Biology of circulating mRNA: still more questions than answers?

abstract：:In South America, human cases of infection by the genus Rickettsia have been described in several countries in the last twenty years. The role of international organizations, such as the Centers for Disease Control and Prevention in Atlanta, Georgia, USA and the World Health Organization Collaborating Center for Tropi...

journal_title：Annals of the New York Academy of Sciences

authors： Galvão MA,Mafra CL,Moron C,Anaya E,Walker DH

更新日期：2003-06-01 00:00:00

abstract：:Fungal pathogens are a growing threat to public health. As human immunodeficiency becomes increasingly common, fungal infections are becoming more prevalent. The use of antifungal agents for prophylaxis and treatment of fungal infections has favored the emergence of previously rare or unidentified species of drug-resi...

journal_title：Annals of the New York Academy of Sciences

authors： Geddes-McAlister J,Shapiro RS

更新日期：2019-01-01 00:00:00

abstract：:Allergic contact dermatitis is a common inflammatory skin disease caused by T cells that recognize environmental and industrial allergens (i.e., haptens). Langerhans' cells (LC), which are skin-specific and "immature" members of the dendritic cell (DC) family of antigen-presenting cells, play crucial roles in the indu...

journal_title：Annals of the New York Academy of Sciences

authors： Takashima A,Mummert M,Kitajima T,Matsue H

更新日期：2000-01-01 00:00:00

abstract：:In recent years, vitamin D has been received increased attention due to the resurgence of vitamin D deficiency and rickets in developed countries and the identification of extraskeletal effects of vitamin D, suggesting unexpected benefits of vitamin D in health and disease, beyond bone health. The possibility of extra...

journal_title：Annals of the New York Academy of Sciences

authors： Christakos S,Hewison M,Gardner DG,Wagner CL,Sergeev IN,Rutten E,Pittas AG,Boland R,Ferrucci L,Bikle DD

更新日期：2013-05-01 00:00:00

abstract：:While there has been substantial growth in early childhood development (ECD) services in low- and middle-income countries (LMICs), there is considerable inequity in their distribution and quality. Evidence-based governance strategies are necessary, but currently they are insufficient for widespread, quality implementa...

journal_title：Annals of the New York Academy of Sciences

authors： Britto PR,Yoshikawa H,van Ravens J,Ponguta LA,Reyes M,Oh S,Dimaya R,Nieto AM,Seder R

更新日期：2014-01-01 00:00:00

abstract：:The activator protein-1 (AP-1) binding activities in the three brain regions (striatum, nucleus accumbens, cingulate cortex) increased after a single methamphetamine (METH, 4 mg/kg) injection and reached maximum levels after 180 min. Pretreatment with SCH 23390 (0.5 mg/kg), a selective dopamine D1 receptor antagonist,...

journal_title：Annals of the New York Academy of Sciences

authors： Akiyama K,Ishihara T,Kashihara K

更新日期：1996-10-31 00:00:00

abstract：:The free radical theory of aging proposes that oxidative stress is one of the determinants of an organism's life span. In Caenorhabditis elegans, genetic or environmental changes have been shown to modulate life span. Here we discuss whether changes in the generation and destruction of free radicals are implicated in ...

journal_title：Annals of the New York Academy of Sciences

authors： Honda Y,Honda S

更新日期：2002-04-01 00:00:00

abstract：:The hypothesis tested was that mutant tumor DNA shed into plasma would show predictive value for monitoring response to therapy in non-small cell lung carcinoma patients. Pretreatment plasma specimens from 25 patients on a phase I trial were evaluated, 12 with paired posttreatment specimens, and 138 patients on the So...

journal_title：Annals of the New York Academy of Sciences

authors： Kimura T,Holland WS,Kawaguchi T,Williamson SK,Chansky K,Crowley JJ,Doroshow JH,Lenz HJ,Gandara DR,Gumerlock PH

更新日期：2004-06-01 00:00:00

abstract：:Despite short halflife in biological fluids, nitric oxide (NO) can produce remote or long lasting effect in the cardiovascular system. Long distance transport or local storage of NO might explain these effects. In blood, recent findings suggest that in addition to being a major consumption pathway, interaction of NO w...

journal_title：Annals of the New York Academy of Sciences

authors： Muller B,Kleschyov AL,Alencar JL,Vanin A,Stoclet JC

更新日期：2002-05-01 00:00:00

abstract：:The LGR7/RXFP1 and LGR8/RXFP2 receptors are unique receptors among the G-protein-coupled receptors (GPCRs) in having a low-density lipoprotein class A (LDL-A) module. Their complex gene organization, among the intron-richest of the GPCRs, suggests that alternative splicing is a common occurrence. We have therefore inv...

