Abstract:
:Imatinib is a selective tyrosine kinase inhibitor used for the treatment of Philadelphia chromosome-positive leukemias and other malignancies. An important clinical observation is that imatinib can affect the function of normal nonmalignant cells resulting in myelosuppression in treated patients. This observation is supported by the recent findings suggesting that imatinib might affect mobilization, proliferation, and differentiation of hematopoietic progenitor cells while leaving hematopoietic stem cells unaffected. Furthermore, the induction of a specific T cell response seems to be impaired in chronic myeloid leukemia (CML) patients treated with imatinib in contrast to patients receiving interferon-alpha. Recent studies demonstrate that in vitro exposure of mobilized human CD34(+) progenitors to imatinib inhibits their differentiation into dendritic cells. This is of importance as some of the therapeutic effects in the treatment of patients with CML are mediated by the induction of leukemia-specific T cell responses. Studies investigating the effects of imatinib on normal hematopoiesis are of interest because they might help us better understand the side effects observed clinically and might lead to the identification of novel therapeutic applications of the drug (e.g., in Bcr-Abl(-) myeloproliferative disorders and potentially as an immunomodulatory agent).
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Balabanov S,Appel S,Kanz L,Brossart P,Brümmendorf THdoi
10.1196/annals.1349.022subject
Has Abstractpub_date
2005-06-01 00:00:00pages
168-77eissn
0077-8923issn
1749-6632pii
1044/1/168journal_volume
1044pub_type
杂志文章,评审abstract::The perceptions of coccidioidomycosis as a medical problem has undergone sequential and dramatic metamorphoses since its first description more than a century ago. First thought to be rare and lethal, coccidioidomycosis was subsequently found to be common and often mild. During World War II, its overall impact upon la...
journal_title:Annals of the New York Academy of Sciences
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abstract::Rodent models have been used for many years to probe the actions of relaxin. Identification of the orthologs of human leucine-rich repeat-containing g-protein-coupled receptor 7 (LGR7), the relaxin receptor, in mouse and rat will enable characterization of the response of LGR7 to relaxin in these species. Partial LGR7...
journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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abstract::Posttraumatic stress disorder (PTSD) is typically accompanied by both acute and chronic alterations in the stress response. These alterations have mostly been described in individuals under baseline conditions, but studies have also used a challenge model to assess the role of the hypothalamic-pituitary-adrenal (HPA) ...
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,meta分析,评审
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journal_title:Annals of the New York Academy of Sciences
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doi:
更新日期:2000-01-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
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更新日期:1992-12-31 00:00:00
abstract::Modern neurostimulation approaches in humans provide controlled inputs into the operations of cortical regions, with highly specific behavioral consequences. This enables causal structure-function inferences, and in combination with neuroimaging, has provided novel insights into the basic mechanisms of action of neuro...
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pub_type: 杂志文章,评审
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更新日期:2003-12-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
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abstract::Since his presidency of the Carnegie Corporation of New York and co-chairmanship of the Carnegie Commission on Preventing Deadly Conflict, David Hamburg has been actively engaged in projects related to the prevention of genocide and other mass violence. In these remarks to the Association for Research in Nervous and M...
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journal_title:Annals of the New York Academy of Sciences
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