Calorie restriction, post-reproductive life span, and programmed aging: a plea for rigor.

abstract：:Critically ill patients admitted to the intensive care unit with severe sepsis or major blunt injury undergo massive changes in body composition. We compared these changes in 12 patients with generalized peritonitis, and in 18 patients with major blunt injury over a 21-day period soon after their admission. Body compo...

journal_title：Annals of the New York Academy of Sciences

authors： Plank LD,Hill GL

更新日期：2000-05-01 00:00:00

abstract：:Mitochondrial dysfunction, due to either environmental or genetic factors, can result in excessive production of reactive oxygen species, triggering the apoptotic death of dopaminergic cells in Parkinson's disease. Mitochondrial free radical production is promoted by the inhibition of electron transport at any point d...

journal_title：Annals of the New York Academy of Sciences

authors： Fiskum G,Starkov A,Polster BM,Chinopoulos C

更新日期：2003-06-01 00:00:00

abstract：:Type 1 diabetes mellitus (T1DM) is an autoimmune disease in which the beta cells in the pancreas are destroyed by the body's own immune system. IL12 plays a role in pathological situations, such as septic shock, tissue damage during inflammation, and organ-specific autoimmune diseases. In NOD mice, administration of I...

journal_title：Annals of the New York Academy of Sciences

authors： Holm P,Luthman H,Kockum I

更新日期：2003-11-01 00:00:00

abstract：:The adrenal glands are a major source of steroid hormone biosynthesis. In normal physiology, the pituitary hormone corticotropin (ACTH) regulates the secretion of glucocorticoids via its G protein-coupled receptor (ACTHR), the product of the MC2R gene. Aldosterone is another major product of the adrenal gland; its reg...

journal_title：Annals of the New York Academy of Sciences

authors： Bourdeau I,Stratakis CA

更新日期：2002-06-01 00:00:00

abstract：:The pronounced increases in gangliosides belonging to the gangliotetraose family during the neurite outgrowth phase of neuronal differentiation have suggested a functional requirement for these substances related to process extension, arborization, and possibly synaptogenesis. Support for this hypothesis has come from...

journal_title：Annals of the New York Academy of Sciences

authors： Ledeen RW,Wu G,Lu ZH,Kozireski-Chuback D,Fang Y

更新日期：1998-06-19 00:00:00

abstract：:The W-curve is a numerical mapping algorithm that provides tertiary information content of long and short genomic sequences. The most popular genomic pattern recognition algorithms depend on string matching of the primary information content of short genomic sequences. Herein, we describe a way to define the fuzzy pro...

journal_title：Annals of the New York Academy of Sciences

authors： Cork DJ,Toguem A

更新日期：2002-12-01 00:00:00

abstract：:Regional climate modeling bridges the gap between the coarse resolution of current global climate models and the regional-to-local scales, where the impacts of climate change are of primary interest. Here, we present a review of the added value of the regional climate modeling approach within the scope of paleoclimate...

journal_title：Annals of the New York Academy of Sciences

authors： Ludwig P,Gómez-Navarro JJ,Pinto JG,Raible CC,Wagner S,Zorita E

更新日期：2019-01-01 00:00:00

abstract：:Caloric restriction (CR) is well described and has received extensive attention for its multiple benefits, including longevity and stress resistance. However, some studies have shown that CR negatively influences bone, although a mechanism hasn't been provided. Adiponectin, an adipocyte-derived hormone, can affect bon...

journal_title：Annals of the New York Academy of Sciences

authors： Zhu J,Liu C,Jia J,Zhang C,Yuan W,Leng H,Xu Y,Song C

更新日期：2020-08-01 00:00:00

abstract：:Like many other transcription factors, the tumor suppressor protein p53 is bound to the nuclear matrix (NM). To study the interaction of p53 with the NM in more detail, we used alkaline and acidic extractions of NM proteins. It was found that there are two forms of p53, alkali- and acid-soluble, in NM of HEK293 cells ...

journal_title：Annals of the New York Academy of Sciences

authors： Lapshina MA,Parkhomenko II,Terentiev AA

更新日期：2006-12-01 00:00:00

abstract：:Cardiac muscle relies highly on aerobic metabolism. Heart muscle has a high oxygen uptake at resting conditions, which increases many fold during exhaustive physical exercise. Such a high rate of oxidative metabolism is often associated with enhanced production of reactive oxygen metabolites. A single bout of strenuou...

