Measuring alertness.

abstract：:This review outlines the scientific rationale supporting the potential use of deep-brain electrical stimulation (DBS) in the central thalamus as a method to improve behavioral responsiveness following severe brain injury. Neurons within the central thalamus are selectively vulnerable to disconnection and dysfunction f...

journal_title：Annals of the New York Academy of Sciences

authors： Schiff ND

更新日期：2009-03-01 00:00:00

abstract：:The expression of beta2-adrenergic receptors (beta2-R) on B lymphocytes and agonist-induced cAMP production is reduced in patients with rheumatoid arthritis (RA). To further study functional consequences of the diminished beta2-R density on B lymphocytes in RA patients, agonist-induced cell death was evaluated and com...

journal_title：Annals of the New York Academy of Sciences

authors： Wahle M,Pierer M,Krause A,Kolker S,Baerwald CG

更新日期：2002-06-01 00:00:00

abstract：:Improved technology and medical advances have increased the lifespan for people with thalassemia. As thalassemia is no longer exclusively a pediatric blood disorder, consideration must now be given to transition planning from pediatric to adult care. The complexity of thalassemia disease, coupled with the changing fac...

journal_title：Annals of the New York Academy of Sciences

authors： Levine L,Levine M

更新日期：2010-08-01 00:00:00

abstract：:The quasibiennial oscillation (QBO) dominates the variability of the equatorial stratosphere and also affects the circulation and temperature of the extratropical region. In this paper we review previous work showing that the mid- to high-latitude circulation is weaker (stronger) when QBO easterlies (westerlies) domin...

journal_title：Annals of the New York Academy of Sciences

authors： Peña-Ortiz C,García-Herrera R,Ribera P,Calvo N

更新日期：2008-12-01 00:00:00

abstract：:A variety of different isoforms of mammalian voltage-gated sodium channels have been identified. These channels can be classified into three different types. Eight type 1 isoforms have been identified in the CNS, PNS, skeletal muscle, and heart. All of these channels have been expressed in exogenous systems, and all o...

journal_title：Annals of the New York Academy of Sciences

authors： Goldin AL

更新日期：1999-04-30 00:00:00

abstract：:Our cumulative experience continues to validate the fetal nucleated erythrocyte as the target fetal cell type of choice, primarily because it reflects the cytogenetic status of the current pregnancy. Additional cell types, such as the granulocyte, await further study. Quantitative PCR is a sensitive and useful new met...

journal_title：Annals of the New York Academy of Sciences

authors： Bianchi DW

更新日期：1994-09-07 00:00:00

abstract：:The objective of this article is to investigate the influence of endothelin-1 (ET-1) on human monocyte Na(+)/H(+) exchanger (NHE) activity and on the atherosclerosis-related monocyte functions. ET-1 caused an increase in pHi and in (22)Na influx of monocytes. A reversal of ET-1 effect on pHi was observed in the presen...

journal_title：Annals of the New York Academy of Sciences

authors： Koliakos G,Befani C,Paletas K,Kaloyianni M

更新日期：2007-01-01 00:00:00

abstract：:Intracerebral administration of the excitotoxin ibotenate to new-born mice induced white-matter lesions mimicking the periventricular leukomalacia occurring in human premature babies. In this model, co-injection of vasoactive intestinal peptide (VIP) prevented white-matter lesions. VIP did not prevent the initial appe...

journal_title：Annals of the New York Academy of Sciences

authors： Gressens P

更新日期：1999-01-01 00:00:00

abstract：:Premenstrual syndrome is a collection of symptoms that may be encountered by up to 95% of the population, although it is estimated to affect 5% of women severely. The use of complementary and alternative therapies is high among this group, but does not seem to compromise conventional treatment. It has been established...

journal_title：Annals of the New York Academy of Sciences

authors： Domoney CL,Vashisht A,Studd JW

更新日期：2003-11-01 00:00:00

abstract：:Basic fibroblast growth factor is a polypeptide belonging to a family of natural proteins also known as heparin-binding growth factors endowed with a pleiotropism of biological activities, the most striking of which are related to wound healing. Large quantities of recombinant human basic fibroblast growth factor (rh-...