journal_title：Annals of the New York Academy of Sciences

authors： Kern A,Bryant-Greenwood GD

更新日期：2009-04-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is one of the most predominant malignancies worldwide. The 5-year survival rate is still relatively low due to few symptoms presenting with the early disease, diagnosis at middle to late stage, and high risk of recurrence after therapy. Novel protein biomarkers for early detec...

journal_title：Annals of the New York Academy of Sciences

authors： Wang M,Smith JS,Wei WQ

更新日期：2018-12-01 00:00:00

abstract：:Various hypotheses on the origin of cerebellar downbeat nystagmus (DBN) have been presented; the exact pathomechanism, however, is still not known. Based on previous anatomical and electrophysiological studies, we propose that an asymmetry in the distribution of on-directions of vertical gaze-velocity Purkinje cells l...

journal_title：Annals of the New York Academy of Sciences

authors： Marti S,Straumann D,Glasauer S

更新日期：2005-04-01 00:00:00

abstract：:The clinical significance of a discovery of anti-histidyl-tRNA synthetase (Jo1) autoantibodies patients was established in the early diagnosis of antisynthetase syndrome (ASS) as the common form of this pathology is characterized by interstitial lung disease (ILD), inflammatory muscle disease, and production of anti-J...

journal_title：Annals of the New York Academy of Sciences

authors： Gomard-Mennesson E,Fabien N,Cordier JF,Ninet J,Tebib J,Rousset H

更新日期：2007-08-01 00:00:00

abstract：:The studies described in this report suggest a rather complex, albeit incomplete, sequence of molecular events that we believe form part of the cascade of reactions through which a series of hormones, via cAMP, regulates the expression of specific gene products. The majority of our own studies relate to cAMP-mediated ...

journal_title：Annals of the New York Academy of Sciences

authors： Jungmann RA,Constantinou AI,Squinto SP,Kwast-Welfeld J,Schweppe JS

更新日期：1986-01-01 00:00:00

abstract：:The aim of this study was to investigate the influence of long-lasting, extensive rowing training on body fluids in 12 experienced rowers (23.3 +/- 6.3 years, 188.7 +/- 5.9 cm, 82.0 +/- 10.8 kg, body mass index [BMI] 23.7 +/- 2.1). All rowers had a light traditional breakfast about 3 h before the training. The subject...

journal_title：Annals of the New York Academy of Sciences

authors： Jürimäe J,Jürimäe T,Pihl E

更新日期：2000-05-01 00:00:00

abstract：:Nitric oxide (NO) is an important signaling molecule that is generated through the catalytic activity of nitric oxide synthase (NOS). In the brain, NO mediates neuronal survival, synaptic plasticity, vascular smooth muscle relaxation, and endothelial cell permeability. Previous studies demonstrated aberrant expression...

journal_title：Annals of the New York Academy of Sciences

authors： de la Monte SM,Sohn YK,Etienne D,Kraft J,Wands JR

更新日期：2000-04-01 00:00:00

abstract：:The present experiments were conducted to determine the effects of neurotensin on secretion of a variety of anterior pituitary hormones. Conscious rats with indwelling cannulae in the third ventricle and external jugular vein were used and the effects on plasma hormone levels measured by radioimmunoassay. Neurotensin ...

journal_title：Annals of the New York Academy of Sciences

authors： McCann SM,Vijayan E,Koenig J,Krulich L

更新日期：1982-01-01 00:00:00

abstract：:With the progressive aging of the world's population, immunosenescence is rapidly becoming a clinical concern as it accounts for a higher incidence of severe infections and poor response to vaccines. To identify nutritional approaches that may counteract immunosenescence is of obvious importance in clinical practice. ...

journal_title：Annals of the New York Academy of Sciences

authors： Freeman SL,Fisher L,German JB,Leung PS,Prince H,Selmi C,Naguwa SM,Gershwin ME

更新日期：2010-03-01 00:00:00

abstract：:Stroke is a common and serious disease. Most studies have shown that basic public knowledge about what a stroke is, symptoms of a stroke, and the proper reaction to a stroke is quite deficient. The fact that a stroke affects cognitive, communicative, and motor functions may partially explain the poor reaction to acute...

journal_title：Annals of the New York Academy of Sciences

authors： Alberts MJ

更新日期：2012-09-01 00:00:00

abstract：:It is thought that human natural killer (NK) lymphocytes should not damage self-tissues due to the inhibiting signal initiated by the engagement of one or another inhibitory receptor superfamily (IRS) members with self-human histocompatibility antigen (HLA)-I. During viral infection, the low expression of self-HLA-I o...