journal_title：Annals of the New York Academy of Sciences

authors： Atalay M,Sen CK

更新日期：1999-06-30 00:00:00

abstract：:It is known that red wines have antioxidant properties owing to the presence of polyphenols and hydroxycinnamates. It has been reported that these compounds are efficient scavengers of peroxynitrite (ONOO(-)). We assayed the ONOO(-)-scavenging activity of plant polyphenols, hydroxycinnamates, and red wines using a flu...

journal_title：Annals of the New York Academy of Sciences

authors： Valdez LB,Actis-Goretta L,Boveris A

更新日期：2002-05-01 00:00:00

abstract：:Proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha) might be, at least partially, responsible for the development of osteopenia or osteoporosis in Crohn's disease. We investigated whether anti-TNF therapy for Crohn's disease could have any skeletal impact. Therefore, we studied the effects of ...

journal_title：Annals of the New York Academy of Sciences

authors： Pazianas M,Rhim AD,Weinberg AM,Su C,Lichtenstein GR

更新日期：2006-04-01 00:00:00

abstract：:Statistical learning is a set of cognitive mechanisms allowing for extracting regularities from the environment and segmenting continuous sensory input into discrete units. The current study used functional magnetic resonance imaging (fMRI) (N = 25) in conjunction with an artificial language learning paradigm to provi...

journal_title：Annals of the New York Academy of Sciences

authors： Ordin M,Polyanskaya L,Soto D

更新日期：2020-05-01 00:00:00

abstract：:Soluble decoy receptor 3 (DcR3), a member of the tumor necrosis factor receptor superfamily, has recently been reported to increase osteoclast (OC) differentiation. Its impact on the skeleton was reinforced by a study on DcR3 transgenic mice showing a decreased bone mass through the elevation of OC number, providing s...

journal_title：Annals of the New York Academy of Sciences

authors： Brunetti G,Oranger A,Mori G,Centonze M,Colaianni G,Rizzi R,Liso V,Zallone A,Grano M,Colucci S

更新日期：2010-03-01 00:00:00

abstract：:GEM 231 is a second-generation antisense oligonucleotide targeted against the RIalpha regulatory subunit of cAMP-dependent protein kinase type I (PKA-I). Excessive expression of PKA-I is associated with cell proliferation and transformation, and increased levels of secreted extracellular PKA (ECPKA) are found in the s...

journal_title：Annals of the New York Academy of Sciences

authors： Mani S,Goel S,Nesterova M,Martin RM,Grindel JM,Rothenberg ML,Zhang R,Tortora G,Cho-Chung YS

更新日期：2003-12-01 00:00:00

abstract：:This study explores the mechanisms dominating the regulation of the biochemical energy consumption and the mechanical output of the actin-myosin motor units, the crossbridges (Xbs), in the cardiac sarcomere. Our analytical model, which couples Xbs cycling dynamics with the kinetics of the free Ca(2+) binding to tropon...

journal_title：Annals of the New York Academy of Sciences

authors： Landesberg A,Levy C,Yaniv Y,Sideman S

更新日期：2004-05-01 00:00:00

abstract：:The term sepsis describes a potentially lethal clinical condition that develops as a result of a dysregulated host response to bacterial infection. The most common bacterial component implicated in initiating the septic syndrome is a cell wall molecule derived from Gram-negative bacteria, known as lipopolysaccharide (...

journal_title：Annals of the New York Academy of Sciences

authors： Bosshart H,Heinzelmann M

更新日期：2007-01-01 00:00:00

abstract：:The data from our study indicate that the magnitude of occupational disease in New York State is considerable, and that a detailed and comprehensive plan must be initiated and implemented if occupational disease is to be controlled. New York State contains slightly less than 10% of the nation's workforce. A direct lin...

journal_title：Annals of the New York Academy of Sciences

authors： Landrigan PJ,Markowitz S

更新日期：1989-01-01 00:00:00

abstract：:The therapeutic value of thymectomy for myasthenia is still questioned although it retains an important place among management modalities that strive for sustained remission. Questions derive from uncertainty as to appropriate timing, variable extent of resection and quantitation of response. Forty-seven patients, fol...

journal_title：Annals of the New York Academy of Sciences

authors： Penn AS,Jaretzki A 3rd,Wolff M,Chang HW,Tennyson V

更新日期：1981-01-01 00:00:00

abstract：:To identify factors regulating neurogenesis and programmed cell death in mouse olfactory epithelium (OE), and to determine the mechanisms by which these factors act, we have studied mouse OE using two major experimental paradigms: tissue culture of embryonic OE and cell types isolated from it; and ablation of the olfa...