journal_title：Annals of the New York Academy of Sciences

authors： Mazué G,Bertolero F,Jacob C,Sarmientos P,Roncucci R

更新日期：1991-01-01 00:00:00

abstract：:The measurement of autoantibodies specific for double-stranded DNA (anti-dsDNA) is a useful tool for the diagnosis and the prognosis of systemic lupus erythematosus (SLE). A new quantitative enzyme-linked immunosorbent assay (ELISA), ORG anti-dsDNA, is recently available for the determination of anti-dsDNA antibodies....

journal_title：Annals of the New York Academy of Sciences

authors： Bardin N,Ragot C,Sanmarco M

更新日期：2007-08-01 00:00:00

abstract：:Morphogenesis in the animal kingdom is closely coupled with the intracellular synthesis and the extracellular deposition of collagen. These morphogenetically important events involve multiple steps which begin in compartments inside the cell and continue in compartments outside the cell. The movement of matrix compone...

journal_title：Annals of the New York Academy of Sciences

authors： Birk DE,Trelstad RL

更新日期：1985-01-01 00:00:00

abstract：:Calpain, an inactive proenzyme, translocates from the cytosol to the membrane upon binding calcium, and is activated at the membrane in the presence of calcium and PIP2. Activated calpain is very unstable and presumably used only once. Thus the primary targets of calpain are considered to be membrane or membrane-assoc...

journal_title：Annals of the New York Academy of Sciences

authors： Suzuki K,Saido TC,Hirai S

更新日期：1992-12-31 00:00:00

abstract：:Recent advances in the development of three different types of antiviral drugs, the nucleotide and non-nucleotide analogues acting as reverse transcriptase inhibitors (NRTIs) and the nonpeptidic viral protease inhibitors (PI), and their introduction in the management of patients with AIDS, either alone or in combinati...

journal_title：Annals of the New York Academy of Sciences

authors： Kino T,Chrousos GP

更新日期：2004-06-01 00:00:00

abstract：:A growing body of literature has investigated the effects of playing video games on brain function and behavior. One key takeaway from this literature has been that not all entertainment video games are created equal with respect to their effects on cognitive functioning. The majority of the research to date has contr...

journal_title：Annals of the New York Academy of Sciences

authors： Dale G,Joessel A,Bavelier D,Green CS

更新日期：2020-03-01 00:00:00

abstract：:In red blood cells as well as in platelets there appears to be a decrease in adenine nucleotides during storage under blood bank conditions. This can be decreased by use of anticoagulant preservatives with higher phosphate content than the standard ACD solution, through the addition of adenine and inosine. Maintenance...

journal_title：Annals of the New York Academy of Sciences

authors： Ambrus JL,Ambrus CM,Odake K,Mink IB,Shields R,Warner W,Bishop C,Tritsch GL,Golden G,Mittelman A

更新日期：1975-08-08 00:00:00

abstract：:Insulin-related peptides (IRPs) from ganglions of mollusk, Anodonta cygnea, were purified and characterized (IRP1-IRP13) using insulin and insulin-like growth factor-I (IGF-I) radioreceptor test systems. The IRPs were able to bind to insulin and IGF-I receptors. Dose-dependent curve slopes indicated that most IRPs bin...

journal_title：Annals of the New York Academy of Sciences

authors： Shipilov VN,Shpakov AO,Rusakov YI

更新日期：2005-04-01 00:00:00

abstract：:Although very few measurements have appeared in the open literature and there seems to be a controversy about the existence of the NDR phenomenon in molecules, the prospects of building such systems have attracted significant attention. In the work reported in this paper we used a model based on DFT calculations of th...

journal_title：Annals of the New York Academy of Sciences

authors： Simón-Manso Y,Gonzalez C,Mujica V,Aray Y,Marquez M

更新日期：2003-12-01 00:00:00

abstract：:The pronounced increases in gangliosides belonging to the gangliotetraose family during the neurite outgrowth phase of neuronal differentiation have suggested a functional requirement for these substances related to process extension, arborization, and possibly synaptogenesis. Support for this hypothesis has come from...

journal_title：Annals of the New York Academy of Sciences

authors： Ledeen RW,Wu G,Lu ZH,Kozireski-Chuback D,Fang Y

更新日期：1998-06-19 00:00:00

abstract：:The autonomic nervous system consists of sympathetic, parasympathetic, and enteric ganglia and also of a specialized neuroendocrine derivative, the adrenomedullary chromaffin cells. ...

