Targeting bacterial endotoxin: two sides of a coin.

abstract：:Our recent work shows that in addition to pumping ions, Na/K-ATPase acts as a signal transducer. Binding of ouabain to Na/K-ATPase changes the interaction of the enzyme with neighboring membrane proteins and induces the formation of multiple signaling modules, resulting in activation of Src, transactivation of the EGF...

journal_title：Annals of the New York Academy of Sciences

authors： Xie Z

更新日期：2003-04-01 00:00:00

abstract：:Calcium-dependent activator protein for secretion (CAPS) was initially identified in brain cytosol based on its ability to reconstitute calcium-triggered dense-core vesicle (DCV) exocytosis in permeable cell lines (PC12) of adrenal chromaffin origin. Current evidence indicates that CAPS functions selectively in DCV ex...

journal_title：Annals of the New York Academy of Sciences

authors： Wassenberg JJ,Martin TF

更新日期：2002-10-01 00:00:00

abstract：:One of the richest reservoirs of antibiotic-resistant bacteria and genes, animal intestinal microbiota contributes to the spread of antibiotic resistance in the environment and, potentially, to human pathogens. Both culture-based genomic technology and culture-independent metagenomics have been developed to investigat...

journal_title：Annals of the New York Academy of Sciences

authors： Su JQ,Cui L,Chen QL,An XL,Zhu YG

更新日期：2017-01-01 00:00:00

abstract：:We have evaluated the performance of a novel line-blot immunoassay (LIA; Mikrogen) and compared results with those obtained by CIE (in-house), ELISA (Pharmacia Diagnostics), and FEIA (Pharmacia Diagnostics). Sera from systemic lupus erythematosus (SLE) patients (n = 123), systemic sclerosis patients (n = 25), and heal...

journal_title：Annals of the New York Academy of Sciences

authors： Damoiseaux J,Boesten K,Giesen J,Austen J,Tervaert JW

更新日期：2005-06-01 00:00:00

abstract：:Sexual dimorphism is a well-documented phenomenon that is observed at all levels of the animal kingdom. Historically, sex hormones (testosterone and estrogen) have been implicated as key players in a wide array of pathologies displaying sexual dimorphism in their etiology and progression. While these hormones clearly ...

journal_title：Annals of the New York Academy of Sciences

authors： Quinn M,Ramamoorthy S,Cidlowski JA

更新日期：2014-05-01 00:00:00

abstract：:Mechanisms governing gene expression and regulation in eukaryotes are remarkably complex. The results from in vivo transgenic and in vitro transfection studies designed to identify cis-element(s) and trans-factor(s) associated with the salivary proline-rich proteins (PRPs) gene expression are utilized as a paradigm to...

journal_title：Annals of the New York Academy of Sciences

authors： Ann DK,Lin HH

更新日期：1998-04-15 00:00:00

abstract：:Humans can discriminate whether a change in the direction of gravito-inertial force (GIF) is caused by body tilt or by linear translation. This ability, attributed to vestibular sensory fusion, is often examined by asking subjects to adjust an indicator to match their subjective earth-fixed vertical (SV). We used two ...

journal_title：Annals of the New York Academy of Sciences

authors： Guenther AL,Bartl K,Nauderer J,Schneider E,Huesmann A,Brandt T,Glasauer S

更新日期：2009-05-01 00:00:00

abstract：:Auditory stimulation via rhythmic cues can be used successfully in the rehabilitation of motor function in patients with motor disorders. A prototypical example is provided by dysfunctional gait in patients with idiopathic Parkinson's disease (PD). Coupling steps to external rhythmic cues (the beat of music or the sou...

journal_title：Annals of the New York Academy of Sciences

authors： Bella SD,Benoit CE,Farrugia N,Schwartze M,Kotz SA

更新日期：2015-03-01 00:00:00

abstract：:Gastrointestinal peptides play important roles regulating feeding and energy homeostasis. Most gastrointestinal peptides including glucagon like peptide-1, peptide YY, amylin, and oxytomodulin are anorectic, and only ghrelin is an orexigenic peptide. Ghrelin increases appetite, modulates energy balance, suppresses inf...

journal_title：Annals of the New York Academy of Sciences

authors： Ueno H,Shiiya T,Nakazato M

更新日期：2010-07-01 00:00:00

abstract：:The constitution of platelet-fibrin(ogen) contacts, the separation of the platelets initially aggregated, and the rearrangement of the platelet cytoskeleton during clot formation (0.5 to 60 minutes after thrombin stimulation) were investigated using ultrastructural and immunocytochemical techniques. After aggregation,...

journal_title：Annals of the New York Academy of Sciences

authors： Morgenstern E,Daub M,Dierichs R

更新日期：2001-01-01 00:00:00

abstract：:To develop new treatments for beta-thalassemia, it is essential to identify the genes involved in the relevant pathophysiological processes. Iron metabolism in thalassemia mice being investigated, focusing on the expression of a gene called hepcidin (Hamp), which is expressed in the liver and whose product (Hamp) is s...

