Abstract:
:The relationship between the concentration of cell-free DNA (cfDNA) and the number of proliferating/apoptotic lymphocytes in peripheral blood of premature newborns of different gestation age and full-term newborns was determined. The experiments were performed using fluorescent spectrophotometry (with Hoechst 33342), flow cytometry, and microscopy (Feulgen staining of lymphocytes). It was determined that the lymphocyte population of premature newborns may consist of 4.6% of proliferating and 22.1% apoptotic cells. For full-term newborns, the percentage was 2.5% and 2.9%, respectively. A direct correlation between the concentration of extracellular DNA and the number of proliferating lymphocytes of full-term newborns was ascertained (r= 0.400; P < 0.05). For premature newborns, the concentration of extracellular DNA correlated both with proliferating lymphocytes and apoptotic cells. The results show that premature birth causes the induction in lymphocytes of both apoptosis and proliferation that are accompanied by an increased extracellular DNA concentration in the blood of newborn babies.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Tuaeva NO,Abramova ZI,Sofronov VVdoi
10.1196/annals.1448.043subject
Has Abstractpub_date
2008-08-01 00:00:00pages
27-30eissn
0077-8923issn
1749-6632pii
NYAS1137043journal_volume
1137pub_type
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