journal_title：Annals of the New York Academy of Sciences

authors： Kalcheim C,Langley K,Unsicker K

更新日期：2002-10-01 00:00:00

abstract：:The disturbances in the balance of pro- and antifibrinolytic activity, as observed in AAA and obesity, respectively, have considerable potential for influencing both intra- and extravascular fibrinolytic events and may be causally related to the development of vascular disease. For example, the wall of the aortic athe...

journal_title：Annals of the New York Academy of Sciences

authors： Samad F,Schneiderman J,Loskutoff D

更新日期：1997-04-15 00:00:00

abstract：:The results reviewed here demonstrate that vestibulospinal and vestibulo-ocular interneurons in the chicken embryo are organized into coherent clusters, each of which occupies a unique spatial domain and has a characteristic axon trajectory. Moreover, the vestibulo-ocular clusters have specific termination patterns in...

journal_title：Annals of the New York Academy of Sciences

authors： Glover JC

更新日期：1996-06-19 00:00:00

abstract：:Advances in understanding the epidemiology of endometriosis have lagged behind other diseases because of methodologic problems related to disease definition and control selection. Nevertheless, a better picture of the epidemiology of endometriosis has emerged over the past few decades. Prevalence estimates of the dise...

journal_title：Annals of the New York Academy of Sciences

authors： Cramer DW,Missmer SA

更新日期：2002-03-01 00:00:00

abstract：:Sarcopenia is the involuntary loss of skeletal muscle mass and strength that occurs with aging, resulting in physical frailty. One potential explanation for sarcopenia is the failure of muscle to regenerate after damage, some of which may be due to changes in the function of satellite cells. Recent studies have identi...

journal_title：Annals of the New York Academy of Sciences

authors： Machida S,Narusawa M

更新日期：2006-05-01 00:00:00

abstract：:Apolipoprotein E is a plasma cholesterol and phospholipid transporter which plays a central role in lipoprotein metabolism in the brain. Apolipoprotein E is a polymorphic protein with three common alleles in the general population, designated epsilon 2, epsilon 3 and epsilon 4 coding for proteins ApoE2, ApoE3 and ApoE...

journal_title：Annals of the New York Academy of Sciences

authors： Beffert U,Poirier J

更新日期：1996-01-17 00:00:00

abstract：:Enhancer DNA decoy oligonucleotides (ODNs) inhibit transcription by competing for transcription factors. A decoy ODN composed of the cAMP response element (CRE) inhibits CRE-directed gene transcription and tumor growth without affecting normal cell growth. We used DNA microarrays to analyze the global gene expression ...

journal_title：Annals of the New York Academy of Sciences

authors： Cho-Chung YS

更新日期：2003-12-01 00:00:00

abstract：:Throughout this century in the United States, tension has existed between those who believe drug abuse is best combatted through the criminal justice system and those who emphasize a medical/public health model of prevention and treatment. In the last decade this debate has centered around the person of the pregnant a...

journal_title：Annals of the New York Academy of Sciences

authors： Chavkin W,Wise PH,Elman D

更新日期：1998-06-21 00:00:00

abstract：:Several years of survey data indicate that illicit drug use among U.S. youth was at its highest level in 1979. Generally, the use of some illicit drugs declined progressively throughout the 1980s, stabilized, and then decreased slightly. Reducing illicit drug use among U.S. youth continues to be a priority of federal,...

journal_title：Annals of the New York Academy of Sciences

authors： Banken JA

更新日期：2004-10-01 00:00:00

abstract：:The presence in the serum of specific autoantibodies, such as antinuclear antibodies (ANA), anti-double-stranded DNA (anti-dsDNA), and antiextractable nuclear antigens (anti-ENA), is one of the diagnostic criteria for autoimmune rheumatic disease, and the requests for these tests in the last few years have grown remar...

journal_title：Annals of the New York Academy of Sciences

authors： Bonaguri C,Melegari A,Dall'Aglio P,Ballabio A,Terenziani P,Russo A,Battistelli L,Aloe R,Camisa R,Campaniello G,Sartori E,Monica C

更新日期：2009-09-01 00:00:00

abstract：:Socioeconomic stress associated with financial and psychosocial stress is widespread in society. A comprehensive body of research indicates that low socioeconomic status and social stress is associated with a broad spectrum of health risks. This paper reviews epidemiological evidence demonstrating the association betw...

journal_title：Annals of the New York Academy of Sciences

authors： Tamashiro KL

更新日期：2011-08-01 00:00:00