Effects of modified low-density lipoproteins on human retinal pericyte survival.

Abstract:

:According to a current paradigm cardiovascular diseases can be initiated by exposure of vascular cells to qualitatively modified low-density lipoproteins (LDL). Capillary leakage, an early feature of diabetic retinopathy, results in the exposure of retinal pericytes to modified LDL, including glycated (G-LDL) and heavily oxidized glycated LDL (HOG-LDL). We demonstrate here that modified LDL inhibits the proliferation and survival of cultured human retinal pericytes. Modified LDL also induced DNA fragmentation in bovine retinal pericytes. Overall, HOG-LDL produced a significantly higher extent of cytotoxicity and apoptosis in retinal pericytes. These results indicate that exposure of pericytes to HOG-LDL could be implicated in the development of diabetic retinopathy.

journal_name

Ann N Y Acad Sci

authors

Song W,Barth JL,Lu K,Yu Y,Huang Y,Gittinger CK,Argraves WS,Lyons TJ

doi

10.1196/annals.1333.045

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

390-5

eissn

0077-8923

issn

1749-6632

pii

1043/1/390

journal_volume

1043

pub_type

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