journal_title：Annals of the New York Academy of Sciences

authors： Breda L,Gardenghi S,Guy E,Rachmilewitz EA,Weizer-Stern O,Adamsky K,Amariglio N,Rechavi G,Giardina PJ,Grady RW,Rivella S

更新日期：2005-01-01 00:00:00

abstract：:Pathogenesis of endometriosis involves growth factors, which are synthesized locally. Insulin-like growth factor-1 (IGF-1) prevents apoptosis and has mitogenic action on endometrial cells. The IGF-1 gene undergoes alternative splicing and results in three isoforms (IGF-1Ea, IGF-1Eb, and IGF-1Ec or MGF). We analyzed th...

journal_title：Annals of the New York Academy of Sciences

authors： Milingos D,Katopodis H,Milingos S,Protopapas A,Creatsas G,Michalas S,Antsaklis A,Koutsilieris M

更新日期：2006-12-01 00:00:00

abstract：:How can a psychoanalyst account for and recount the process of understanding the therapeutic endeavor? What happens in those moments, co-created by patient and analyst, when the consultation room comes "alive" in ways that defy easy or simplistic answers? How does an analyst come to understand psychoanalytic treatment...

journal_title：Annals of the New York Academy of Sciences

authors： Gotthold JJ

更新日期：2009-04-01 00:00:00

abstract：:Long-term changes in catecholamine levels and expression of their biosynthetic enzymes are associated with several stress-related disorders such as elevated plasma norepinephrine in posttraumatic stress disorder and increased postmortem tyrosine hydroxylase in the locus coeruleus with major depression. Stress elevates...

journal_title：Annals of the New York Academy of Sciences

authors： Sabban EL,Hebert MA,Liu X,Nankova B,Serova L

更新日期：2004-12-01 00:00:00

abstract：:Posttraumatic stress disorder (PTSD) is typically accompanied by both acute and chronic alterations in the stress response. These alterations have mostly been described in individuals under baseline conditions, but studies have also used a challenge model to assess the role of the hypothalamic-pituitary-adrenal (HPA) ...

journal_title：Annals of the New York Academy of Sciences

authors： Vermetten E,Vythilingam M,Schmahl C,DE Kloet C,Southwick SM,Charney DS,Bremner JD

更新日期：2006-07-01 00:00:00

abstract：:The characterization of the molecular mechanisms involved in low-oxygen chemotransduction has been an active field of research since the first description of an oxygen-sensitive K(+) channel in rabbit carotid body (CB) chemoreceptor cells. As a result, a large number of components of the transduction cascade, from O(2...

journal_title：Annals of the New York Academy of Sciences

authors： Gonzalez C,Vaquero LM,López-López JR,Pérez-García MT

更新日期：2009-10-01 00:00:00

abstract：:The airway disease termed asthma has been recognized for centuries but is now receiving increased attention because of chronicity, high incidence in the population and rising mortality rate. Asthma is now recognized as a disease of unknown etiology characterized by a hyperactive airway which can be demonstrated by res...

journal_title：Annals of the New York Academy of Sciences

authors： Patterson R,Greenberger PA

更新日期：1991-01-01 00:00:00

abstract：:3-Nitropropionic acid (3-NPA) is a model mitochondrial inhibitor that causes selective neurodegeneration in brain. 3-NPA-induced neurodegeneration occurs via a secondary neurotoxicity, caused initially by ATP depletion and redox changes in the cell. It is known that the hippocampal degeneration caused by mitochondrial...

journal_title：Annals of the New York Academy of Sciences

authors： Przybyla-Zawislak BD,Thorn BT,Ali SF,Dennis RA,Amato A,Virmani A,Binienda ZK

更新日期：2005-08-01 00:00:00

abstract：:Vaccinia virus encodes secretory proteins termed virokines. One of the major virokines encoded by the N1L open reading frame is the 13.8 kDa protein. A recombinant virus, termed vGK5, lacking this protein when injected intracranially into mice, has one of the highest levels of in vivo attenuation achieved by deletion ...

journal_title：Annals of the New York Academy of Sciences

authors： Billings B,Smith SA,Zhang Z,Lahiri DK,Kotwal GJ

更新日期：2004-12-01 00:00:00

abstract：:The quest for new control strategies for ticks can profit from high throughput genomics. In order to identify genes that are involved in oogenesis and development, in defense, and in hematophagy, the transcriptomes of ovaries, hemocytes, and salivary glands from rapidly ingurgitating females, and of salivary glands fr...

journal_title：Annals of the New York Academy of Sciences

authors： Santos IK,Valenzuela JG,Ribeiro JM,de Castro M,Costa JN,Costa AM,da Silva ER,Neto OB,Rocha C,Daffre S,Ferreira BR,da Silva JS,Szabó MP,Bechara GH

