Impairing the mitochondrial fission and fusion balance: a new mechanism of neurodegeneration.

abstract：:Patients with systemic lupus erythematosus (SLE) have an increased incidence of vascular disease, and oxidative stress is recognized as an important feature in this condition, despite the underlying mechanisms not being fully understood. In these patients, an interaction between lipoproteins and the immune system has ...

journal_title：Annals of the New York Academy of Sciences

authors： Batuca JR,Ames PR,Isenberg DA,Alves JD

更新日期：2007-06-01 00:00:00

abstract：:Many autoimmune diseases are chronic conditions that progress over the course of years, and are characterized by the presence of autoantibodies that precede the overt disease by months or years. As examples, the presence of two islet cell antibodies (ICA) are associated with a 50% risk of developing diabetes mellitus ...

journal_title：Annals of the New York Academy of Sciences

authors： Harel M,Shoenfeld Y

更新日期：2006-06-01 00:00:00

abstract：:Over most of the past century, it was thought that the adult brain was completely incapable of generating new neurons. However, in the last decade, the development of new techniques has resulted in an explosion of new research showing that (i) neurogenesis, the birth of new neurons, is not restricted to embryonic deve...

journal_title：Annals of the New York Academy of Sciences

authors： Arlotta P,Magavi SS,Macklis JD

更新日期：2003-06-01 00:00:00

abstract：:This study examined the functional response to human relaxin 2 (H2 relaxin), human relaxin 3 (H3 relaxin), porcine relaxin, and human INSL3 in the cytosensor microphysiometer, using CHO-K1 cells stably expressing human GPCR135. CHO-K1 cells stably expressing GPCR135 were generated by the serial dilution method and rec...

journal_title：Annals of the New York Academy of Sciences

authors： Van der Westhuizen ET,Sexton PM,Bathgate RA,Summers RJ

更新日期：2005-05-01 00:00:00

abstract：:In this review we will evaluate evidence that altered gene dosage and structure impacts neurodevelopment and neural connectivity through deleterious effects on synaptic structure and function, and evidence that the latter are key contributors to the risk for autism. We will review information on alterations of structu...

journal_title：Annals of the New York Academy of Sciences

authors： Smith M,Spence MA,Flodman P

更新日期：2009-01-01 00:00:00

abstract：:The relationship between the concentration of cell-free DNA (cfDNA) and the number of proliferating/apoptotic lymphocytes in peripheral blood of premature newborns of different gestation age and full-term newborns was determined. The experiments were performed using fluorescent spectrophotometry (with Hoechst 33342), ...

journal_title：Annals of the New York Academy of Sciences

authors： Tuaeva NO,Abramova ZI,Sofronov VV

更新日期：2008-08-01 00:00:00

abstract：:A new autoimmune disease affecting the neuromuscular junction has been defined. Acquired neuromyotonia is associated with antibodies to voltage-gated potassium channels that act, at least in part, by reducing potassium channel function with resulting neuronal hyperactivity. This condition is quite frequently associate...

journal_title：Annals of the New York Academy of Sciences

authors： Vincent A,Jacobson L,Plested P,Polizzi A,Tang T,Riemersma S,Newland C,Ghorazian S,Farrar J,MacLennan C,Willcox N,Beeson D,Newsom-Davis J

更新日期：1998-05-13 00:00:00

abstract：:Two kinds of active protein fraction, TP1 and TP2, were isolated from bovine thymus extracts. Both these fractions showed a single band in polyacrylamide gel disc electrophoresis. Though these two fractions showed a difference in potency, they both lowered serum calcium in rabbits and increased lymphocytes in mice. Mo...

journal_title：Annals of the New York Academy of Sciences

authors： Mizutani Shimizu M,Suzuki I,Mizutani T,Hayase S,Mizutani A

更新日期：1975-02-28 00:00:00

abstract：:Western lifestyle, characterized by reduced physical activity and a diet rich in fat, refined carbohydrates, and animal protein is associated with high prevalence of overweight, metabolic syndrome, insulin resistance, and high plasma levels of several growth factors and sex hormones. Most of these factors are associat...

journal_title：Annals of the New York Academy of Sciences

authors： Berrino F,Villarini A,De Petris M,Raimondi M,Pasanisi P

更新日期：2006-11-01 00:00:00

abstract：:Mounting evidence suggests that oxidative processes contribute to the pathogenesis of atherosclerosis and that antioxidants may represent a strategy to complement the lowering of lipids in the therapy of this disease. Although multiple molecular events have been identified in vitro and although it is tempting to ascri...