journal_title：Annals of the New York Academy of Sciences

authors： Calof AL,Rim PC,Askins KJ,Mumm JS,Gordon MK,Iannuzzelli P,Shou J

更新日期：1998-11-30 00:00:00

abstract：:Studies in humans and in animal models have demonstrated that the receptor-dependent actions of 1,25-dihydroxyvitamin D are required for normal skeletal growth and maturation. Investigations were undertaken to address which consequences of vitamin D receptor deficiency are a direct result of impaired receptor-dependen...

journal_title：Annals of the New York Academy of Sciences

authors： Demay MB

更新日期：2006-04-01 00:00:00

abstract：:Coccidioides causes coccidioidomycosis in the southwestern United States. Its clinical manifestations range from the primary asymptomatic to progressive pulmonary and extrapulmonary disease. Because of endemicity, frequent relapse, and virulent nature of Coccidioides, there is an urgent need for the development of eff...

journal_title：Annals of the New York Academy of Sciences

authors： Awasthi S

更新日期：2007-09-01 00:00:00

abstract：:Using a newly developed algorithm in conjunction with the front tracking scheme, we have evaluated the transport associated with a deformable bubble moving in a tube in the presence of a soluble or an insoluble surfactant. Such evaluations are useful to the understanding of gas embolism--a common syndrome for decompre...

journal_title：Annals of the New York Academy of Sciences

authors： Ayyaswamy PS,Zhang J,Eckmann DM

更新日期：2006-09-01 00:00:00

abstract：:tRNA prepared from cells of E. coli B that had been incubated with 0.5% DL-ethionine (Ethio sRNA) was found to accept methyl groups from 14CH3-S-adenosyl-methionine in the enzymatic reaction catalyzed in vitro by tRNA methyl transferases from untreated cells of the same organism. tRNA from cells that were not exposed ...

journal_title：Annals of the New York Academy of Sciences

authors： Wainfan E,Maschio FA

更新日期：1975-08-08 00:00:00

abstract：:Bacterial protein, staphylocoagulase, binds stoichiometrically to human prothrombin resulting in a coagulant complex, staphylothrombin. The enzymatic properties of staphylothrombin differ from those of alpha-thrombin in their substrate specificities toward natural and synthetic substrates, in addition to their interac...

journal_title：Annals of the New York Academy of Sciences

authors： Kawabata S,Morita T,Miyata T,Kaida S,Igarashi H,Iwanaga S

更新日期：1986-01-01 00:00:00

abstract：:After nearly a century of inquiry, the cause of Alzheimer's disease (AD) remains to be found. In this review, basic and clinical evidence is presented that assembles and hypothetically explains most of the key pathologic events associated with the development of AD. These pathologic events are triggered in AD by impai...

journal_title：Annals of the New York Academy of Sciences

authors： de la Torre JC

更新日期：2000-01-01 00:00:00

abstract：:Recognizing the self-activity of matter through complexification can lead to seeing evolution as a process of union. This process approach emphasizes a metaphysics of becoming rather than of being. Advances in the science of thermodynamics lead to understanding chemical self-organization as a stage in this process of ...

journal_title：Annals of the New York Academy of Sciences

authors： Salmon JF

更新日期：2003-05-01 00:00:00

abstract：:Over the past two decades, many clinical trials have been conducted using different forms of estrogen therapy with and without progestin supplementation in an effort to treat diagnosed Alzheimer's disease. Design variations among these trials may account for the inconsistent results of these investigations and the per...

journal_title：Annals of the New York Academy of Sciences

authors： Mulnard RA

更新日期：2005-06-01 00:00:00

abstract：:It has been proposed that spacetime should be regarded as an evolving block universe, bounded to the future by the present time, which continually extends to the future. This future boundary is defined at each time by measuring proper time along Ricci eigenlines from the start of the universe. A key point, then, is th...

journal_title：Annals of the New York Academy of Sciences

authors： Ellis GF

更新日期：2014-10-01 00:00:00

abstract：:Present information technologies use semiconductor devices and magnetic/optical disks; however, they are all foreseen to face fundamental limitations within a decade. Therefore, superceding devices are required for the next paradigm of high-performance information technologies. The paper first describes architectures ...

journal_title：Annals of the New York Academy of Sciences

authors： Wada Y

更新日期：2002-04-01 00:00:00