Prevention against oxidative stress of eukaryotic cell membranes by selenium compounds of the rat.

Abstract:

:By a combination of trace techniques and various biochemical methods, information about the characteristics of a 15-kDa selenoprotein was obtained. After labeling of rats in vivo with [(75)Se]selenite, subcellular fractionation of the homogenates of the prostate, lung, brain, thyroid gland, and large intestine, and gel electrophoretic separation of the proteins and subcellular fractionation, 15-kDa (75)Se was found in the cytosols of the tissues prostate > brain > lung > thyroid gland > large intestine after autoradiography. After coelectrophoresis of the separated 15-kDa labeled band obtained from each cytosolic fraction, the 15-kDa (75)Se band migrated in the same way as the combined bands isolated from the five tissue cytosols. After proteolytic cleavage in the gel of the 15-kDa labeled band obtained from the cytosol of each tissue and re-electrophoresis, the same labeled peptide pattern was found in each gel slice after autoradiography. By means of reversed-phase HPLC, we characterized a selenocysteine-containing protein that has enzymatic activity like that of glutathione peroxidase.

journal_name

Ann N Y Acad Sci

authors

Kyriakopoulos A,Bukalis K,Roethlein D,Hoppe B,Graebert A,Behne D

doi

10.1196/annals.1329.057

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

458-61

eissn

0077-8923

issn

1749-6632

pii

1030/1/458

journal_volume

1030

pub_type

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