Abstract:
:The large-scale differential gene expression in lymphomononuclear cells of six patients with recently diagnosed type), and six normal individuals matched to patients for sex and age were studied. Glass slides containing 4608 cDNAs from the IMAGE library were spotted using robotic technology. Statistical analysis was carried out by the SAM program, and gene function assessed by the FATIGO program. Thirty differentially expressed genes (21 induced and 9 repressed) were disclosed when DM-1 patients were compared with controls. Although presenting with distinct biological function, most of the induced or repressed genes were related with protein, phosphate, DNA, RNA, carboxylic acid, and fatty acid metabolism. Although some of these genes have been previously associated with the pathogenesis of T1DM, many other genes were identified for further studies.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Rassi DM,Junta CM,Fachin AL,Sandrin-Garcia P,Mello S,Marques MM,Fernandes AP,Foss-Freitas MC,Foss MC,Sakamoto-Hojo ET,Passos GA,Donadi EAdoi
10.1196/annals.1375.026subject
Has Abstractpub_date
2006-10-01 00:00:00pages
171-6eissn
0077-8923issn
1749-6632pii
1079/1/171journal_volume
1079pub_type
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journal_title:Annals of the New York Academy of Sciences
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