journal_title：Annals of the New York Academy of Sciences

authors： Poggi A,Prevosto C,Zancolli M,Canevali P,Musso A,Zocchi MR

更新日期：2007-08-01 00:00:00

abstract：:We have developed a rabbit model of in utero exposure to intravenous injections of cocaine given twice daily to dams from gestational days 8-29. At the doses employed (4 mg/kg, injected twice daily), no differences were found in the body weight gain of dams, time to delivery, litter size, and body weight or other phys...

journal_title：Annals of the New York Academy of Sciences

authors： Romano AG,Harvey JA

更新日期：1998-06-21 00:00:00

abstract：:Now that the human genome has been mapped, a new challenge has emerged: deciphering the various products of individual genes. Consequently, new proteomic technologies are being developed to monitor and identify protein function and interactions responsible for the total activities of the cell. The application of these...

journal_title：Annals of the New York Academy of Sciences

authors： Leak LV,Petricoin EF 3rd,Jones M,Paweletz CP,Ardekani AM,Fusaro VA,Ross S,Liotta LA

更新日期：2002-12-01 00:00:00

abstract：:The musical pitch of harmonic complex sounds, such as instrumental sounds, is perceived primarily by decoding either the fundamental pitch (keynote) or spectral aspects of the stimuli, for example, single harmonics. We divided 334 professional musicians, including symphony orchestra musicians, 75 amateur musicians, an...

journal_title：Annals of the New York Academy of Sciences

authors： Schneider P,Sluming V,Roberts N,Bleeck S,Rupp A

更新日期：2005-12-01 00:00:00

abstract：:G3139 is an 18mer phosphorothioate oligonucleotide targeted to the initiation codon region of the Bcl-2 mRNA. Because of the ability of this antisense construct to downregulate the expression of Bcl-2 mRNA and protein, it has entered phase III clinical trials in a number of human cancers, including advanced melanoma. ...

journal_title：Annals of the New York Academy of Sciences

authors： Benimetskaya L,Lai JC,Khvorova A,Wu S,Miller P,Stein CA

更新日期：2005-11-01 00:00:00

abstract：:Consumers of marijuana typically feel a strong, compulsive desire to consume food. Although past research revealed that the CB1 cannabinoid receptor is a potent regulator of food intake, the functional presence of neuronal CB2 cannabinoid receptors in the brain has been controversial. The role of CB2 receptors in food...

journal_title：Annals of the New York Academy of Sciences

authors： Onaivi ES,Carpio O,Ishiguro H,Schanz N,Uhl GR,Benno R

更新日期：2008-10-01 00:00:00

abstract：:Internuclear ophthalmoparesis (INO) is the most common saccadic eye movement disorder observed in patients with multiple sclerosis (MS). It is characterized by slowing of the adducting eye during horizontal saccades, and most commonly results from a demyelinating lesion in the medial longitudinal fasciculus (MLF) with...

journal_title：Annals of the New York Academy of Sciences

authors： Frohman TC,Davis SL,Frohman EM

更新日期：2011-09-01 00:00:00

abstract：:The hypothalamus is one of the master regulators of various physiological processes, including energy balance and nutrient metabolism. These regulatory functions are mediated by discrete hypothalamic regions that integrate metabolic sensing with neuroendocrine and neural controls of systemic physiology. Neurons and no...

journal_title：Annals of the New York Academy of Sciences

authors： Cai D,Liu T

更新日期：2011-12-01 00:00:00

abstract：:Insulin-like factor 3 (INSL3), previously known as the relaxin-like factor (RLF), is a major peptide hormone secreted from the testicular Leydig cells of adult men and circulating in the blood at a concentration of approximately 1 ng/mL. Women also produce INSL3 in the theca interna cells of ovarian follicles, but cir...

journal_title：Annals of the New York Academy of Sciences

authors： Ivell R,Hartung S,Anand-Ivell R

更新日期：2005-05-01 00:00:00

abstract：:Corticosteroids have potent immunosuppressive and anti-inflammatory effects. Although corticosteroids are an important weapon in the clinical arsenal for treating inflammatory episodes, the mechanisms underlying the actions and regulation of endogenous corticosteroids remain obscure. In the late 1980s and early 1990s,...

journal_title：Annals of the New York Academy of Sciences

authors： Harbuz MS,Chover-Gonzalez AJ,Jessop DS

更新日期：2003-05-01 00:00:00

abstract：:It is well known that women with breast cancer who undergo therapies beyond the surgical intervention (adjuvant chemotherapy, hormone therapy, or both) often suffer from the lack of estrogen, manifesting as climacteric symptoms in either treated premenopausal or postmenopausal women. Although HRT (hormone replacement ...

journal_title：Annals of the New York Academy of Sciences

authors： Xydakis AM,Sakkas EG,Mastorakos G

更新日期：2006-12-01 00:00:00