更新日期：2004-10-01 00:00:00

abstract：:With the progressive aging of the world's population, immunosenescence is rapidly becoming a clinical concern as it accounts for a higher incidence of severe infections and poor response to vaccines. To identify nutritional approaches that may counteract immunosenescence is of obvious importance in clinical practice. ...

journal_title：Annals of the New York Academy of Sciences

authors： Freeman SL,Fisher L,German JB,Leung PS,Prince H,Selmi C,Naguwa SM,Gershwin ME

更新日期：2010-03-01 00:00:00

abstract：:The objective of this study was to visualize androgen receptors (ARs) in the testis, epididymis, and prostate of the stallion by means of immunohistochemistry. Nuclear immunostaining was found in all somatic cells in the testis--Leydig, Sertoli, and peritubular myoid cells; in both types of epithelial cells of the epi...

journal_title：Annals of the New York Academy of Sciences

authors： Bilinska B,Hejmej A,Gancarczyk M,Sadowska J

更新日期：2005-04-01 00:00:00

abstract：:We have employed antisense methods to study the transcriptional functions of c-fos protein (Fos). Clones expressing inducible anti-fos RNA have been employed to inhibit c-fos expression, resulting in activation of c-fos transcription by inhibiting its normal repressor function. The sites of negative regulation by Fos ...

journal_title：Annals of the New York Academy of Sciences

authors： Holt JT

更新日期：1992-10-28 00:00:00

abstract：:Adult (3-month-old) and aged (28-month-old) rats that had been pretreated with 5,7-DHT in both lateral ventricles received grafts of cell suspensions taken from the RR or MR regions taken from the embryonic stages E12-21. These cell suspensions were implanted unilaterally into the rostral part of the hippocampus or th...

journal_title：Annals of the New York Academy of Sciences

authors： Steinbusch HW,Beek A,Frankhuyzen AL,Tonnaer JA,Gage FH,Björklund A

更新日期：1987-01-01 00:00:00

abstract：:Astrocytes and serotoninergic neurons play a role in central nervous system (CNS) development, probably through serotonin (5HT) stimulation of the glial 5HT(1A) receptor. Activation of 5HT(1A) receptors causes the release of S-100 beta, a glial derived growth factor. In vitro, astrocytes are profoundly altered by chro...

journal_title：Annals of the New York Academy of Sciences

authors： Ramos AJ,Evrard SG,Tagliaferro P,Tricárico MV,Brusco A

更新日期：2002-06-01 00:00:00

abstract：:Although the hippocampus expresses nicotinic acetylcholine receptors (nAChRs) and receives cholinergic innervation, the functional roles of these receptors are not completely understood. Our results indicated that presynaptic nAChRs mediated a calcium influx that enhanced the release of both glutamate and GABA. Fura-2...

journal_title：Annals of the New York Academy of Sciences

authors： Radcliffe KA,Fisher JL,Gray R,Dani JA

更新日期：1999-04-30 00:00:00

abstract：:Scleroderma renal crisis (SRC) is a major complication in patients with systemic sclerosis (SSc). SRC occurs during the first 4 years of disease evolution in more than 75% of the cases, almost exclusively in patients with diffuse SSc. Other risk factors, including preceding corticosteroid therapy, have been associated...

journal_title：Annals of the New York Academy of Sciences

authors： Teixeira L,Mahr A,Berezné A,Noël LH,Guillevin L,Mouthon L

更新日期：2007-06-01 00:00:00

abstract：:Flow cytometry was used to separate Xenopus melanotrope cells according to their size. The cells were then submitted to real-time RT-PCR to determine the level of POMC-gene expression. The results show a positive correlation between cell size and gene expression for cells from black-background (but not white-backgroun...

journal_title：Annals of the New York Academy of Sciences

authors： Corstens GJ,Roubos EW,Jenks BG,Van Erp PE

更新日期：2005-04-01 00:00:00

abstract：:This volume provides a small sampling of the rapidly growing science of cancer immunology. Growth in the field includes advances on the requirements for immunization or vaccination and the ways in which immunity can be suppressed or blocked, including active tumor-based mechanisms. I would like to introduce the papers...

journal_title：Annals of the New York Academy of Sciences

authors： Steinman RM

更新日期：2009-09-01 00:00:00

abstract：:Adult animals that had been subjected to a single prolonged episode of maternal deprivation (MD) [24 h, postnatal day (PND) 9-10] show long-term behavioral alterations that resemble specific symptoms of schizophrenia. Moreover, at adolescence MD rats showed depressive-like behavior and altered motor responses. Accordi...

journal_title：Annals of the New York Academy of Sciences

authors： De la Fuente M,Llorente R,Baeza I,De Castro NM,Arranz L,Cruces J,Viveros MP

更新日期：2009-02-01 00:00:00