Abstract:
:Mass production of Ehrlichia ruminantium variants from different regions of sub-Saharan Africa is one of the difficulties that must be overcome in producing a heartwater vaccine. Vaccine productivity can be limited by endogenous induction of interferon (IFN), which inhibits the propagation of Ehrlichia ruminantium (ER) in cell culture. Different kinds of endothelial cells, in which ER multiply efficiently, could be grown in a scalable way in VueLife Teflon bags on Cytodex 3 microcarriers where bead-to-bead transfer of cells occurs. The digital holographic microscope designed at the Université Libre de Bruxelles allows detection of the most appropriate time to harvest intracellular microorganisms for vaccine production.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Pedregal A,de Sousa DR,Nguyen HN,das Neves EA,Lowagie S,Marique T,Kagye N,Guerra IT,Kamba Y,Totte P,Vachiéry N,Lefrançois T,Martinez D,Yourassowsky C,Callens N,Monnom O,Dubois F,Wérenne Jdoi
10.1196/annals.1428.091subject
Has Abstractpub_date
2008-12-01 00:00:00pages
286-91eissn
0077-8923issn
1749-6632pii
NYAS1149091journal_volume
1149pub_type
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