Abstract:
:Child maltreatment (CM) not only has detrimental and lifelong psychological consequences, but also can lead to lasting alterations in core physiological systems--a biological memory of CM. Furthermore, some of these alterations might even be transmitted to the next generation. This article describes current knowledge about the effects of CM on the stress system (i.e., the hypothalamus-pituitary-adrenal axis), on cellular aging (i.e., telomere length and telomerase activity), and on the immune system. Furthermore, we want to initiate research on the question of transmission of the described physiological alterations subsequent to CM to the next generation--possibly through epigenetic imprinting. As diverse neurobiological factors and epigenetics are closely linked, these different research fields should join forces to gain a deeper understanding of the biological determinants and sequelae of CM and its transmission.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Schury K,Kolassa ITdoi
10.1111/j.1749-6632.2012.06617.xsubject
Has Abstractpub_date
2012-07-01 00:00:00pages
93-100eissn
0077-8923issn
1749-6632journal_volume
1262pub_type
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journal_title:Annals of the New York Academy of Sciences
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