Polyphenols in red wines prevent NADH oxidation induced by peroxynitrite.

Abstract:

:It is known that red wines have antioxidant properties owing to the presence of polyphenols and hydroxycinnamates. It has been reported that these compounds are efficient scavengers of peroxynitrite (ONOO(-)). We assayed the ONOO(-)-scavenging activity of plant polyphenols, hydroxycinnamates, and red wines using a fluormetric assay that involves the participation of ONOO(-) (200 microM) as oxidant and NADH (50-100 microM) as a target molecule. NADH oxidation was prevented by pure polyphenols and hydroxycinnamates. With the wines, the Cabernet Sauvignon showed more potent ONOO(-)-scavenging ability than the Malbecs and the blended wines. These results correlate well with the total phenol content determined by Folin-Ciocalteau assay.

journal_name

Ann N Y Acad Sci

authors

Valdez LB,Actis-Goretta L,Boveris A

doi

10.1111/j.1749-6632.2002.tb02924.x

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

274-8

eissn

0077-8923

issn

1749-6632

journal_volume

957

pub_type

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