journal_title：Annals of the New York Academy of Sciences

authors： Sigal E,Laughton CW,Mulkins MA

更新日期：1994-04-18 00:00:00

abstract：:Myasthenia gravis (MG) is usually caused by autoantibodies against muscle nicotinic acetylcholine receptor (AChR), which is composed of five subunits (alpha(2)betagammadelta or alpha(2)betaepsilondelta). Current treatments, including plasmapheresis, are nonspecific, causing several side effects. We aim to develop an a...

journal_title：Annals of the New York Academy of Sciences

authors： Tzartos SJ,Bitzopoulou K,Gavra I,Kordas G,Jacobson L,Kostelidou K,Lagoumintzis G,Lazos O,Poulas K,Sideris S,Sotiriadis A,Trakas N,Zisimopoulou P

更新日期：2008-01-01 00:00:00

abstract：:We are performing genomic searches in randomly ascertained families to identify new quantitative trait loci (QTLs) that influence atherosclerosis and its risk factors. The genetic markers used for genomic searches are random microsatellite markers distributed throughout the human chromosomes. These markers are used fo...

journal_title：Annals of the New York Academy of Sciences

authors： Hixson JE,Blangero J

更新日期：2000-05-01 00:00:00

abstract：:We studied 13 patients with unilateral peripheral vestibular lesions following removal of acoustic neurinomas. The time constant of the VOR after surgery was 6.4 +/- 2.6 seconds (normal is 18.5 +/- 7.7 seconds). The time constant of OKAN after surgery was 7.2 +/- 1.8 seconds (normal is 11.3 +/- 3.2 seconds). The mean ...

journal_title：Annals of the New York Academy of Sciences

authors： Hain TC,Zee DS

更新日期：1992-05-22 00:00:00

abstract：:Child maltreatment (CM) not only has detrimental and lifelong psychological consequences, but also can lead to lasting alterations in core physiological systems--a biological memory of CM. Furthermore, some of these alterations might even be transmitted to the next generation. This article describes current knowledge ...

journal_title：Annals of the New York Academy of Sciences

authors： Schury K,Kolassa IT

更新日期：2012-07-01 00:00:00

abstract：UNLABELLED:This article suggests eight high-level concepts that can promote convergence by identifying analogies across fields of science and engineering. CONSERVATION: Many properties are conserved, through symmetries, parity laws, and feedback-regulated stabilities in complex adaptive systems. INDECISION: Inconsisten...

journal_title：Annals of the New York Academy of Sciences

authors： Bainbridge WS

更新日期：2006-12-01 00:00:00

abstract：:We have evaluated the performance of a novel line-blot immunoassay (LIA; Mikrogen) and compared results with those obtained by CIE (in-house), ELISA (Pharmacia Diagnostics), and FEIA (Pharmacia Diagnostics). Sera from systemic lupus erythematosus (SLE) patients (n = 123), systemic sclerosis patients (n = 25), and heal...

journal_title：Annals of the New York Academy of Sciences

authors： Damoiseaux J,Boesten K,Giesen J,Austen J,Tervaert JW

更新日期：2005-06-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) is a 28-amino acid peptide that has several functions, including the regulation of water and electrolyte secretion, hormone and cytokine release, bronchodilitation, and neurogenesis. VIP effects are mediated by specific G-protein coupled receptors. Three distinct receptor subtypes, ...

journal_title：Annals of the New York Academy of Sciences

authors： Karacay B,O'Dorisio MS,Summers M,Bruce J

更新日期：2000-01-01 00:00:00

abstract：:Neocortex is an important part of the mammalian brain that is quite different from its homologue of the dorsal cortex in the reptilian brain. Whereas dorsal cortex is small, thin, and composed of a single layer of neurons, neocortex is thick and has six layers, while being variable across species in size, number of fu...

journal_title：Annals of the New York Academy of Sciences

authors： Kaas JH

更新日期：2011-04-01 00:00:00

abstract：:Science is concerned not just with objects but also with their various aspects, such as their colors, temperatures, sizes, and shapes. These aspects, or properties, are generally thought to be of at least two kinds: primary properties, such as shape, size, and motion and secondary ones, such as temperature and color. ...

journal_title：Annals of the New York Academy of Sciences

authors： Vollmer SH

更新日期：2003-05-01 00:00:00

abstract：:IRAS, a putative clone of the I(1)-imidazoline receptor, possesses a proline-rich region (PRR) motif, which might interact with SH3 regions on tyrosine kinases, and an integrin-binding motif. Receptors with a PRR motif can generally assemble onto multi-element signaling complexes (eg., the beta(3)-receptor on the EGF ...

