renz H

更新日期：2007-06-01 00:00:00

abstract：:The Pawtucket Heart Health Program, a research effort testing a process of community activation for cardiovascular risk factor behavior change, risk factor change, and coronary heart disease event rate change, utilizes risk factor behavior change programs for the entire population of a northeastern city. A diversity o...

journal_title：Annals of the New York Academy of Sciences

authors： Carleton RA,Sennett L,Gans KM,Levin S,Lefebvre C,Lasater TM

更新日期：1991-01-01 00:00:00

abstract：:Ischemia and reperfusion injure the heart, as manifested by myocardial infarction, postischemic ventricular functional dysfunctions, arrhythmias, and cardiomyocyte apoptosis. Hearts can be adapted to ischemic-reperfusion injury by subjecting them to non-lethal cyclic episodes of short-term ischemia and reperfusion. Th...

journal_title：Annals of the New York Academy of Sciences

authors： Maulik N,Sasaki H,Galang N

更新日期：1999-06-30 00:00:00

abstract：:Rheumatoid arthritis (RA) is associated with accelerated atherosclerosis. Fractalkine, a CX3C/chemokine (CX3CL1), mediates monocytes-macrophage infiltration in activated endothelium, suggesting its specific role in atherosclerosis-related inflammation. In this study, we evaluate the following in early RA patients: the...

journal_title：Annals of the New York Academy of Sciences

authors： Pingiotti E,Cipriani P,Marrelli A,Liakouli V,Fratini S,Penco M,Giacomelli R

更新日期：2007-06-01 00:00:00

abstract：:Neurologic symptoms were the earliest and most prominent symptoms recorded in Michigan farm residents exposed to PBB as compared to a non-PBB exposed control farm population in Wisconsin. In Michigan (particularly among males) those who exhibited the most marked symptoms tended to show diminished performance as assess...

journal_title：Annals of the New York Academy of Sciences

authors： Valciukas JA,Lilis R,Anderson HA,Wolff MS,Petrocci M

更新日期：1979-05-31 00:00:00

abstract：:Vitamin E is essential for normal neurological function. It is the major lipid-soluble, chain-breaking antioxidant in the body, protecting the integrity of membranes by inhibiting lipid peroxidation. Mostly on the basis of symptoms of primary vitamin E deficiency, it has been demonstrated that vitamin E has a central ...

journal_title：Annals of the New York Academy of Sciences

authors： Sen CK,Khanna S,Roy S

更新日期：2004-12-01 00:00:00

abstract：:A few years after the first description of free-circulating DNA in plasma and serum, the detection of tumor-associated overexpressed mRNA in plasma was also reported. This observation has been confirmed and it seems to be clear that the presence of free-circulating RNA is a ubiquitous phenomenon. In this short review ...

journal_title：Annals of the New York Academy of Sciences

authors： Fleischhacker M

更新日期：2006-09-01 00:00:00

abstract：:Bacterial cell division is facilitated by the divisome, a dynamic multiprotein assembly localizing at mid-cell to synthesize the stress-bearing peptidoglycan and to constrict all cell envelope layers. Divisome assembly occurs in two steps and involves multiple interactions between more than 20 essential and accessory ...

journal_title：Annals of the New York Academy of Sciences

authors： Egan AJ,Vollmer W

更新日期：2013-01-01 00:00:00

abstract：:Gastrointestinal peptides play important roles regulating feeding and energy homeostasis. Most gastrointestinal peptides including glucagon like peptide-1, peptide YY, amylin, and oxytomodulin are anorectic, and only ghrelin is an orexigenic peptide. Ghrelin increases appetite, modulates energy balance, suppresses inf...

journal_title：Annals of the New York Academy of Sciences

authors： Ueno H,Shiiya T,Nakazato M

更新日期：2010-07-01 00:00:00

abstract：:Apoptosis protease-activating factor-1 (Apaf-1), which plays a central role in the formation of the apoptosome, is absent or poorly expressed (because of a transcriptional silencing by methylation) in a substantial percentage of metastatic melanomas and melanoma cell lines, which are unable to activate caspase-9 and e...

journal_title：Annals of the New York Academy of Sciences

authors： Del Bello B,Valentini MA,Comporti M,Maellaro E

更新日期：2003-12-01 00:00:00

abstract：:T-lymphocytes from three species of New World monkeys were susceptible to transformation in vitro with human T-cell leukemia virus. Marmoset T-lymphocytes transformed in vitro with HVS or HVA, T-lymphotropic herpesviruses of New World monkeys, were also transformed with HTLV resulting in doubly transformed T-cells. Th...

journal_title：Annals of the New York Academy of Sciences

authors： Falk LA Jr,Byington R,Silva DP

更新日期：1984-01-01 00:00:00

abstract：:The flash thermal diffusivity measurement technique is applied to tissue for the first time. Making use of its minimal contact with the specimen, the flash technique is extended to allow for well-defined, biaxial, finite strain. As an example application, the radial component of thermal diffusivity of bovine descendin...

journal_title：Annals of the New York Academy of Sciences

authors： Doss DJ,Humphrey JD,Wright NT

更新日期：1998-09-11 00:00:00

abstract：:A generation of research in cognitive psychology has given rise to many tasks that tap at various aspects of attention. It is now widely agreed that attention is not a single thing and that its measurement needs a strategy to study each of its various aspects. While there is no widely agreed taxonomy of attentional op...

journal_title：Annals of the New York Academy of Sciences

authors： Posner MI

更新日期：2008-01-01 00:00:00

abstract：:The psychostimulant 3,4-,ethylenedioxymethamphetamine (MDMA, "ecstasy") is known to induce hyperthermia and alterations in neurochemical metabolism in the CNS. However, the detailed cellular or molecular mechanisms behind MDMA-induced neurotoxicity are still not well known. Since MDMA induces profound hyperthermia tha...

journal_title：Annals of the New York Academy of Sciences

authors： Sharma HS,Ali SF

更新日期：2008-10-01 00:00:00