journal_title：Annals of the New York Academy of Sciences

authors： Musgrave IF,Dehle FC,Piletz J

更新日期：2003-12-01 00:00:00

abstract：:Cancer is a primary public health problem and the second leading cause of death worldwide. It causes life-threatening malignancies and results in high financial costs for both patients and the healthcare system. Hence, it is important to develop effective long-term strategies pertaining to prevention and control of ca...

journal_title：Annals of the New York Academy of Sciences

authors： Ganesan K,Xu B

更新日期：2017-08-01 00:00:00

abstract：:Invasive plants cause substantial economic and environmental damage throughout the world. However, eradication of most invasive species is impossible and, in some cases, undesirable. An alternative is to slow the spread of an invasive species, which can delay impacts or reduce their extent. We identify three main area...

journal_title：Annals of the New York Academy of Sciences

authors： Caplat P,Coutts S,Buckley YM

更新日期：2012-02-01 00:00:00

abstract：:Since the publication of Heinz Kohut's last book in 1984, "self psychology" has become much more diverse in its perspectives and even fragmented in its applications. Perhaps due in large part to Kohut's own inconsistencies and lack of clarity on certain major points of theory and technique, self psychology currently l...

journal_title：Annals of the New York Academy of Sciences

authors： Gehrie MJ

更新日期：2009-04-01 00:00:00

abstract：:The quantitative analysis of nerve growth dynamics is critical to our understanding of nerve development and regeneration, but only recently has a quantitative framework begun to emerge to help define key objectives and to direct experimental measurements towards achieving this goal. Conceptually, the framework center...

journal_title：Annals of the New York Academy of Sciences

authors： Buettner HM

更新日期：1994-11-30 00:00:00

abstract：:Allergic contact dermatitis is a common inflammatory skin disease caused by T cells that recognize environmental and industrial allergens (i.e., haptens). Langerhans' cells (LC), which are skin-specific and "immature" members of the dendritic cell (DC) family of antigen-presenting cells, play crucial roles in the indu...

journal_title：Annals of the New York Academy of Sciences

authors： Takashima A,Mummert M,Kitajima T,Matsue H

更新日期：2000-01-01 00:00:00

abstract：:The constitution of platelet-fibrin(ogen) contacts, the separation of the platelets initially aggregated, and the rearrangement of the platelet cytoskeleton during clot formation (0.5 to 60 minutes after thrombin stimulation) were investigated using ultrastructural and immunocytochemical techniques. After aggregation,...

journal_title：Annals of the New York Academy of Sciences

authors： Morgenstern E,Daub M,Dierichs R

更新日期：2001-01-01 00:00:00

abstract：:Relaxin has been validated as a cardiotropic hormone, being produced by the heart and acting on specific heart receptors. Evidence is accumulating that it could hamper the pathophysiologic mechanisms of ischemic heart disease. Time is ripe to study relaxin as a cardiotropic drug, as recombinant human relaxin (hrRLX) i...

journal_title：Annals of the New York Academy of Sciences

authors： Bani D,Nistri S,Sacchi TB,Bigazzi M

更新日期：2005-05-01 00:00:00

abstract：:The harmful effects of oxidative processes in living organisms, in addition to chemical and biochemical media, can be reduced by antioxidants. The efficacy of an antioxidant depends on its reduction potential and kinetics of elimination of diverse free radicals. Redox potentials and reaction rate constants of selected...

journal_title：Annals of the New York Academy of Sciences

authors： Jovanovic SV,Simic MG

更新日期：2000-01-01 00:00:00

abstract：:The results of this study indicate that the presence of plants did enhance TNT and TNB removal from IAAP groundwater. Most effective at 25 degrees C were reed canary grass, coontail and pondweed. Groundwater and plant tissue analyses indicate that in presence of the plants tested TNT is degraded to reduced by-products...

journal_title：Annals of the New York Academy of Sciences

authors： Best EP,Zappi ME,Fredrickson HL,Sprecher SL,Larson SL,Ochman M

更新日期：1997-11-21 00:00:00

abstract：:During their development, mononuclear phagocytes express a changing profile of proteinases that may participate in the degradation of elastin and other extracellular matrix components. Neutrophil elastase is produced and stored in azurophil-like granules in immature mononuclear phagocytes. Monocytes contain small amou...

journal_title：Annals of the New York Academy of Sciences

authors： Shapiro SD,Campbell EJ,Welgus HG,Senior RM

更新日期：1991-01-01 00:00:00